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FDA Approves Intrarosa (prasterone) for Postmenopausal Women Experiencing Dyspareunia

Posted 16 days ago by Drugs.com

November 17, 2016 – The U.S. Food and Drug Administration approved Intrarosa (prasterone) to treat women experiencing moderate to severe pain during sexual intercourse (dyspareunia), a symptom of vulvar and vaginal atrophy (VVA), due to menopause. Intrarosa is the first FDA approved product containing the active ingredient prasterone, which is also known as dehydroepiandrosterone (DHEA). During menopause, levels of estrogen decline in vaginal tissues, which may cause a condition known as VVA, leading to symptoms such as pain during sexual intercourse. “Pain during sexual intercourse is one of the most frequent symptoms of VVA reported by postmenopausal women,” said Audrey Gassman, M.D., deputy director of the Division of Bone, Reproductive, and Urologic Products (DBRUP) in the Office of Drug Evaluation III in the FDA’s Center for Drug Evaluation and Research (CDER). “Intrarosa provide ... Read more

Related support groups: Menopausal Disorders, Postmenopausal Symptoms, Dyspareunia, Intrarosa, Vaginal Dryness, Prasterone

Intarosa Approved for Post-Menopausal Pain During Sex

Posted 17 Nov 2016 by Drugs.com

THURSDAY, Nov. 17, 2016 – Intarosa has been approved by the U.S. Food and Drug Administration to treat women who have moderate-to-severe pain during sexual intercourse caused by post-menopausal vulvar and vaginal atrophy (VVA). As the FDA explained, during menopause estrogen levels can decline in vaginal tissues, leading to VVA. The product, contained in a once-daily insert, is the first approved to include the active ingredient prasterone, also known as dehydroepiandrosterone (DHEA), the agency said Thursday in a news release. The product's effectiveness was established in two 12-week clinical trials involving 406 post-menopausal women, aged 40 to 80. The most common adverse reactions included vaginal discharge and abnormal Pap smear, a test used to detect cervical cancer. DHEA is contained in some dietary supplements, although the FDA said it hasn't evaluated the safety and ... Read more

Related support groups: Menopausal Disorders, Postmenopausal Symptoms, Atrophic Vaginitis, DHEA, Dyspareunia, Vaginal Dryness, Dehydroepiandrosterone

Sexual Pain for Women With Cancer Should Not Be Overlooked: Report

Posted 11 Nov 2016 by Drugs.com

FRIDAY, Nov. 11, 2016 – Painful sex is common, though often treatable, in women with cancer, yet doctors often overlook it, researchers say. "Sexual pain is often written off as 'in people's heads,' but it is more often a result of physical issues that can be helped," said Dr. Vanessa Kennedy, an assistant professor of gynecologic oncology at the University of California, Davis, Health System. "It is important to be able to have the conversation comfortably and to know how to address the common issues that are often predictable, depending on a patient's treatment course," she said in a university news release. In their review paper, Kennedy and co-author Dr. Deborah Coady, from NYU Langone Medical Center, outlined several causes of painful sex in women with cancer, and listed treatments such as surgery, chemotherapy, radiation and hormone therapy. A low estrogen level is most often to ... Read more

Related support groups: Cancer, Menopausal Disorders, Postmenopausal Symptoms, Atrophic Vaginitis, Perimenopausal Symptoms, Dyspareunia, Hypoestrogenism, Vaginal Dryness

Memory Can Fade After Menopause

Posted 9 Nov 2016 by Drugs.com

WEDNESDAY, Nov. 9, 2016 – Middle-aged women can remember more than men their own age, but new research suggests that memory may fade as estrogen levels drop during menopause. Memory loss is a common age-related complaint, affecting up to 75 percent of older people, the study's authors explained. The researchers noted that many women going through menopause report being more forgetful, though they still outperform men on memory tests. "Brain fog and complaints of memory issues should be taken seriously," said Dr. JoAnn Pinkerton, executive director of the North American Menopause Society (NAMS). "This study and others have shown that these complaints are associated with memory deficits," she said in a society news release. The study by Harvard Medical School researchers was led by Jill Goldstein, a professor of psychiatry and medicine. It included 212 men and women, between 45 and 55 ... Read more

