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Clues to MS May Lurk in Gut Bacteria

Posted 10 days ago by Drugs.com

TUESDAY, Sept. 12, 2017 – Certain types of bacteria in the gut may play a role in the progression of multiple sclerosis, according to researchers working with mice. The research, the study authors believe, could lead to new ways to treat multiple sclerosis (MS), an autoimmune neurodegenerative disease that affects about 2.5 million people worldwide. "The [gut] microbiome is very malleable," study senior author Sergio Baranzini said. "You could relatively easily change it in an adult who has MS or is susceptible – something you cannot do with their genetics. This is not a magical approach, but it is hopeful." MS occurs when the immune system attacks the insulation (myelin) around nerve cells. This can lead to vision loss, weakness, problems with coordination and balance and, in some cases, paralysis. The study included 71 MS patients and a "control" group of 71 healthy people. Specific ... Read more

Related support groups: Multiple Sclerosis, Chronic Spasticity, Central Nervous System Disorders, Spasticity, Diagnosis and Investigation, Upper Limb Spasticity, Spinal Spasticity, Lower Limb Spasticity

More Evidence Links the 'Mono' Virus to MS Risk

Posted 30 Aug 2017 by Drugs.com

WEDNESDAY, Aug. 30, 2017 – There's more evidence that having mononucleosis may up the risk for multiple sclerosis (MS), with researchers reporting that the link isn't limited to whites. In fact, while "mono consistently increases the risk of developing MS by two- to threefold" among whites, blacks and Hispanics saw a fourfold increased risk in the new study, said lead author Dr. Annette Langer-Gould. She is a neuroscience researcher with Southern California Permanente Medical Group. If exposed in childhood, the Epstein-Barr virus that causes mono involves hardly any symptoms. But exposure in adolescence or adulthood can trigger severe symptoms such as fatigue, fever, sore throat and swollen lymph nodes, according to the U.S. Centers for Disease Control and Prevention. "The main theory is that by delaying infection with this common childhood virus into adulthood, it alters the immune ... Read more

Related support groups: Multiple Sclerosis, Infectious Mononucleosis, Mononucleosis, Spasticity

Resistance Training May Slow MS, Study Says

Posted 4 Aug 2017 by Drugs.com

FRIDAY, Aug. 4, 2017 – Resistance training may help slow progression of multiple sclerosis, a small study suggests. "Among persons with multiple sclerosis, the brain shrinks markedly faster than normal," said study researcher Ulrik Dalgas. "Drugs can counter this development, but we saw a tendency that training further minimizes brain shrinkage in patients already receiving medication." Moreover, "we saw that several smaller brain areas actually started to grow in response to training," said Dalgas, an associate professor of public health at Aarhus University in Denmark. MS is a potentially disabling disease of the central nervous system. It occurs when the immune system attacks the protective sheath that covers nerve fibers, disrupting communication between the brain and the rest of the body. Symptoms vary in severity, but some patients lose the ability to walk. For this study, the ... Read more

Related support groups: Multiple Sclerosis, Chronic Spasticity, Spasticity, Upper Limb Spasticity, Lower Limb Spasticity, Spinal Spasticity

Breast-Feeding May Lower Risk of MS, Study Says

Posted 12 Jul 2017 by Drugs.com

WEDNESDAY, July 12, 2017 – Women with a longer history of breast-feeding may be less likely to develop multiple sclerosis than mothers who skip breast-feeding or nurse for briefer periods, a new study suggests. Researchers compared nearly 400 women with MS or its precursor, known as clinically isolated syndrome (CIS), with a similar healthy group. They found that mothers who had breast-fed one or more children for a total of 15 months or longer were 53 percent less likely to develop MS or CIS than those with zero to four months of total breast-feeding. "No one has shown before that breast-feeding could have a prolonged benefit on the mother's immune system," said study author Dr. Annette Langer-Gould. She's a research scientist in neurology at Kaiser Permanente in Pasadena, Calif. "This is one more piece of evidence that women who want to breast-feed should be supported to do so," ... Read more

Related support groups: Birth Control, Contraception, Multiple Sclerosis, Delivery, Vitamin/Mineral Supplementation during Pregnancy/Lactation, Chronic Spasticity, Spasticity, Upper Limb Spasticity, Cesarean Section, Lower Limb Spasticity, Labor and Delivery including Augmentation, Lactation Augmentation, Spinal Spasticity

