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Sepsis News

Anti-Inflammatory Agent in Cord Blood Shows Promise in Mice

Posted 9 Sep 2016 by Drugs.com

FRIDAY, Sept. 9, 2016 – Scientists report that a factor found in umbilical cord blood helped fight harmful inflammation in mice, and could point the way to new treatments for humans. Inflammation is common, and in certain circumstances it damages healthy tissue. Out-of-control inflammation is associated with a number of conditions, including rheumatoid arthritis and sepsis, a common cause of hospital patient deaths. Sepsis is the body's overreaction to infection. Scientists from the University of Utah School of Medicine isolated neonatal NET inhibitory factor (nNIF) from cord blood. The factor occurs in the blood of newborns for about two weeks after birth. It is not found in older babies or adults. When given to mice, nNIF reduced inflammation and sepsis-related problems such as fever, breathing fluctuations and death, according to the study. Without treatment, only 20 percent of the ... Read more

Related support groups: Rheumatoid Arthritis, Inflammatory Conditions, Juvenile Rheumatoid Arthritis, Sepsis, Diagnosis and Investigation

Patients May Quickly Lose Beneficial Gut Bacteria in the ICU

Posted 31 Aug 2016 by Drugs.com

WEDNESDAY, Aug. 31, 2016 – Intensive care patients have a significant loss of helpful gut bacteria within days of entering the hospital, a new study finds. These bacteria help keep people well. Losing them puts patients at risk for hospital-acquired infections that may lead to sepsis, organ failure and even death, according to the researchers. For the study, the investigators analyzed gut bacteria from 115 intensive care unit (ICU) patients at four hospitals in the United States and Canada. Measurements were taken 48 hours after admission and after either 10 days in the ICU or leaving the hospital. Compared with healthy people, the ICU patients had lower levels of helpful bacteria and higher levels of potentially harmful bacteria, the findings showed. "The results were what we feared them to be. We saw a massive depletion of normal, health-promoting species," study leader Dr. Paul ... Read more

Related support groups: Infections, Bacterial Infection, Gastrointestinal Disorders, Sepsis, Organ Transplant, Septicemia, Wound Sepsis

Fast Action Can Prevent Sepsis Death: CDC

Posted 23 Aug 2016 by Drugs.com

TUESDAY, Aug. 23, 2016 – Many cases of life-threatening sepsis could be recognized and treated long before it causes severe illness or death, U.S. health officials report. Sepsis, or septicemia, occurs when the body has an extreme response to an infection. Without prompt treatment, organ failure can quickly follow. Researchers from the U.S. Centers for Disease Control and Prevention found that about 70 percent of patients with sepsis had used health care services recently or had chronic diseases that required regular medical care. That means there are many opportunities for health care providers to intercept sepsis along its potentially deadly course, according to the CDC report. "When sepsis occurs, it should be treated as a medical emergency," CDC Director Dr. Tom Frieden said in an agency news release. "Doctors and nurses can prevent sepsis and also the devastating effects of ... Read more

Related support groups: Infections, Sepsis, Bacteremia, Septicemia, Wound Cleansing, Wound Sepsis, Wound Debridement

Persistent Critical Illness May Keep Patients From Leaving ICU

Posted 5 May 2016 by Drugs.com

WEDNESDAY, May 4, 2016 – A small group of patients uses one-third of intensive care unit resources, a new study contends. Researchers analyzed data from more than one million ICU patients in Australia and New Zealand, and found that just 5 percent of them accounted for 33 percent of all days that ICU beds got used. These are critically ill patients who go from one health crisis to another and may never get well enough to leave the ICU, according to the study authors. The findings could lead to better care and efforts to find ways to prevent patients from slipping into this situation, which the researchers called persistent critical illness. "We have found that this truly is a separate 'thing' – a state patients transition into where you're there because you're there, stuck in this cascade that we can't get you out of," said study leader Dr. Theodore Iwashyna. He is a University of ... Read more

Related support groups: Infections, Sepsis, Bacteremia, Septicemia, ICU Agitation, Wound Sepsis

Families Like Looser ICU Visitation Policies

Posted 4 Jan 2016 by Drugs.com

MONDAY, Jan. 4, 2016 – Many hospitals still restrict who can visit critically ill patients and when. But new survey results suggest that lifting such restrictions can improve family satisfaction and patient well-being. "The term 'visiting hours' is obsolete due to the growing evidence related to the wide-ranging benefits of open access for ICU [intensive-care unit] families," said senior study author Dr. Samuel Brown. He is director of the Center for Humanizing Critical Care at Intermountain Medical Center in Murray, Utah. The study involved 103 family members visiting patients in the intensive care unit and 128 ICU nurses. About half were surveyed before an unrestricted patient visitation policy was implemented at the medical center and half were questioned after. With the new policy, visitors are allowed at all times, if patients agree and are well enough. Previously, visits were ... Read more

