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Related terms: Cancer, Lung, Small Cell, Lung Cancer, Small Cell, SCLC

Smoking Wreaks Genetic Havoc on Lungs, Study Warns

Posted 4 Nov 2016 by Drugs.com

FRIDAY, Nov. 4, 2016 – Smoking is linked to significant genetic damage in the lungs and other organs of the body, according to new research. "This study offers fresh insights into how tobacco smoke causes cancer," said co-lead author Ludmil Alexandrov, the Oppenheimer Fellow at Los Alamos National Laboratory in New Mexico. "Our analysis demonstrates that tobacco smoking causes mutations that lead to cancer by multiple distinct mechanisms," he said in a Los Alamos news release. "Tobacco smoking damages DNA in organs directly exposed to smoke as well as speeds up a mutational cellular clock in organs that are both directly and indirectly exposed to smoke." In the study, researchers from Los Alamos, the Wellcome Trust Sanger Institute in England and other institutions analyzed more than 5,000 cancer tumors from smokers and nonsmokers. Cancer is caused by mutations in the DNA of a cell, ... Read more

Related support groups: Smoking, Smoking Cessation, Lung Cancer, Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Diagnosis and Investigation, Bronchogenic Carcinoma

New Type of Radiation Treatment May Up Survival for Older Lung Cancer Patients

Posted 26 Sep 2016 by Drugs.com

MONDAY, Sept. 26, 2016 – Cutting-edge radiation therapy seems to provide a significant survival advantage for older people with early stage lung cancer who aren't strong enough for surgery, a pair of new studies suggests. The therapy is called stereotactic body radiation therapy (SBRT) and it's been available for about a decade. The first study reviewed national cancer data and found that survival rates for older lung cancer patients treated with radiation therapy increased dramatically between 2004 and 2012. Those are the years during which SBRT use became widespread in the United States, said lead researcher Dr. Andrew Farach, a radiation oncologist at Houston Methodist Hospital. A second study based on Veterans Affairs cancer treatment data appears to corroborate the national findings, directly linking increased use of SBRT with improved survival rates in elderly patients. Farach ... Read more

Related support groups: Surgery, Lung Cancer, Non-Small Cell Lung Cancer, Small Cell Lung Cancer, History - Radiation Therapy, Bronchogenic Carcinoma

14 Genes That May Affect Cancer Treatment

Posted 31 Aug 2016 by Drugs.com

WEDNESDAY, Aug. 31, 2016 – Researchers say they've identified 14 genes that may help determine whether a cancer treatment could help a patient. The researchers also say the findings suggest it could be possible to help people avoid unnecessary cancer treatments that won't likely benefit them. "The history of cancer treatment is filled with overreaction," said principal investigator Gary Karpen, a senior scientist at the U.S. Department of Energy's Lawrence Berkeley National Laboratory in Berkeley, Calif. "It is part of the ethics of cancer treatment to err on the side of overtreatment, but these treatments have serious side effects associated with them. For some people, it may be causing more trouble than if the growth was left untreated," Karpen said in a Berkeley Lab release. However, there has not been a reliable way to determine which early stage cancer patients will respond to ... Read more

Related support groups: Cancer, Lung Cancer, Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Diagnosis and Investigation, Bronchogenic Carcinoma

Smog May Shorten Lives of Lung Cancer Patients

Posted 5 Aug 2016 by Drugs.com

FRIDAY, Aug. 5, 2016 – Air pollution may shorten the lives of lung cancer patients, a new study suggests. Researchers led by Sandrah Eckel, who's with the department of preventive medicine at the University of Southern California in Los Angeles, analyzed data from more than 352,000 people in California who were diagnosed with lung cancer between 1988 and 2009. Higher exposure to the pollutants nitrogen dioxide, ozone and airborne particles was associated with an increased risk of early death. The association was strongest in patients with early stage disease, particularly adenocarcinoma, which accounts for 80 percent of lung cancer cases, the researchers said. Early stage patients with greater exposure to pollutants survived on average 2.4 years compared to 5.7 years for those with low exposure, the study found. The study was published online Aug. 4 in the journal Thorax. Since this ... Read more

Related support groups: Lung Cancer, Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Bronchogenic Carcinoma

Do Too Many Lung Cancer Patients Miss Out on Surgery?

