I had been taking synthroid for the past 20 years when in May of 2011 it started causing severe stomach issues. I have been in mexedema more times than I care to count, I could tolerate it for a few months then have to stop a while which then sends me into mexedema restart and do it all over. My tsh is currently 203 my t3 is .21 but now everytime I start the pills I get so ill I have to stop again. Does anyone have any suggestions? I have tried every pill from armour to synthroid and levothyroxine causes headaches and heart palpitations so severe I cannot function. Is there an injectable formula anyone knows about to avoid the gastrointestinal issue?