I suffer from major depression, anxiety and mood disorder and have been on Lamictal 200mg for 7 years. I did take anti depressants on and off over this period and never really found one that I felt comfortable with. Last year I was put on moclobomide which has helped tremendously for anxiety ( i no longer suffer) but its doing NOTHING for depression. I need to change this drug and am considering either Lexapro or Effexor. Was wondering if anyone has weened off moclobomide for Lexapro and the effect on depression. I'm making no change with Lamictal