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Prolia News

Breast Cancer Drugs Battle Disease's Return

Posted 9 Dec 2015 by Drugs.com

WEDNESDAY, Dec. 9, 2015 – A pair of drugs already on the market appear to reduce the recurrence of breast cancer in women who've already undergone treatment, two new clinical trials show. The chemotherapy drug capecitabine (Afinitor) seems to reduce by nearly a third the risk of breast cancer recurrence if women receive the drug following surgery to remove their cancer, researchers were to report Wednesday at the 2015 San Antonio Breast Cancer Symposium. In addition, an osteoporosis medication called denosumab appears to reduce recurrence risk by 18 percent in women who have HR-positive breast cancer, a second study reports. Denosumab (Xgeva) is usually given to women undergoing breast cancer treatment because hormone therapy for their disease can make their bones brittle, explained lead researcher Dr. Michael Gnant, a professor of surgery at the Medical University of Vienna in ... Read more

Related support groups: Breast Cancer, Osteoporosis, Prolia, Fracture, bone, Xeloda, Breast Cancer - Adjuvant, Xgeva, Breast Cancer, Prevention, Capecitabine, Denosumab

Strong Bones After 50? Women May Not Need Next Test Until 65

Posted 9 Jun 2015 by Drugs.com

TUESDAY, June 9, 2015 – A postmenopausal woman who is 50 and still shows "normal" readings on her bone density test may not need her next such test for 10 or even 15 years, a new study finds. However, researchers led by Dr. Margaret Gourlay of the University of North Carolina at Chapel Hill stressed that younger women who do show signs of bone loss are at high risk for a major fracture, and do require regular testing. The study involved almost 4,100 postmenopausal American women between the ages of 50 and 64 who took part in the ongoing Women's Health Initiative study. All of the women had undergone a bone mineral density test to assess their risk for fractures and osteoporosis. The women were not taking hormones, calcium or vitamin D supplements. They also had never had a broken bone, the team said. The results: Among women whose tests showed no signs of osteoporosis, it took nearly ... Read more

Related support groups: Hot Flashes, Menopausal Disorders, Osteoporosis, Fosamax, Postmenopausal Symptoms, Boniva, Alendronate, Prolia, Reclast, Fracture, bone, Actonel, Prevention of Osteoporosis, Zometa, Xgeva, Aclasta, Zoledronic Acid, Atelvia, Ibandronate, Risedronate, Caltrate 600 with D

Osteoporosis Drugs Work, But Review Finds No Clear Winner

Posted 8 Sep 2014 by Drugs.com

MONDAY, Sept. 8, 2014 – Many osteoporosis drugs cut women's risk of suffering a bone fracture, though it's not clear whether any one medication works better than others, a new research review finds. Reporting Sept. 8 in Annals of Internal Medicine, researchers said that for women with the bone-thinning disease osteoporosis, various drugs cut the risk of a spine fracture by 40 to 60 percent, compared to a placebo. When it comes to other bone breaks, including hip fractures, the drugs lower the risk by 20 to 40 percent, the study said. The beneficial drugs included bisphosphonates, sold under brand names such as Actonel (risedronate), Boniva (ibandronate) and Fosamax (alendronate), and the injection drugs denosumab (Prolia) and teriparatide (Forteo). Meanwhile, raloxifene (Evista) – a daily pill that has estrogen-like effects on bones – seems to cut the risk of spine fractures only, ... Read more

Related support groups: Osteoporosis, Fosamax, Forteo, Boniva, Alendronate, Prolia, Reclast, Fracture, bone, Evista, Actonel, Prevention of Osteoporosis, Zometa, Xgeva, Aclasta, Zoledronic Acid, Atelvia, Risedronate, Ibandronate, Raloxifene, Pamidronate

