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Doctors Perform 1st U.S. Living-Donor Uterine Transplant

Posted 5 Oct 2016 by Drugs.com

WEDNESDAY, Oct. 5, 2016 – A team of doctors in Dallas is "cautiously optimistic" of success in what would be the first living-donor uterine transplant in the United States. Doctors at Baylor University Medical Center said Wednesday that they performed four of the transplants in September, but only one has proven successful. "During the past three weeks since the first surgery, we performed routine follow-up testing as part of the trial protocol on all four patients," Baylor said in a statement. "In three patients, we determined after several tests the transplanted organs were not receiving viable blood flow and the uteri were removed. Those patients are now doing well and will soon be back to normal activity." However, "The fourth patient's follow-up tests currently indicate a much different result," Baylor said. "Her tests are showing good blood flow to the uterus. There are also no ... Read more

Related support groups: Birth Control, Contraception, Female Infertility, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Diagnosis and Investigation, Rejection Prophylaxis

Organ Transplants Linked to Higher Skin Cancer Risk

Posted 21 Sep 2016 by Drugs.com

WEDNESDAY, Sept. 21, 2016 – People who have an organ transplant may be more likely to develop skin cancer, new research suggests. The finding applies to all transplant patients, even those who are nonwhite and dark-skinned, according to Dr. Christina Lee Chung, an associate professor of dermatology at Drexel University in Philadelphia, and colleagues. The researchers said the risk increases over time with ongoing exposure to medications that suppress the immune system to prevent organ rejection. Total-body skin exams should be a routine part of care after transplant surgery, the study authors advised. For the study, the researchers analyzed medical records of 413 organ transplant recipients, 63 percent of whom were not white. The investigators found 19 new skin cancers in 15 of the nonwhite patients. That group included six black patients, five Asians and four Hispanics. Among the ... Read more

Related support groups: Basal Cell Carcinoma, Renal Transplant, Melanoma, Skin Cancer, Melanoma - Metastatic, Organ Transplant - Rejection Prophylaxis, Squamous Cell Carcinoma, Organ Transplant, Kidney Transplant, Graft-versus-host disease, History - Skin Cancer, Rejection Prophylaxis

Obama's 3-Pronged Effort to Speed Organ Transplants

Posted 13 Jun 2016 by Drugs.com

MONDAY, June 13, 2016 – The Obama administration on Monday announced wide-ranging public and private measures to speed the wait for lifesaving organ transplants in the United States. The goals include making it easier for Americans to become organ donors and increasing the number of organ transplants. Also, almost $200 million in new investments will "facilitate breakthrough research and development," the White House said in a media release. "New breakthroughs in bioengineering, transplantation, and organ preservation can further increase the number of organ transplants and improve outcomes," the President's office said. The administration has enlisted the cooperation of dozens of corporations, universities, hospitals, foundations and patient advocacy organizations in this ongoing project. Last year, more than 30,000 transplants took place in the United States, a record number. Yet ... Read more

Related support groups: Renal Transplant, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Organ Transplant - Rejection Reversal, Kidney Transplant, Graft-versus-host disease, Rejection Prophylaxis, Rejection Reversal

Doctors Report Groundbreaking HIV-to-HIV Organ Transplants

Posted 31 Mar 2016 by Drugs.com

WEDNESDAY, March 30, 2016 – Trailblazing liver and kidney transplants from an HIV-positive donor to HIV-positive recipients were announced Wednesday by surgeons at Johns Hopkins University. "A couple of weeks ago, we performed the first HIV-to-HIV liver transplant in the world and the first HIV-to-HIV kidney transplant in the United States," Dr. Dorry Segev said during a midday media briefing. Before 2013 and passage of the HIV Organ Policy Equity Act, this kind of medical advance would not have been possible, because it was illegal for HIV-positive patients to donate organs in the United States. The act allows HIV-positive donors to donate organs to patients infected with the AIDS-causing virus, Segev said. Until the law was changed, thousands of patients with HIV in need of organ transplants often risked death while waiting for a donated organ, he said. At the same time, "we were ... Read more

Related support groups: HIV Infection, Pre-Exposure Prophylaxis, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Graft-versus-host disease, Rejection Prophylaxis

