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'Old' Lungs May Be Good Transplant Options

Posted 9 Nov 2017 by Drugs.com

THURSDAY, Nov. 9, 2017 – Lungs from older donors are a viable option for lung transplants and should be considered more often, a new study suggests. Survival rates for younger recipients of lung transplants from donors older than 60 are similar to those who receive lungs from younger donors, researchers found. The University of Louisville team analyzed more than 14,000 lung transplants received by people 18 and older in the United States between 2005 and 2014. About 26 percent of the recipients were 50 or younger, with 2 percent having received lungs from donors older than 60. Among those transplant recipients, five-year survival rates were similar between people who received older donor lungs and those who received younger donor lungs, the findings showed. Further analysis revealed that younger patients who received older donor lungs had much better outcomes when they'd had a double ... Read more

Related support groups: Organ Transplant - Rejection Prophylaxis, Organ Transplant, Organ Transplant - Rejection Reversal, Respiratory Tract Disease, Diagnosis and Investigation, Rejection Reversal, Rejection Prophylaxis

Limiting 'Cold Time' Could Make More Organs Available for Transplant

Posted 6 Oct 2017 by Drugs.com

THURSDAY, Oct. 5, 2017 – By improving the way certain donated organs are handled before a transplant, more organs could end up being used, new research suggests. The concern centers on organs donated following "circulatory death" (DCD). That means a patient's heart, breathing and circulation stop functioning. Most donated organs come from people who are brain dead, but their circulation is continued with machines. Organs donated by DCD must undergo a controlled cooling process (called "cold ischemia") after the organ loses its original blood supply. The organ is then re-warmed when blood supply is renewed at the time of transplant. This process leads to a heightened risk for tissue damage. But a team led by Dr. John Gill of the University of British Columbia and Vancouver's Providence Health Care found that by limiting the cooling process to a period of no more than 12 hours, DCD ... Read more

Related support groups: Renal Failure, Chronic Kidney Disease, Organ Transplant - Rejection Prophylaxis, Peritoneal dialysis, Organ Transplant, Kidney Transplant, Organ Transplant - Rejection Reversal, Rejection Reversal, Hyperphosphatemia of Renal Failure, Rejection Prophylaxis

Are Doctors Discarding Donor Kidneys That Could Save Lives?

Posted 7 Jul 2017 by Drugs.com

THURSDAY, July 6, 2017 – U.S. doctors are discarding donated kidneys that could keep people alive for years, simply because the organs are not top-quality, a new study claims. "Suboptimal" kidneys from older donors with health problems perform much better than expected, and would preserve a patient's life much longer than dialysis, said lead researcher Dr. Sumit Mohan, an assistant professor at Columbia University's Mailman School of Public Health. About 73 percent of lower-quality kidneys received by Columbia patients were still functioning five years after transplant, Mohan and his colleagues found. "To our surprise, yes, they did worse than the best-quality kidneys, but they didn't do that poorly," Mohan said. By comparison, the five-year survival rate for kidney patients on dialysis is about 35 percent, Mohan said. "If I don't get a kidney, my alternative is to stay on dialysis," ... Read more

Related support groups: Renal Failure, Renal Transplant, Chronic Kidney Disease, Peritoneal dialysis, Organ Transplant, Kidney Transplant, Organ Transplant - Rejection Reversal, Nephropathy, Rejection Reversal, Rejection Prophylaxis, Renal and Genitourinary Disorders, Hyperphosphatemia of Renal Failure

Cancer Risk Rises After Childhood Organ Transplant: Study

Posted 26 Apr 2017 by Drugs.com

WEDNESDAY, April 26, 2017 – Children given an organ transplant have a substantially higher risk of developing cancer – in some cases up to 200 times higher – than the general population, a new study finds. But the individual risk of any one child getting cancer still remains very small, the study authors stressed. Overall, the U.S. National Cancer Institute (NCI) study found that the risk for cancer among children who received transplants was 19 times higher than in the general population. Non-Hodgkin's lymphoma was the cancer with a 200 times higher risk. Seventy-one percent of those who developed cancer after a pediatric organ transplant had non-Hodgkin's lymphoma, the study findings showed. "We knew going into the study that the risk of lymphoma would be very high," explained Dr. Eric Engels, the study's senior investigator. "That's been seen in much smaller studies, and it's been ... Read more

Related support groups: Cancer, Leukemia, Renal Transplant, Non-Hodgkin's Lymphoma, Organ Transplant - Rejection Prophylaxis, Viral Infection, Organ Transplant, Kidney Transplant, Organ Transplant - Rejection Reversal, Rejection Reversal, Rejection Prophylaxis

Cystic Fibrosis Survival Better in Canada Than in U.S.