Ipsen Announces FDA approval of Dysport (abobotulinumtoxinA) for the Treatment of Lower Limb Spasticity in Adults

Posted 21 Jun 2017 by Drugs.com

June 16, 2017 – Ipsen (Euronext: IPN; ADR: IPSEY) (Ipsen) today announced that the U.S. Food and Drug Administration (FDA) has expanded the approved use of Dysport (abobotulinumtoxinA) for injection for the treatment of spasticity in adults, based on its supplemental Biologics License Application (sBLA) in lower limb spasticity. In July 2015, Dysport® was approved for the treatment of upper limb spasticity in adults. In July 2016, Dysport® was approved to treat pediatric patients with lower limb spasticity aged two and older, making it the first and only botulinum toxin that the FDA approved for this indication. In a Phase III, multi-center, prospective, double-blind, randomized placebo-controlled study, adult patients treated with Dysport® following a stroke or traumatic brain injury showed improvement in muscle tone at the ankle joint, measured by the mean change from baseline on the ... Read more

Related support groups: Spasticity, Dysport, Lower Limb Spasticity, Abobotulinumtoxina

MS-Related Brain Changes May Affect Social Skills

Posted 1 Jun 2017 by Drugs.com

THURSDAY, June 1, 2017 – Subtle brain changes may explain why some people with multiple sclerosis (MS) lose their ability to interpret clues about what other people are thinking and feeling, a new study suggests. Until now, there has been little study of the way MS affects the so-called "social brain." Portuguese researchers wanted to learn why some people with MS develop a social disconnect that can hurt relationships and breed isolation. It doesn't happen to everyone with MS, but experts agree that it's a big deal for those who experience it. "It could interfere with all spheres of social interaction," said lead researcher Dr. Sonia Batista, a neurologist at the University of Coimbra in Portugal. "The ability to interpret other people's feelings and intentions may influence people's ability to maintain a job and their relationships with family and friends," said Batista. That's ... Read more

Related support groups: Anxiety, Generalized Anxiety Disorder, Anxiety and Stress, Social Anxiety Disorder, Multiple Sclerosis, Performance Anxiety, Chronic Spasticity, Spasticity, Diagnosis and Investigation, Upper Limb Spasticity, Spinal Spasticity, Lower Limb Spasticity

Immune-Based Therapy Shows Early Promise Against MS

Posted 21 Apr 2017 by Drugs.com

THURSDAY, April 20, 2017 – An experimental immune-system therapy appears safe for people with progressive forms of multiple sclerosis. And it may ease symptoms in some, a preliminary study suggests. The findings are based on just six patients, and the Australian researchers stressed that a lot of work still lies ahead. But they were encouraged that this new approach to MS had no major side effects. In addition, three of the six patients showed symptom improvements, including reduced fatigue and better mobility. It's not clear, however, what to make of those improvements, said Bruce Bebo, executive vice president of research for the National Multiple Sclerosis Society. The study was a "phase 1" trial, meaning it was designed only to test the therapy's safety. "Based on this very preliminary study, the therapy appears safe," said Bebo, who was not involved in the research. "But I'd be ... Read more

Related support groups: Multiple Sclerosis, Chronic Spasticity, Spasticity, Diagnosis and Investigation, Upper Limb Spasticity, Spinal Spasticity, Lower Limb Spasticity

Ocrevus Approved to Treat Severe Form of Multiple Sclerosis

Posted 29 Mar 2017 by Drugs.com

WEDNESDAY, March 29, 2017 – The injected drug Ocrevus (ocrelizumab) has been approved by the U.S. Food and Drug Administration to treat adults with primary progressive multiple sclerosis (PPMS) and relapsing forms of the disease, the agency said Wednesday in a news release. MS is an inflammatory autoimmune disease of the central nervous system, characterized by periods of active symptoms (relapses) and recovery periods (remission). Disrupting communication between the brain and the rest of the body, it's among the most common neurological causes of disability in young adults. More women than men are diagnosed, typically between ages 20 and 40. About 15 percent of people with MS have PPMS, the FDA said, citing the U.S. Centers for Disease Control and Prevention. In clinical trials, upper respiratory infection was the most common side effect of Ocrevus among users with either PPMS or ... Read more

