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Renal Transplant News

Donor Kidneys Rejected by Centers 7 Times on Average

Posted 27 Jul 2017 by Drugs.com

THURSDAY, July 27, 2017 – A donated kidney is turned away for transplant an average of seven times before reaching the patient who finally receives it, a new study shows. Transplant centers regularly reject kidneys based on a donor's age or perceived quality of the organ, even though these kidneys are eventually accepted and work well for people farther down the waiting list, explained lead researcher Dr. Anne Huml, a nephrologist and health disparities fellow with Case Western Reserve University in Cleveland. The centers are likely being appropriately picky in selecting organs, to ensure the greatest chance of success by carefully matching each kidney to each recipient, Huml said. "If someone's been waiting five years, why rush and take the first kidney offered when within a month they'll be offered a better kidney and their outcome will be better?" Huml said. But such hesitation can ... Read more

Related support groups: Renal Transplant, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Kidney Transplant, Graft-versus-host disease, Rejection Prophylaxis

Researchers Grow Functioning Liver Tissue in Mice

Posted 19 Jul 2017 by Drugs.com

WEDNESDAY, July 19, 2017 – Researchers say they were able to coax tiny "seeds" of liver tissue into fully functioning livers in mice. If this approach works in people, it could help reduce long wait lists for liver transplants. It might also benefit people with failing livers who don't quality for liver transplants, according to the researchers. The scientists placed three types of liver cells – the seeds – into biodegradable tissue scaffolds. They then implanted those scaffolds in mice with damaged livers. Once inside the mice, the tiny structures grew 50-fold and were able to perform normal liver tissue functions. "There are just not enough organs to go around. Our goal is that one day we could use this technology to increase the number of transplants that are done for patients, which right now is very limited," said senior author Dr. Sangeeta Bhatia. She's a professor of health ... Read more

Related support groups: Renal Failure, Renal Transplant, Chronic Kidney Disease, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Kidney Transplant, Liver and Pancreatic Disease

Are Doctors Discarding Donor Kidneys That Could Save Lives?

Posted 7 Jul 2017 by Drugs.com

THURSDAY, July 6, 2017 – U.S. doctors are discarding donated kidneys that could keep people alive for years, simply because the organs are not top-quality, a new study claims. "Suboptimal" kidneys from older donors with health problems perform much better than expected, and would preserve a patient's life much longer than dialysis, said lead researcher Dr. Sumit Mohan, an assistant professor at Columbia University's Mailman School of Public Health. About 73 percent of lower-quality kidneys received by Columbia patients were still functioning five years after transplant, Mohan and his colleagues found. "To our surprise, yes, they did worse than the best-quality kidneys, but they didn't do that poorly," Mohan said. By comparison, the five-year survival rate for kidney patients on dialysis is about 35 percent, Mohan said. "If I don't get a kidney, my alternative is to stay on dialysis," ... Read more

Related support groups: Renal Failure, Renal Transplant, Chronic Kidney Disease, Peritoneal dialysis, Organ Transplant, Kidney Transplant, Organ Transplant - Rejection Reversal, Rejection Reversal, Nephropathy, Rejection Prophylaxis, Renal and Genitourinary Disorders, Hyperphosphatemia of Renal Failure

Kidneys From Deceased Diabetics Might Ease Organ Shortage: Study

Posted 25 May 2017 by Drugs.com

THURSDAY, May 25, 2017 – Kidneys from deceased diabetic donors can save the lives of patients on the transplant wait-list, researchers say. For the study, investigators compared U.S. data from more than 8,100 recipients of kidneys from deceased diabetic donors with data from people on the kidney transplant wait-list. The patients were followed for an average of nearly nine years. People who received kidneys from diabetic donors were 9 percent less likely to die during that follow-up period than those who were still on the wait-list or were seeking a kidney from a non-diabetic donor, the study found. The people who benefited most from diabetic donor kidneys were those who were most likely to die while on the wait-list, the researchers said. But poor-quality kidneys from deceased diabetic donors did not improve survival chances, the findings showed. And people under age 40 didn't benefit ... Read more

Related support groups: Renal Transplant, Diabetes Mellitus, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Kidney Transplant, Rejection Prophylaxis

A 2nd Life for Risky Kidney Transplants?

