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HRT Won't Lower Women's Alzheimer's Risk, Study Finds

Posted 16 Feb 2017 by Drugs.com

THURSDAY, Feb. 16, 2017 – Women who use hormone therapy after menopause may not have a lower risk of developing Alzheimer's, a new study suggests. However, there was some evidence that long-term use – over a decade – might be tied to a lower risk of the memory-robbing brain disease. But the results were far from definitive, the researchers added. The study is the latest to delve into the question of whether menopausal hormone therapy can benefit women's brains. Research so far has yielded conflicting findings. On one hand, a number of trials have found no brain benefits for women using hormone therapy, said Dr. JoAnn Pinkerton, executive director of the North American Menopause Society. On the other hand, small trials have found that when hormone therapy is given after surgical menopause, women can see "cognitive benefits," said Pinkerton, who was not involved in the new study. On ... Read more

Related support groups: Plan B, Mirena, Nexplanon, NuvaRing, Provera, Depo-Provera, Sprintec, Implanon, Hot Flashes, Ortho Tri-Cyclen, Tri-Sprintec, Microgestin Fe 1/20, Yasmin, Loestrin 24 Fe, Plan B One-Step, Ortho Evra, TriNessa, Menopausal Disorders, Estradiol, Mononessa

Fat Near the Heart a Hazard for Postmenopausal Women

Posted 31 Jan 2017 by Drugs.com

TUESDAY, Jan. 31, 2017 – When a certain type of fat collects around the heart, it may be a sign of developing heart disease in postmenopausal women, a new study suggests. As estrogen levels fall during menopause, deposits of "paracardial" fat increase, the researchers found. This may cause more calcium build-up in the heart's arteries, an early sign of heart disease. Paracardial fat sits in pockets around the heart. These pockets lie between the heart and another type of fat that covers the heart called epicardial fat, the study authors explained. Epicardial fat provides energy to the heart, but paracardial fat has no known beneficial function, the researchers said. "We are showing for the first time that paracardial fat is associated with greater risk of calcification [calcium build-up] in postmenopausal women, more than in premenopausal women," said lead researcher Samar El Khoudary. ... Read more

Related support groups: Obesity, Hot Flashes, Heart Disease, High Cholesterol, Menopausal Disorders, Estradiol, Premarin, Ethinyl Estradiol, Estrace, Postmenopausal Symptoms, Vagifem, Estrace Vaginal Cream, Vivelle, Atrophic Vaginitis, Climara, Hypertriglyceridemia, Estring, Vivelle-Dot, Premarin Vaginal, Estradiol Patch

'Chemo Brain' Lasts for Months in Many Breast Cancer Survivors

Posted 11 Jan 2017 by Drugs.com

WEDNESDAY, Jan. 11, 2017 – "Chemo brain" – the mental fog common after breast cancer treatment – can persist for six months, new research shows. The finding comes from one of the largest studies to date to look at chemotherapy-related thinking problems that plague many women treated for breast cancer. Those problems can include memory lapses, attention issues and difficulty processing information. When researchers compared hundreds of U.S. women six months after chemotherapy ended with hundreds of healthy women, they found more than one-third of the chemotherapy group had a decline in thinking scores versus less than 15 percent of the others. "The bottom line is, this is a real problem, patients are having difficulties and we need to acknowledge it is one of the difficulties of treatment," said Dr. Patricia Ganz. Ganz is director of cancer prevention and control research at the ... Read more

Related support groups: Cancer, Provera, Depo-Provera, Breast Cancer, Lupron, Medroxyprogesterone, Tamoxifen, Arimidex, Lupron Depot, Femara, Zoladex, Anastrozole, Breast Cancer, Metastatic, Letrozole, Evista, Megestrol, Megace, Afinitor, Herceptin, Aromasin

Study Casts More Doubt on Value of Mammograms

Posted 10 Jan 2017 by Drugs.com

MONDAY, Jan. 9, 2017 – Mammograms frequently detect small breast tumors that might never become life-threatening, causing women to receive treatment they likely don't need, a new Danish study finds. About one in every three women between the ages of 50 and 69 who was diagnosed with breast cancer wound up having a tumor that posed no immediate threat to her health, the researchers reported. At the same time, mammography did not reduce the number of advanced breast cancers found in women in the study. "This means that breast screening is unlikely to improve breast cancer survival or reduce the use of invasive surgery," said study author Dr. Karsten Juhl Jorgensen, deputy director of research for the Nordic Cochrane Center at the Rigshospitalet in Copenhagen. "It also means that breast screening leads to unnecessary detection and treatment of many breast cancers." Dr. Otis Brawley, chief ... Read more

