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Study Hints at Link Between Some Statins, Parkinson's Risk

Posted 20 Jun 2017 by Drugs.com

TUESDAY, June 20, 2017 – People on cholesterol-lowering statins may have a slightly increased risk of developing Parkinson's disease, a new study suggests. Researchers said the finding doesn't prove statins are to blame. But, they added, the findings undercut the notion that statins might help protect against Parkinson's. Where does that idea come from? Past research has shown that people with high cholesterol tend to have a lower risk of Parkinson's, explained Dr. Xuemei Huang, a professor of neurology at Penn State College of Medicine. Since many of those people are treated with statins, that led to speculation that the drugs – rather than high cholesterol itself – might be protective. But so far, studies have come to mixed conclusions, according to Huang. Some have tied statins to a lower Parkinson's risk, while others have found either no connection or an increased risk. Enter ... Read more

Related support groups: Lipitor, Simvastatin, Parkinson's Disease, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Vytorin, Rosuvastatin, Pravachol, Livalo, Red Yeast Rice, Caduet, Simcor, Lescol, Parkinsonism, Parkinsonian Tremor, Lescol XL, Mevacor

Conflicting Statin Guidelines Leave Millions in 'Gray Zone'

Posted 18 Apr 2017 by Drugs.com

TUESDAY, April 18, 2017 – Conflicting guidelines on statin use could leave about 9 million Americans unsure about treatment, a new study suggests. Researchers estimate that if all doctors followed the latest guidelines from the U.S. Preventive Services Task Force (USPSTF) for the cholesterol-lowering drugs, the number of Americans aged 40 to 75 on statin medications would rise by 16 percent. In absolute numbers, that would mean another 17 million statin users. If that sounds like a big jump, consider what would happen if all doctors followed the advice of the American College of Cardiology/American Heart Association: Statin use would climb by 24 percent – for an additional 26 million Americans on the drugs, the study authors estimated. The difference between the two sets of guidelines leaves 9 million Americans in a statin "gray zone." So, which guidelines are "right"? That's not ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Vytorin, Rosuvastatin, Hypertriglyceridemia, High Cholesterol - Familial Heterozygous, Pravachol, Livalo, Red Yeast Rice, High Cholesterol - Familial Homozygous, Caduet, Simcor, Lescol, Hyperlipoproteinemia

Guidelines May Miss Need for Statins in Many U.S. Blacks

Posted 19 Mar 2017 by Drugs.com

SATURDAY, March 18, 2017 – U.S. medical organizations have conflicting guidelines on the use of cholesterol-lowering statin drugs in blacks, a new study finds. Researchers say that about one in four black Americans who are recommended to take a statin under guidelines from the American College of Cardiology/American Heart Association would no longer qualify for such therapy under new guidelines from the U.S. Preventive Services Task Force (USPSTF). The USPSTF is an influential government-appointed group whose decisions often influence health care, including insurance coverage. The new study was led by Dr. Venkatesh Murthy of the University of Michigan, in Ann Arbor. His team noted that while many studies have used artery scans to assess the need for statins by white patients, no such studies have focused on black patients. However, compared with whites, black Americans are at higher ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Vytorin, Rosuvastatin, Hypertriglyceridemia, Pravachol, Livalo, Red Yeast Rice, Simcor, Lescol, Hyperlipoproteinemia, Lescol XL, Mevacor, Altoprev

Many Young Adults With High Cholesterol Not on Statins as Recommended

Posted 4 Jan 2017 by Drugs.com

WEDNESDAY, Jan. 4, 2017 – Too few Americans who need them – especially young adults – are getting cholesterol-lowering statin medications, a new study suggests. The study of nearly 3 million adults found that more than half of younger patients under 40 with too-high blood levels of LDL "bad" cholesterol are getting statins as recommended. "This article clearly articulates the under-usage of statins in young people with severe elevations of LDL cholesterol," said heart specialist Dr. Carl Reimers. Reimers is associate chair of cardiovascular medicine at Lenox Hill Hospital in New York City. He reviewed the new findings but wasn't involved in the research. Reimers said that younger patients often show early signs of heart trouble linked to cholesterol, but too often aren't treated with statins. That's a shame, he said, because "it is well-established that treating these patients with ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Vytorin, Rosuvastatin, Hypertriglyceridemia, Pravachol, Livalo, Red Yeast Rice, Caduet, Simcor, Lescol, Hyperlipoproteinemia, Lescol XL, Mevacor