Posted 11 May 2017 by Drugs.com

THURSDAY, May 11, 2017 – Philadelphia doctors say they cleared hepatitis C infections in 10 patients who received kidneys from deceased donors who had the virus. The findings suggest hundreds more of these transplants could take place each year, thus reducing wait time for a lifesaving kidney, the doctors said. "Our pilot data demonstrate the ability to cure the contracted virus following transplantation in this patient population," said the study co-leader, Dr. David Goldberg. "If future studies are successful, this may be a viable option for patients who may otherwise never see a transplant," added Goldberg, an assistant professor of medicine and epidemiology at the University of Pennsylvania School of Medicine. In the United States, more than 97,000 people need a kidney transplant. Many must wait for five or more years, the researchers said in background notes. Kidneys from donors ... Read more

Related support groups: Hepatitis C, Renal Transplant, Organ Transplant, Kidney Transplant

Cancer Risk Rises After Childhood Organ Transplant: Study

Posted 26 Apr 2017 by Drugs.com

WEDNESDAY, April 26, 2017 – Children given an organ transplant have a substantially higher risk of developing cancer – in some cases up to 200 times higher – than the general population, a new study finds. But the individual risk of any one child getting cancer still remains very small, the study authors stressed. Overall, the U.S. National Cancer Institute (NCI) study found that the risk for cancer among children who received transplants was 19 times higher than in the general population. Non-Hodgkin's lymphoma was the cancer with a 200 times higher risk. Seventy-one percent of those who developed cancer after a pediatric organ transplant had non-Hodgkin's lymphoma, the study findings showed. "We knew going into the study that the risk of lymphoma would be very high," explained Dr. Eric Engels, the study's senior investigator. "That's been seen in much smaller studies, and it's been ... Read more

Related support groups: Cancer, Leukemia, Renal Transplant, Non-Hodgkin's Lymphoma, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Viral Infection, Kidney Transplant, Organ Transplant - Rejection Reversal, Rejection Reversal, Rejection Prophylaxis

Baseball Great Rod Carew Owes His Life to NFL Player's Transplanted Organs

Posted 17 Apr 2017 by Drugs.com

MONDAY, April 17, 2017 – When Baseball Hall of Famer Rod Carew received a new heart and kidney last December, he and his family had no idea who they had to thank for the lifesaving organs. But some good sleuthing by Carew's wife and the mother of the anonymous donor unearthed a startling discovery: The organs had come from former National Football League tight end Konrad Reuland, who was only 29 when he died after suffering a brain aneurysm. Carew, 71, needed the new organs because of a massive heart attack he had in 2015, which was followed by subsequent complications. He received the new organs in an operation performed at Cedars-Sinai Medical Center in Los Angeles. After the transplant, a number of Carew's family and friends asked Carew's wife, Rhonda, if the new organs might have come from Reuland. That prompted her to begin investigating. She learned the donor was a healthy local ... Read more

Related support groups: Renal Transplant, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Kidney Transplant, Cardiothoracic Surgery, Rejection Prophylaxis

Weight, Gender Appear to Play Part in Kidney Transplant Success

Posted 31 Mar 2017 by Drugs.com

THURSDAY, March 30, 2017 – Weight and gender differences between donors and recipients can affect the success of kidney transplants, a new study says. Researchers reviewed data from more than 115,000 people in the United States who received a kidney from a deceased donor. The transplants took place between 2000 and 2014. The average follow-up time was about four years. During that time, more than 21,000 patients developed transplant failure. After accounting for other possible causes, the researchers concluded that weight was a factor in transplant failure. Specifically, if a kidney transplant recipient was more than 66 pounds heavier than the donor, there was a 28 percent higher risk of transplant failure, compared with recipients who weighed about the same as donors. The researchers also noted a difference if the donor and recipient's genders were mismatched. The risk of transplant ... Read more

