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Some Advanced Kidney Cancer Patients May Postpone Treatment

Posted 4 Aug 2016 by Drugs.com

THURSDAY, Aug. 4, 2016 – Not all adults with advanced kidney cancer that has spread require immediate, aggressive treatment, a small new study suggests. "A subset of adults with advanced kidney cancer have slow-growing disease that can be safely managed using active surveillance," explained study lead author Brian Rini, of the Cleveland Clinic's Taussig Cancer Institute. This "watch and wait" approach, instead of active treatment, "could spare them the inconvenience and debilitating side effects of aggressive treatments for about a year, and in some cases several years, without worsening anxiety and depression," Rini said in a news release from The Lancet Oncology. The journal published the findings Aug. 4. In advanced kidney cancer, drugs such as sunitinib and sorafenib are typically used. While they can slow disease progression, they do not cure it, the researchers said. Could some ... Read more

Related support groups: Cancer, Renal Failure, Chronic Kidney Disease, Sutent, Nexavar, Sunitinib, Sorafenib, Wilms' Tumor, Urinary Tract Cancer

Cancer's Heavy Financial Burden

Posted 8 Jun 2016 by Drugs.com

WEDNESDAY, June 8, 2016 – Many cancer patients can't afford to see their doctor or take the medications they've been prescribed, a new study finds. And the problem will likely only get worse as the cost of cancer treatments continues to rise, the study authors said. "You can prescribe the best drug in the world, but if patients can't afford it and they can't get it, then it won't be effective," said study author Dr. Greg Knight. He is chief fellow with the University of North Carolina School of Medicine's division of hematology and oncology. "We saw a significant portion of patients in our study who were stretching their prescriptions or not coming to the doctor's office," Knight said in a university news release. The researchers reviewed survey results from nearly 2,000 patients at the N.C. Cancer Hospital in Chapel Hill, N.C. The participants were all 18 and older, and had been ... Read more

Related support groups: Cancer, Breast Cancer, Prostate Cancer, Lung Cancer, Gleevec, Colorectal Cancer, Brain Tumor, Votrient, Avastin, Tarceva, Melanoma, Skin Cancer, Nausea/Vomiting - Chemotherapy Induced, Tasigna, Sutent, Ovarian Cancer, Endometrial Cancer, Sprycel, Afinitor, Herceptin

U.S. Pays Highest Prices for Cancer Meds: Study

Posted 6 Jun 2016 by Drugs.com

MONDAY, June 6, 2016 – The United States pays the highest prices in the world for generic and brand-name cancer drugs, a new study has found. However, as the world's wealthiest nation, the United States is better able to pay for those pricey drugs than poorer countries with somewhat lower medication prices, added study lead author Dr. Daniel Goldstein. People in China and India are much less able to afford cancer drugs than Americans, he said, even though U.S. monthly drug prices are about three to six times higher in the United States. That doesn't mean America came out on top in overall drug affordability, however. Developed nations such as Australia, England and Israel had the "best deal" in the world on cancer drugs, thanks to government programs that regulate drug pricing, the study found. "America is the wealthiest nation, but its drug prices are significantly higher – so much ... Read more

Related support groups: Cancer, Provera, Depo-Provera, Methotrexate, Breast Cancer, Accutane, Lupron, Tamoxifen, Medroxyprogesterone, Arimidex, Tretinoin, Fluorouracil, Lupron Depot, Femara, Lung Cancer, Gleevec, Colorectal Cancer, Isotretinoin, Rituxan, Claravis

