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Arthritis Drug Shows Promise for Ulcerative Colitis

Posted 4 May 2017 by Drugs.com

WEDNESDAY, May 3, 2017 – A new study finds that people with moderate to severe ulcerative colitis who haven't done well on other treatments may find relief with Xeljanz (tofacitinib), a drug currently used to treat arthritis. Ulcerative colitis is a chronic inflammatory bowel disease. It affects about 700,000 Americans, according to the Crohn's and Colitis Foundation (CCF). The illness causes inflammation, irritation, swelling and sores on the lining of the large intestine. Symptoms include diarrhea with blood or pus and abdominal discomfort, according to CCF. "There is still a substantial unmet need for new treatments for patients with ulcerative colitis," said study lead author Dr. William Sandborn. He is professor of medicine and chief of the division of gastroenterology at the University of California, San Diego. Xeljanz targets certain proteins involved in the body's inflammatory ... Read more

Related support groups: Ulcerative Colitis, Ulcerative Colitis - Active, Ulcerative Colitis - Maintenance, Xeljanz, Tofacitinib, Xeljanz XR

FDA Approves Renflexis (infliximab-abda), a Biosimilar to Remicade

Posted 27 Apr 2017 by Drugs.com

INCHEON, Korea – April 24, 2017 – Samsung Bioepis Co., Ltd. today announced that the U.S. Food and Drug Administration (FDA) has approved Renflexis (infliximab-abda), a biosimilar referencing Remicade®i (infliximab), across all eligible indications. In the US, Renflexis is indicated for reducing signs and symptoms in patients with adult and pediatric Crohn’s disease, adult ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis, and for the treatment of adult plaque psoriasis. Renflexis is the first Samsung Bioepis product approved for marketing in the United States (US). “Since our company was established five years ago, we have strived day in and day out to realize the promise of biosimilars for patients across the United States by offering them treatment options at a lower cost. We hope this regulatory milestone will bring us a step closer to achievin ... Read more

Related support groups: Rheumatoid Arthritis, Crohn's Disease, Remicade, Ulcerative Colitis, Psoriatic Arthritis, Ankylosing Spondylitis, Crohn's Disease - Maintenance, Plaque Psoriasis, Ulcerative Colitis - Active, Crohn's Disease - Acute, Ulcerative Colitis - Maintenance, Infliximab, Renflexis

New Meds Make Inroads Against Crohn's Disease

Posted 13 Apr 2017 by Drugs.com

THURSDAY, April 13, 2017 – Fewer Americans with Crohn's disease are ending up in the hospital than in the past, according to a new federal study. Crohn's is a chronic inflammatory bowel disorder that often leads to surgery for most with the disease. Hospitalization rates for Crohn's disease remained stable in the United States between 2003 and 2013. That's a change from a study done from 1998 to 2004 that saw more than 4 percent increases in Crohn's hospitalizations each year, researchers with the U.S. Centers for Disease Control and Prevention said. The stable hospital rates are likely due to the 1998 introduction of a new class of biologic drugs. Examples of these medications used to treat Crohn's disease include: adalimumab (Humira), infliximab (Remicade), certolizumab (Cimzia) and ustekinumab (Stelara), according to the U.S. National Institute of Diabetes and Digestive and Kidney ... Read more

Related support groups: Humira, Crohn's Disease, Remicade, Ulcerative Colitis, Crohn's Disease - Maintenance, Inflammatory Bowel Disease, Ulcerative Colitis - Active, Stelara, Crohn's Disease - Acute, Cimzia, Ulcerative Colitis - Maintenance, Infliximab, Adalimumab, Inflectra, Ustekinumab, Amjevita, Certolizumab

Special Diet May Be Boon for Kids With Crohn's, Colitis

Posted 10 Jan 2017 by Drugs.com

MONDAY, Jan. 9, 2017 – Children with Crohn's disease and ulcerative colitis may be able to achieve relief without medications by eating a special diet, a small study suggests. The diet includes non-processed foods, such as fruits, vegetables, meats and nuts. Over 12 weeks, the diet appeared to ease all signs of these inflammatory bowel diseases in eight of the 10 affected children, researchers report. "The study shows that without other intervention, other changes, we can improve individuals' clinical as well as laboratory markers," said study author Dr. David Suskind. He's a professor of pediatrics and director of clinical gastroenterology at Seattle Children's Hospital. "I'm not surprised," Suskind added, "primarily because preliminary studies ... opened our eyes to the idea that diet had an impact." Inflammatory bowel disease (IBD) affects about 1.6 million Americans, according to ... Read more

