I was slowly increased to .6mg. IGF-1 level now 168 from before where it was 80-100 on .2 and .4 mg. I am a 48yr old female with a TBI diagnosed with AGHD. Felt better for awhile. Able to get through errands and the day with more energy and positive outlook. Now I am back to being tired and not having energy, depressed, no interests. Can a person become "resistant" to the effects of Genotropin and require a higher dose?