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Intense Chemo Offers Little Benefit for Early Breast Cancer: Study

Posted 9 Nov 2016 by Drugs.com

WEDNESDAY, Nov. 9, 2016 – A more intense type of chemotherapy offers little benefit over standard chemotherapy for women with high-risk early breast cancer, European researchers report. Known as tailored dose-dense chemotherapy, the treatments are given over a shorter period of time without increasing the overall dose. It has been suggested as a way to improve the effectiveness of the treatment for early breast cancer. However, the European study did not find a difference in recurrence-free survival or overall survival after five years of follow-up. The investigators did find that the dose-dense group had better event-free survival, defined as the time to any breast cancer relapse, cancer in the opposite breast, other malignant growths or death from any cause. Despite the results, a U.S. breast cancer expert said there is still a role for the approach in certain women. Researchers from ... Read more

Related support groups: Provera, Depo-Provera, Breast Cancer, Lupron, Tamoxifen, Medroxyprogesterone, Arimidex, Femara, Lupron Depot, Breast Cancer, Metastatic, Anastrozole, Evista, Zoladex, Megestrol, Letrozole, Megace, Aromasin, Herceptin, Exemestane, Breast Cancer - Adjuvant

More Evidence Tamoxifen, Other Meds Help Limit Breast Cancer's Spread

Posted 6 Oct 2016 by Drugs.com

THURSDAY, Oct. 6, 2016 – Treatment with tamoxifen or another class of drugs called aromatase inhibitors does cut breast cancer patients' risk of developing cancer in their other breast, a new study finds. Some breast cancers rely on estrogen to help them grow, and drugs like tamoxifen or the aromatase inhibitors (which include anastrozole) have long been prescribed to certain breast cancer survivors. Tamoxifen blocks estrogen receptors in the breast cells to hamper cancer growth. Anastrozole stops estrogen production in fat tissue, which makes small amounts of the hormone. According to background information in the new study, about 5 percent of breast cancer patients develop cancer in their other breast (contralateral breast cancer) within 10 years after their initial breast cancer diagnosis. Prior clinical trials had concluded that tamoxifen and aromatase inhibitors reduce this risk, ... Read more

Related support groups: Breast Cancer, Tamoxifen, Arimidex, Femara, Breast Cancer, Metastatic, Anastrozole, Letrozole, Aromasin, Exemestane, Breast Cancer - Adjuvant, Breast Cancer, Prevention, Breast Cancer - Palliative, Tamoxifen Hexal, Nolvadex, Tamofen, Tamosin, Testolactone, Soltamox, Tamone, Emblon

Tamoxifen OK for Breast Cancer Patients Without Uterine Abnormalities: Study

Posted 22 Sep 2016 by Drugs.com

THURSDAY, Sept. 22, 2016 – For most women, taking the breast cancer drug tamoxifen doesn't increase their risk of uterine cancer, a new study suggests. For women who don't already have precancerous abnormalities in the uterine lining (endometrium), the risk is small, according to the Loyola Medicine study. The researchers said a pretreatment ultrasound may ease women's concerns. "Many women who would benefit from taking tamoxifen fail to do so because they fear getting endometrial cancer," first author Dr. Ronald Potkul said in a Loyola news release. "Our study found that for women who did not have endometrial abnormalities when they began taking tamoxifen, there was a very low rate of developing pre-malignant conditions." Potkul is chairman of obstetrics and gynecology and director of gynecologic oncology for the Loyola University Health System in Maywood, Ill. The study, funded by ... Read more

Related support groups: Breast Cancer, Tamoxifen, Endometrial Cancer, Breast Cancer - Adjuvant, Breast Cancer, Prevention, Tamoxifen Hexal, Nolvadex, Tamoxen, Genox, Nolvadex D, Tamofen, Tamosin, Emblon, Soltamox, Tamone

Longer Use of Certain Drugs Cuts Recurrence for Breast Cancer Survivors

Posted 6 Jun 2016 by Drugs.com

MONDAY, June 6, 2016 – Many survivors of breast cancers that are sensitive to estrogen are advised to take hormone-suppressing drugs such as tamoxifen for five years, to cut their odds for a recurrence. Tamoxifen can have onerous side effects, however. Now, new research finds that taking an alternative, and less troublesome, class of medications for a full decade can reduce the risk for recurrence even more – without affecting a woman's quality of life. The newer class of hormone-suppressing drugs are called aromatase inhibitors, and include drugs such as letrozole (Femara), anastrozole (Arimidex) and exemestane (Aromasin). "Aromatase inhibitors do not have all the side effects of tamoxifen and overall are much better tolerated than tamoxifen," explained one breast cancer expert, Dr. Stephanie Bernik. She believes the new study supports the benefit of aromatase inhibitors, and "women ... Read more

