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Novel Procedure Improves Kidney Transplant Success

Posted 3 Aug 2017 by Drugs.com

WEDNESDAY, Aug. 2, 2017 – A new treatment might open the door for more patients with advanced kidney disease to get a transplant, a preliminary study suggests. Of the 100,000-plus Americans waiting for a donor kidney, about one-third are "sensitized," said Dr. Robert Montgomery, director of the Transplant Institute at NYU Langone in New York City. Those patients face a tough situation: They harbor immune system antibodies that are primed to attack a donor organ. The antibodies can form when a person is exposed to foreign tissue, Montgomery explained. So a patient who's had a prior kidney transplant may be highly sensitized – meaning they have a large number of the offending antibodies. It can also happen to patients who've had blood transfusion or ever been pregnant, Montgomery said. It's almost impossible to find a compatible donor for those patients. But they might be able to ... Read more

Related support groups: Anxiety, Generalized Anxiety Disorder, Anxiety and Stress, Social Anxiety Disorder, Renal Failure, Rituxan, Rituximab, Chronic Kidney Disease, Organ Transplant - Rejection Prophylaxis, Hyqvia, Rejection Prophylaxis, Rituxan Hycela, Hyaluronidase/immune Globulin, Hyaluronidase/rituximab

Donor Kidneys Rejected by Centers 7 Times on Average

Posted 27 Jul 2017 by Drugs.com

THURSDAY, July 27, 2017 – A donated kidney is turned away for transplant an average of seven times before reaching the patient who finally receives it, a new study shows. Transplant centers regularly reject kidneys based on a donor's age or perceived quality of the organ, even though these kidneys are eventually accepted and work well for people farther down the waiting list, explained lead researcher Dr. Anne Huml, a nephrologist and health disparities fellow with Case Western Reserve University in Cleveland. The centers are likely being appropriately picky in selecting organs, to ensure the greatest chance of success by carefully matching each kidney to each recipient, Huml said. "If someone's been waiting five years, why rush and take the first kidney offered when within a month they'll be offered a better kidney and their outcome will be better?" Huml said. But such hesitation can ... Read more

Related support groups: Renal Transplant, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Kidney Transplant, Graft-versus-host disease, Rejection Prophylaxis

Are Doctors Discarding Donor Kidneys That Could Save Lives?

Posted 7 Jul 2017 by Drugs.com

THURSDAY, July 6, 2017 – U.S. doctors are discarding donated kidneys that could keep people alive for years, simply because the organs are not top-quality, a new study claims. "Suboptimal" kidneys from older donors with health problems perform much better than expected, and would preserve a patient's life much longer than dialysis, said lead researcher Dr. Sumit Mohan, an assistant professor at Columbia University's Mailman School of Public Health. About 73 percent of lower-quality kidneys received by Columbia patients were still functioning five years after transplant, Mohan and his colleagues found. "To our surprise, yes, they did worse than the best-quality kidneys, but they didn't do that poorly," Mohan said. By comparison, the five-year survival rate for kidney patients on dialysis is about 35 percent, Mohan said. "If I don't get a kidney, my alternative is to stay on dialysis," ... Read more

Related support groups: Renal Failure, Renal Transplant, Chronic Kidney Disease, Peritoneal dialysis, Organ Transplant, Kidney Transplant, Organ Transplant - Rejection Reversal, Nephropathy, Rejection Prophylaxis, Renal and Genitourinary Disorders, Hyperphosphatemia of Renal Failure, Rejection Reversal

Kidneys From Deceased Diabetics Might Ease Organ Shortage: Study

Posted 25 May 2017 by Drugs.com

THURSDAY, May 25, 2017 – Kidneys from deceased diabetic donors can save the lives of patients on the transplant wait-list, researchers say. For the study, investigators compared U.S. data from more than 8,100 recipients of kidneys from deceased diabetic donors with data from people on the kidney transplant wait-list. The patients were followed for an average of nearly nine years. People who received kidneys from diabetic donors were 9 percent less likely to die during that follow-up period than those who were still on the wait-list or were seeking a kidney from a non-diabetic donor, the study found. The people who benefited most from diabetic donor kidneys were those who were most likely to die while on the wait-list, the researchers said. But poor-quality kidneys from deceased diabetic donors did not improve survival chances, the findings showed. And people under age 40 didn't benefit ... Read more

