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Organ Transplant - Rejection Reversal News

Are Doctors Discarding Donor Kidneys That Could Save Lives?

Posted 7 Jul 2017 by Drugs.com

THURSDAY, July 6, 2017 – U.S. doctors are discarding donated kidneys that could keep people alive for years, simply because the organs are not top-quality, a new study claims. "Suboptimal" kidneys from older donors with health problems perform much better than expected, and would preserve a patient's life much longer than dialysis, said lead researcher Dr. Sumit Mohan, an assistant professor at Columbia University's Mailman School of Public Health. About 73 percent of lower-quality kidneys received by Columbia patients were still functioning five years after transplant, Mohan and his colleagues found. "To our surprise, yes, they did worse than the best-quality kidneys, but they didn't do that poorly," Mohan said. By comparison, the five-year survival rate for kidney patients on dialysis is about 35 percent, Mohan said. "If I don't get a kidney, my alternative is to stay on dialysis," ... Read more

Related support groups: Renal Failure, Renal Transplant, Chronic Kidney Disease, Peritoneal dialysis, Organ Transplant, Kidney Transplant, Organ Transplant - Rejection Reversal, Nephropathy, Rejection Prophylaxis, Renal and Genitourinary Disorders, Hyperphosphatemia of Renal Failure, Rejection Reversal

Cancer Risk Rises After Childhood Organ Transplant: Study

Posted 26 Apr 2017 by Drugs.com

WEDNESDAY, April 26, 2017 – Children given an organ transplant have a substantially higher risk of developing cancer – in some cases up to 200 times higher – than the general population, a new study finds. But the individual risk of any one child getting cancer still remains very small, the study authors stressed. Overall, the U.S. National Cancer Institute (NCI) study found that the risk for cancer among children who received transplants was 19 times higher than in the general population. Non-Hodgkin's lymphoma was the cancer with a 200 times higher risk. Seventy-one percent of those who developed cancer after a pediatric organ transplant had non-Hodgkin's lymphoma, the study findings showed. "We knew going into the study that the risk of lymphoma would be very high," explained Dr. Eric Engels, the study's senior investigator. "That's been seen in much smaller studies, and it's been ... Read more

Related support groups: Cancer, Leukemia, Renal Transplant, Non-Hodgkin's Lymphoma, Organ Transplant - Rejection Prophylaxis, Viral Infection, Organ Transplant, Kidney Transplant, Organ Transplant - Rejection Reversal, Rejection Prophylaxis, Rejection Reversal

Non-English Speakers Less Likely to Be on Kidney Transplant List

Posted 9 Feb 2017 by Drugs.com

THURSDAY, Feb. 9, 2017 – Language barriers may prevent some eligible U.S. patients from receiving a kidney transplant, a new study suggests. Specifically, those who don't speak English may be less likely to complete the kidney transplant evaluation necessary for them to be placed on a waiting list for a kidney from a deceased donor. For the study, researchers analyzed data from kidney failure patients across the United States. The investigators found that patients who lived in neighborhoods where more than 20 percent of households didn't speak English were 29 percent less likely to be on a kidney transplant waiting list than those in neighborhoods where less than 1 percent of households didn't speak English. Although the study can't prove a cause-and-effect relationship, the researchers found the link between not speaking English and not being on a kidney transplant waiting list was ... Read more

Related support groups: Renal Failure, Renal Transplant, Chronic Kidney Disease, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Organ Transplant - Rejection Reversal, Hyperphosphatemia of Renal Failure

Depression Often Untreated in Dialysis Patients

Posted 27 Jan 2017 by Drugs.com

THURSDAY, Jan. 26, 2017 – Depression is common among kidney failure patients undergoing dialysis. But efforts to get them on antidepressants often fail, a new study finds. Many patients refuse to start or modify depression treatment. And in some cases kidney specialists don't want their patients taking antidepressant medication, researchers reported. "Our study demonstrated that many patients on chronic hemodialysis have depressive symptoms but do not wish to receive aggressive treatment to alleviate these symptoms," said study co-leader Dr. Steven Weisbord. "We also noted that when patients are willing to accept treatment, renal [kidney care] providers commonly do not prescribe treatment," said Weisbord, who's with the VA Pittsburgh Healthcare System. When kidneys fail, dialysis treatment is needed to remove wastes and salt from the blood. It's often done at a hospital, dialysis ... Read more

Related support groups: Depression, Lexapro, Zoloft, Cymbalta, Effexor, Prozac, Major Depressive Disorder, Celexa, Citalopram, Paxil, Sertraline, Pristiq, Amitriptyline, Venlafaxine, Fluoxetine, Effexor XR, Mirtazapine, Escitalopram, Savella, Remeron

Should a Mental Disability Keep Patients Off Organ Transplant Lists?