U.S. Oncologists Decry High Cost of Cancer Drugs

Posted 23 Jul 2015 by Drugs.com

THURSDAY, July 23, 2015 – Soaring costs for cancer drugs are hurting patient care in the United States, a group of top oncologists claim. "High cancer-drug prices are affecting the care of patients with cancer and our health care system," Dr. Ayalew Tefferi, a hematologist at Mayo Clinic in Rochester, Minn., said in a Mayo news release. Tefferi and his colleagues made a number of recommendations on how to address the problem in a commentary published July 23 in the Mayo Clinic Proceedings. Allowing Medicare to negotiate drug prices is one of the suggestions the team of 118 leading cancer experts offered as a possible solution. Along with their recommendations, the group also expressed support for a patient-based grassroots movement on change.org that is demanding action on the issue. "The average gross household income in the U.S. is about $52,000 per year. For an insured patient with ... Read more

Related support groups: Cancer, Provera, Depo-Provera, Methotrexate, Breast Cancer, Accutane, Lupron, Prostate Cancer, Tamoxifen, Medroxyprogesterone, Arimidex, Tretinoin, Fluorouracil, Femara, Lupron Depot, Lung Cancer, Gleevec, Renal Cell Carcinoma, Colorectal Cancer, Isotretinoin

Medicines Are Biggest Culprit in Fatal Allergic Reactions: Study

Posted 10 Oct 2014 by Drugs.com

THURSDAY, Oct. 9, 2014 – Although food allergies have garnered a lot of attention lately, a new study reports that medications are actually the biggest cause of sudden deaths related to allergy. Over a little more than a decade, nearly 60 percent of the allergy-related deaths were caused by medications, while less than 7 percent were caused by food allergies, the study found. "Medications can be dangerous," said study researcher Dr. Elina Jerschow, director of the Drug Allergy Center at Montefiore Medical Center and assistant professor of medicine at Albert Einstein College of Medicine, in New York City. While research from other countries has reported medications as a major culprit in anaphylaxis-related deaths, Jerschow said, the problem has been less defined in the United States. One reason is that there is no national registry for anaphylaxis deaths, she said. The study was ... Read more

Related support groups: Provera, Depo-Provera, Amoxicillin, Metronidazole, Doxycycline, Cephalexin, Clindamycin, Penicillin, Methotrexate, Azithromycin, Bactrim, Cipro, Ciprofloxacin, Accutane, Levaquin, Augmentin, Lupron, Flagyl, Keflex, Zithromax

Liver Cancer Drug Fails to Live Up to Early Promise

Posted 1 Jul 2014 by Drugs.com

TUESDAY, July 1, 2014 – Although it looked promising in early studies, the drug everolimus didn't improve survival for people with advanced liver cancer in its latest trial, a new study found. The findings from the phase 3 clinical trial are disappointing because earlier research suggested that everolimus (Afinitor) prevented tumor progression and improved survival for in advanced liver cancer. Normally, these patients can expect a median overall survival of less than one year. The only drug currently shown to significantly improve survival of advanced liver cancer patients is sorafenib (Nexavar). But that drug's benefits are temporary and the cancer eventually progresses, according to background information in the new study. The current study included 546 adults with advanced liver cancer whose disease progressed during or after treatment with sorafenib, or who could not take ... Read more

Related support groups: Afinitor, Nexavar, Sorafenib, Everolimus, Zortress, Hepatic Tumor

FDA Approves Nexavar to Treat Metastatic Differentiated Thyroid Cancer

Posted 22 Nov 2013 by Drugs.com

November 22, 2013 – The U.S. Food and Drug Administration today expanded the approved uses of Nexavar (sorafenib) to treat late-stage (metastatic) differentiated thyroid cancer. Thyroid cancer is a cancerous growth of the thyroid gland, which is located in the neck. Differentiated thyroid cancer is the most common type of thyroid cancer. The National Cancer Institute estimates that 60,220 Americans will be diagnosed with thyroid cancer and 1,850 will die from the disease in 2013. Nexavar works by inhibiting multiple proteins in cancer cells, limiting cancer cell growth and division. The drug’s new use is intended for patients with locally recurrent or metastatic, progressive differentiated thyroid cancer that no longer responds to radioactive iodine treatment. “Differentiated thyroid cancer can be challenging to treat, especially when unresponsive to conventional therapies,” said ... Read more