Transplant From Incompatible Living Donor Boosts Kidney Patients' Survival

Posted 10 Mar 2016 by Drugs.com

WEDNESDAY, March 9, 2016 – In what experts call a possible "paradigm shift," a new study shows kidney disease patients may live far longer if they receive a transplant from an incompatible living donor rather than wait for a good match. The findings could offer another choice for kidney patients who might otherwise die waiting for a compatible deceased donor. Specifically, experts said the results offer hope to "highly sensitized" transplant candidates. That refers to patients who have a large number of immune system antibodies ready to attack a donor organ. It's common among people who've had a prior kidney transplant, according to the United Network for Organ Sharing. Patients who have had multiple blood transfusions while on dialysis, or who have been pregnant several times, can also become sensitized. Finding a compatible donor for sensitized patients is "nearly impossible," said ... Read more

Related support groups: Infections, Bacterial Infection, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Organ Transplant - Rejection Reversal, Rejection Prophylaxis, Rejection Reversal

Woman Who Had 1st U.S. Uterus Transplant Loses the Organ Due to Complication

Posted 9 Mar 2016 by Drugs.com

WEDNESDAY, March 9, 2016 – The first U.S. woman to receive a transplanted uterus has had the implanted organ removed due to an unnamed "sudden complication," her doctors at the Cleveland Clinic announced Wednesday. "At this time, the circumstance of the complication is under review and more information will be shared as it becomes available," the hospital said in a statement. "There is a known risk in solid organ transplantation that the transplanted organ may have to be removed should a complication arise," the clinic added. "The medical team took all necessary precautions and measures to ensure the safety of our patient." The patient is a 26-year-old woman, identified only as Lindsey. Along with her husband Blake, she has adopted three children, but always longed to give birth to her own child. "At 16, I was told I would never have children. From that moment on," she said in a news ... Read more

Related support groups: Female Infertility, Ovulation Induction, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Organ Transplant - Rejection Reversal, Primary Ovarian Failure, Rejection Prophylaxis

Surgeons Perform First U.S. Uterus Transplant

Posted 26 Feb 2016 by Drugs.com

FRIDAY, Feb. 26, 2016 – Cleveland Clinic surgeons this week performed the nation's first uterus transplant, an experimental procedure offering women without a womb the possibility of pregnancy. The transplanted uterus came from a deceased donor, and the 26-year-old recipient was in stable condition following the nine-hour procedure, her doctors said Thursday. "Cleveland Clinic began screening candidates for uterus transplants late last year," according to a hospital news release. Women who might be candidates for such a transplant have ovaries but were either born without a uterus, have lost it or have suffered irreversible uterine damage, the hospital explained. The condition, called uterine factor infertility, affects 3 percent to 5 percent of women worldwide. One expert not involved in the procedure said it was a real advance for these patients. "The procedure is groundbreaking for ... Read more

Related support groups: Abnormal Uterine Bleeding, Delivery, Uterine Bleeding, Uterine Leiomyomata / Fibroids, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Diagnosis and Investigation, Labor Pain, Cesarean Section, Body Imaging, Rejection Prophylaxis, Labor and Delivery including Augmentation

Many Donor Livers for Sickest Patients Rejected, Study Finds

Posted 5 Feb 2016 by Drugs.com

FRIDAY, Feb. 5, 2016 – It's common for transplant centers to reject donor livers for the sickest patients on the transplant waiting list, a new study suggests. That means those patients have a higher risk of death while they wait for a lifesaving transplant, the researchers found. The new study reviewed 23,000 donor liver offers to 13,255 U.S. patients on the liver transplant waiting list between May 2007 and June 2013. It found that only 37 percent of the organ offers were accepted for the sickest patients on the list. "We found that not only is there a wide variation in acceptance rates for donor organs among transplant centers, these variations directly correlated with whether the sickest patients would die waiting for a lifesaving transplant, with patients 27 percent more likely to die without a transplant for every 5 percent decrease in a center's adjusted organ offer acceptance ... Read more

Related support groups: Cirrhosis, Organ Transplant - Rejection Prophylaxis, Liver and Pancreatic Disease, Organ Transplant, Rejection Prophylaxis