Posted 14 Mar 2017 by Drugs.com

MONDAY, March 13, 2017 – People with cystic fibrosis are living longer than ever, but those in Canada live nearly 10 years longer than those in the United States, a new study finds. Cystic fibrosis is a genetic disease that affects the lungs and digestive tract. It causes the production of a thick, sticky mucus that clogs the lungs. This may cause life-threatening lung infections. People with cystic fibrosis also have difficulty properly breaking down and absorbing nutrients from food, the researchers explained. Between 2009 and 2013, the average Canadian with cystic fibrosis lived to just under 51 years. In the United States, someone with the lung disorder could expect to live an average of close to 41 years, the study found. Why the difference? Although the study didn't specifically look at the reasons behind the gap, possible reasons include diet, better access to lung transplants ... Read more

Related support groups: Cystic Fibrosis, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Respiratory Tract Disease, Rejection Reversal, Cystic Fibrosis with Ileus, Rejection Prophylaxis

Obama's 3-Pronged Effort to Speed Organ Transplants

Posted 13 Jun 2016 by Drugs.com

MONDAY, June 13, 2016 – The Obama administration on Monday announced wide-ranging public and private measures to speed the wait for lifesaving organ transplants in the United States. The goals include making it easier for Americans to become organ donors and increasing the number of organ transplants. Also, almost $200 million in new investments will "facilitate breakthrough research and development," the White House said in a media release. "New breakthroughs in bioengineering, transplantation, and organ preservation can further increase the number of organ transplants and improve outcomes," the President's office said. The administration has enlisted the cooperation of dozens of corporations, universities, hospitals, foundations and patient advocacy organizations in this ongoing project. Last year, more than 30,000 transplants took place in the United States, a record number. Yet ... Read more

Related support groups: Renal Transplant, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Kidney Transplant, Organ Transplant - Rejection Reversal, Graft-versus-host disease, Rejection Reversal, Rejection Prophylaxis

Cancer History May Affect Survival After Organ Transplant

Posted 22 Apr 2016 by Drugs.com

FRIDAY, April 22, 2016 – Organ transplant patients who previously had cancer may be at increased risk for new cancer and early death compared to organ recipients with no cancer history, new research suggests. The findings indicate that transplant patients with a history of cancer may need closer monitoring to detect recurrent and new cancers early, the study's senior author, Dr. Nancy Baxter, said in a news release from St. Michael's Hospital in Toronto. Baxter is chief of the hospital's General Surgery Department. She and her colleagues reviewed 33 studies that included a total of nearly 400,000 patients in 12 countries. They found that organ recipients with previous cancer were 1.5 times more likely to die prematurely from any cause than those with no previous cancer. Moreover, those with previous cancer were nearly twice as likely to develop a new cancer and had three times higher ... Read more

Related support groups: Surgery, Cancer, Renal Transplant, Organ Transplant - Rejection Prophylaxis, Kidney Transplant, Graft-versus-host disease, Rejection Reversal

Hepatitis C-Infected Liver Transplants May Work Well for Those With the Virus

Posted 15 Apr 2016 by Drugs.com

THURSDAY, April 14, 2016 – Here's some potentially good news for people with hepatitis C who are waiting for liver transplants: Hepatitis C-infected livers seem to do as well as healthy livers in these patients, a new study indicates. The findings suggest that using hepatitis C-infected (HCV-positive) livers could help reduce wait times for people with hepatitis C who need a transplant, the researchers said. Hepatitis C is a virus that can infect the liver, leading to inflammation, scarring and liver cancer. More than 15,000 people in the United States are on the liver transplant waiting list, and about 16 percent will die before they receive a new liver, according to background notes with the study. In the United States, use of HCV-positive livers for liver transplants in people with hepatitis C has tripled, from less than 3 percent in 1995 to more than 9 percent in 2013. Researchers ... Read more

Related support groups: Hepatitis C, Liver and Pancreatic Disease, Organ Transplant - Rejection Reversal, Rejection Reversal