Related support groups: Infections, Sepsis, Septicemia, ICU Agitation

Families of Critically Ill Patients Need Extra Support, Too

Posted 31 Dec 2015 by Drugs.com

THURSDAY, Dec. 31, 2015 – When a loved one is admitted to a hospital intensive care unit (ICU), family members need support, too. "Families are totally unprepared for a sudden injury and overwhelmed when it is a very serious injury. Families need a road map to guide them through their worst moments, and that is my job," said Kelly McElligott, a clinical social worker in the burn center at Loyola University Health System in Maywood, Ill. Each year, roughly 2.1 million patients are transferred from an emergency room to an intensive care unit, according to the U.S. Centers for Disease Control and Prevention. McElligott described several ways people can deal with the sudden hospitalization of a critically ill loved one, including: Take care of yourself. "If you do not take care of yourself, you cannot take care of someone else," she said. "Many family members, especially parents, feel ... Read more

Related support groups: Infections, Sepsis, Septicemia

Extreme Exercising Can Lead to Blood Poisoning, Study Reveals

Posted 19 Jun 2015 by Drugs.com

FRIDAY, June 19, 2015 – Extreme exercise may trigger blood poisoning in people who haven't trained properly, a new study suggests. Researchers in Australia looked at athletes who took part in extreme endurance events. Examples of such events include 24-hour ultra-marathons and multi-stage ultra-marathons run on consecutive days. The investigators found this type of exertion can cause intestinal bacteria to leak into the bloodstream. This can potentially lead to blood poisoning, they said. Blood samples were taken before and after the events, and compared with a control group. The researchers said these samples proved that "exercise over a prolonged period of time causes the gut wall to change, allowing the naturally present bacteria, known as endotoxins, in the gut to leak into the bloodstream." Once those bacteria are in the bloodstream, the immune system responds, causing ... Read more

Related support groups: Sepsis

Recent Hospitalization Might Raise Blood Infection Risk, Study Says

Posted 3 Jun 2015 by Drugs.com

WEDNESDAY, June 3, 2015 – A routine hospital stay may put older adults at risk for a potentially deadly condition called sepsis, according to a new study. Sepsis is a catastrophic, whole-body response to infection, according to the researchers. The study looked at data from nearly 11,000 older Americans. Over 12 years, there were 43,000 hospitalizations. The researchers found people were three times more likely to develop sepsis within three months after leaving the hospital than at any other time. The analysis also showed that the risk of sepsis three months after a hospital stay was 30 percent higher for those who received care for any type of infection. The risk of sepsis three months after hospitalization was 70 percent higher for those who had an intestinal infection caused by Clostridium difficile (or C. difficile) bacteria, the study revealed. One in 10 C. difficile infection ... Read more

Related support groups: Sepsis, Clostridial Infection, Wound Sepsis

Improper Antibiotic Use Often Due to Misdiagnosis: Study

Posted 20 May 2015 by Drugs.com

WEDNESDAY, May 20, 2015 – Misdiagnosis often leads to improper antibiotic use in hospitals, new research finds. Incorrect antibiotic use can cause patient harm, reduce the effectiveness of antibiotics and increase health care costs, the researchers noted. "Antibiotic therapies are used for approximately 56 percent of inpatients in U.S. hospitals, but are found to be inappropriate in nearly half of these cases, and many of these failures are connected with inaccurate diagnoses," study author Dr. Greg Filice said in a news release from the Society for Healthcare Epidemiology of America. Filice, an internist with the Minneapolis Veterans Affairs Health Care System, and his colleagues analyzed 500 inpatient cases at the Minneapolis VA Medical Center. They found that inappropriate use of antibiotics occurred with 95 percent of patients who received an incorrect or indeterminate diagnosis, ... Read more

Related support groups: Urinary Tract Infection, Metronidazole, Bactrim, Bladder Infection, Pneumonia, Flagyl, Kidney Infections, Bactrim DS, Sulfamethoxazole/Trimethoprim, Xifaxan, Polymyxin B, Septra, Sepsis, Zyvox, Bacitracin, Metro, Rifaximin, Septra DS, SMZ-TMP DS, Chloramphenicol

Researchers Hone in on Genes Linked to Serious Blood Infection

Posted 13 May 2015 by Drugs.com

WEDNESDAY, May 13, 2015 – It might be possible to develop a blood test that would diagnose severe blood infections (sepsis) at an earlier stage than can be done currently, new research suggests. Stanford University researchers have identified a pattern of gene activity associated specifically with sepsis. Sepsis is the leading cause of hospital deaths in the United States, according to the researchers. The condition is associated with the early deaths of at least 750,000 Americans a year and costs the health care system more than $24 billion annually. "It's critical for clinicians to diagnose sepsis accurately and quickly, because the risk of death from this condition increases with every passing hour it goes untreated," study senior author Purvesh Khatri, an assistant professor of biomedical informatics research, said in a university news release. However, it can be difficult to ... Read more

