The determination of an appropriate dose to be administered is partly a medical determination, made by the prescribing physician, and partly the result of scientific testing and development by the manufacturer of the product. Before a drug may be marketed in most countries of the world, the drug and its anticipated effect on the body must be tested, using human subjects. The investigative process is generally referred to as the clinical trial, or the clinical study, of the drug in question
The clinical trial begins with experimental testing that, if successful, will lead to preclinical testing with animals, to assess the effect on live subjects. If the preclinical testing shows sufficient promise, three stages of clinical tests will be conducted: one, to ascertain safe human use; two, the sampling of a broader range of human subjects; and three, to expand the human subject range and to finalize dosages to be recommended.
(Paracetamol is referred to acetaminophen in the US)
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Posted 24 Aug 2009 • 1 answer
Posted 12 Oct 2011 • 1 answer
Posted 26 Jan 2012 • 2 answers
Posted 29 May 2012 • 1 answer
Posted 30 Dec 2012 • 1 answer