Posted 21 Jun 2016 by Drugs.com

TUESDAY, June 21, 2016 – Many patients with advanced lung cancer might live longer if treated surgically, but few go that route, new research indicates. A study of U.S. patients with late-stage non-small cell lung cancer found only 11 percent underwent surgery – and 27 percent got no treatment at all. Yet surgery, either alone or with other treatments, prolonged survival by as much as 41 months, researchers said. "We were surprised by the findings, but they have to be considered with caution," said study lead author Dr. Elizabeth David, an assistant professor of surgery at the University of California, Davis Medical Center, in Sacramento. "Surgery is not appropriate for every patient with stage 3 or 4 lung cancer," she noted. "We just need to make sure that appropriate patients are evaluated by surgeons, and we are working on ways to make that easier." At stages 3 and 4, the cancer ... Read more

Related support groups: Surgery, Lung Cancer, Non-Small Cell Lung Cancer, Small Cell Lung Cancer, History - Radiation Therapy, Bronchogenic Carcinoma

Middle-Aged More Often Diagnosed With Late-Stage Lung Cancer

Posted 17 Jun 2016 by Drugs.com

THURSDAY, June 16, 2016 – British middle-aged adults are more likely to be diagnosed with late-stage lung cancer than those who are slightly older, a new study finds. Researchers reviewed information from about 34,000 lung cancer patients in England in 2013. They found that a higher percentage of those ages 50 to 64 were diagnosed with late-stage disease than those ages 65 to 69. Patients in their 70s were more likely to be diagnosed with early stage disease. "Our results show that younger patients in their 50s and early 60s are more likely to be diagnosed with advanced lung cancer compared to patients in older age groups," David Kennedy, a data and research analyst at Cancer Research UK, said in a news release from the organization. It's not clear why younger patients are more likely to be diagnosed with the advanced stage of the disease, said Dr. Julie Sharp, Cancer Research UK's ... Read more

Related support groups: Cough, Lung Cancer, Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Diagnosis and Investigation, Body Imaging, Bronchogenic Carcinoma

Better Lung Cancer Survival? There's an App for That

Posted 9 Jun 2016 by Drugs.com

THURSDAY, June 9, 2016 – A new smartphone app may help lung cancer patients live longer and better by monitoring their symptoms and alerting doctors to potential problems, researchers report. The Moovcare smartphone and web application proved so effective that researchers ended the clinical trial early, said study author Dr. Fabrice Denis, a researcher at the Institut Inter-regional de Cancerologie Jean Bernard in Le Mans, France. About 75 percent of high-risk lung cancer patients were alive one year after they started using the Moovcare app, compared with 49 percent of patients provided typical cancer care, Denis said. Patients also lived seven months longer, on average, when using Moovcare – about 19 months compared to an average of 12 months for nonusers. Further, Moovcare patients required less regular CT scanning. "The number of imaging scans were reduced by 50 percent per ... Read more

Related support groups: Lung Cancer, Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Diagnosis and Investigation, Bronchogenic Carcinoma

Exercise May Cut Risk of 13 Cancers, Study Suggests

Posted 16 May 2016 by Drugs.com

MONDAY, May 16, 2016 – Exercise may significantly reduce your risk for many types of cancer, including some of the most lethal forms of the disease, a large review suggests. Working out for even a couple of hours a week appears to shrink the risk of breast, colon and lung cancer, said researchers who looked at 1.4 million adults. "Those are three of the four major cancers that affect Americans today," said Marilie Gammon. She is a professor of epidemiology with the University of North Carolina at Chapel Hill Gillings School of Public Health. And fitness buffs, take heart – your cancer risk appears to continue to decline as you rack up hours of physical activity, with no apparent upper plateau, said study lead author Steven Moore, an investigator with the U.S. National Cancer Institute. "The more activity, the more the benefit," Moore said. "As people did more, their risk continued to ... Read more

