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Testosterone Therapy May Be Linked to Serious Blood Clots

Posted 5 days ago by Drugs.com

WEDNESDAY, Nov. 30, 2016 – Testosterone treatment can increase a man's risk of potentially fatal blood clots, a new study suggests. Researchers found that men taking the male hormone seem to have a 63 percent increased risk of a blood clot forming in a vein, a condition known as venous thromboembolism (VTE). These clots can cause a heart attack, stroke, organ damage or even death, according to the American Heart Association. "Risk peaks rapidly in the first six months of treatment and lasts for about nine months, and fades gradually thereafter," said lead researcher Dr. Carlos Martinez of the Institute for Epidemiology, Statistics and Informatics in Frankfurt, Germany. Millions of American men currently use testosterone pills, gels or injections, hoping that the male hormone will boost their sex drive, stamina and strength. It's been known for a while that the estrogen in birth control ... Read more

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Male Birth Control in a Shot: Promising, But More Work Needed

Posted 27 Oct 2016 by Drugs.com

THURSDAY, Oct. 27, 2016 – A birth control shot for men shows some promise, but researchers are still struggling to improve its effectiveness and deal with severe side effects caused by the injections. Only four pregnancies occurred among 266 men receiving the treatment, which is an effectiveness rate comparable to other contraceptive methods, according to results from a new international clinical trial. But the men also experienced mood swings and depression so frequently that a safety review committee halted the study early, the researchers reported. No further development is planned for this particular birth control shot for men, but the clinical trial showed that such an injection can suppress sperm counts and prevent pregnancy, said researcher Dr. Mario Festin. He is a medical officer with department of reproductive health and research at the World Health Organization. "A male ... Read more

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FDA Warns of Dangers From Testosterone Supplements

Posted 26 Oct 2016 by Drugs.com

WEDNESDAY, Oct. 26, 2016 – Supplemental testosterone and related anabolic-androgenic steroids (AAS) can cause heart attacks, personality changes and infertility, and are easily abused, the U.S. Food and Drug Administration warns. The agency said Monday that labeling on all prescription testosterone products – which are approved to treat men with low testosterone due to certain medical conditions – will be revised. Millions of American men currently use testosterone pills, gels or get injections in hopes of boosting their physical health or libido. Anabolic steroids are synthetic variations of testosterone and are legally prescribed to treat conditions such as delayed puberty and diseases that cause muscle loss, such as cancer or AIDS. But "testosterone and other AAS are abused by adults and adolescents, including athletes and body builders," according to an FDA news release. "Abuse ... Read more

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FDA Medwatch Alert: Testosterone and Other Anabolic Androgenic Steroids (AAS): FDA Statement - Risks Associated With Abuse and Dependence

Posted 25 Oct 2016 by Drugs.com

ISSUE: FDA approved class-wide labeling changes for all prescription testosterone products, adding a new Warning and updating the Abuse and Dependence section to include new safety information from published literature and case reports regarding the risks associated with abuse and dependence of testosterone and other AAS.  The Anabolic Steroids Control Act of 1990 placed AAS, including testosterone, in Schedule III of the Controlled Substances Act. Testosterone and other AAS are abused by adults and adolescents, including athletes and body builders. Abuse of testosterone, usually at doses higher than those typically prescribed and usually in conjunction with other AAS, is associated with serious safety risks affecting the heart, brain, liver, mental health, and endocrine system. Reported serious adverse outcomes include heart attack, heart failure, stroke, depression, hostility, ... Read more

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Hormone Therapy for Prostate Cancer Less Safe for Men With Prior Heart Attack

Posted 30 Sep 2016 by Drugs.com

FRIDAY, Sept. 30, 2016 – Men diagnosed with prostate cancer often receive hormone-depleting therapy to help fight the tumor. But a new study suggests that the treatment may pose a risk to men who've previously suffered a heart attack. "Patient age, cardiac risk, and disease recurrence risk should be considered when selecting candidates for hormone therapy in this patient population," lead researcher Dr. Nataniel Lester-Coll of Yale University said in a Yale news release. He's a resident doctor at the Yale School of Medicine's department of therapeutic radiology in New Haven, Conn. Because prostate tumors typically grow in the presence of hormones such as testosterone, doctors often recommend therapies that temporarily deplete hormone levels. But might that approach affect heart health? To find out, the Yale team analyzed data from patients with intermediate- and high-risk prostate ... Read more