Transplant From Incompatible Living Donor Boosts Kidney Patients' Survival

Posted 10 Mar 2016 by Drugs.com

WEDNESDAY, March 9, 2016 – In what experts call a possible "paradigm shift," a new study shows kidney disease patients may live far longer if they receive a transplant from an incompatible living donor rather than wait for a good match. The findings could offer another choice for kidney patients who might otherwise die waiting for a compatible deceased donor. Specifically, experts said the results offer hope to "highly sensitized" transplant candidates. That refers to patients who have a large number of immune system antibodies ready to attack a donor organ. It's common among people who've had a prior kidney transplant, according to the United Network for Organ Sharing. Patients who have had multiple blood transfusions while on dialysis, or who have been pregnant several times, can also become sensitized. Finding a compatible donor for sensitized patients is "nearly impossible," said ... Read more

Related support groups: Infections, Bacterial Infection, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Organ Transplant - Rejection Reversal, Rejection Reversal, Rejection Prophylaxis

Kidney Transplant Prospects Worse for Native Americans: Study

Posted 5 Dec 2015 by Drugs.com

FRIDAY, Dec. 4, 2015 – Native Americans are less likely than whites to get kidney transplants and more likely to die while waiting for a new organ, researchers say. The investigators also found that Native Americans who do receive kidney transplants have slightly lower three-year survival rates compared to whites in the United States. The results from an analysis of 16 years of national data were presented recently at a meeting of the American Society of Nephrology, in San Diego. The lower three-year survival rate "is driven primarily by the prevalence of lower-quality donors among Native Americans and a greater negative impact from such donor characteristics on survival among Native Americans," lead researcher Sarah Stith, from the University of New Mexico, and colleagues said in a society news release. "Native Americans also tend to receive transplants at centers associated with ... Read more

Related support groups: Renal Failure, Chronic Kidney Disease, Organ Transplant - Rejection Prophylaxis, Peritoneal dialysis, Organ Transplant, Organ Transplant - Rejection Reversal, Graft-versus-host disease, Rejection Reversal, Rejection Prophylaxis

Smog Linked to Organ Rejection, Deaths in Lung Transplant Patients

Posted 29 Sep 2015 by Drugs.com

TUESDAY, Sept. 29, 2015 – Living near busy roads with high levels of air pollution raises lung transplant patients' risk of organ rejection and death, but some antibiotics lower that risk, a new study shows. Researchers examined data gathered from more than 5,700 lung transplant patients in 10 European countries between 1987 and 2013. The analysis revealed that patients who lived in areas where air pollution was above maximum levels recommended by the World Health Organization (WHO) were 10 percent more likely to die than those in areas with lower levels of pollution. But this increased risk of death was not seen among patients who took a class of antibiotics called macrolides, which include azithromycin (Zithromax) and clarithromycin (Biaxin), according to the study presented Tuesday at a meeting of the European Respiratory Society in Amsterdam. "Short and long-term exposure to air ... Read more

Related support groups: Azithromycin, Zithromax, Erythromycin, Clarithromycin, Upper Respiratory Tract Infection, Biaxin, Immunosuppression, Zithromax Z-Pak, Z-Pak, Organ Transplant - Rejection Prophylaxis, MY-E, Organ Transplant, Biaxin XL, Respiratory Tract Disease, Pulmonary Impairment, Dificid, Respiratory Distress Syndrome, Organ Transplant - Rejection Reversal, Azithromycin Dose Pack, Immunodeficiency

Transplant Procedure Creates 'Hybrid' Immune System to Combat Rejection

Posted 7 Mar 2012 by Drugs.com

WEDNESDAY, March 7 – Researchers report that they were able to create a kind of hybrid immune system in patients who received kidney transplants, a process that appeared to allow the recipients' bodies to accept a foreign organ instead of trying to reject it. There are caveats. The research is preliminary and only involved a tiny number of patients. Also, the required procedure is expensive and its long-term effects aren't known. But if it works, the process – which involves transferring bone marrow cells from the kidney donor to the patient – could allow organ transplant recipients to avoid a lifetime of taking dozens of pills a day. "It's a huge step forward," said Dr. Suzanne Ildstad, director of the University of Louisville's Institute for Cellular Therapeutics, and co-author of the study published in the March 7 issue of Science Translational Medicine. The immune system's job is ... Read more

Related support groups: Organ Transplant - Rejection Prophylaxis, Organ Transplant, Organ Transplant - Rejection Reversal, Rejection Reversal, Rejection Prophylaxis

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