I took Sulfamethoxazole/trimethoprim for moderate ance for a 6 month period, then went off for 4 months, but my acne became severe after going off. So I went back on and after about 4 months, my skin cleared up again. My doctor recently switched me to Doxycycline for acne instead of Sulfamethoxazole/trimethoprim because the sulpha is not supposed to be used as a long term medication. I've only been on the Doxy for a week now but have noticed a few small bumps showing up. Does anyone have experience with switching from sulpha to doxy? Should I expect to see acne come back before it improves? And is it possible to take the sulpha with the doxy until the doxy starts working in order to avoid unwanted acne and breakouts?