Drug Combo for Irregular Heartbeat Might Raise Bleeding Risk

Posted 21 Nov 2016 by Drugs.com

MONDAY, Nov. 21, 2016 – Because the irregular heartbeat known as atrial fibrillation can trigger stroke-inducing clots, many patients are prescribed a blood thinner. But a new Canadian study suggests that combining one blood thinner, Pradaxa, with certain statin medications could raise the odds for bleeding in these patients. "An increase in the risk of bleeding requiring hospital admission or emergency department visits was seen with lovastatin [Mevacor] and simvastatin [Zocor] compared with the other statins," said study author Tony Antoniou, a pharmacist at St. Michael's Hospital in Toronto. His team tracked outcomes for nearly 46,000 patients ages 65 and older. All had atrial fibrillation and took Pradaxa (dabigatran) to reduce their risk of stroke. Those who also took either lovastatin or simvastatin had a 40 percent higher risk of bleeding than those who took other statins, the ... Read more

Related support groups: Bleeding Disorder, Atrial Fibrillation, Lipitor, Simvastatin, Crestor, Atorvastatin, Pradaxa, Pravastatin, Zocor, Lovastatin, Prevention of Thromboembolism in Atrial Fibrillation, Vytorin, Rosuvastatin, Pravachol, Livalo, Red Yeast Rice, Caduet, Simcor, Lescol, Dabigatran

Are There Alternatives to Statins?

Posted 27 Sep 2016 by Drugs.com

TUESDAY, Sept. 27, 2016 – Statins are the go-to therapy for lowering "bad" LDL cholesterol, but other treatments also can effectively reduce risk of future heart problems, a new evidence review reports. These alternative therapies – including a heart-healthy diet, other cholesterol-lowering medications, and even intestinal bypass surgery – seem to confer the same level of heart health protection as statins when cholesterol levels decrease, according to the findings. Nonstatin therapies reduced the risk of heart problems by 25 percent for each 1 millimole per liter (mmol/L) decrease in LDL cholesterol levels. That's very similar to the 23 percent reduction per 1 mmol/L decrease seen with statins like atorvastatin (Lipitor) and simvastatin (Zocor), the researchers said. What's more, the benefits of these therapies stack up if more than one proves effective at lowering a person's ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Welchol, Cholestyramine, Zocor, Lovastatin, Zetia, Vytorin, Rosuvastatin, Hypertriglyceridemia, High Cholesterol - Familial Heterozygous, Gastric Bypass Surgery, Questran, Pravachol, Livalo, Red Yeast Rice

Just a Little of Statins' Effect Enough to Help Heart: Study

Posted 20 Jun 2016 by Drugs.com

MONDAY, June 20, 2016 – Giving high doses of statins to patients with heart disease doesn't lower the risk of future heart trouble any more than moderate doses of the cholesterol-lowering drugs do, a new study finds. Having heart disease raises the risk of heart attack and stroke, as blood vessels become clogged and cut the normal flow of blood and oxygen to the heart. These patients are typically prescribed statins on a long-term basis, to lower levels of vessel-clogging LDL ("bad") cholesterol. But experts remain conflicted about exactly how low LDL cholesterol levels should go. "Our study demonstrates that physicians treating patients with heart disease and elevated levels of cholesterol with statins have to ensure that patients meet a target of less than 100 mg/dL to prevent future [heart] events," said study author Dr. Morton Leibowitz. He is a senior physician with the Clalit ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Vytorin, Rosuvastatin, Pravachol, Livalo, Prevention of Cardiovascular Disease, Red Yeast Rice, Cardiovascular Risk Reduction, Caduet, Simcor, Lescol, Lescol XL, Mevacor

Statins Might Not Lower Colon Cancer Risk: Study

Posted 26 Apr 2016 by Drugs.com

TUESDAY, April 26, 2016 – Long-term use of cholesterol-lowering statins does not appear to reduce the risk of colon cancer, but a person's cholesterol levels might affect risk, a new study suggests. Both statins and cholesterol levels have been linked with lower colon cancer risk, but pinpointing which one is actually responsible has been difficult, the University of Pennsylvania researchers explained. So, they compared statin use and cholesterol levels in more than 22,000 British patients with colon cancer and more than 86,500 without the disease. The results confirmed findings from previous studies that showed a lower risk of colon cancer in people who take statins. But the risk was not significantly different between people who kept taking statins and those who stopped taking the drugs. Instead, the higher the cholesterol level, the lower the colon cancer risk for patients, ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Colonoscopy, Crestor, Atorvastatin, Pravastatin, Colorectal Cancer, Zocor, Lovastatin, Vytorin, Rosuvastatin, Pravachol, Livalo, Red Yeast Rice, Caduet, Simcor, Lescol, Lescol XL, Mevacor