Related support groups: Hot Flashes, Menopausal Disorders, Postmenopausal Symptoms, Atrophic Vaginitis, Mild Cognitive Impairment, Perimenopausal Symptoms, Dyspareunia, Atrophic Urethritis, Vaginal Dryness, Premenopausal Anovulation

Menopause and a Decline in Intimacy

Posted 2 Nov 2016 by Drugs.com

WEDNESDAY, Nov. 2, 2016 – Women might say "not tonight, dear" a lot more often in the year and a half before their final period, a new study finds. Sexual decline typically starts 20 months before a woman's final period and continues for several years after menstruation ends, the study authors reported. The researchers analyzed data from nearly 1,400 U.S. women at midlife, and also found that menopause-related declines in sexual function can vary according to race and ethnicity. A diminishing sex life is a serious issue, the researchers said, noting three-quarters of study participants said sex was moderately to extremely important to them. "This study highlights the need for health-care providers to have open conversations with their patients about their sexual issues, because there are many options for women to help maintain or improve their sexual lives as they transition to and ... Read more

Related support groups: Depression, Anxiety, Anxiety and Stress, Major Depressive Disorder, Hot Flashes, Menopausal Disorders, Postmenopausal Symptoms, Atrophic Vaginitis, Perimenopausal Symptoms, Dyspareunia, Sexual Deviations or Disorders, Hypoactive Sexual Desire Disorder, Vaginal Dryness

For Many Women, Sex Gets Better at Midlife

Posted 5 Oct 2016 by Drugs.com

WEDNESDAY, Oct. 5, 2016 – Here's good news for middle-aged women who fear their sexual satisfaction is destined to decline: Aging can provide benefits that might make lovemaking even more enjoyable, a small study suggests. Interviews with more than three dozen women ages 45 to 60 revealed that some were more satisfied with sex at midlife even though they had it less often. These women "felt more confident and more comfortable in their own skin as they got older, and this allowed them to feel more free in the bedroom," said study lead author Dr. Holly Thomas. "They had a better knowledge and understanding of their own bodies as they got older. And they felt more comfortable and empowered to communicate their sexual needs to their partner than when they were younger," said Thomas, an assistant professor of medicine at the University of Pittsburgh. Other research has examined the rates of ... Read more

Related support groups: Hot Flashes, Menopausal Disorders, Postmenopausal Symptoms, Perimenopausal Symptoms, Sexual Deviations or Disorders, Vaginal Dryness

Early Menopause Linked to Higher Heart Disease, Death Risks

Posted 15 Sep 2016 by Drugs.com

THURSDAY, Sept. 15, 2016 – Women who enter menopause early may be at greater risk for heart disease and premature death, a new analysis suggests. To reach this conclusion, the Dutch researchers reviewed 32 studies involving more than 300,000 women. The investigators compared women who were younger than 45 at the start of menopause with those who were aged 45 and older when it began. Overall, heart disease risk appeared to be 50 percent greater for the women who were under 45 when menopause began. Early menopause also appeared to boost the risk of cardiovascular death and death from all causes. But, it showed no association with stroke risk, the study authors said. However, the study only uncovered an association – not a cause-and-effect connection – between early menopause and heart and death risk. The study findings were published Sept. 14 online in JAMA Cardiology. "These findings ... Read more

Related support groups: Hot Flashes, Menopausal Disorders, Postmenopausal Symptoms, Perimenopausal Symptoms, Prevention of Cardiovascular Disease, Cardiovascular Risk Reduction, Dyspareunia, Atrophic Urethritis, Vaginal Dryness

Heart Risk Factors Rise Before Menopause

Posted 3 Aug 2016 by Drugs.com

WEDNESDAY, Aug. 3, 2016 – Heart disease risk factors – such as abnormal cholesterol levels and high blood pressure – appear to increase before a woman goes through menopause, not after, new research finds. "These risk factors related to heart disease and stroke appear to worsen rapidly in the years leading up to menopause, and during the postmenopausal period they progress less rapidly," said Dr. Mark DeBoer, the study's senior author. He's an associate professor of pediatric endocrinology at the University of Virginia. In the past, he said, experts believed that a rapid increase in heart disease and stroke risk factors took place in women after menopause. They thought this was when women "catch up" to men's risk. However, the new research finds the rapid increase in risk factors starts well before the last menstrual period. The real danger zone, DeBoer's team concluded, was before ... Read more