Related support groups: Breast Cancer, Tamoxifen, Arimidex, Femara, Breast Cancer, Metastatic, Anastrozole, Letrozole, Aromasin, Exemestane, Breast Cancer - Adjuvant, Breast Cancer, Prevention, Breast Cancer - Palliative, Osteolytic Bone Metastases of Breast Cancer, Tamoxifen Hexal, Nolvadex, Tamofen, Tamosin, Soltamox, Tamone, Emblon

U.S. Pays Highest Prices for Cancer Meds: Study

Posted 6 Jun 2016 by Drugs.com

MONDAY, June 6, 2016 – The United States pays the highest prices in the world for generic and brand-name cancer drugs, a new study has found. However, as the world's wealthiest nation, the United States is better able to pay for those pricey drugs than poorer countries with somewhat lower medication prices, added study lead author Dr. Daniel Goldstein. People in China and India are much less able to afford cancer drugs than Americans, he said, even though U.S. monthly drug prices are about three to six times higher in the United States. That doesn't mean America came out on top in overall drug affordability, however. Developed nations such as Australia, England and Israel had the "best deal" in the world on cancer drugs, thanks to government programs that regulate drug pricing, the study found. "America is the wealthiest nation, but its drug prices are significantly higher – so much ... Read more

Related support groups: Cancer, Provera, Depo-Provera, Methotrexate, Breast Cancer, Accutane, Lupron, Tamoxifen, Medroxyprogesterone, Arimidex, Tretinoin, Fluorouracil, Lupron Depot, Femara, Gleevec, Lung Cancer, Colorectal Cancer, Isotretinoin, Rituxan, Claravis

Breast Cancer Meds Won't Raise Chances of Heart Attack, Stroke, Study Suggests

Posted 21 Apr 2016 by Drugs.com

THURSDAY, April 21, 2016 – Treatment with estrogen-lowering drugs called aromatase inhibitors doesn't raise the risk of heart attacks and strokes among breast cancer survivors, a new study suggests. However, the researchers did find that women who took the drugs had a slightly higher risk of less serious heart problems, such as an abnormal heart beat or swelling and irritation of the membrane surrounding the heart. "Our study is a comprehensive assessment of the impact aromatase inhibitors have on cardiovascular risk and provides reassurance that the hormone therapy to reduce breast cancer recurrence does not increase risk of the most fatal cardiovascular events," said study author Reina Haque. She is a research scientist at Kaiser Permanente's Southern California Department of Research and Evaluation. "A particular strength of our study is that we accounted for women's other potential ... Read more

Related support groups: Heart Disease, Breast Cancer, Tamoxifen, Arimidex, Femara, Breast Cancer, Metastatic, Anastrozole, Letrozole, Aromasin, Exemestane, Breast Cancer - Adjuvant, Breast Cancer, Prevention, Breast Cancer - Palliative, Breast Cancer - Male, Tamoxifen Hexal, Nolvadex, Tamofen, Tamosin, Soltamox, Testolactone

1 in 4 Breast Cancer Lumpectomies Requires Follow-Up Surgery

Posted 17 Feb 2016 by Drugs.com

WEDNESDAY, Feb. 17, 2016 – Women with early stage breast cancer who opt for a breast-conserving surgery known as a lumpectomy have a one in four chance they will need a second operation within 90 days, researchers report. "The chance of getting a second surgery has gone down a little, but it is still high and it is substantial," said study author Dr. Art Sedrakyan. He is a professor of health care policy and research at Weill Cornell Medical Center in New York City. In a lumpectomy, the tumor tissue, along with a margin of surrounding tumor-free tissue, is removed. However, if the tissue in the margin is not completely free of tumor cells, a second operation is needed. During the study period, which ran from 2003 through 2013, the overall rate of re-operation within 90 days was almost 31 percent, Sedrakyan said. It declined from nearly 40 percent in 2003 through 2004, to 23 percent ... Read more

Related support groups: Surgery, Breast Cancer, Tamoxifen, Breast Cancer - Adjuvant, Breast Cancer, Prevention, Surgical Prophylaxis, Breast Cancer - Palliative, Vascular Surgery, Tamoxifen Hexal, Nolvadex, Tamoxen, Genox, Nolvadex D, Tamofen, Tamosin, Emblon, Soltamox, Tamone

Early Chemo Less Likely to Help Black Breast Cancer Patients: Study

Posted 12 Dec 2015 by Drugs.com

FRIDAY, Dec. 11, 2015 – Early chemotherapy is less likely to benefit black women with breast cancer than those in other racial and ethnic groups, a new study finds. Advanced breast cancer is more common among black, Hispanic and Asian women than it is in white women. As a result, black women often receive chemotherapy before surgery in an effort to improve their outcomes, the Yale University Cancer Center researchers said. But their study of 27,300 women with stage 1 to 3 breast cancer showed that early (neoadjuvant) chemotherapy was less effective in black patients than in other women. "Even when we controlled for the fact that minority women often present with more advanced-stage, higher-grade tumors, and more aggressive types of breast cancer overall, our team was surprised to find that black women did not respond as well to neoadjuvant chemotherapy compared to other racial groups," ... Read more