Racial Disparity in Kidney Transplant Outcomes Narrows: Study

Posted 5 Feb 2016 by Drugs.com

THURSDAY, Feb. 4, 2016 – Racial disparities in kidney transplant outcomes are shrinking, new research indicates. Previous studies had shown that black patients who received kidney transplants had worse outcomes compared with white patients. But a new analysis of roughly 200,000 kidney transplants revealed that the success of surgeries involving black people improved between 1990 and 2012, with fewer organ rejections and deaths among these patients. The study authors compared information on almost 64,000 black and more than 145,400 white adults who received a kidney from a living or deceased donor. The findings were published online Feb. 4 in the Journal of the American Society of Nephrology. "We hypothesized that advances in immunosuppression and post-transplant management might differentially benefit black kidney transplant recipients, who were disproportionately burdened by ... Read more

Related support groups: Renal Failure, Chronic Kidney Disease, Organ Transplant - Rejection Prophylaxis, Peritoneal dialysis, Organ Transplant, Renal Osteodystrophy, Graft-versus-host disease, Rejection Prophylaxis, Hyperphosphatemia of Renal Failure

New Kidney Transplant Drug Cuts Risk of Earlier Death: Study

Posted 28 Jan 2016 by Drugs.com

WEDNESDAY, Jan. 27, 2016 – A newer drug used for preventing organ rejection might improve the long-term outlook for kidney transplant recipients, a new study finds. Over seven years, patients given the drug belatacept (brand name: Nulojix) were 43 percent less likely to die or see their donor kidney fail compared to patients given an older drug called cyclosporine. Experts said the findings should encourage more doctors and patients to choose belatacept over standard anti-rejection medications. "This is a potentially transformational drug," said study lead researcher Dr. Flavio Vincenti, a transplant specialist at the University of California, San Francisco. The study – funded by the drug's maker, Bristol-Myers Squibb – was published in the Jan. 28 issue of the New England Journal of Medicine. Belatacept was first approved by the U.S. Food and Drug Administration in 2011 for ... Read more

Related support groups: Renal Failure, Kidney Infections, Restasis, Cyclosporine, Chronic Kidney Disease, Organ Transplant - Rejection Prophylaxis, Peritoneal dialysis, Organ Transplant, Neoral, Organ Transplant - Rejection Reversal, Pyelonephritis, Renal Osteodystrophy, Graft-versus-host disease, Gengraf, Rejection Prophylaxis, Sandimmune, Nulojix, Hyperphosphatemia of Renal Failure, Belatacept

Kidney Transplant Prospects Worse for Native Americans: Study

Posted 5 Dec 2015 by Drugs.com

FRIDAY, Dec. 4, 2015 – Native Americans are less likely than whites to get kidney transplants and more likely to die while waiting for a new organ, researchers say. The investigators also found that Native Americans who do receive kidney transplants have slightly lower three-year survival rates compared to whites in the United States. The results from an analysis of 16 years of national data were presented recently at a meeting of the American Society of Nephrology, in San Diego. The lower three-year survival rate "is driven primarily by the prevalence of lower-quality donors among Native Americans and a greater negative impact from such donor characteristics on survival among Native Americans," lead researcher Sarah Stith, from the University of New Mexico, and colleagues said in a society news release. "Native Americans also tend to receive transplants at centers associated with ... Read more

Related support groups: Renal Failure, Chronic Kidney Disease, Organ Transplant - Rejection Prophylaxis, Peritoneal dialysis, Organ Transplant, Organ Transplant - Rejection Reversal, Graft-versus-host disease, Rejection Prophylaxis, Rejection Reversal

Rule Changes Might Lead to More Lung Transplants for Kids

Posted 5 Nov 2015 by Drugs.com

THURSDAY, Nov. 5, 2015 – Twice as many young people in the United States could get lung transplants if donor lungs were available from a wider geographic area, a new study contends. "Children are dying while waiting for an organ. Geography should be one less barrier to pediatric patients receiving a potentially lifesaving transplant," said senior study author Dr. Maryam Valapour. She is a senior lung investigator at the Cleveland Clinic's Scientific Registry of Transplant Recipients and director of Lung Transplant Outcomes. Currently, donor lungs are first offered to transplant candidates near the donor hospital. If there are no local candidates, the lungs are offered beyond the local area in 500-mile radius increments. Child candidates are given priority for child donor lungs within a 1,000-mile radius of the donor hospital, followed by teens and then adults. Teen candidates get ... Read more