Negative News on Statins Tied to Dropped Prescriptions

Posted 2 Dec 2015 by Drugs.com

WEDNESDAY, Dec. 2, 2015 – News reports on the downsides of statins may push some people to stop taking the cholesterol-lowering drugs, a new study hints. The findings, published Dec. 2 in the European Heart Journal, cannot prove that media stories drive statin users to give up their prescriptions. Instead, Danish researchers found a broad correlation between "negative" media coverage and people's odds of quitting a statin within six months of their first prescription. But even without a clear cause-and-effect connection, experts said it's reasonable to assume that media stories had an influence over some statin users in the study. It rings true to Dr. Thomas Whayne Jr., of the Gill Heart Institute at the University of Kentucky. "I've seen this happen a lot," said Whayne, who was not involved in the study. "News stories come out, and you have patients saying, 'I'm not going to take ... Read more

Related support groups: Diabetes, Type 2, Muscle Pain, Heart Disease, High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Zetia, Pre-Diabetes, Vytorin, Rosuvastatin, Hypertriglyceridemia, Pravachol, Livalo, Red Yeast Rice, Repatha

One-Third of Americans Have Dangerous Mix of Heart Risk Factors

Posted 19 May 2015 by Drugs.com

TUESDAY, May 19, 2015 – More than one-third of U.S. adults have a combination of health problems collectively known as metabolic syndrome that increase the risk of heart disease and diabetes, according to new research. What's worse, the researchers found the rate of metabolic syndrome increases dramatically with age. Almost half of people 60 or older in the United States have metabolic syndrome, the study found. "That's concerning, because we know the population of the U.S. is aging," said senior author Dr. Robert Wong, an assistant clinical professor at University of California, San Francisco. "I think it will potentially place a huge burden on our health care system." Metabolic syndrome is a "perfect storm" of conditions that include high blood pressure, abnormal cholesterol levels, increased levels of blood sugar, and a wider waist circumference, Wong said. Medical experts are ... Read more

Related support groups: High Blood Pressure, Diabetes, Type 2, Hypertension, Heart Disease, High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Angina, Niacin, Insulin Resistance, Niaspan, Zocor, Lovastatin, Pre-Diabetes, Vytorin, Rosuvastatin, Hypertriglyceridemia

Can Statins Help Lower Lung Cancer Death Risk?

Posted 1 May 2015 by Drugs.com

FRIDAY, May 1, 2015 – Taking the cholesterol-lowering medications known as statins for a year before getting a diagnosis of lung cancer was associated with a 12 percent lower risk of dying from that cancer, new research suggests. The researchers from Northern Ireland also found indications that those who had a minimum of 12 statin prescriptions filled after being diagnosed with lung cancer saw their lung cancer death risk drop by as much as 19 percent. But, study lead author Chris Cardwell stressed that the degree of the association seen between statin use and a lower risk for lung cancer death was "relatively small." And while the study found an association between statin use and a lower risk of lung cancer death, it wasn't designed to prove a cause-and-effect relationship. Cardwell said there are any number of other differences between patients who take statins and patients who don't ... Read more

Related support groups: Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Lung Cancer, Zocor, Lovastatin, Non-Small Cell Lung Cancer, Vytorin, Rosuvastatin, Pravachol, Livalo, Red Yeast Rice, Caduet, Simcor, Lescol, Lescol XL, Mevacor, Amlodipine/Atorvastatin

FDA Medwatch Alert: Statin Drugs - Drug Safety Communication: Class Labeling Change

Posted 29 Feb 2012 by Drugs.com

ISSUE: FDA has approved important safety label changes for the class of cholesterol-lowering drugs known as statins. The changes include removal of routine monitoring of liver enzymes from drug labels. Information about the potential for generally non-serious and reversible cognitive side effects and reports of increased blood sugar and glycosylated hemoglobin (HbA1c) levels has been added to the statin labels. The lovastatin label has been extensively updated with new contraindications and dose limitations when it is taken with certain medicines that can increase the risk for muscle injury. Read the FDA Drug Safety Communication for more information.   BACKGROUND: Statins are a class of prescription drugs used together with diet and exercise to reduce blood levels of low-density lipoprotein (LDL) cholesterol (“bad cholesterol”). Marketed as single-ingredient products, including Lipitor ... Read more