Related support groups: Multiple Sclerosis, Chronic Spasticity, Spasticity, Ocrevus, Upper Limb Spasticity, Lower Limb Spasticity, Spinal Spasticity

FDA-OK'd Drug Offers Hope to Sickest MS Patients

Posted 29 Mar 2017 by Drugs.com

WEDNESDAY, March 29, 2017 – A new multiple sclerosis drug approved by the U.S. Food and Drug Administration late Tuesday offers hope to patients with the most severe form of the progressive disease. The intravenous drug, made by Genentech, is called ocrelizumab (Ocrevus). Given every six months, it worked best for patients with relapsing multiple sclerosis (MS) – the most common form of the disease, the FDA reported. But Ocrevus also appeared to slow progression of a more severe type of the disease, called primary progressive MS. "If the side effect profile continues to hold up ... I think ocrelizumab will become the leading MS therapy," said Dr. Steven Galetta, chairman of neurology at NYU Langone Medical Center in New York City. He wasn't involved in the clinical trials that led to the drug's approval. "The drug offers the first option for patients with primary progressive MS," he ... Read more

Related support groups: Multiple Sclerosis, Rebif, Chronic Spasticity, Spasticity, Ocrevus, Upper Limb Spasticity, Spinal Spasticity, Lower Limb Spasticity

Controversial MS Treatment Seems Ineffective

Posted 8 Mar 2017 by Drugs.com

WEDNESDAY, March 8, 2017 – An invasive multiple sclerosis treatment called liberation therapy is not only costly, it's also ineffective, new research contends. Since 2009, thousands of multiple sclerosis (MS) patients have undergone the controversial treatment. Liberation therapy involves opening up narrowed veins from the brain and spinal cord. However, many specialists have had doubts about the success of the procedure, the study authors said in background notes. In this Canadian study, 49 MS patients underwent liberation therapy and 55 other patients received a sham procedure. One year later, brain scans, doctors' reports and patient self-assessments of MS symptoms found no differences between the two groups of patients. "We hope these findings, coming from a carefully controlled, 'gold standard' study, will persuade people with MS not to pursue liberation therapy," said Dr. Anthony ... Read more

Related support groups: Multiple Sclerosis, Autoimmune Disorders, Chronic Spasticity, Caltrate 600 with D, Spasticity, Citracal + D, Upper Limb Spasticity, Calcium/Vitamin D, Citracal Petites, Oysco 500 with D, Citracal Creamy Bites, Calcium 600 D, Calcet, Lower Limb Spasticity, Calcarb with D, Spinal Spasticity, Oyster Shell Calcium, Oyster-D, UPCal D, Os-Cal 500 + D

Immune Disorders Such as MS, Psoriasis May Be Tied to Dementia Risk

Posted 2 Mar 2017 by Drugs.com

WEDNESDAY, March 1, 2017 – People with autoimmune diseases – conditions that cause a person's immune system to turn against the body – appear to have an increased risk of developing dementia, a new British study suggests. Researchers found that 18 out of 25 different autoimmune diseases, such as lupus, psoriasis or multiple sclerosis, "showed a statistically significant association with dementia," said study co-author Dr. Michael Goldacre. He's a professor of public health at the University of Oxford. But Goldacre and other experts stressed that the study didn't prove that autoimmune diseases cause dementia. The research only showed that these conditions are associated with a higher risk of dementia. Specifically, the study found that people with multiple sclerosis appeared to have nearly double the risk of dementia. Psoriasis was associated with a 29 percent increased risk of ... Read more

Related support groups: Multiple Sclerosis, Heart Disease, Ischemic Stroke, Psoriasis, Dementia, Alzheimer's Disease, Transient Ischemic Attack, Plaque Psoriasis, Ischemic Stroke - Prophylaxis, Chronic Spasticity, Spasticity, Ischemic Heart Disease, Psoriatic Arthropathy

Stem Cell Transplants May Help Some With Multiple Sclerosis

Posted 20 Feb 2017 by Drugs.com

MONDAY, Feb. 20, 2017 – Stem cell transplants may halt the progression of aggressive multiple sclerosis (MS) in nearly half of those with the debilitating disease, but picking the right patients for the treatment is key, a new study suggests. Specifically, younger patients with a relapsing form of MS who were not severely disabled and who hadn't found relief with other treatments fared better than others over five years, the international team of researchers found. However, in some cases the treatment proved fatal, the researchers reported. "Stem cell transplantation cannot be considered a cure for MS. However, it can be considered a concrete option for patients showing aggressive MS who have not responded to approved treatments," said study co-author Dr. Riccardo Saccardi. He's from the cell therapy and transfusion medicine unit at Careggi University Hospital in Florence, Italy. Using ... Read more