Related support groups: Cancer, Breast Cancer, Leukemia, Lung Cancer, Colorectal Cancer, Non-Small Cell Lung Cancer, Multiple Myeloma, Endometrial Cancer, Small Cell Lung Cancer, Bladder Cancer, Acute Myeloid Leukemia, Stomach Cancer, Head and Neck Cancer, Breast Cancer, Prevention, Acute Lymphoblastic Leukemia, Gastric Cancer, Osteolytic Bone Lesions of Multiple Myeloma, Urinary Tract Cancer, Acute Myeloblastic Leukemia

Radon in the Home May Be Linked to Blood Cancers in Women

Posted 3 May 2016 by Drugs.com

TUESDAY, May 3, 2016 – New research suggests a strong link between exposure to high levels of radon in the home and women's risk of blood cancers. Radon is a naturally occurring radioactive gas, the U.S. Environmental Protection Agency says. It's known to cause lung cancer and is the second leading cause of lung cancer in the United States, the researchers said. The American Cancer Society collected information over 19 years on more than 140,000 Americans as part of a prevention study. During that time, just over 3,000 cases of blood cancer were diagnosed. The cancers included leukemia, lymphoma and myeloma, the study found. Women who lived in counties with the highest radon levels were 63 percent more likely to develop blood cancers than those in counties with the lowest radon levels. There was no link seen among men, the study noted. The study was published online recently in the ... Read more

Related support groups: Cancer, Leukemia, Lung Cancer, Lymphoma, Non-Small Cell Lung Cancer, Poisoning, Multiple Myeloma, Small Cell Lung Cancer, Toxic Reactions Incl Drug and Substance Abuse

Could Talk Therapy Ease Chemo-Related Memory Issues?

Posted 2 May 2016 by Drugs.com

MONDAY, May 2, 2016 – A type of psychotherapy might help cancer survivors deal with the long-term thinking problems some experience after chemotherapy, researchers say. It's estimated that about half of those who undergo chemotherapy for cancer develop what's often called "chemo brain." For instance, they may have trouble following conversations or remembering the steps in a project, according to background notes with the new study. Although usually mild, these changes can affect quality of life, job performance and relationships, said the researchers from the Eastern Maine Medical Center and Lafayette Family Cancer Center in Bangor, Maine. The researchers developed a cognitive-behavioral therapy (CBT) program called Memory and Attention Adaptation Training to help cancer survivors prevent or manage these memory problems. Their study involved 47 breast cancer survivors who underwent ... Read more

Related support groups: Cancer, Methotrexate, Breast Cancer, Prostate Cancer, Fluorouracil, Gleevec, Lung Cancer, Colorectal Cancer, Renal Cell Carcinoma, Breast Cancer, Metastatic, Non-Small Cell Lung Cancer, Brain Tumor, Melanoma, Xeloda, Pancreatic Cancer, Skin Cancer, Nausea/Vomiting - Chemotherapy Induced, Tasigna, Ovarian Cancer, Endometrial Cancer

Drug Seems to Extend Survival for Advanced Melanoma Patients

Posted 18 Apr 2016 by Drugs.com

MONDAY, April 18, 2016 – More than one-third of advanced melanoma patients were still alive five years after starting therapy with the cancer drug nivolumab (Opdivo), researchers are reporting. "In 2012, we saw some very promising early evidence that this drug could not only cause the regression of very advanced cancer in patients with melanoma, lung or kidney cancers that had not responded to other forms of therapy, but we also saw that these responses appeared to be very durable," said lead researcher Dr. Suzanne Topalian. She is a professor of surgery and oncology at Johns Hopkins University School of Medicine, in Baltimore. Opdivo was approved for the treatment of advanced melanoma by the U.S. Food and Drug Administration in 2014. The results of this follow-up study, funded by Bristol-Myers Squibb, which makes Opdivo, were to be presented Sunday at the American Association for ... Read more

