Hello, I live in England and a very popular drug for depression is Ciprelex which I have been taking for 5 years, trouble is I work out a lot and the drug has now stopped working! And I have put on 2 stone in weight!! My doctor recommended Prozac as a replacement antidepressant, how do you switch from one to another? Without side effects? I must say that Ciprelex has been great for anxiety and depression, but boy the the weight gain is terrible and the fatigue is just to much to bear. Would love to hear other peoples opinions on Prozac, I do have bipolar 2 and have never taken a mood stabiliser as I use exercise instead.