Related support groups: Thyroid Cancer, Nexavar, Sorafenib

Cancer Drug Nexavar Tied to Pancreas Damage in Two Patients

Posted 9 Oct 2013 by Drugs.com

WEDNESDAY, Oct. 9 – The cancer drug sorafenib, known by its trade name Nexavar, could have a toxic effect on the pancreas of patients who take it for extended periods. Sorafenib works by inhibiting or halting the creation of new blood vessels into a tumor. It is mainly used to treat liver and kidney cancer, and is being considered by the U.S. Food and Drug Administration as a treatment for thyroid cancer. But the drug can also harm a person's pancreas by interfering with blood flow to the vital organ, researchers from the University of Paris Descartes wrote in a letter published in the Oct. 10 issue of the New England Journal of Medicine. CT scans showed that long-term use may cause a patient's pancreas to shrink by as much as one-third. "We report reproducible evidence of irreversible pancreatic atrophy in two patients after long-term treatment with sorafenib," the French researchers ... Read more

Related support groups: Nexavar, Sorafenib

Drug May Work Against Advanced Thyroid Cancer

Posted 3 Jun 2013 by Drugs.com

SUNDAY, June 2 – A drug already used for advanced kidney and liver cancers may help slow the progression of thyroid cancers that do not respond to standard treatment, a new clinical trial finds. Researchers found that the drug, called sorafenib (Nexavar), taken as a pill, nearly doubled the length of time that patients remained progression-free – from about six months to 11 months. It's not a cure, and no one knows yet whether sorafenib can ultimately extend people's lives. But experts said the findings offer some hope to a group of patients who currently lack good options. "If we can control the disease, and do it with tolerable toxicity, that's a good thing," said Dr. Gregory Masters, a medical oncologist who was not involved in the research. In general, thyroid cancer is a highly curable disease. But about 10 percent of patients do not respond to the mainstays of treatment: surgery ... Read more

Related support groups: Thyroid Cancer, Nexavar, Sorafenib

Cancer Chemotherapy Tied to Slight Rise in Risk for Leukemia

Posted 14 Feb 2013 by Drugs.com

THURSDAY, Feb. 14 – Chemotherapy can be a lifesaver for thousands of cancer patients, but a new study suggests that it might slightly raise the odds for a type of leukemia later in life. Over the past 30 years, the risk for acute myeloid leukemia (AML) has increased for patients who underwent chemotherapy for certain forms of cancer, particularly non-Hodgkin lymphoma, the new study found. On the other hand, the researchers from the U.S. National Cancer Institute said other cancer survivors may have a reduced risk for AML due to a change in chemotherapy agents that occurred decades ago. One expert not connected to the study stressed that cancer patients need to put the findings into perspective. "It's important to realize that the risk of developing acute myeloid leukemia related to prior chemotherapy is small and increases with the number of chemotherapy treatments given over time," ... Read more

Related support groups: Cancer, Provera, Depo-Provera, Methotrexate, Accutane, Lupron, Tamoxifen, Medroxyprogesterone, Arimidex, Tretinoin, Fluorouracil, Lupron Depot, Femara, Gleevec, Isotretinoin, Rituxan, Claravis, Votrient, Anastrozole, Avastin

Certain Cancer Drugs May Have Fatal Side Effects: Analysis

Posted 6 Feb 2012 by Drugs.com

MONDAY, Feb. 6 – Treatment with three relatively new cancer drugs may be linked to a slightly increased risk of death, a new analysis suggests. While the risk is low, it should be taken into account by doctors and patients, according to Dana-Farber Cancer Institute scientists and colleagues. The investigators analyzed the findings of 10 clinical trials that included nearly 4,700 patients treated with sorafenib (Nexavar) for kidney and liver cancer; sunitinib (Sutent) for kidney cancer and gastrointestinal stromal tumor; or pazopanib (Votrient) for kidney cancer. These so-called "targeted" drugs are used to stop the growth or spread of cancer by blocking the vascular endothelial growth factor tyrosine kinase receptors in cancer cells, the researchers explained in a Dana-Farber news release. The analysis of the clinical trials revealed that the incidence of fatal complications was 1.5 ... Read more

