I've been taking for 3 years two standard Ibuprofen pills when I go to bed as I found that it reduces my getting up at night to urinate from twice to once Several months ago I developed PAC (Premature Atrial Contractions) My doctor ran tests for 24 hours and indicated that the PAC is nothing for me to worry about. Could the continued use of 2 Ibuprofen at night have caused this problem ?