Related support groups: Provera, Depo-Provera, Breast Cancer, Lupron, Medroxyprogesterone, Tamoxifen, Arimidex, Lupron Depot, Femara, Zoladex, Anastrozole, Letrozole, Evista, Megestrol, Megace, Herceptin, Aromasin, Exemestane, Casodex, Eligard

New Drug Combo Shows Promise Curbing Tough-to-Treat Breast Cancer

Posted 8 Dec 2016 by Drugs.com

THURSDAY, Dec. 8, 2016 – In women with a certain form of tough-to-treat breast cancer, treatment with a combination of two drugs appeared to keep the cancer at bay longer – from about five months to 10, a new study says. The cancer is known as "advanced hormone receptor positive, HER 2 negative" breast cancer. Women with these tumors are often given drugs called aromatase inhibitors, which work by reducing estrogen in the body and slowing the growth of the cancer. However, patients commonly develop resistance to aromatase inhibitor drugs, and they stop working. This is also known as endocrine therapy resistance. The new research may offer these patients some hope, researchers said. "Our study has shown that combining a newer medicine called everolimus [Afinitor] with a more established medicine, fulvestrant [Faslodex], has demonstrated benefit in aromatase inhibitor resistant breast ... Read more

Related support groups: Breast Cancer, Estradiol, Premarin, Ethinyl Estradiol, Estrace, Arimidex, Femara, Vagifem, Estrace Vaginal Cream, Vivelle, Anastrozole, Breast Cancer, Metastatic, Climara, Letrozole, Estring, Vivelle-Dot, Premarin Vaginal, Afinitor, Estradiol Patch, Aromasin

Breast Cancer Cells May Change When They Spread to Brain: Study

Posted 7 Dec 2016 by Drugs.com

WEDNESDAY, Dec. 7, 2016 – When breast cancer spreads to the brain, important molecular changes may occur in the cancer, a small study found. The discovery of these changes could lead to improved diagnosis and treatment, the researchers said. About 20 percent of breast cancers are a type known as HER2-positive, which typically respond to targeted therapies. However, HER2-negative breast cancer that has spread to the brain doesn't respond to the same therapies. In this study, researchers analyzed tumors from 20 patients in the United States and Ireland. They found that primary breast cancer identified as HER2-negative switched to HER2-positive when it spread to the brain. The findings show that treatments should target not only the original breast cancer, but also brain tumors, said study author Adrian Lee, director of the Institute for Precision Medicine, part of the University of ... Read more

Related support groups: Breast Cancer, Estradiol, Premarin, Ethinyl Estradiol, Estrace, Arimidex, Femara, Vagifem, Estrace Vaginal Cream, Vivelle, Anastrozole, Breast Cancer, Metastatic, Climara, Letrozole, Estring, Vivelle-Dot, Premarin Vaginal, Estradiol Patch, Herceptin, Aromasin

Intense Chemo Offers Little Benefit for Early Breast Cancer: Study

Posted 9 Nov 2016 by Drugs.com

WEDNESDAY, Nov. 9, 2016 – A more intense type of chemotherapy offers little benefit over standard chemotherapy for women with high-risk early breast cancer, European researchers report. Known as tailored dose-dense chemotherapy, the treatments are given over a shorter period of time without increasing the overall dose. It has been suggested as a way to improve the effectiveness of the treatment for early breast cancer. However, the European study did not find a difference in recurrence-free survival or overall survival after five years of follow-up. The investigators did find that the dose-dense group had better event-free survival, defined as the time to any breast cancer relapse, cancer in the opposite breast, other malignant growths or death from any cause. Despite the results, a U.S. breast cancer expert said there is still a role for the approach in certain women. Researchers from ... Read more

Related support groups: Provera, Depo-Provera, Breast Cancer, Lupron, Medroxyprogesterone, Tamoxifen, Arimidex, Lupron Depot, Femara, Zoladex, Anastrozole, Breast Cancer, Metastatic, Letrozole, Evista, Megestrol, Megace, Herceptin, Aromasin, Exemestane, Breast Cancer - Adjuvant

Hormone Therapy Won't Help Memory After Menopause

Posted 19 Jul 2016 by Drugs.com

TUESDAY, July 19, 2016 – Women who take estrogen after menopause may believe it helps them maintain their memory and thinking skills, but a new study suggests they are mistaken. Researchers found no change in mental ability associated with estrogen therapy among women who used it after menopause, no matter when they started taking it. "There is no important benefit, there is no important risk cognitively associated with the use of hormone therapy over at least five years," said lead researcher Dr. Victor Henderson. He is a professor of health research and policy, and neurology and neurological science at Stanford University School of Medicine, in Palo Alto, Calif. "If a postmenopausal woman is considering taking hormone therapy with the thought that it might improve memory or other aspects of cognition, she should know that there is no evidence that it does benefit cognition," he said. ... Read more