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Bodybuilders' Steroid Abuse Linked to Pre-Diabetic Condition

Posted 14 Sep 2016 by Drugs.com

WEDNESDAY, Sept. 14, 2016 – Weightlifters' abuse of anabolic steroids – synthetic drugs that closely mimic male sex hormones, such as testosterone – may also lead to insulin resistance, a new study suggests. Insulin resistance is a condition where the muscles, liver and fat cells don't use insulin properly, according to the U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). It can lead to the development of type 2 diabetes, NIDDK says. A team of researchers led by Dr. Jon Rasmussen from Herlev University Hospital in Copenhagen investigated the effects of anabolic steroids on the belly fat and insulin sensitivity of 100 men who were 50 years old or younger. All of the men were involved in strength training. The researchers divided the men into three groups based on their use of anabolic steroids: 37 men were currently using the drugs, 33 had done so in the ... Read more

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Hormone Therapy for Prostate Cancer Tied to Depression

Posted 12 Apr 2016 by Drugs.com

MONDAY, April 11, 2016 – Older men who receive testosterone-suppressing therapy for prostate cancer may be at increased risk of developing depression, a new, large study suggests. The findings are based on over 78,000 U.S. men treated for earlier-stage prostate cancer. Researchers found that among those given hormone-suppressing therapy, 7 percent developed clinical depression in the next few years. That compared with 5 percent of men who did not have the treatment. The findings do not prove that hormone therapy is to blame. But they do offer "pretty strong evidence" that might be the case, said senior researcher Dr. Paul Nguyen. He is director of prostate brachytherapy at Brigham and Women's Hospital, in Boston. Nguyen said his team accounted for some other factors that could affect depression risk – including the severity of a man's cancer, his age and education. And there was still ... Read more

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Young Athletes Pressured by Parents May Resort to 'Doping'

Posted 1 Mar 2016 by Drugs.com

MONDAY, Feb. 29, 2016 – Young male athletes under parental pressure to succeed are more likely to use banned substances to boost their sports performance, a new study finds. Researchers at the University of Kent in England asked 129 young male athletes, average age 17, about their attitudes on "doping" – the use of prohibited drugs, such as steroids, hormones or stimulants, to boost athletic ability. These substances, sometimes called performance-enhancing drugs, can potentially alter the human body and biological functions. However, they can be extremely harmful to a person's health, experts warn. In addition, the study participants were also asked about four different aspects of perfectionism. The four areas were: parental pressure; self-striving for perfection; concerns about making mistakes; and pressure from coaches. Only parental pressure was linked to positive feelings about ... Read more

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Testosterone Therapy May Boost Sex Drive in Older Men ...

Posted 18 Feb 2016 by Drugs.com

WEDNESDAY, Feb. 17, 2016 – Testosterone therapy may restore some sexual desire and function in older men whose natural hormone levels have declined, clinical trials suggest. However, the treatments didn't do much to improve vitality or physical function in men 65 or older, as many have believed, said co-researcher Dr. Thomas Gill. "Men who are experiencing low desire or low sexual activity and are interested in improving in those areas, testosterone treatment would be reasonable to consider," Gill said. But, "a physician probably wouldn't be encouraged to prescribe testosterone solely for problems with physical function or solely for low energy, based on these results," he added. Gill is a professor of geriatrics and epidemiology at Yale University and director of the Yale Program on Aging in New Haven, Conn. The use of testosterone replacement therapy has nearly doubled in recent ... Read more

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Obsessed Athletes More Likely to Approve of Performance-Enhancing Drugs: Study

Posted 15 Feb 2016 by Drugs.com

SATURDAY, Feb. 13, 2016 – The more obsessed that college athletes are with their sport, the more likely they are to approve of using performance-enhancing drugs, a new Canadian study finds. Two types of passion are associated with sports, the University of Waterloo researchers explained. "Harmonious passion" involves feelings of enjoyment, and the sport blends with the athlete's life. "Obsessive passion" means not being able to disconnect from a sport and having feelings of guilt when not participating. The researchers surveyed nearly 600 male and female varsity/all-star athletes at four universities in the province of Ontario. "We found that regardless of gender, athletes who reported higher obsessive passion indicated more lenient attitudes towards [performance-enhancing drugs], while athletes who reported higher harmonious passion held more conservative attitudes towards them," ... Read more