Related support groups: Obesity, Renal Transplant, Organ Transplant, Kidney Transplant

Many Dialysis Patients Get Unnecessary Colonoscopies

Posted 24 Mar 2017 by Drugs.com

FRIDAY, March 24, 2017 – Older Americans on kidney dialysis have high rates of colonoscopy screening for colon cancer, but most get little benefit from the screening, a new study suggests. Dialysis patients have high rates of death, so routine colon cancer screening doesn't improve survival for most dialysis patients who don't qualify for a kidney transplant. Therefore, dialysis patients who have a limited life expectancy and no signs or symptoms of colon cancer shouldn't undergo screening for the disease, according to the American Society of Nephrology. "Physicians should carefully evaluate patients' prognoses and consider the likelihood that they will truly benefit before ordering screening tests," said study co-leader Dr. Christopher Carlos, from the University of California, San Francisco. In this study, researchers reviewed data from more than 469,000 Medicare beneficiaries. They ... Read more

Related support groups: Colonoscopy, Renal Failure, Colorectal Cancer, Renal Transplant, Chronic Kidney Disease, Hemodialysis, Peritoneal dialysis

Kidney Transplant Survival Up Among Babies, Kids

Posted 7 Mar 2017 by Drugs.com

MONDAY, March 6, 2017 – Survival rates for children who get kidney transplants have improved significantly over the last half-century, a new study finds. "The outlook for infants and children with end-stage kidney disease was once dismal, with poor survival rates after transplant. There has been great progress in pediatric kidney transplantation, and now the patient survival rate is almost 100 percent," said the study's principal investigator, Dr. Srinath Chinnakotla. Chinnakotla is an associate professor of surgery at the University of Minnesota Masonic Children's Hospital in Minneapolis, where the study was done. Since 2002, 97 percent of children who had kidney transplants at the hospital were alive a year later. That compares to 85 percent 40 to 50 years ago, the study showed. Long-term outcomes have also improved. Only 42 percent of kids who got a new kidney between 1963 and 1983 ... Read more

Related support groups: Renal Transplant, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Kidney Transplant, Rejection Prophylaxis

Non-English Speakers Less Likely to Be on Kidney Transplant List

Posted 9 Feb 2017 by Drugs.com

THURSDAY, Feb. 9, 2017 – Language barriers may prevent some eligible U.S. patients from receiving a kidney transplant, a new study suggests. Specifically, those who don't speak English may be less likely to complete the kidney transplant evaluation necessary for them to be placed on a waiting list for a kidney from a deceased donor. For the study, researchers analyzed data from kidney failure patients across the United States. The investigators found that patients who lived in neighborhoods where more than 20 percent of households didn't speak English were 29 percent less likely to be on a kidney transplant waiting list than those in neighborhoods where less than 1 percent of households didn't speak English. Although the study can't prove a cause-and-effect relationship, the researchers found the link between not speaking English and not being on a kidney transplant waiting list was ... Read more

Related support groups: Renal Failure, Renal Transplant, Chronic Kidney Disease, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Organ Transplant - Rejection Reversal, Hyperphosphatemia of Renal Failure

Should a Mental Disability Keep Patients Off Organ Transplant Lists?

Posted 25 Jan 2017 by Drugs.com

WEDNESDAY, Jan. 25, 2017 – Pressure is mounting for the U.S. organ donation network to tackle one of the thorniest ethical questions it's ever faced – whether a person with intellectual disabilities should be denied access to a transplant. A bipartisan group of 30 legislators from the U.S. Congress petitioned the Department of Health and Human Services in October to "issue guidance on organ transplant discrimination with regards to persons with disabilities," according to a new opinion piece in the Jan. 26 New England Journal of Medicine. The legislators' request follows several highly publicized cases in which people with intellectual disabilities have either fought to receive a transplant or have been outright denied a place on a waiting list, said co-author Dr. Scott Halpern. He's an associate professor of medical ethics and health policy at the University of Pennsylvania's ... Read more