Related support groups: Hot Flashes, Menopausal Disorders, Estradiol, Premarin, Ethinyl Estradiol, Estrace, Postmenopausal Symptoms, Vagifem, Estrace Vaginal Cream, Vivelle, Atrophic Vaginitis, Climara, Estring, Vivelle-Dot, Premarin Vaginal, Estradiol Patch, Perimenopausal Symptoms, Mild Cognitive Impairment, Minivelle, Evamist

U.S. Pays Highest Prices for Cancer Meds: Study

Posted 6 Jun 2016 by Drugs.com

MONDAY, June 6, 2016 – The United States pays the highest prices in the world for generic and brand-name cancer drugs, a new study has found. However, as the world's wealthiest nation, the United States is better able to pay for those pricey drugs than poorer countries with somewhat lower medication prices, added study lead author Dr. Daniel Goldstein. People in China and India are much less able to afford cancer drugs than Americans, he said, even though U.S. monthly drug prices are about three to six times higher in the United States. That doesn't mean America came out on top in overall drug affordability, however. Developed nations such as Australia, England and Israel had the "best deal" in the world on cancer drugs, thanks to government programs that regulate drug pricing, the study found. "America is the wealthiest nation, but its drug prices are significantly higher – so much ... Read more

Related support groups: Cancer, Provera, Depo-Provera, Methotrexate, Breast Cancer, Accutane, Lupron, Medroxyprogesterone, Tamoxifen, Arimidex, Fluorouracil, Tretinoin, Lupron Depot, Femara, Lung Cancer, Gleevec, Colorectal Cancer, Rituxan, Isotretinoin, Zoladex

Exploring the Link Between Estrogen and Migraines

Posted 1 Jun 2016 by Drugs.com

WEDNESDAY, June 1, 2016 – Researchers are getting a better understanding of the link between estrogen levels and migraine headaches in women. A new study finds that for women who get these intense headaches, levels of the hormone estrogen drop more rapidly in the days before menstruation than in women without the headaches. "These results suggest that a 'two-hit' process may link estrogen withdrawal to menstrual migraine," said study author Dr. Jelena Pavlovic, of the Albert Einstein College of Medicine/Montefiore Medical Center in New York City. "More rapid estrogen decline may make women vulnerable to common triggers for migraine attacks such as stress, lack of sleep, foods and wine." Researchers looked at urine samples of 114 women with migraines and 223 women without migraines, average age 47. Estrogen levels among those with migraines dropped 40 percent in the days just before ... Read more

Related support groups: Migraine, Estradiol, Migraine Prevention, Premarin, Ethinyl Estradiol, Estrace, Migraine Prophylaxis, Vagifem, Estrace Vaginal Cream, Vivelle, Climara, Estring, Vivelle-Dot, Premarin Vaginal, Estradiol Patch, Minivelle, Evamist, Cenestin, Femring, Enjuvia

The Pill, Hormone Therapy Safe for Women Taking Blood Thinners: Study

Posted 22 Dec 2015 by Drugs.com

TUESDAY, Dec. 22, 2015 – Women on blood thinners can also take contraceptives that contain estrogen, or hormone replacement therapy, without raising their risk for blood clots or uterine bleeding, a new Italian study finds. Currently, women diagnosed with blood clots may be advised to stop hormone therapy or use of the contraceptive pill – even if they are already on a blood thinner. The reason: Doctors are often concerned that these drug combinations might raise the patient's risk for more clots. However, "there has been no evidence to support this decision," said the study's senior author, Dr. Ida Martinelli, of the A. Bianchi Bonomi Hemophilia and Thrombosis Center in Milan. "We conducted this study to address the fear felt by both the physician and patient when making the decision to stop or continue hormone therapy in this setting," she explained in a news release from the ... Read more

Related support groups: Birth Control, Contraception, Blood Disorders, Emergency Contraception, Bleeding Disorder, Hot Flashes, Warfarin, Coumadin, Menopausal Disorders, Estradiol, Xarelto, Premarin, Pradaxa, Postcoital Contraception, Ethinyl Estradiol, Estrace, Lovenox, Eliquis, Postmenopausal Symptoms, Vagifem