Related support groups: Infections, Sepsis, Diagnosis and Investigation, Septicemia

Simpler Antibiotic Regimen Helps Sick Babies in Developing Nations

Posted 2 Apr 2015 by Drugs.com

WEDNESDAY, April 1, 2015 – Newborns and young infants in developing nations who have suspected severe bacterial infections can be effectively treated outside a hospital, two new studies suggest. The findings indicate that the World Health Organization's guidelines on treating newborns and young infants with possible bacterial infections – such as pneumonia and sepsis (blood infection) – should be altered, the researchers said. About one in five babies worldwide develops severe bacterial infections during the first month of life, leading to about 700,000 deaths in newborns every year, the researchers explained. Current WHO guidelines recommend that newborns and young infants believed to have such infections be hospitalized and treated with antibiotic injections for at least seven to 10 days. However, many parents in developing nations can't afford, or don't have access to, such ... Read more

Related support groups: Amoxicillin, Bacterial Infection, Pneumonia, Amoxil, Sepsis, Amoxil Pediatric Drops, Biomox, Trimox, Moxatag, Amoxicot, DisperMox, Apo-Amoxi, Moxilin, Wymox

Hospitalizations After Severe Blood Infections May Be Preventable

Posted 10 Mar 2015 by Drugs.com

TUESDAY, March 10, 2015 – When people survive life-threatening blood infections, it's common for them to land back in the hospital within a few months. But a new study suggests that could often be avoided. The research, published in the March 10 issue of the Journal of the American Medical Association, focused on older Americans who were hospitalized for a severe blood infection, also known as sepsis. Sepsis arises from a powerful immune reaction to an infection, such as pneumonia or urinary tract infection: Chemicals released to fight the bacteria or virus begin to trigger inflammatory responses throughout the body – potentially causing blood clots, leaky blood vessels and multiple organ failure. Severe sepsis is often fatal, but even when people survive, they commonly land back in the hospital within 90 days, said study author Dr. Hallie Prescott, a researcher at the University of ... Read more

Related support groups: Sepsis, Septicemia, Wound Sepsis

Hospital Infection Rates Falling, But More Improvement Needed: CDC

Posted 14 Jan 2015 by Drugs.com

WEDNESDAY, Jan. 14, 2015 – Rates of many types of hospital-acquired infections are on the decline, but more work is needed to protect patients, according to a U.S. Centers for Disease Control and Prevention report. "Hospitals have made real progress to reduce some types of health care-associated infections – it can be done," CDC Director Dr. Tom Frieden said Wednesday in an agency news release. The study used national data to track outcomes at more than 14,500 health care centers across the United States. The researchers found a 46 percent drop in "central line-associated" bloodstream infections between 2008 and 2013. This type of infection occurs when a tube placed in a large vein is either not put in correctly or not kept clean, the CDC explained. During that same time, there was a 19 percent decrease in surgical site infections among patients who underwent the 10 types of surgery ... Read more

Related support groups: Sepsis, Septicemia, Wound Sepsis

Long ICU Stays May Alter Gut Microbes

Posted 24 Sep 2014 by Drugs.com

WEDNESDAY, Sept. 24, 2014 – Long stays in intensive care lead to a big reduction in the types of microbes in patients' intestines, and some of those that remain are potentially deadly, a new study indicates. University of Chicago researchers investigated what happens to the gut microbes of intensive care unit (ICU) patients who receive repeated courses of multiple antibiotics to protect them from infection. Patients who stayed in an ICU for longer than one month had only one to four types of microbes in the intestine, while healthy study volunteers had about 40 types, according to the study published Sept. 23 in the online journal mBio. Some of the few remaining types of microbes in the ICU patients may increase the risk of a life-threatening systemic infection called sepsis, the researchers said. "I have watched patients die from sepsis – it isn't their injuries or mechanical ... Read more

Related support groups: Sepsis

Blood Test for Yeast Infections Approved

Posted 23 Sep 2014 by Drugs.com

TUESDAY, Sept. 23, 2014 – The first blood test to detect five strains of yeast that cause rare blood infections in people with weakened immune systems has been approved by the U.S. Food and Drug Administration. The five types of yeast pathogen detected by the T2Candida test can cause deadly bloodstream infections if not treated quickly, the FDA said in a news release. People at greatest risk of the infections include those being treated for cancer, those who have been given immune system-suppressing drugs after an organ transplant and severely ill people in intensive care. Results from the new test are available in three to five hours, compared to six days or longer from traditional methods, the FDA said. The faster results may allow doctors to begin treatment sooner. But since false positives are possible from the new test, results should be confirmed by blood culture, the agency ... Read more

Related support groups: Sepsis, Diagnosis and Investigation

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