Related support groups: Crohn's Disease, Dietary Supplementation, Colitis, Ulcerative Colitis, Asacol, Crohn's Disease - Maintenance, Creon, Inflammatory Bowel Disease, Sulfasalazine, Ulcerative Colitis - Active, Pentasa, Lialda, Crohn's Disease - Acute, Ulcerative Colitis - Maintenance, Lactaid, Apriso, Mesalamine, Pancrease, Zenpep, Canasa

Amjevita OK'd to Treat Inflammatory Diseases

Posted 27 Sep 2016 by Drugs.com

MONDAY, Sept. 26, 2016 – Amjevita (adalimumab-atto) – a biosimilar drug similar to the popular anti-inflammatory drug Humira – has been approved by the U.S. Food and Drug Administration. Amjevita has been approved for moderate-to-severe rheumatoid arthritis; psoriatic arthritis; ankylosing spondylitis (an arthritis that affects the spine); Crohn's disease; ulcerative colitis; plaque psoriasis and juvenile idiopathic arthritis, the FDA said in a news release. Biological drugs are generally derived from a living organism and can come from many sources, including humans, animals, microorganisms or yeast, the FDA said. A biosimilar drug is a biological product that's sanctioned after its maker proves it is "highly similar" to an already-approved biologic drug. The manufacturer of the biosimilar drug must prove that the product has "no clinically meaningful differences" in safety, purity ... Read more

Related support groups: Rheumatoid Arthritis, Humira, Crohn's Disease, Ulcerative Colitis, Psoriatic Arthritis, Ankylosing Spondylitis, Crohn's Disease - Maintenance, Plaque Psoriasis, Ulcerative Colitis - Active, Crohn's Disease - Acute, Ulcerative Colitis - Maintenance, Juvenile Idiopathic Arthritis, Adalimumab, Amjevita

FDA Approves Amjevita (adalimumab-atto), a Biosimilar to Humira

Posted 26 Sep 2016 by Drugs.com

September 23, 2016 – The U.S. Food and Drug Administration today approved Amjevita (adalimumab-atto) as a biosimilar to Humira (adalimumab) for multiple inflammatory diseases. Amjevita is approved for the following indications in adult patients: moderately to severely active rheumatoid arthritis; active psoriatic arthritis; active ankylosing spondylitis (an arthritis that affects the spine); moderately to severely active Crohn’s disease; moderately to severely active ulcerative colitis; and moderate to severe plaque psoriasis. Amjevita is also indicated for moderately to severely active polyarticular juvenile idiopathic arthritis in patients four years of age and older. Health care professionals should review the prescribing information in the labeling for detailed information about the approved uses. “This is the fourth FDA-approved biosimilar. The biosimilar pathway is still a new fr ... Read more

Related support groups: Rheumatoid Arthritis, Psoriasis, Humira, Crohn's Disease, Ulcerative Colitis, Psoriatic Arthritis, Ankylosing Spondylitis, Crohn's Disease - Maintenance, Plaque Psoriasis, Ulcerative Colitis - Maintenance, Adalimumab, Amjevita

Vitamin A Compound Might Aid in Colon Cancer Fight

Posted 30 Aug 2016 by Drugs.com

TUESDAY, Aug. 30, 2016 – Retinoic acid, a compound derived in the body from vitamin A, might have a role in suppressing colon cancer, new animal research suggests. "Retinoic acid has been known for years to be involved in suppressing inflammation in the intestine," said study senior author Dr. Edgar Engleman, professor of pathology and medicine at Stanford University School of Medicine in Palo Alto, Calif. Meanwhile, the development of colon cancer has been linked to inflammation. For example, inflammatory bowel disease, such as ulcerative colitis, has been associated with colon cancer, he said in a university news release. "We wanted to connect the dots and learn whether and how retinoic acid levels directly affect cancer development," Engleman added. When the researchers looked at mice with colon cancer, they saw lower levels of retinoic acid in the intestines of the mice. The ... Read more

Related support groups: Cancer, Ulcerative Colitis, Colorectal Cancer, Ulcerative Colitis - Active, A-25, Ulcerative Colitis - Maintenance, Vitamin A, Diagnosis and Investigation, Retinol, Familial Adenomatous Polyposis, A/Fish Oil, Aquasol A, Vitamin A Topical