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Knee Arthritis: Steroid Shots May Not Help Long-Term, Ozone Injections Promising

Posted 10 Nov 2015 by Drugs.com

TUESDAY, Nov. 10, 2015 – Millions of aging Americans are plagued by arthritic knees, and two new studies offer insight into what might – or might not – help curb the condition. Both studies were presented this week at the American College of Rheumatology's annual meeting in San Francisco. One study found that a popular therapy, steroid drug injections, do nothing to slow progression of osteoarthritis in the knee. This type of treatment is common, but has never been specifically tested, and there are concerns about its safety, according to a team led by Dr. Tim McAlindon, chief of rheumatology at Tufts Medical Center in Boston. His team tracked outcomes for 140 people – mainly overweight white women – with knee arthritis who averaged 58 years of age. The patients received either injections of the steroid triamcinolone hexacetonide, or placebo injections of saline, every three months ... Read more

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Rare Condition Can 'Masculinize' Women

Posted 21 Oct 2015 by Drugs.com

WEDNESDAY, Oct. 21, 2015 – For most women, some hair loss from the scalp along with more body hair are just regular signs of aging. In some cases, though, these changes may stem from a little-known condition that sends testosterone levels soaring. Writing in the Oct. 22 New England Journal of Medicine, doctors describe just such a case: A 57-year-old woman who came to them with body-hair growth, balding, an increasingly male-sounding voice, and other signs of excessive testosterone levels. After ruling out some of the usual suspects – including tumors of the adrenal glands and ovaries – her doctors eventually settled on an obscure diagnosis known as ovarian hyperthecosis. It's a condition that many doctors may not be aware of. Even endocrinologists – specialists in hormonal disorders – see relatively few cases come their way, said Dr. Graham McMahon, an endocrinologist who was at ... Read more

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Some Prostate Cancer Patients May Not Benefit From Hormone Therapy

Posted 22 Sep 2015 by Drugs.com

TUESDAY, Sept. 22, 2015 – Men with prostate cancer who also have had a heart attack may fare better with radiation therapy alone rather than with the standard treatment of radiation plus hormone therapy, a new analysis suggests. Over an average of 17 years of follow-up, men with high-risk prostate cancer who also had a heart condition lived longer after radiation treatment alone than similar men who had radiation and hormone therapy. Men who didn't have heart problems lived longer if they had both treatments, the researchers added. "There have been several trials looking at radiation with or without hormone therapy in high-risk prostate cancer which found a survival benefit from combined treatment," said lead researcher Dr. Anthony D'Amico, chief of radiation oncology at Brigham and Women's Hospital in Boston. However, whether hormone therapy causes an increase in death from heart ... Read more

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'Low T' Therapy Has Yet to Be Proven: FDA

Posted 19 Aug 2015 by Drugs.com

WEDNESDAY, Aug. 19, 2015 – Testosterone supplements have long been marketed to aging men as a fountain of youth and virility, but there is still no proof they are safe or effective, according to the U.S. Food and Drug Administration. Writing in the Aug. 20 edition of the New England Journal of Medicine, FDA officials said that only controlled clinical trials can show whether men benefit from treatment to reverse age-related dips in testosterone. The agency is now requiring product manufacturers to conduct those trials. As it stands, testosterone supplements are approved only for men with certain medical conditions that cause abnormally low levels of the hormone – such as damage to brain areas that control testosterone production. But once the FDA approves a drug, doctors are free to prescribe it as they see fit. And most American men on testosterone therapy have no clear medical ... Read more

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Mixed Results on Value of Testosterone Supplements for Men's Health

Posted 11 Aug 2015 by Drugs.com

TUESDAY, Aug. 11, 2015 – Testosterone therapy may not be as bad for men's heart health as previously thought, but it doesn't seem to turn back time on their sex lives either, a new trial shows. "That was the surprising thing," said senior study author Dr. Shalender Bhasin, director of the Boston Claude D. Pepper Older Americans Independence Center at Brigham and Women's Hospital in Boston. "Many middle-aged and older men take testosterone because they feel it will improve their sex life, but the study showed that men who had low-normal or slightly low levels did not show any improvement." Testosterone therapy has become big business in the United States, as baby boomers seek ways to counter the effects of aging, Bhasin said. Sales of testosterone amounted to around $20 million a year in the early 1990s, but by 2012 it had grown into a $2 billion industry, he said. However, recent ... Read more

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