Early Chemo Less Likely to Help Black Breast Cancer Patients: Study

Posted 12 Dec 2015 by Drugs.com

FRIDAY, Dec. 11, 2015 – Early chemotherapy is less likely to benefit black women with breast cancer than those in other racial and ethnic groups, a new study finds. Advanced breast cancer is more common among black, Hispanic and Asian women than it is in white women. As a result, black women often receive chemotherapy before surgery in an effort to improve their outcomes, the Yale University Cancer Center researchers said. But their study of 27,300 women with stage 1 to 3 breast cancer showed that early (neoadjuvant) chemotherapy was less effective in black patients than in other women. "Even when we controlled for the fact that minority women often present with more advanced-stage, higher-grade tumors, and more aggressive types of breast cancer overall, our team was surprised to find that black women did not respond as well to neoadjuvant chemotherapy compared to other racial groups," ... Read more

Related support groups: Provera, Depo-Provera, Breast Cancer, Lupron, Medroxyprogesterone, Tamoxifen, Arimidex, Lupron Depot, Femara, Zoladex, Anastrozole, Breast Cancer, Metastatic, Letrozole, Evista, Megestrol, Megace, Herceptin, Aromasin, Exemestane, Breast Cancer - Adjuvant

Two Drugs Equal in Preventing Early Breast Cancer's Return: Study

Posted 11 Dec 2015 by Drugs.com

FRIDAY, Dec. 11, 2015 – Postmenopausal women who have an early, noninvasive form of breast cancer had similar recurrence rates of disease whether they took the drug tamoxifen or the aromatase inhibitor anastrozole after surgery, new research shows. However, the side effects of the two medications differed greatly, said study author Jack Cuzick, director of the Wolfson Institute of Preventive Medicine at Queen Mary University of London, England. His team looked at nearly 3,000 women, all past menopause, who had hormone-receptor positive ductal carcinoma in situ (DCIS) breast cancer and underwent surgery to excise it. With DCIS, the cells that line the milk ducts have changed but not spread into the surrounding breast tissue. Half the women were randomly assigned to take 1 milligram (mg) a day of anastrozole (Arimidex), while the other half took 20 mg a day of tamoxifen (Nolvadex). Each ... Read more

Related support groups: Provera, Depo-Provera, Breast Cancer, Lupron, Medroxyprogesterone, Tamoxifen, Arimidex, Lupron Depot, Femara, Zoladex, Anastrozole, Breast Cancer, Metastatic, Letrozole, Evista, Megestrol, Megace, Herceptin, Aromasin, Exemestane, Breast Cancer - Adjuvant

Timing May Be Key to Success of Surgery, Chemo for Early Breast Cancer

Posted 10 Dec 2015 by Drugs.com

THURSDAY, Dec. 10, 2015 – The sooner early stage breast cancer patients have surgery following their diagnosis, and chemotherapy after their surgery, the better their chances of survival, two new studies find. In one study, researchers at Fox Chase Cancer Center in Philadelphia analyzed data from more than 94,500 American women aged 66 and older. All were diagnosed with breast cancer between 1992 and 2009. The team, led by Dr. Richard Bleicher, found a 9 percent increased risk of death from all causes for each 30-day delay in the time from diagnosis to surgery. The link between time to surgery and risk of death from all causes was only statistically significant for patients with earlier stages of cancer, the researchers noted. In the study, delays seemed to affect prognosis for patients with stage 1 and stage 2 cancers, but not for those with stage 3 cancers. The findings were similar ... Read more

Related support groups: Surgery, Provera, Depo-Provera, Breast Cancer, Lupron, Medroxyprogesterone, Tamoxifen, Arimidex, Lupron Depot, Femara, Zoladex, Anastrozole, Breast Cancer, Metastatic, Letrozole, Evista, Megestrol, Megace, Herceptin, Aromasin, Exemestane

Depression May Be Tied to Lower Breast Cancer Survival

Posted 10 Dec 2015 by Drugs.com

THURSDAY, Dec. 10, 2015 – Breast cancer patients with depression may have a much higher risk of death than those without the mental illness, a new study suggests. "Low mood and depression are understandable reactions to a breast cancer diagnosis. Clinicians generally know to look out for this, but these findings emphasize the need to ask patients with cancer about their mood and for women to know it's OK to ask for help," Elizabeth Davies, of the division of health and social care research and cancer studies at King's College London, said in a school news release. "It is important women feel they can talk about these feelings and do not feel guilty about difficulty coping or depression, which can be a natural response to cancer diagnosis," she added. Although this study found a link between depression and breast cancer survival, it's important to note that the research can't prove ... Read more

Related support groups: Depression, Lexapro, Zoloft, Cymbalta, Effexor, Prozac, Provera, Depo-Provera, Celexa, Major Depressive Disorder, Citalopram, Paxil, Sertraline, Pristiq, Effexor XR, Amitriptyline, Venlafaxine, Fluoxetine, Breast Cancer, Mirtazapine

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