Related support groups: Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Vytorin, Rosuvastatin, Pravachol, Livalo, Red Yeast Rice, Simcor, Lescol, Lescol XL, Mevacor, Advicor, Baycol, Fluvastatin, Altoprev

FDA Adds Safety Warnings to Statins

Posted 28 Feb 2012 by Drugs.com

TUESDAY, Feb. 28 – The popular cholesterol-lowering drugs called statins will now come with revised labels warning of a slight increased risk of elevated blood sugar levels, which could lead to type 2 diabetes, as well as a warning on rare cases of confusion and memory loss, U.S. drug regulators said Tuesday. But the U.S. Food and Drug Administration, which made the announcement, and health-care professionals all stressed that the heart-protective benefits of statins – which include drugs such as Crestor, Lipitor, Pravachol and Zocor – far outweigh the risks spelled out on the new labels. "We want health-care professionals and patients to have the most current information on the risks of statins, but also to assure them that these medications continue to provide an important health benefit of lowering cholesterol," Dr. Mary Parks, director of the FDA's Division of Metabolism and ... Read more

Related support groups: Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Vytorin, Rosuvastatin, Pravachol, Livalo, Red Yeast Rice, Simcor, Lescol, Lescol XL, Mevacor, Advicor, Baycol, Fluvastatin, Altoprev

FDA Medwatch Alert: Zocor (simvastatin): Label Change - New Restrictions, Contraindications, and Dose Limitations

Posted 19 Dec 2011 by Drugs.com

Simvastatin sold under the brand-name Zocor, as a single-ingredient generic product, and sold in combination with ezetimibe as Vytorin and in combination with niacin as Simcor [UPDATED 12/15/2011] FDA notified the public that it has revised the dose limitation for simvastatin from 10 mg to 20 mg when it is co-administered with the cardiac drug amiodarone. The simvastatin drug labels (Zocor and generics, Vytorin) have been updated to reflect this correction.   [Posted 06/08/2011] ISSUE: FDA notified healthcare professionals that it is recommending limiting the use of the highest approved dose of the cholesterol-lowering medication simvastatin (80 mg) because of increased risk of muscle damage. Patients taking simvastatin 80 mg daily have an increased risk of myopathy compared to patients taking lower doses of this drug or other drugs in the same class. This risk appears to be higher ... Read more

Related support groups: Simvastatin, Zocor, Vytorin, Simcor, Ezetimibe/Simvastatin, Juvisync, Niacin/Simvastatin, Simvastatin/sitagliptin

No Benefit From Niacin for Heart Patients in Study

Posted 15 Nov 2011 by Drugs.com

TUESDAY, Nov. 15 – Patients with cardiovascular disease who add niacin to the statin drug Zocor (simvastatin) to help lower their cholesterol get no additional clinical benefit, a new study finds. Even though niacin appeared to increase HDL cholesterol – the good cholesterol – and decrease triglycerides, another type of fat in the blood, it did not reduce the risk of heart attack, stroke or death, the researchers found. "The data we had previously on niacin was not very strong and mostly came from one very old study," said Dr. Robert Giugliano, from the cardiovascular medicine division at Brigham and Women's Hospital and Harvard Medical School in Boston, who was not involved with the study. The report was published online Nov. 15 in the New England Journal of Medicine to coincide with the presentation of the findings at an American Heart Association meeting in Orlando, Fla. ... Read more

Related support groups: Heart Disease, High Cholesterol, Simvastatin, Niacin, Niaspan, Zocor, Prevention of Cardiovascular Disease, Slo-Niacin, Simcor, Niaspan ER, Nicotinic Acid, Niacin SR, B3-500-Gr, Nicolar, Niacor, Niaspan ER Starter Pack, B-3-50, Nicobid Tempules, Nicotinex, Niacor B3

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High Cholesterol, Hyperlipoproteinemia, Hyperlipoproteinemia Type IIa (Elevated LDL), Hyperlipoproteinemia Type IIb (Elevated LDL + VLDL), Hyperlipoproteinemia Type IV (Elevated VLDL)

Simcor Patient Information at Drugs.com