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What is the systemic clearance of Tramadol 50 mg?

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masso 1 May 2016

Medical literature indicates that Tramadol’s elimination half-life is around 6.3 hours.

With this information we can estimate that upon complete cessation of Tramadol, it’ll stay in your system for approximately 1.44 days. Despite the fact that Tramadol should be out of your system within 48 hours after your last dose, it is necessary to consider that its primary metabolite “O-desmethyltramadol” (M1) has a longer half-life of 7.4 hours. For complete systemic elimination of Tramadol and its O-desmethyltramadol (M1) metabolite, it’ll take around 1.7 days.

Hepatic + Renal function: Tramadol is extensively metabolized by enzymes within the liver and processed by the kidneys prior to excretion. Should an individual exhibit hepatic impairment, the elimination half-life of Tramadol may increase. In other words, it may take longer for the liver to “break down” the drug and its metabolites as a result of its impaired function.

This may result in heightened levels of Tramadol circulating throughout the body, taking longer to eliminate. To a lesser extent, a person’s renal function will also affect excretion of Tramadol. Someone with suboptimal kidney performance may excrete the drug at a slower rate (with less efficiency) compared to those with normative renal function.

Source: ncbi.nlm.nih.gov/pubmed/14650359

Delila 2 May 2016

Great answer Masso!

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