Related support groups: Organ Transplant - Rejection Prophylaxis, Organ Transplant, Respiratory Distress Syndrome, Organ Transplant - Rejection Reversal, Respiratory Failure, Graft-versus-host disease, Rejection Prophylaxis

Smog Linked to Organ Rejection, Deaths in Lung Transplant Patients

Posted 29 Sep 2015 by Drugs.com

TUESDAY, Sept. 29, 2015 – Living near busy roads with high levels of air pollution raises lung transplant patients' risk of organ rejection and death, but some antibiotics lower that risk, a new study shows. Researchers examined data gathered from more than 5,700 lung transplant patients in 10 European countries between 1987 and 2013. The analysis revealed that patients who lived in areas where air pollution was above maximum levels recommended by the World Health Organization (WHO) were 10 percent more likely to die than those in areas with lower levels of pollution. But this increased risk of death was not seen among patients who took a class of antibiotics called macrolides, which include azithromycin (Zithromax) and clarithromycin (Biaxin), according to the study presented Tuesday at a meeting of the European Respiratory Society in Amsterdam. "Short and long-term exposure to air ... Read more

Related support groups: Azithromycin, Zithromax, Erythromycin, Clarithromycin, Upper Respiratory Tract Infection, Biaxin, Immunosuppression, Zithromax Z-Pak, MY-E, Organ Transplant - Rejection Prophylaxis, Z-Pak, Respiratory Tract Disease, Erythrocin, Organ Transplant, Ery-Tab, Azithromycin Dose Pack, Biaxin XL, Immunodeficiency, Respiratory Distress Syndrome, Pulmonary Impairment

Deadly Skin Cancer More Common in Organ Transplant Recipients: Study

Posted 17 Aug 2015 by Drugs.com

MONDAY, Aug. 17, 2015 – People who've received organ transplants may face an increased risk for the deadly skin cancer melanoma, a new study suggests. The researchers said the increased risk may stem from the immune system-suppressing drugs that must be taken to prevent rejection of the new organs. The analysis of data from hundreds of thousands of transplant recipients and melanoma patients in the United States showed that transplant recipients were twice as likely to develop melanoma and three times more likely to die of the disease than people who had not undergone a transplant. The researchers also found that transplant recipients were four times more likely to be diagnosed with melanomas that had already spread to other parts of the body. "We knew that melanoma was more likely in transplant recipients, but we thought it might be a function of intensive screening since they are ... Read more

Related support groups: Melanoma, Skin Cancer, Melanoma - Metastatic, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Immunodeficiency, Rejection Prophylaxis

FDA Approves Envarsus XR (tacrolimus) for Prevention of Organ Rejection in Kidney Transplant Patients

Posted 24 Jul 2015 by Drugs.com

Hørsholm, Denmark, July 10, 2015 – Veloxis Pharmaceuticals A/S (OMX: VELO) today announced U.S. Food and Drug Administration (FDA) approval of Envarsus XR (tacrolimus extended-release tablets) for the prophylaxis of rejection in kidney transplant patients who require or desire conversion from other twice-daily tacrolimus products to once-daily Envarsus XR. Veloxis expects Envarsus XR to be available to patients in the United States and their physicians in 4Q 2015. Envarsus XR is an extended release formulation of tacrolimus designed for once-daily dosing, with flatter pharmacokinetics and greater bioavailability compared to twice-daily tacrolimus. The FDA marketing approval is based on the review of two Phase III trials and several Phase II trials in kidney transplant recipients. In all of the clinical trials, Envarsus XR dosed once daily demonstrated significantly higher ... Read more

Related support groups: Tacrolimus, Envarsus XR, Rejection Prophylaxis

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Organ Transplant - Rejection Prophylaxis

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Myfortic, Orthoclone OKT3, Nulojix, belatacept, mycophenolic acid, muromonab-cd3