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Epilepsy Drug, #Topiramate, Could Raise Birth Defect Risks

Posted 29 Dec 2017 by Drugs.com

WEDNESDAY, Dec. 27, 2017 – A common anti-seizure drug may pose a birth defect problem for pregnant women, a new study warns. Researchers found that pregnant women with epilepsy who take the drug topiramate during their first trimester may boost the risk that their child will be born with a cleft lip or cleft palate. That risk increase specifically applies to women with epilepsy, who typically take topiramate at an average daily dosage of 200 milligrams (mg). However, topiramate is also sometimes taken at a lower dosage to control migraines, treat bipolar disorder or in combination with other drugs to lose weight. Pregnant women who take it for these reasons also may face an increased risk. The study found that pregnant women who take it during their first trimester at an average dosage of 100 mg for reasons other than epilepsy boost their child's risk for a cleft lip or palate by ... Read more

Related support groups: Birth Control, Contraception, Seizures, Topamax, Topiramate, Qsymia, Folic Acid, Seizure Prevention, Seizure Prophylaxis, Vitamin/Mineral Supplementation during Pregnancy/Lactation, Trokendi XR, Topamax Sprinkle, Qudexy XR, Labor and Delivery including Augmentation, Tandem F, Topiragen, Folic Acid/lactobacillus Casei, Ferrocite F, Focalgin-B, B-Nexa

Many Migraine Sufferers Given Unecessary Opioids, Study Finds

Posted 25 Aug 2017 by Drugs.com

FRIDAY, Aug. 25, 2017 – Too many people with migraines are prescribed potentially addictive opiate painkillers, while too few may be getting recommended medications, a new study suggests. Researchers found that of nearly 2,900 Americans who visited the doctor for migraine relief, 15 percent were prescribed opioids such as oxycodone (OxyContin or Percocet) or hydrocodone (Norco, Vicoprofen). That's despite the fact that the drugs should really be used only as a "last resort," said study lead researcher Dr. Larry Charleston IV. Opioids are not only less effective than recommended migraine drugs, they're also risky, said Charleston, an assistant professor of neurology at the University of Michigan Medical School. Repeated opioid use, he explained, can actually lead to more frequent, or even chronic, migraines. And by now, it's no secret that the drugs have the potential for abuse and ... Read more

Related support groups: Suboxone, Oxycodone, Tramadol, Hydrocodone, Methadone, Percocet, OxyContin, Vicodin, Norco, Fentanyl, Opiate Dependence, Morphine, Metoprolol, Codeine, Lortab, Tylenol, Ibuprofen, Topamax, Opana, Naproxen

Pot Compound Alters Levels of Seizure Drug in Epilepsy Patients

Posted 11 Aug 2017 by Drugs.com

FRIDAY, Aug. 11, 2017 – Scientists experimenting with the marijuana compound cannabidiol as an epilepsy treatment must evaluate any interactions with other anti-seizure drugs patients are taking, researchers report. The new research from the University of Alabama at Birmingham suggests cannabidiol affects blood levels of several anti-seizure drugs, especially clobazam. Cannabidiol (CBD) has shown promise as a potential anti-seizure compound in animal and human studies, the Alabama researchers said. They are testing it as a therapy for difficult-to-control epilepsy in 39 adults and 42 children. Other drugs that the participants are taking include clobazam (Onfi), topiramate (Topamax), rufinamide (Banzel), zonisamide (Zonegran), valproate (Depakote) and eslicarbazepine. Blood levels of some of the drugs changed significantly, but except for clobazam, they did not deviate from the ... Read more

Related support groups: Seizures, Topamax, Epilepsy, Topiramate, Qsymia, Seizure Prevention, Zonisamide, Zonegran, Cannabis, Valproic Acid, Seizure Prophylaxis, Aptiom, Depakene, Onfi, Clobazam, West Syndrome, Status Epilepticus, Lennox-Gastaut Syndrome, Banzel, Trokendi XR

Number of Americans With Epilepsy at Record Level

Posted 10 Aug 2017 by Drugs.com

THURSDAY, Aug. 10, 2017 – More Americans than ever are living with epilepsy, federal health officials reported Thursday. According to the new report, 1.2 percent of the population – about 3 million adults and 470,000 children – were being treated for epilepsy or had experienced recent seizures in 2015, the researchers from the U.S. Centers for Disease Control and Prevention said. The number of adults with active epilepsy rose from 2.3 million in 2010. Epilepsy among children rose by 20,000 between 2007 and 2015, according to the report's coauthor, Rosemarie Kobau, the head of the CDC's epilepsy program. "The increase is probably because of population growth," Kobau said. "We don't know if other factors are involved." The report, published Aug. 11 in the CDC's Morbidity and Mortality Weekly Report, offers epilepsy estimates for every state for the first time, which shows the condition ... Read more

Related support groups: Klonopin, Gabapentin, Seizures, Clonazepam, Ativan, Lyrica, Valium, Topamax, Lorazepam, Neurontin, Epilepsy, Diazepam, Topiramate, Dilantin, Pregabalin, Seizure Prevention, Diamox, Zonisamide, Phenytoin, Zonegran

Seizure Control Key to Avoiding Sudden Death With Epilepsy

Posted 25 Apr 2017 by Drugs.com

TUESDAY, April 25, 2017 – In rare cases, seizures that cause convulsions and a loss of consciousness can raise the odds of sudden death in people with epilepsy, neurologists warn. These attacks are known as generalized tonic-clonic seizures, according to a new guideline from the American Academy of Neurology (AAN) and the American Epilepsy Society. Just how rare is sudden death linked to these seizures? According to guideline researchers, these tragedies occur in 1 in 1,000 men and women each year and only 1 in 4,500 children annually. Still, although rare, it's crucial that the possibility of sudden death linked to seizures and risk factors for these events "are communicated to persons and families affected by epilepsy," said guideline author Dr. Cynthia Harden. She's with Mount Sinai Health System in New York City. "Our guideline brings clarity to the discussion, giving health care ... Read more