Stool Transplant Soothes Tough-to-Treat Colitis in Study

Posted 23 May 2016 by Drugs.com

MONDAY, May 23, 2016 – Stool transplants helped ease debilitating symptoms and heal the colons of tough-to-treat ulcerative colitis patients, new research shows. Australian scientists said the findings could pave the way for such transplants to be used on a more widespread basis. Transferring fecal matter from healthy donors into these patients alters the composition of their gut bacteria, circumventing one of the drivers of ulcerative colitis, experts said. "We were not completely surprised by the study findings, as . . . smaller studies along with unpublished experience suggested repeated fecal microbiota transplantation may be an effective treatment for ulcerative colitis," said study author Dr. Sudarshan Paramsothy, a gastroenterologist at University of New South Wales. "This study shows that [stool transplant] is a very promising therapeutic option for ulcerative colitis ... Read more

Related support groups: Ulcerative Colitis, Ulcerative Colitis - Active, Ulcerative Colitis - Maintenance, Diagnosis and Investigation, Fecal Incontinence

Inflectra Approved as 'Biosimilar' to Remicade

Posted 7 Apr 2016 by Drugs.com

WEDNESDAY, April 6, 2016 – The U.S. Food and Drug Administration has approved its second-ever "biosimilar" drug, Inflectra, for adults with Crohn's disease, rheumatoid arthritis or chronic plaque psoriasis, among other prescribed uses. In a media release, the agency said Inflectra was biosimilar to Janssen Biotech's Remicade (infliximab), first licensed in 1998. A biosimilar drug is sanctioned based on its maker's ability to show that it is "highly similar" to an already-approved biological drug that is generally derived from a living organism, such as a person, animal, microorganism or yeast, the FDA said. The maker of a biosimilar drug also must prove that the product has no "clinically meaningful difference" in safety and effectiveness from the original drug, and that the newer product has only "minor differences in clinically inactive components" from the original. Inflectra's most ... Read more

Related support groups: Rheumatoid Arthritis, Psoriasis, Crohn's Disease, Remicade, Ulcerative Colitis, Psoriatic Arthritis, Ankylosing Spondylitis, Crohn's Disease - Maintenance, Plaque Psoriasis, Ulcerative Colitis - Active, Crohn's Disease - Acute, Ulcerative Colitis - Maintenance, Infliximab, Inflectra

FDA Approves Inflectra (infliximab-dyyb) a Biosimilar to Remicade

Posted 7 Apr 2016 by Drugs.com

April 5, 2016 – The U.S. Food and Drug Administration today approved Inflectra (infliximab-dyyb) for multiple indications. Inflectra is administered by intravenous infusion. This is the second biosimilar approved by the FDA. Inflectra is biosimilar to Janssen Biotech, Inc.’s Remicade (infliximab), which was originally licensed in 1998. Inflectra is approved and can be prescribed by a health care professional for the treatment of: adult patients and pediatric patients (ages six years and older) with moderately to severely active Crohn’s disease who have had an inadequate response to conventional therapy; adult patients with moderately to severely active ulcerative colitis who have had an inadequate response to conventional therapy; patients with moderately to severely active rheumatoid arthritis in combination with methotrexate; patients with active ankylosing spondylitis (arthritis of ... Read more

Related support groups: Rheumatoid Arthritis, Psoriasis, Crohn's Disease, Remicade, Ulcerative Colitis, Psoriatic Arthritis, Ankylosing Spondylitis, Plaque Psoriasis, Infliximab, Inflectra

Ultrasound Might Speed Up Digestive Drug Delivery: Animal Study

Posted 21 Oct 2015 by Drugs.com

WEDNESDAY, Oct. 21, 2015 – Ultrasound waves could be used to rapidly deliver drugs to the digestive system, new animal research suggests. This new approach to drug delivery might potentially benefit people with inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis. However, this new method of drug delivery hasn't yet been tested in humans. "With additional research, our technology could prove invaluable in both clinical and research settings, enabling improved therapies and expansion of research techniques applied to the [gastrointestinal] tract," said co-senior study author Daniel Blankschtein, a professor of chemical engineering at Massachusetts Institute of Technology (MIT) in Cambridge. "[Our study] demonstrates for the first time the active administration of drugs, including biologics, through the GI tract," he said in an MIT news release. The ... Read more

Related support groups: Crohn's Disease, Colitis, Ulcerative Colitis, Crohn's Disease - Maintenance, Inflammatory Bowel Disease, Ulcerative Colitis - Active, Crohn's Disease - Acute, Ulcerative Colitis - Maintenance, Diagnosis and Investigation

