... be anxious and depressed, but after Zoloft, I felt calm, relaxed, and focused. I have been trying to get pregnant and throughout the past 3 months I have reduced my Zoloft dosage down to 25mg. At first, I felt fine, but then in the past two weeks, I've been having extreme mood swings, confusing, and daily panic attacks. I am not pregnant, so I'm thinking it may be zoloft withdrawals. I've lost my appetite, am angry all the time, and just not myself. Does anyone have experience/advice about this?