Related support groups: Provera, Depo-Provera, Breast Cancer, Lupron, Tamoxifen, Medroxyprogesterone, Arimidex, Femara, Lupron Depot, Breast Cancer, Metastatic, Anastrozole, Zoladex, Evista, Megestrol, Letrozole, Megace, Aromasin, Herceptin, Exemestane, Casodex

Two Drugs Equal in Preventing Early Breast Cancer's Return: Study

Posted 11 Dec 2015 by Drugs.com

FRIDAY, Dec. 11, 2015 – Postmenopausal women who have an early, noninvasive form of breast cancer had similar recurrence rates of disease whether they took the drug tamoxifen or the aromatase inhibitor anastrozole after surgery, new research shows. However, the side effects of the two medications differed greatly, said study author Jack Cuzick, director of the Wolfson Institute of Preventive Medicine at Queen Mary University of London, England. His team looked at nearly 3,000 women, all past menopause, who had hormone-receptor positive ductal carcinoma in situ (DCIS) breast cancer and underwent surgery to excise it. With DCIS, the cells that line the milk ducts have changed but not spread into the surrounding breast tissue. Half the women were randomly assigned to take 1 milligram (mg) a day of anastrozole (Arimidex), while the other half took 20 mg a day of tamoxifen (Nolvadex). Each ... Read more

Related support groups: Provera, Depo-Provera, Breast Cancer, Lupron, Tamoxifen, Medroxyprogesterone, Arimidex, Femara, Lupron Depot, Breast Cancer, Metastatic, Anastrozole, Zoladex, Evista, Megestrol, Letrozole, Megace, Aromasin, Herceptin, Exemestane, Casodex

Timing May Be Key to Success of Surgery, Chemo for Early Breast Cancer

Posted 10 Dec 2015 by Drugs.com

THURSDAY, Dec. 10, 2015 – The sooner early stage breast cancer patients have surgery following their diagnosis, and chemotherapy after their surgery, the better their chances of survival, two new studies find. In one study, researchers at Fox Chase Cancer Center in Philadelphia analyzed data from more than 94,500 American women aged 66 and older. All were diagnosed with breast cancer between 1992 and 2009. The team, led by Dr. Richard Bleicher, found a 9 percent increased risk of death from all causes for each 30-day delay in the time from diagnosis to surgery. The link between time to surgery and risk of death from all causes was only statistically significant for patients with earlier stages of cancer, the researchers noted. In the study, delays seemed to affect prognosis for patients with stage 1 and stage 2 cancers, but not for those with stage 3 cancers. The findings were similar ... Read more

Related support groups: Surgery, Provera, Depo-Provera, Breast Cancer, Lupron, Tamoxifen, Medroxyprogesterone, Arimidex, Femara, Lupron Depot, Breast Cancer, Metastatic, Anastrozole, Zoladex, Evista, Megestrol, Letrozole, Megace, Aromasin, Herceptin, Exemestane

Depression May Be Tied to Lower Breast Cancer Survival

Posted 10 Dec 2015 by Drugs.com

THURSDAY, Dec. 10, 2015 – Breast cancer patients with depression may have a much higher risk of death than those without the mental illness, a new study suggests. "Low mood and depression are understandable reactions to a breast cancer diagnosis. Clinicians generally know to look out for this, but these findings emphasize the need to ask patients with cancer about their mood and for women to know it's OK to ask for help," Elizabeth Davies, of the division of health and social care research and cancer studies at King's College London, said in a school news release. "It is important women feel they can talk about these feelings and do not feel guilty about difficulty coping or depression, which can be a natural response to cancer diagnosis," she added. Although this study found a link between depression and breast cancer survival, it's important to note that the research can't prove ... Read more

Related support groups: Depression, Lexapro, Zoloft, Cymbalta, Effexor, Prozac, Provera, Celexa, Depo-Provera, Citalopram, Paxil, Major Depressive Disorder, Sertraline, Pristiq, Amitriptyline, Fluoxetine, Venlafaxine, Effexor XR, Breast Cancer, Mirtazapine