Related support groups: Renal Transplant, Diabetes Mellitus, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Kidney Transplant, Rejection Prophylaxis

Cancer Risk Rises After Childhood Organ Transplant: Study

Posted 26 Apr 2017 by Drugs.com

WEDNESDAY, April 26, 2017 – Children given an organ transplant have a substantially higher risk of developing cancer – in some cases up to 200 times higher – than the general population, a new study finds. But the individual risk of any one child getting cancer still remains very small, the study authors stressed. Overall, the U.S. National Cancer Institute (NCI) study found that the risk for cancer among children who received transplants was 19 times higher than in the general population. Non-Hodgkin's lymphoma was the cancer with a 200 times higher risk. Seventy-one percent of those who developed cancer after a pediatric organ transplant had non-Hodgkin's lymphoma, the study findings showed. "We knew going into the study that the risk of lymphoma would be very high," explained Dr. Eric Engels, the study's senior investigator. "That's been seen in much smaller studies, and it's been ... Read more

Related support groups: Cancer, Leukemia, Renal Transplant, Non-Hodgkin's Lymphoma, Organ Transplant - Rejection Prophylaxis, Viral Infection, Organ Transplant, Kidney Transplant, Organ Transplant - Rejection Reversal, Rejection Prophylaxis, Rejection Reversal

Baseball Great Rod Carew Owes His Life to NFL Player's Transplanted Organs

Posted 17 Apr 2017 by Drugs.com

MONDAY, April 17, 2017 – When Baseball Hall of Famer Rod Carew received a new heart and kidney last December, he and his family had no idea who they had to thank for the lifesaving organs. But some good sleuthing by Carew's wife and the mother of the anonymous donor unearthed a startling discovery: The organs had come from former National Football League tight end Konrad Reuland, who was only 29 when he died after suffering a brain aneurysm. Carew, 71, needed the new organs because of a massive heart attack he had in 2015, which was followed by subsequent complications. He received the new organs in an operation performed at Cedars-Sinai Medical Center in Los Angeles. After the transplant, a number of Carew's family and friends asked Carew's wife, Rhonda, if the new organs might have come from Reuland. That prompted her to begin investigating. She learned the donor was a healthy local ... Read more

Related support groups: Renal Transplant, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Kidney Transplant, Rejection Prophylaxis, Cardiothoracic Surgery

Cystic Fibrosis Survival Better in Canada Than in U.S.

Posted 14 Mar 2017 by Drugs.com

MONDAY, March 13, 2017 – People with cystic fibrosis are living longer than ever, but those in Canada live nearly 10 years longer than those in the United States, a new study finds. Cystic fibrosis is a genetic disease that affects the lungs and digestive tract. It causes the production of a thick, sticky mucus that clogs the lungs. This may cause life-threatening lung infections. People with cystic fibrosis also have difficulty properly breaking down and absorbing nutrients from food, the researchers explained. Between 2009 and 2013, the average Canadian with cystic fibrosis lived to just under 51 years. In the United States, someone with the lung disorder could expect to live an average of close to 41 years, the study found. Why the difference? Although the study didn't specifically look at the reasons behind the gap, possible reasons include diet, better access to lung transplants ... Read more

Related support groups: Cystic Fibrosis, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Respiratory Tract Disease, Rejection Prophylaxis, Cystic Fibrosis with Ileus, Rejection Reversal

Kidney Transplant Survival Up Among Babies, Kids

Posted 7 Mar 2017 by Drugs.com

MONDAY, March 6, 2017 – Survival rates for children who get kidney transplants have improved significantly over the last half-century, a new study finds. "The outlook for infants and children with end-stage kidney disease was once dismal, with poor survival rates after transplant. There has been great progress in pediatric kidney transplantation, and now the patient survival rate is almost 100 percent," said the study's principal investigator, Dr. Srinath Chinnakotla. Chinnakotla is an associate professor of surgery at the University of Minnesota Masonic Children's Hospital in Minneapolis, where the study was done. Since 2002, 97 percent of children who had kidney transplants at the hospital were alive a year later. That compares to 85 percent 40 to 50 years ago, the study showed. Long-term outcomes have also improved. Only 42 percent of kids who got a new kidney between 1963 and 1983 ... Read more

Related support groups: Renal Transplant, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Kidney Transplant, Rejection Prophylaxis

Should a Mental Disability Keep Patients Off Organ Transplant Lists?