Related support groups: Lung Cancer, Renal Cell Carcinoma, Non-Small Cell Lung Cancer, Melanoma, Small Cell Lung Cancer, Melanoma - Metastatic, Opdivo, Nivolumab, Wilms' Tumor

Black Smokers Less Likely to Get Lung Cancer Screening

Posted 19 Mar 2016 by Drugs.com

FRIDAY, March 18, 2016 – Differences in smoking habits between black and white Americans may lead to lower lung cancer screening rates for blacks, new research suggests. Researchers reviewed federal government data from 1965 to 2012. They found that blacks are less likely than whites to start smoking in their late teens, but also less likely to quit as they get older. The study also found that black smokers use fewer cigarettes a day than white smokers. These racial differences result in important and somewhat contradictory differences in lifetime cigarette exposure, the Yale School of Public Health team said. While blacks tend to continue smoking into their later years, the fact that they tend to smoke fewer cigarettes means that have fewer average "pack-years," calculated by multiplying the number of packs smoked per day by years of smoking, the researchers noted. "Pack-years" is one ... Read more

Related support groups: Smoking, Smoking Cessation, Lung Cancer, Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Diagnosis and Investigation

Can Certain 'Poor Carb' Diets Raise Nonsmokers' Lung Cancer Risk?

Posted 4 Mar 2016 by Drugs.com

FRIDAY, March 4, 2016 – Even people who've never smoked can get lung cancer, and a new study suggests their risk for the disease may rise if they eat a diet rich in certain carbohydrates. These so-called "high glycemic index" diets – regimens that trigger higher levels of insulin in the blood – tend to be heavy in refined, "poor quality" carbs, one expert explained. "The glycemic index and glycemic load are methods to estimate the quality and quantity of dietary carbohydrates," said Dr. Rishi Jain, a medical oncologist at Fox Chase Cancer Center in Philadelphia. "Examples of foods with a high glycemic index include white bread and white potatoes." Jain explained that as rates of obesity and heart risk factors rise in the United States, so does the number of Americans with "insulin resistance," a precursor to diabetes. And he said insulin-linked disorders, which are often tied to ... Read more

Related support groups: Smoking, Smoking Cessation, Dietary Supplementation, Lung Cancer, Non-Small Cell Lung Cancer, Small Cell Lung Cancer

Lung Cancer Survivors May Be Getting Too Many PET Scans

Posted 23 Feb 2016 by Drugs.com

MONDAY, Feb. 22, 2016 – Many lung and esophageal cancer survivors have PET imaging scans as part of ongoing monitoring for the possible return of cancer, but a new study suggests that many of those scans may be unnecessary. In addition, the researchers found that having the pricey scans as the first line of imaging detection might not improve survival rates. PET scans can detect early signs of cancer. But these tests can be expensive and aren't recommended by experts as the first option for long-term monitoring of cancer survivors. Medicare limits follow-up PET scans for cancer survivors to three per patient, the study authors noted. "PET scanning is a great technology and very effective, but using it [to screen for cancer recurrence] doesn't seem to make any difference for these cancers that have a relatively poor prognosis," said study author Dr. Mark Healy, a surgical resident and ... Read more

Related support groups: Lung Cancer, Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Body Imaging

Weight May Influence Outcomes After Lung Cancer Surgery

Posted 26 Jan 2016 by Drugs.com

TUESDAY, Jan. 26, 2016 – Lung cancer surgery patients are most likely to have complications and to die if they're either too thin or fat, a new study suggests. The study included more than 41,000 people who had lung cancer surgery between 2009 and 2014. Patients were categorized according to their body mass index (BMI) – an estimate of body fat based on weight and height. While the study couldn't prove cause-and-effect, people who were either underweight or severely obese had the highest rates of complications and death following surgery, according to the study. The findings were to be presented Tuesday at the annual meeting of the Society of Thoracic Surgeons in Phoenix. Weight "is associated with a patient's overall physiology and health, but overweight people need to have more muscle to carry the extra weight around," study co-leader Dr. Trevor Williams of the University of ... Read more

Related support groups: Surgery, Obesity, Lung Cancer, Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Vascular Surgery, Bronchogenic Carcinoma

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