Related support groups: Klonopin, Seizures, Clonazepam, Ativan, Valium, Topamax, Lorazepam, Epilepsy, Diazepam, Topiramate, Dilantin, Seizure Prevention, Phenobarbital, Diamox, Zonisamide, Phenytoin, Primidone, Zonegran, Acetazolamide, Seizure Prophylaxis

Study Sheds Light on Safety of Driving With Epilepsy

Posted 5 Dec 2016 by Drugs.com

SUNDAY, Dec. 4, 2016 – People with epilepsy who experienced longer seizures during a simulated driving test may face an increased risk for crashes while on the road, a new study suggests. About 75 percent of people with epilepsy use medication to control their seizures and are able to drive. The remainder of patients typically keep a journal of seizures, noting how long they last, and doctors use that information to determine whether patients can drive safely, the study authors explained. The new study included 16 people with epilepsy who used a driving simulator for between one to 10 hours, most for an average of three to four hours. In total, the patients had 20 seizures, seven of which resulted in "crashes." The longer the seizure, the greater the chance of a "crash." Seizures lasted an average of 75 seconds among patients who crashed and 30 seconds among those who didn't crash. The ... Read more

Related support groups: Seizures, Topamax, Epilepsy, Keppra, Topiramate, Tegretol, Qsymia, Dilantin, Carbamazepine, Seizure Prevention, Levetiracetam, Phenytoin, Tegretol XR, Valproic Acid, Keppra XR, Seizure Prophylaxis, Carbatrol, Epitol, Depakene, West Syndrome

Study Questions Use of Migraine Meds in Kids, Teens

Posted 28 Oct 2016 by Drugs.com

THURSDAY, Oct. 27, 2016 – A new study raises questions about the effectiveness of medicines commonly prescribed to prevent migraines in children and teens. The 24-week clinical trial involving 328 patients found no significant differences between the drugs amitriptyline (Elavil), topiramate (Topamax) and a placebo sugar pill in reducing the number of days with a migraine or migraine-related disability. Fifty-two percent of those taking amitriptyline and 55 percent of those taking topiramate saw the number of days they had a headache drop by 50 percent or more, while 61 percent of those taking a placebo pill saw the same benefit, the findings showed. The patients taking the prescription drugs also had much higher rates of side effects, such as fatigue, dry mouth, mood changes, and tingling in the hands, arms, legs or feet. "The study was intended to demonstrate which of the commonly ... Read more

Related support groups: Migraine, Amitriptyline, Topamax, Migraine Prevention, Topiramate, Elavil, Qsymia, Migraine Prophylaxis, Endep, Limbitrol, Trokendi XR, Limbitrol DS, Topamax Sprinkle, Amitriptyline/Perphenazine, Triavil, Trochleitis, Qudexy XR, Vanatrip, Etrafon 2-10, Topiragen

Newer Epilepsy Drugs May Be Safer During Pregnancy

Posted 1 Sep 2016 by Drugs.com

THURSDAY, Sept. 1, 2016 – Women who take the new epilepsy drugs levetiracetam and topiramate during pregnancy don't run the risk of harming their infant's mental development, British researchers report. But the commonly prescribed anti-seizure drug valproate was linked with lower IQs in children, especially when taken at higher doses, researchers say. "The treatment of epilepsy in women who are considering a pregnancy or are pregnant involves optimizing the health of the mother as well as keeping the risk to the fetus as low as possible," said lead researcher Rebecca Bromley, a research fellow at the Institute for Human Development at the University of Manchester. In the study, children exposed to levetiracetam (Keppra) or topiramate (Topamax) in the womb did not differ from children not exposed to these drugs. And they had better outcomes than the children exposed to valproate ... Read more

Related support groups: Birth Control, Contraception, Emergency Contraception, Seizures, Topamax, Epilepsy, Keppra, Topiramate, Postcoital Contraception, Qsymia, Seizure Prevention, Levetiracetam, Keppra XR, Seizure Prophylaxis, Vitamin/Mineral Supplementation during Pregnancy/Lactation, Status Epilepticus, West Syndrome, Trokendi XR, Lennox-Gastaut Syndrome, Topamax Sprinkle

Girls Given Risky Meds Don't Get Contraceptive Advice

Posted 16 Dec 2015 by Drugs.com

WEDNESDAY, Dec. 16, 2015 – New research from a Midwestern hospital suggests a wide majority of teen girls and young women fail to get information about contraceptives when they take medications that could cause birth defects. At issue are so-called "teratogenic" medications, used for conditions ranging from acne to anxiety, that boost the risk of birth defects when taken during pregnancy. Physicians often tell sexually active women to take birth control while they're on the drugs to avoid becoming pregnant, but it's unclear whether younger females routinely get the same kind of guidance. In the new study, researchers examined the medical records of nearly 1,700 females aged 14 to 25 who received just over 4,500 prescriptions for teratogenic medications in more than 4,100 visits from 2008-2012. All the participants had visited a large, unidentified pediatric medical center in the ... Read more

Related support groups: Birth Control, Xanax, Contraception, Plan B, Emergency Contraception, Klonopin, Depo-Provera, Nexplanon, Mirena, NuvaRing, Clonazepam, Provera, Sprintec, Ativan, Implanon, Valium, Ortho Tri-Cyclen, Topamax, Microgestin Fe 1/20, Lorazepam

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