Combo Drug Therapy May Work Best to Strengthen Bones: Study

Posted 14 May 2013 by Drugs.com

TUESDAY, May 14 – A new combination drug therapy for osteoporosis appears to increase bone density more effectively than any treatment now on the market, according to the results of a small clinical trial. Researchers found that postmenopausal women experienced significant amounts of bone growth by taking a bone-building drug called teriparatide with denosumab, a targeted therapy drug used to stop bone loss. "A combination of these two medications increased bone density more than either does on its own, and it is more effective than any currently approved therapy," said study author Dr. Benjamin Leder, who is with the endocrine unit at Massachusetts General Hospital in Boston. The 12-month study, published online May 15 in The Lancet, was funded in part by the drugs' makers, Eli Lilly and Amgen. It involved 94 postmenopausal women being treated for osteoporosis, a bone-thinning ... Read more

Related support groups: Osteoporosis, Forteo, Prolia, Xgeva, Teriparatide, Denosumab

Newer Bone Drug Better for Advanced Breast Cancer Patients: Study

Posted 14 Aug 2012 by Drugs.com

TUESDAY, Aug. 14 – The relatively new drug denosumab (Xgeva) reduces bone complications of advanced breast cancer more effectively than another osteoporosis drug, zoledronic acid (Zometa), according to new research. Zoledronic acid belongs to a class of drugs known as bisphosphonates, which help delay bone complications such as fractures, spinal cord compression and bone pain. But zoledronic acid has been linked with kidney toxicity and other reactions. Denosumab, a newer drug called a monoclonal antibody, is superior to zoledronic acid in reducing skeletal problems and better tolerated, the study found. "It's more effective at preventing bone destruction caused by breast cancer that has spread to the bone," said Dr. Alison Stopeck, associate professor of medicine at the University of Arizona, Tucson, and an investigator on the study, which was published Aug. 14 in the journal Clinical ... Read more

Related support groups: Fosamax, Boniva, Alendronate, Prolia, Reclast, Actonel, Zometa, Xgeva, Aclasta, Zoledronic Acid, Atelvia, Ibandronate, Risedronate, Pamidronate, Fosamax Plus D, Skelid, Osteolytic Bone Metastases of Breast Cancer, Aredia, Denosumab, Actonel with Calcium

FDA Approves New Indications for Prolia (denosumab) for the Treatment of Bone Loss in Patients With Prostate or Breast Cancer Undergoing Hormone Ablation Therapy

Posted 19 Sep 2011 by Drugs.com

THOUSAND OAKS, Calif., September 19, 2011, 2011 /PRNewswire/ – Amgen today announced that the U.S. Food and Drug Administration (FDA) approved two new indications for Prolia (denosumab) as a treatment to increase bone mass in women at high risk for fracture receiving adjuvant aromatase inhibitor therapy for breast cancer and as a treatment to increase bone mass in men at high risk for fracture receiving androgen deprivation therapy for non-metastatic prostate cancer. In patients with prostate cancer, Prolia also reduced the incidence of vertebral fractures. Prolia is the first-and-only therapy approved by the FDA for cancer treatment-induced bone loss in patients undergoing hormone ablation therapy. Aromatase inhibitors are often used in patients with breast cancer to prevent recurrence of disease, and androgen deprivation therapy is often used in patients with prostate cancer to ... Read more

Related support groups: Breast Cancer, Prostate Cancer, Prolia, Denosumab

Newer Drug May Help Prevent Fracture in Men With Prostate Cancer

Posted 25 Feb 2011 by Drugs.com

WEDNESDAY, Feb. 23 – A new drug called denosumab (Xgeva) performed somewhat better than the current standard treatment of zoledronic acid (Zometa) for preventing fractures and other bone problems in men with hormone-resistant prostate cancer, a new study suggests. In many patients, prostate cancer becomes resistant to initial hormone treatment within the first few years of diagnosis. As a result, tumors begin to grow again and spread to other parts of the body, including bones. This increases the risk of fractures and other bone problems that cause pain and disability, which can greatly reduce a man's quality of life, according to background information in the study. Helping to prevent these bone troubles can prove very important to these patients, one expert said. "The successful treatment of osteoporosis, bone pain, and complications of advanced boney disease in men with ... Read more

Related support groups: Prostate Cancer, Prolia, Xgeva, Denosumab

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