Posted 25 Jan 2017 by Drugs.com

WEDNESDAY, Jan. 25, 2017 – Pressure is mounting for the U.S. organ donation network to tackle one of the thorniest ethical questions it's ever faced – whether a person with intellectual disabilities should be denied access to a transplant. A bipartisan group of 30 legislators from the U.S. Congress petitioned the Department of Health and Human Services in October to "issue guidance on organ transplant discrimination with regards to persons with disabilities," according to a new opinion piece in the Jan. 26 New England Journal of Medicine. The legislators' request follows several highly publicized cases in which people with intellectual disabilities have either fought to receive a transplant or have been outright denied a place on a waiting list, said co-author Dr. Scott Halpern. He's an associate professor of medical ethics and health policy at the University of Pennsylvania's ... Read more

Related support groups: Depression, Bipolar Disorder, Major Depressive Disorder, Obsessive Compulsive Disorder, Schizophrenia, Mania, Paranoid Disorder, Borderline Personality Disorder, Schizoaffective Disorder, Psychosis, Autism, Renal Transplant, Psychiatric Disorders, Organ Transplant - Rejection Prophylaxis, Body Dysmorphic Disorder, Severe Mood Dysregulation, Organ Transplant, Neurosis, Organ Transplant - Rejection Reversal, Rejection Prophylaxis

Don't Rule Out Kidneys From Elderly Donors

Posted 16 Dec 2016 by Drugs.com

THURSDAY, Dec. 15, 2016 – Healthy kidneys from elderly donors are often rejected, but even kidneys from donors 80 and older can function for years after transplantation, Italian researchers report. The results were published online Dec. 15 in the Clinical Journal of the American Society of Nephrology. "The results of this study support the use of extended criteria donors, even donors older than 80 years, but they have to be accurately selected and managed with dedicated protocols," Dr. Luigi Biancone, of the University of Turin, said in a journal news release. Researchers analyzed results of deceased donor kidney transplants performed at the Turin University Renal Transplant Center between 2003 and 2013. They focused on almost 650 transplants from so-called "extended criteria" donors – donors older than 60 and those aged 50 to 59 with certain risk factors. After a follow-up of nearly ... Read more

Related support groups: Renal Failure, Renal Transplant, Chronic Kidney Disease, Organ Transplant - Rejection Prophylaxis, Peritoneal dialysis, Organ Transplant, Kidney Transplant, Graft-versus-host disease, Rejection Prophylaxis, Hyperphosphatemia of Renal Failure

Doctors Perform 1st U.S. Living-Donor Uterine Transplant

Posted 5 Oct 2016 by Drugs.com

WEDNESDAY, Oct. 5, 2016 – A team of doctors in Dallas is "cautiously optimistic" of success in what would be the first living-donor uterine transplant in the United States. Doctors at Baylor University Medical Center said Wednesday that they performed four of the transplants in September, but only one has proven successful. "During the past three weeks since the first surgery, we performed routine follow-up testing as part of the trial protocol on all four patients," Baylor said in a statement. "In three patients, we determined after several tests the transplanted organs were not receiving viable blood flow and the uteri were removed. Those patients are now doing well and will soon be back to normal activity." However, "The fourth patient's follow-up tests currently indicate a much different result," Baylor said. "Her tests are showing good blood flow to the uterus. There are also no ... Read more

Related support groups: Birth Control, Contraception, Female Infertility, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Diagnosis and Investigation, Rejection Prophylaxis