Related support groups: Multiple Sclerosis, Chronic Spasticity, Spasticity, Diagnosis and Investigation, Upper Limb Spasticity, Spinal Spasticity, Lower Limb Spasticity

U.S. Report Cites the Good and Bad on Marijuana

Posted 12 Jan 2017 by Drugs.com

THURSDAY, Jan. 12, 2017 – Current medical science has proven there are legitimate medical uses for marijuana and cannabis-derived drugs, a new report from the National Academy of Sciences states. Conclusive or substantial scientific evidence has shown that marijuana products are effective at treating chronic pain, calming muscle spasms caused by multiple sclerosis, and easing nausea from chemotherapy, the report said. However, there's little to no evidence supporting any of the other numerous health claims related to marijuana, the report said. And there's a downside as well – marijuana use comes with a host of potential health risks, whether someone is using the drug medicinally or recreationally, according to the report. The report calls on government to ease regulations that hamper research into marijuana, so scientists can sort the wheat from the chaff when it comes to medical ... Read more

Related support groups: Pain, Anxiety, Anxiety and Stress, Muscle Spasm, Chronic Pain, Muscle Pain, Social Anxiety Disorder, Multiple Sclerosis, Schizophrenia, Schizoaffective Disorder, Breakthrough Pain, Cannabis, Chronic Spasticity, Spasticity, Spinal Spasticity, Lower Limb Spasticity

New MS Drug Shows 'Breakthrough' Promise for Advanced Disease

Posted 22 Dec 2016 by Drugs.com

THURSDAY, Dec. 22, 2016 – A new drug slows the progress of multiple sclerosis, including an advanced form of the degenerative nerve disease for which there currently is no treatment, according to a pair of new clinical trials. One MS specialist called the intravenous drug, ocrelizumab, a "breakthrough." Ocrelizumab reduced the advance of MS-related disability by 24 percent in people with primary progressive MS compared to a placebo, results from one clinical trial show. Researchers compared ocrelizumab against a placebo, or dummy drug, because there's no approved treatment available for primary progressive MS. This form affects about 15 percent of MS patients, said Dr. Stephen Hauser, chair of neurology at the University of California, San Francisco. "It does represent new hope for people with progressive MS," said Hauser, who worked on both reports. Ocrelizumab also proved superior in ... Read more

Related support groups: Multiple Sclerosis, Chronic Spasticity, Spasticity, Upper Limb Spasticity, Lower Limb Spasticity, Spinal Spasticity

Could Low Vitamin D Levels at Birth Mean Higher MS Risk?

Posted 2 Dec 2016 by Drugs.com

THURSDAY, Dec. 1, 2016 – Newborns with low levels of vitamin D may have higher odds of developing multiple sclerosis (MS) later in life, new research suggests. Vitamin D deficiency is common among the general population, including pregnant women. But the researchers said it's too soon to routinely recommend "sunshine vitamin" supplements for mothers-to-be. "The study does not prove that increasing vitamin D levels reduces the risk of MS. Further studies are needed to confirm our results," said study leader Dr. Nete Munk Nielsen, a researcher at the Statens Serum Institute in Copenhagen, Denmark. About 2.5 million people worldwide have MS. It's a chronic disease of the central nervous system characterized by damage to myelin, the fatty substance coating nerve fibers. MS symptoms vary, but can include walking difficulties, fatigue, numbness and vision problems. A growing body of evidence ... Read more

Related support groups: Multiple Sclerosis, Vitamin D Deficiency, Vitamin/Mineral Supplementation and Deficiency, Delivery, Chronic Spasticity, Vitamin/Mineral Supplementation during Pregnancy/Lactation, Caltrate 600 with D, Spasticity, Vitamin D Insufficiency, Citracal + D, Calcium/Vitamin D, Upper Limb Spasticity, Citracal Petites, Oysco 500 with D, Spinal Spasticity, Citracal Creamy Bites, Oyster Shell Calcium, Calcet, Prematurity/Underweight in Infancy, Calcium 600 D

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