Related support groups: High Blood Pressure, Hypertension, Hot Flashes, High Cholesterol, Menopausal Disorders, Postmenopausal Symptoms, Perimenopausal Symptoms, Prevention of Cardiovascular Disease, Cardiovascular Risk Reduction, Dyspareunia, Vaginal Dryness, Hypertensive Heart Disease

Menopause: Not All Hot Flashes Are Created Equal

Posted 22 Jul 2016 by Drugs.com

FRIDAY, July 22, 2016 – The hot flashes and night sweats of menopause don't play out the same for all women, new research shows. Almost 80 percent of women do get hot flashes, night sweats or both during menopause, the researchers found. But the timing of these symptoms and how long they last appear to vary a great deal, with factors such as body weight, race, education and dietary habits tending to predict the patterns. "We used to think these symptoms lasted from three to five years, right around the time of the final menstrual period," said senior study author Rebecca Thurston. She is director of the Women's Biobehavioral Health Lab at the University of Pittsburgh. "We now know that these symptoms persist for far longer – typically seven to 10 years – and occur at different times for different women," she added. Thurston's team followed nearly 1,500 women as they transitioned ... Read more

Related support groups: Anxiety and Stress, Obesity, Hot Flashes, Menopausal Disorders, Weight Loss, Postmenopausal Symptoms, Atrophic Vaginitis, Perimenopausal Symptoms, Dyspareunia, Atrophic Urethritis, Vaginal Dryness, Premenopausal Anovulation

Hormone Therapy Won't Help Memory After Menopause

Posted 19 Jul 2016 by Drugs.com

TUESDAY, July 19, 2016 – Women who take estrogen after menopause may believe it helps them maintain their memory and thinking skills, but a new study suggests they are mistaken. Researchers found no change in mental ability associated with estrogen therapy among women who used it after menopause, no matter when they started taking it. "There is no important benefit, there is no important risk cognitively associated with the use of hormone therapy over at least five years," said lead researcher Dr. Victor Henderson. He is a professor of health research and policy, and neurology and neurological science at Stanford University School of Medicine, in Palo Alto, Calif. "If a postmenopausal woman is considering taking hormone therapy with the thought that it might improve memory or other aspects of cognition, she should know that there is no evidence that it does benefit cognition," he said. ... Read more

Related support groups: Hot Flashes, Menopausal Disorders, Estradiol, Premarin, Ethinyl Estradiol, Estrace, Postmenopausal Symptoms, Vagifem, Estrace Vaginal Cream, Vivelle, Climara, Atrophic Vaginitis, Estring, Vivelle-Dot, Premarin Vaginal, Estradiol Patch, Mild Cognitive Impairment, Perimenopausal Symptoms, Minivelle, Cenestin

Estrogen for Vaginal Symptoms OK for Breast Cancer Survivors: Experts

Posted 22 Feb 2016 by Drugs.com

MONDAY, Feb. 22, 2016 – Women who've battled or survived an estrogen-dependent form of breast cancer often encounter vaginal symptoms linked to their treatment, especially around the time of menopause. Now, new guidelines from the American College of Obstetricians and Gynecologists (ACOG) advise that the use of symptom-relieving estrogen therapy is warranted for these patients. "These new recommendations are especially important and helpful because they provide the patient with the information needed to make an informed decision with the input of her health care provider," Dr. Diana Nancy Contreras, chair of ACOG's Subcommittee on Gynecologic Oncology, said in a college news release. One expert in women's health explained that patients with an estrogen-dependent breast cancer often suffer vaginal symptoms linked to treatment. "Many estrogen-dependent breast cancer treatments may bring ... Read more

Related support groups: Hot Flashes, Breast Cancer, Menopausal Disorders, Estradiol, Estrace, Postmenopausal Symptoms, Vagifem, Estrace Vaginal Cream, Vivelle, Climara, Atrophic Vaginitis, Natazia, Estring, Vivelle-Dot, Estradiol Patch, Perimenopausal Symptoms, Breast Cancer - Adjuvant, Minivelle, Cervical Cancer, Estradiol/Norethindrone