More Evidence High-Fiber, Mediterranean Diet Is Good for You

Posted 29 Sep 2015 by Drugs.com

TUESDAY, Sept. 29, 2015 – Numerous studies have extolled the health benefits of the Mediterranean diet. Now, research suggests the regimen may also boost levels of beneficial fatty acids. These so-called "short chain fatty acids" are produced by bacteria in the intestine during fermentation of insoluble fiber from fruits, vegetables and legumes. The fatty acids are believed to provide a number of health benefits, including a lower risk of diabetes, heart disease and inflammatory diseases, an Italian team reports in the Sept. 29 issue of the journal Gut. "We provide here tangible evidence of the impact of a healthy diet and a Mediterranean dietary pattern," wrote the team led by Danilo Ercolini, a professor of microbiology at the University of Naples in Italy. The study of 153 Italian adults found higher levels of short chain fatty acids in vegans, vegetarians and those who closely ... Read more

Related support groups: Diabetes, Type 2, Heart Disease, Crohn's Disease, Ulcerative Colitis, Fish Oil, Lovaza, Inflammatory Bowel Disease, Omega-3, Dietary Fiber Supplementation, Omacor, Omega-3 Polyunsaturated Fatty Acids, MaxEPA, Marine Lipid Concentrate, Omega 3-6-9 Complex, EPA Fish Oil, Restora, Animi-3, Super-EPA, Mi-Omega, MegaKrill

Childhood Abuse Linked to Ulcerative Colitis Later in Life

Posted 11 Sep 2015 by Drugs.com

FRIDAY, Sept. 11, 2015 – Adults who were physically or sexually abused as children may be at increased risk for the inflammatory bowel disease ulcerative colitis, a new study finds. University of Toronto researchers analyzed data from nearly 22,000 Canadians aged 18 and older. They found that those with a history of childhood abuse were nearly twice as likely to have ulcerative colitis as those who hadn't suffered abuse. In ulcerative colitis, inflammation and sores develop in the innermost lining of the large intestine, according to the Crohn's & Colitis Foundation of America. Symptoms include diarrhea, bloody stools and abdominal pain. "We found that one-quarter of adults with ulcerative colitis reported they had been physically abused during their childhood, compared to one in 10 of those without inflammatory bowel disease," study lead author Esme Fuller-Thomson, a professor in the ... Read more

Related support groups: Ulcerative Colitis, Ulcerative Colitis - Active, Ulcerative Colitis - Maintenance

Crohn's Disease, Colitis Tied to Anxiety in Study

Posted 4 Aug 2015 by Drugs.com

TUESDAY, Aug. 4, 2015 – People with inflammatory bowel disease, such as Crohn's disease or ulcerative colitis, have an increased risk for an anxiety disorder, especially women, a new study suggests. Inflammatory bowel disease (IBD) is a group of disorders that cause chronic inflammation of the digestive tract. "Patients with IBD face substantial chronic physical problems associated with the disease," lead author Esme Fuller-Thomson, a professor from the University of Toronto, said in a university news release. "The additional burden of anxiety disorders makes life much more challenging so this 'double jeopardy' must be addressed." The study authors looked at 269 Canadian adults who had been diagnosed with an inflammatory bowel disease. The researchers found that these patients were two times more likely to have had generalized anxiety disorder at some point in their lives than adults ... Read more

Related support groups: Anxiety, Generalized Anxiety Disorder, Panic Disorder, Anxiety and Stress, Post Traumatic Stress Disorder, Social Anxiety Disorder, Crohn's Disease, Colitis, Ulcerative Colitis, Crohn's Disease - Maintenance, Ulcerative Colitis - Active, Performance Anxiety, Crohn's Disease - Acute, Ulcerative Colitis - Maintenance, Lymphocytic Colitis, Allergic Colitis

Surgery May Beat Drugs for Ulcerative Colitis: Study

Posted 13 Jul 2015 by Drugs.com

MONDAY, July 13, 2015 – Surgery may extend the lives of older adults with the inflammatory bowel disease ulcerative colitis, new research suggests. A study of thousands of adults with the condition compared results of surgery to those of long-term drug treatment. It found that surgery's survival benefit was greatest for those 50 and older who had advanced disease. "Surgery has always been an option," said study leader Dr. Meenakshi Bewtra, but many experts look at it as a last resort. Bewtra, assistant professor of medicine and epidemiology at the University of Pennsylvania Perelman School of Medicine, used data from Medicare and Medicaid for the study. She and her colleagues followed 830 patients who had elective surgery – known as colectomy – and more than 7,500 who took medicine to manage the condition. Surgery involves removal of the colon, sometimes followed by additional ... Read more

Related support groups: Surgery, Ulcerative Colitis, Ulcerative Colitis - Active, Ulcerative Colitis - Maintenance, Gastrointestinal Surgery

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