Related support groups: Depression, Bipolar Disorder, Major Depressive Disorder, Obsessive Compulsive Disorder, Schizophrenia, Mania, Paranoid Disorder, Borderline Personality Disorder, Schizoaffective Disorder, Autism, Psychosis, Psychiatric Disorders, Renal Transplant, Neurosis, Organ Transplant - Rejection Prophylaxis, Body Dysmorphic Disorder, Severe Mood Dysregulation, Organ Transplant, Organ Transplant - Rejection Reversal, Rejection Prophylaxis

For Kids With Kidney Disease, Race May Play Role in Outcomes

Posted 30 Dec 2016 by Drugs.com

THURSDAY, Dec. 29, 2016 – Black children are about one-third more likely to die from kidney failure than white children, and access to kidney transplants may be a crucial factor explaining the discrepancy, a new study suggests. Dr. Elaine Ku, of the University of California, San Francisco, and colleagues tracked the health of more than 12,000 black, Hispanic and white children who had chronic kidney failure. All had been treated for kidney disease with either dialysis or transplants between 1995 and 2011. The investigators followed the kids' health until 2012 for a median of 7 years. Over the follow-up period, 1,600 of the children died. Black children were 36 percent more likely than white children to die, the findings showed. The researchers said that they believe this difference mostly has to do with limited access to kidney transplants. However, Hispanic children were less likely ... Read more

Related support groups: Renal Failure, Renal Transplant, Chronic Kidney Disease

Don't Rule Out Kidneys From Elderly Donors

Posted 16 Dec 2016 by Drugs.com

THURSDAY, Dec. 15, 2016 – Healthy kidneys from elderly donors are often rejected, but even kidneys from donors 80 and older can function for years after transplantation, Italian researchers report. The results were published online Dec. 15 in the Clinical Journal of the American Society of Nephrology. "The results of this study support the use of extended criteria donors, even donors older than 80 years, but they have to be accurately selected and managed with dedicated protocols," Dr. Luigi Biancone, of the University of Turin, said in a journal news release. Researchers analyzed results of deceased donor kidney transplants performed at the Turin University Renal Transplant Center between 2003 and 2013. They focused on almost 650 transplants from so-called "extended criteria" donors – donors older than 60 and those aged 50 to 59 with certain risk factors. After a follow-up of nearly ... Read more

Related support groups: Renal Failure, Renal Transplant, Chronic Kidney Disease, Organ Transplant - Rejection Prophylaxis, Peritoneal dialysis, Organ Transplant, Kidney Transplant, Graft-versus-host disease, Hyperphosphatemia of Renal Failure, Rejection Prophylaxis

Organ Transplants Linked to Higher Skin Cancer Risk

Posted 21 Sep 2016 by Drugs.com

WEDNESDAY, Sept. 21, 2016 – People who have an organ transplant may be more likely to develop skin cancer, new research suggests. The finding applies to all transplant patients, even those who are nonwhite and dark-skinned, according to Dr. Christina Lee Chung, an associate professor of dermatology at Drexel University in Philadelphia, and colleagues. The researchers said the risk increases over time with ongoing exposure to medications that suppress the immune system to prevent organ rejection. Total-body skin exams should be a routine part of care after transplant surgery, the study authors advised. For the study, the researchers analyzed medical records of 413 organ transplant recipients, 63 percent of whom were not white. The investigators found 19 new skin cancers in 15 of the nonwhite patients. That group included six black patients, five Asians and four Hispanics. Among the ... Read more

Related support groups: Basal Cell Carcinoma, Renal Transplant, Skin Cancer, Melanoma, Organ Transplant - Rejection Prophylaxis, Melanoma - Metastatic, Squamous Cell Carcinoma, Organ Transplant, Kidney Transplant, Graft-versus-host disease, History - Skin Cancer, Rejection Prophylaxis

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