Sham Acupuncture Equals Real Acupuncture for Hot Flashes: Study

Posted 20 Jan 2016 by Drugs.com

WEDNESDAY, Jan. 20, 2016 – Sham acupuncture is as effective as real acupuncture in treating hot flashes in women, and the placebo effect likely plays a role in both, according to a new Australian study. In real acupuncture, thin needles are inserted into the skin at specific points. Sham acupuncture uses blunt-tipped needles that don't penetrate the skin. The study included 327 Australian women older than 40 who had at least seven moderate hot flashes a day. Half received 10 sessions of real acupuncture over eight weeks and the other half received the same number of sessions of sham acupuncture. By the end of the treatment period, women in both groups had a 40 percent reduction in the severity and frequency of their hot flashes. The benefits were still evident six months after treatment, the University of Melbourne researchers found. There are a number of possible explanations for the ... Read more

Related support groups: Hot Flashes, Menopausal Disorders, Postmenopausal Symptoms, Atrophic Vaginitis, Perimenopausal Symptoms, Dyspareunia, Atrophic Urethritis, Vaginal Dryness

Can Early Menopause Trigger Depression Later in Life?

Posted 6 Jan 2016 by Drugs.com

WEDNESDAY, Jan. 6, 2016 – Premature menopause may increase a woman's later risk of depression, a new review suggests. If further studies confirm the findings, doctors might try to identify women most likely to need psychiatric or hormonal treatment after their periods end, the researchers said. For the study, published online Jan. 6 in the journal JAMA Psychiatry, researchers analyzed the results of 14 studies that included nearly 68,000 older women. Those whose menopause began when they were 40 and older had a lower risk of depression later in life than those with premature menopause, the study found. Women who are older when menopause begins and have a longer reproductive life have greater exposure to the hormone estrogen, the study authors said in a journal news release. The findings suggest "a potentially protective effect of increasing duration of exposure to [natural] estrogens ... Read more

Related support groups: Depression, Lexapro, Zoloft, Wellbutrin, Cymbalta, Effexor, Prozac, Celexa, Citalopram, Paxil, Major Depressive Disorder, Trazodone, Sertraline, Pristiq, Bupropion, Amitriptyline, Hot Flashes, Fluoxetine, Viibryd, Venlafaxine

Suppository Eases Vaginal Dryness in Small Study

Posted 6 Jan 2016 by Drugs.com

TUESDAY, Jan. 5, 2016 – For postmenopausal women, suppositories containing the hormone DHEA may reduce vaginal dryness, discomfort and pain during sex without raising overall estrogen levels, researchers report. DHEA is an anti-aging hormone produced by both women and men. In supplement form, it is used to improve thinking skills in older people. But DHEA is also a hormonal precursor of estrogen and testosterone, so some women who have low levels of certain hormones take it to improve well-being and sexuality, according to the U.S. National Library of Medicine. "Although this medication is considered 'hormonal,' the mechanism appears to be primarily local with minimal side effects beyond vaginal discharge from the suppository," said Dr. JoAnn Pinkerton, executive director of the North American Menopause Society (NAMS). Generally, without hormonal treatment after menopause, vaginal ... Read more

Related support groups: Menopausal Disorders, Postmenopausal Symptoms, Atrophic Vaginitis, Perimenopausal Symptoms, Dyspareunia, Vaginal Dryness

The Pill, Hormone Therapy Safe for Women Taking Blood Thinners: Study

Posted 22 Dec 2015 by Drugs.com

TUESDAY, Dec. 22, 2015 – Women on blood thinners can also take contraceptives that contain estrogen, or hormone replacement therapy, without raising their risk for blood clots or uterine bleeding, a new Italian study finds. Currently, women diagnosed with blood clots may be advised to stop hormone therapy or use of the contraceptive pill – even if they are already on a blood thinner. The reason: Doctors are often concerned that these drug combinations might raise the patient's risk for more clots. However, "there has been no evidence to support this decision," said the study's senior author, Dr. Ida Martinelli, of the A. Bianchi Bonomi Hemophilia and Thrombosis Center in Milan. "We conducted this study to address the fear felt by both the physician and patient when making the decision to stop or continue hormone therapy in this setting," she explained in a news release from the ... Read more

Related support groups: Birth Control, Contraception, Blood Disorders, Emergency Contraception, Bleeding Disorder, Warfarin, Coumadin, Hot Flashes, Menopausal Disorders, Estradiol, Xarelto, Premarin, Pradaxa, Ethinyl Estradiol, Postcoital Contraception, Estrace, Postmenopausal Symptoms, Lovenox, Eliquis, Vagifem

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