Lumpectomy Plus Radiation May Beat Mastectomy for Early Breast Cancer

Posted 10 Dec 2015 by Drugs.com

THURSDAY, Dec. 10, 2015 – Women with early stage breast cancer may survive longer if they opt for the less-extensive surgery called lumpectomy, followed by radiation, rather than a mastectomy, a new study suggests. "I think these results offer women important information to discuss with their doctors when making a treatment decision for early stage breast cancer," said lead researcher Sabine Seisling, of the Netherlands Comprehensive Cancer Organization, in Utrecht. Mastectomy removes the entire the breast, while lumpectomy involves removing only the tumor with some surrounding tissue. Some studies have suggested that women with early stage breast cancer have a better five-year survival rate after lumpectomy. The new study, which included 37,000 Dutch women, found that the advantage may also extend to the longer term. Of nearly 22,000 patients who underwent lumpectomy plus radiation, ... Read more

Related support groups: Surgery, Cancer, Provera, Depo-Provera, Breast Cancer, Lupron, Tamoxifen, Medroxyprogesterone, Arimidex, Femara, Lupron Depot, Anastrozole, Zoladex, Evista, Megestrol, Letrozole, Megace, Aromasin, Exemestane, Casodex

Cooling Cap to Reduce Chemo-Linked Hair Loss OK'd

Posted 9 Dec 2015 by Drugs.com

WEDNESDAY, Dec. 9, 2015 – The Dignitana Cooling System cap has been approved by the U.S. Food and Drug Administration to help prevent hair loss in women undergoing chemotherapy for breast cancer. A computer-controlled system circulates cooled liquid to the cap during chemotherapy. This is designed to constrict blood vessels in the scalp, limiting the amount of chemotherapy drugs that reach the hair follicles, the agency said in a news release. In clinical testing, more than two-thirds of women who wore the cap reported losing less than half of their hair. And the likelihood of chemotherapy drugs missing an isolated cluster of breast cancer cells in the scalp because of the cap was "extremely rare," the FDA said. But since the cap doesn't work with all chemotherapy drugs, any woman interested in using the product should speak with her doctor, the FDA advised. The most common side ... Read more

Related support groups: Provera, Depo-Provera, Breast Cancer, Lupron, Alopecia, Tamoxifen, Medroxyprogesterone, Arimidex, Femara, Lupron Depot, Anastrozole, Zoladex, Evista, Megestrol, Letrozole, Megace, Aromasin, Herceptin, Exemestane, Casodex

Drugs May Protect the Heart During Chemotherapy

Posted 9 Dec 2015 by Drugs.com

WEDNESDAY, Dec. 9, 2015 – Two kinds of medications can prevent heart damage in breast cancer patients as they undergo chemotherapy, a new study suggests. Chemotherapy improves survival among women with early-stage breast cancer, but can dramatically increase their risk of heart failure, the researchers explained. This five-year study of 100 early-stage breast cancer patients in Canada found that two kinds of heart medicines – beta blockers and ACE inhibitors – seem to protect the heart during chemotherapy. "We think this is practice-changing. This will improve the safety of the cancer treatment that we provide," study co-investigator Edith Pituskin, an assistant professor in the Faculty of Nursing and Faculty of Medicine and Dentistry at the University of Alberta in Canada, said in a university news release. The heart medications not only protect the heart, but may also improve ... Read more

Related support groups: Lisinopril, Provera, Depo-Provera, Metoprolol, Atenolol, Breast Cancer, Propranolol, Heart Failure, Lupron, Congestive Heart Failure, Bystolic, Tamoxifen, Medroxyprogesterone, Carvedilol, Ramipril, Bisoprolol, Arimidex, Coreg, Lupron Depot, Femara

Experts Issue Guidelines on Caring for Breast Cancer Survivors

Posted 7 Dec 2015 by Drugs.com

MONDAY, Dec. 7, 2015 – Battling breast cancer is tough, but survivors need care, too. Now, two major groups in cancer care have issued guidelines on the type of follow-up these patients require. The protocols, released jointly by the American Cancer Society and the American Society of Clinical Oncology, are "much needed for the 3.1 million breast cancer survivors who are alive in the United States today," said one expert, Dr. Eleonora Teplinsky, a medical oncologist with North Shore-LIJ Cancer Institute in Lake Success, N.Y. "Survivorship is defined as living with, through and beyond cancer, and each of these phases comes with unique concerns and challenges," she said. According to the new guidelines, regular monitoring of patients for the return of any cancer is one key recommendation. This monitoring should include evaluation – such as a detailed cancer history and physical ... Read more

Related support groups: Breast Cancer, Tamoxifen, Breast Cancer, Metastatic, Breast Cancer - Adjuvant, Breast Cancer, Prevention, Breast Cancer - Palliative, Osteolytic Bone Metastases of Breast Cancer, Breast Cancer - Male, Tamoxifen Hexal, Nolvadex, Tamoxen, Genox, Nolvadex D, Tamofen, Tamosin, Emblon, Soltamox, Tamone

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