Related support groups: Votrient, Sutent, Nexavar, Pazopanib, Sunitinib, Sorafenib

Mixed News on Tough-to-Treat Lung Cancer

Posted 10 Jan 2012 by Drugs.com

TUESDAY, Jan. 10 – Dutch researchers report disappointing results from an early clinical trial of the drug Nexavar (sorafenib) in fighting a tough-to-treat form of lung cancer. But, in better news, an experimental drug known as ganetespib showed promise in laboratory and animal experiments. The results of both studies were to be presented Tuesday at an American Association for Cancer Research/International Association for the Study of Lung Cancer meeting in San Diego. In recent years, researchers have made some headway in finding treatments to combat lung cancer, which often doesn't respond well to chemotherapy, explained Dr. Len Lichtenfeld, deputy chief medical officer of the American Cancer Society. Those treatments include drugs such as crizotinib (Xalkori) and erlotinib (Tarceva), which are most effective in tumors that contain certain genetic mutations. However, those drugs tend ... Read more

Related support groups: Lung Cancer, Non-Small Cell Lung Cancer, Tarceva, Small Cell Lung Cancer, Nexavar, Xalkori, Sorafenib, Erlotinib, Crizotinib

Cancer Patients Should Ask Doctors to Use Simple Terms

Posted 28 Sep 2011 by Drugs.com

WEDNESDAY, Sept. 28 – Cancer patients are often faced with many difficult-to-understand treatment choices that can have serious side effects and even mean the difference between life and death. That's why it's crucial that patients insist doctors use plain language in explaining the options, advised Angela Fagerlin, an associate professor of internal medicine at the University of Michigan Medical School and a researcher at the U-M Comprehensive Cancer Center. "People are making life and death decisions that may affect their survival and they need to know what they're getting themselves into. Cancer treatments and tests can be serious. Patients need to know what kind of side effects they might experience as a result of the treatment they undergo," Fagerlin said in a university news release. She and her colleagues outlined a number of tips to help patients get the information they need ... Read more

Related support groups: Cancer, Provera, Depo-Provera, Methotrexate, Breast Cancer, Accutane, Lupron, Prostate Cancer, Tamoxifen, Medroxyprogesterone, Arimidex, Tretinoin, Fluorouracil, Lupron Depot, Femara, Lung Cancer, Gleevec, Renal Cell Carcinoma, Colorectal Cancer, Isotretinoin

Certain Cancer Drugs Don't Interfere With Flu Vaccine: Study

Posted 28 Jun 2011 by Drugs.com

TUESDAY, June 28 – Cancer patients taking the drugs sunitinib and sorafenib respond to the flu vaccine, which suggests that the drugs don't cause as much damage to the immune system as previously believed, researchers say. The small study included 40 volunteers in the Netherlands, including 16 who were treated with sunitinib and six who were treated with sorafenib. Seven patients with metastatic renal cell (kidney) cancer received neither drug, nor did 11 healthy people. When given a flu vaccine, all of the cancer patients had an antibody response similar to that of the healthy participants. The study appears in the current issue of the journal Clinical Cancer Research. "The exact incidence of influenza in patients with cancer is not known, however, it is definitely higher than in the general population," study leader Dr. Carla van Herpen, a medical oncologist at the Radboud University ... Read more

Related support groups: Sutent, Nexavar, Sunitinib, Sorafenib, Influenza Prophylaxis, Influenza Virus Vaccine, H1n1, Inactivated

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Hepatocellular Carcinoma, Hepatic Tumor, Thyroid Cancer, Renal Cell Carcinoma

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