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Probenecid and Colchicine News
Newly-Published Colchicine Safety Data Provide First Evidence-Based Dosing Guidance to Avoid Potentially Serious Interactions With Commonly Prescribed Drugs
Posted 11 Aug 2011 by Drugs.com
- Paper Published in August Issue of Arthritis & Rheumatism Highlights Several Previously Unknown Drug-Drug Interactions - Colchicine Dose Reductions Necessary in Presence of Certain CYP3A4 or P-gp Inhibitors - Studies Supported URL Pharma Clinical Research Program that Led to FDA Approval of Colcrys® PHILADELPHIA, Aug. 11, 2011 /PRNewswire/ – Newly-published results from a series of colchicine safety studies provide physicians with the first evidence-based dosing guidance for colchicine when co-administered with certain commonly prescribed drugs, helping doctors and patients avoid serious and potentially life-threatening drug-drug interactions. The study results, published in a paper titled "Evidence Basis of a Novel Colchicine Dose Reduction Algorithm to Predict and Prevent Colchicine Toxicity in the Presence of P-gp/CYP450 3A4 Inhibitors," appear in the August issue of Arthritis ... Read more
FDA Medwatch Alert: Colchicine Compounded Injectable Products (Posted 05/02/2007)
Posted 2 May 2007 by Drugs.com
[Posted 05/02/2007] ApothéCure and FDA notified all healthcare professionals of recent deaths associated with the use of compounded injectable Colchicine 0.5mg/ml, 4ml vials, lot number 20070122@26. The company issued an immediate drug recall for all strengths, sizes and lots of compounded Injectable Colchicine sold within the last year. Customers are asked to examine their stock for ApothéCure compounded Colchicine on hand and to discontinue use immediately and prepare the product for return to the company.[April 30, 2007 - Recall Notice - ApothéCure] Read more