Organ Transplants Linked to Higher Skin Cancer Risk

Posted 21 Sep 2016 by Drugs.com

WEDNESDAY, Sept. 21, 2016 – People who have an organ transplant may be more likely to develop skin cancer, new research suggests. The finding applies to all transplant patients, even those who are nonwhite and dark-skinned, according to Dr. Christina Lee Chung, an associate professor of dermatology at Drexel University in Philadelphia, and colleagues. The researchers said the risk increases over time with ongoing exposure to medications that suppress the immune system to prevent organ rejection. Total-body skin exams should be a routine part of care after transplant surgery, the study authors advised. For the study, the researchers analyzed medical records of 413 organ transplant recipients, 63 percent of whom were not white. The investigators found 19 new skin cancers in 15 of the nonwhite patients. That group included six black patients, five Asians and four Hispanics. Among the ... Read more

Related support groups: Basal Cell Carcinoma, Renal Transplant, Melanoma, Skin Cancer, Melanoma - Metastatic, Organ Transplant - Rejection Prophylaxis, Squamous Cell Carcinoma, Organ Transplant, Kidney Transplant, Graft-versus-host disease, History - Skin Cancer, Rejection Prophylaxis

Obama's 3-Pronged Effort to Speed Organ Transplants

Posted 13 Jun 2016 by Drugs.com

MONDAY, June 13, 2016 – The Obama administration on Monday announced wide-ranging public and private measures to speed the wait for lifesaving organ transplants in the United States. The goals include making it easier for Americans to become organ donors and increasing the number of organ transplants. Also, almost $200 million in new investments will "facilitate breakthrough research and development," the White House said in a media release. "New breakthroughs in bioengineering, transplantation, and organ preservation can further increase the number of organ transplants and improve outcomes," the President's office said. The administration has enlisted the cooperation of dozens of corporations, universities, hospitals, foundations and patient advocacy organizations in this ongoing project. Last year, more than 30,000 transplants took place in the United States, a record number. Yet ... Read more

Related support groups: Renal Transplant, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Kidney Transplant, Organ Transplant - Rejection Reversal, Graft-versus-host disease, Rejection Prophylaxis, Rejection Reversal

Doctors Report Groundbreaking HIV-to-HIV Organ Transplants

Posted 31 Mar 2016 by Drugs.com

WEDNESDAY, March 30, 2016 – Trailblazing liver and kidney transplants from an HIV-positive donor to HIV-positive recipients were announced Wednesday by surgeons at Johns Hopkins University. "A couple of weeks ago, we performed the first HIV-to-HIV liver transplant in the world and the first HIV-to-HIV kidney transplant in the United States," Dr. Dorry Segev said during a midday media briefing. Before 2013 and passage of the HIV Organ Policy Equity Act, this kind of medical advance would not have been possible, because it was illegal for HIV-positive patients to donate organs in the United States. The act allows HIV-positive donors to donate organs to patients infected with the AIDS-causing virus, Segev said. Until the law was changed, thousands of patients with HIV in need of organ transplants often risked death while waiting for a donated organ, he said. At the same time, "we were ... Read more

Related support groups: HIV Infection, Pre-Exposure Prophylaxis, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Graft-versus-host disease, Rejection Prophylaxis

Transplant From Incompatible Living Donor Boosts Kidney Patients' Survival

Posted 10 Mar 2016 by Drugs.com

WEDNESDAY, March 9, 2016 – In what experts call a possible "paradigm shift," a new study shows kidney disease patients may live far longer if they receive a transplant from an incompatible living donor rather than wait for a good match. The findings could offer another choice for kidney patients who might otherwise die waiting for a compatible deceased donor. Specifically, experts said the results offer hope to "highly sensitized" transplant candidates. That refers to patients who have a large number of immune system antibodies ready to attack a donor organ. It's common among people who've had a prior kidney transplant, according to the United Network for Organ Sharing. Patients who have had multiple blood transfusions while on dialysis, or who have been pregnant several times, can also become sensitized. Finding a compatible donor for sensitized patients is "nearly impossible," said ... Read more

Related support groups: Infections, Bacterial Infection, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Organ Transplant - Rejection Reversal, Rejection Prophylaxis, Rejection Reversal

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