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Injected Drug May Help Fight Osteoporosis in Women

Posted 16 Aug 2016 by Drugs.com

TUESDAY, Aug. 16, 2016 – An experimental drug appears to reduce the risk of bone fractures in postmenopausal women with osteoporosis better than a placebo and the currently available drug, a new study finds. In this phase 3 trial funded by the drug's maker, Radius Health, fewer women on the injectable drug abaloparatide had spine fractures (0.58 percent) than women receiving a placebo (4.22 percent) and slightly fewer than those taking a similar injectable drug, teriparatide (Forteo) (0.84 percent). "If this gets approved, and there is no reason to think it won't, this will be the second drug available for the treatment of high-risk osteoporosis," said lead researcher Dr. Paul Miller of the Colorado Center for Bone Research. Forteo has been in use for the past 16 years, he said. Abaloparatide works differently from Forteo and improves bone density more than Forteo, Miller said. Women ... Read more

Related support groups: Osteoporosis, Forteo, Fracture, bone, Prevention of Osteoporosis, Osteopenia, Teriparatide, Compression Fracture of Vertebral Column, Osteomalacia, Prevention of Fractures

Osteoporosis Drugs Work, But Review Finds No Clear Winner

Posted 8 Sep 2014 by Drugs.com

MONDAY, Sept. 8, 2014 – Many osteoporosis drugs cut women's risk of suffering a bone fracture, though it's not clear whether any one medication works better than others, a new research review finds. Reporting Sept. 8 in Annals of Internal Medicine, researchers said that for women with the bone-thinning disease osteoporosis, various drugs cut the risk of a spine fracture by 40 to 60 percent, compared to a placebo. When it comes to other bone breaks, including hip fractures, the drugs lower the risk by 20 to 40 percent, the study said. The beneficial drugs included bisphosphonates, sold under brand names such as Actonel (risedronate), Boniva (ibandronate) and Fosamax (alendronate), and the injection drugs denosumab (Prolia) and teriparatide (Forteo). Meanwhile, raloxifene (Evista) – a daily pill that has estrogen-like effects on bones – seems to cut the risk of spine fractures only, ... Read more

Related support groups: Osteoporosis, Fosamax, Forteo, Boniva, Alendronate, Prolia, Reclast, Fracture, bone, Evista, Actonel, Prevention of Osteoporosis, Zometa, Aclasta, Xgeva, Zoledronic Acid, Atelvia, Risedronate, Ibandronate, Teriparatide, Pamidronate

Combo Drug Therapy May Work Best to Strengthen Bones: Study

Posted 14 May 2013 by Drugs.com

TUESDAY, May 14 – A new combination drug therapy for osteoporosis appears to increase bone density more effectively than any treatment now on the market, according to the results of a small clinical trial. Researchers found that postmenopausal women experienced significant amounts of bone growth by taking a bone-building drug called teriparatide with denosumab, a targeted therapy drug used to stop bone loss. "A combination of these two medications increased bone density more than either does on its own, and it is more effective than any currently approved therapy," said study author Dr. Benjamin Leder, who is with the endocrine unit at Massachusetts General Hospital in Boston. The 12-month study, published online May 15 in The Lancet, was funded in part by the drugs' makers, Eli Lilly and Amgen. It involved 94 postmenopausal women being treated for osteoporosis, a bone-thinning ... Read more

Related support groups: Osteoporosis, Forteo, Prolia, Xgeva, Teriparatide, Denosumab

Implanted Microchip Might Be Future of Drug Delivery

Posted 16 Feb 2012 by Drugs.com

THURSDAY, Feb. 16 – Remote controls may not be for just appliances anymore. In a new small study, women with severe osteoporosis were implanted with a microchip that releases bone-building drugs at the push of a button, a delivery method that could someday become common for various health conditions. Roughly 1.5-by-2.5 inches in size, the microchip significantly improved patient compliance with a drug regimen that normally requires painful daily self-injections, study authors said. The clinical trial, conducted on seven osteoporosis patients in Denmark, was the first to test a wirelessly controlled microchip in this capacity. "It frees patients from the burden of managing their disease on a daily basis," said Robert Farra, co-author of the study and president and chief operating officer of MicroCHIPS Inc., the Waltham, Mass., company that funded and supervised the trial. "I think there ... Read more

Related support groups: Osteoporosis, Forteo, Teriparatide

Study Suggests Osteoporosis Drug Might Treat Loss of Bone in Jaw

Posted 17 Oct 2010 by Drugs.com

SATURDAY, Oct. 15 – People suffering from a disfiguring loss of bone in the jaw may find help in the form of a long-used osteoporosis drug, two new studies suggest. Besides being linked to chronic, severe gum disease, this type of bone loss has also been connected in rare cases to the use of bisphosphonates, a different class of osteoporosis drugs. But the two papers in the Oct. 16 online issue of the New England Journal of Medicine report success with teriparatide (Forteo) in rebuilding bone. One report describes the case of an 88-year-old woman who had been taking the bisphosphonate alendronate (Fosamax) since suffering a hip fracture 10 years earlier. She had also been taking the corticosteroid prednisone for two decades. Experts have already noticed an uptick in the incidence of this rare but devastating condition in patients using bisphosphonates. According to an editorial ... Read more

Related support groups: Fosamax, Forteo, Boniva, Alendronate, Reclast, Actonel, Zometa, Aclasta, Zoledronic Acid, Periodontitis, Ibandronate, Risedronate, Teriparatide, Pamidronate, Fosamax Plus D, Aredia, Skelid, Alendronate/Cholecalciferol, Etidronate, Actonel with Calcium

Better Drug Emerges for Steroid-Induced Bone Loss

Posted 1 Dec 2009 by Drugs.com

THURSDAY, Oct. 29 – The drug teriparatide is better at increasing bone density and reducing vertebral fractures in patients with glucocorticoid-induced osteoporosis than the drug alendronate, a new study finds. Glucocorticoids are steroid hormones produced in the body or contained in drugs that are used to control inflammation in patients with autoimmune diseases, such as rheumatoid arthritis, lupus and Crohn's disease, as well as inflammatory conditions such as asthma. Glucocorticoid-induced osteoporosis can occur in people taking steroid medications such as prednisone, prednisolone, dexamethasone and cortisone, according to background information provided in a news release about the study. The study participants included 428 patients, aged 22 to 89, with confirmed osteoporosis who had received more than 5 milligrams a day of prednisone or the equivalent for more than three months. ... Read more

Related support groups: Prednisone, Osteoporosis, Methylprednisolone, Prednisolone, Hydrocortisone, Forteo, Medrol, Cortisone, Dexamethasone, Triamcinolone, Betamethasone, Budesonide, Prevention of Osteoporosis, Decadron, Entocort, Solu-Medrol, Entocort EC, Medrol Dosepak, Cortef, Celestone

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Related Condition Support Groups

Osteoporosis, Hypoparathyroidism

Related Drug Support Groups

Forteo

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