Posted 25 Jan 2017 by Drugs.com

WEDNESDAY, Jan. 25, 2017 – Pressure is mounting for the U.S. organ donation network to tackle one of the thorniest ethical questions it's ever faced – whether a person with intellectual disabilities should be denied access to a transplant. A bipartisan group of 30 legislators from the U.S. Congress petitioned the Department of Health and Human Services in October to "issue guidance on organ transplant discrimination with regards to persons with disabilities," according to a new opinion piece in the Jan. 26 New England Journal of Medicine. The legislators' request follows several highly publicized cases in which people with intellectual disabilities have either fought to receive a transplant or have been outright denied a place on a waiting list, said co-author Dr. Scott Halpern. He's an associate professor of medical ethics and health policy at the University of Pennsylvania's ... Read more

Related support groups: Depression, Bipolar Disorder, Major Depressive Disorder, Obsessive Compulsive Disorder, Schizophrenia, Mania, Paranoid Disorder, Borderline Personality Disorder, Schizoaffective Disorder, Autism, Psychosis, Renal Transplant, Psychiatric Disorders, Organ Transplant - Rejection Prophylaxis, Body Dysmorphic Disorder, Severe Mood Dysregulation, Organ Transplant, Neurosis, Organ Transplant - Rejection Reversal, Rejection Prophylaxis

New Technique Keeps Donor Lungs Viable Longer: Study

Posted 18 Nov 2016 by Drugs.com

FRIDAY, Nov. 18, 2016 – A technique that allows lungs destined for transplants to be preserved longer works well, a new Canadian study finds. The strategy, called ex-vivo lung perfusion (EVLP), allows preservation of lungs for up to 12 hours, instead of the standard six to eight hours. "We have been using EVLP ... to assess high-risk donor lungs [less healthy] for the last decade, and almost 300 patients have benefited from this technology at our centre to date," said study author Dr. Marcelo Cypel, a thoracic surgeon at Toronto General Hospital. With standard lung transplants, "donor lungs are transported cold to the hospital where they are warmed, evaluated and then cooled again until they are transplanted into the recipient," Cypel explained. The EVLP technique, which has now become more common, allows doctors to preserve lungs for longer periods by pumping them with a solution of ... Read more

Related support groups: Organ Transplant - Rejection Prophylaxis, Organ Transplant, Organ Transplant - Rejection Reversal, Respiratory Failure, Graft-versus-host disease

Obama's 3-Pronged Effort to Speed Organ Transplants

Posted 13 Jun 2016 by Drugs.com

MONDAY, June 13, 2016 – The Obama administration on Monday announced wide-ranging public and private measures to speed the wait for lifesaving organ transplants in the United States. The goals include making it easier for Americans to become organ donors and increasing the number of organ transplants. Also, almost $200 million in new investments will "facilitate breakthrough research and development," the White House said in a media release. "New breakthroughs in bioengineering, transplantation, and organ preservation can further increase the number of organ transplants and improve outcomes," the President's office said. The administration has enlisted the cooperation of dozens of corporations, universities, hospitals, foundations and patient advocacy organizations in this ongoing project. Last year, more than 30,000 transplants took place in the United States, a record number. Yet ... Read more

Related support groups: Renal Transplant, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Kidney Transplant, Organ Transplant - Rejection Reversal, Graft-versus-host disease, Rejection Prophylaxis, Rejection Reversal

Hepatitis C-Infected Liver Transplants May Work Well for Those With the Virus

Posted 15 Apr 2016 by Drugs.com

THURSDAY, April 14, 2016 – Here's some potentially good news for people with hepatitis C who are waiting for liver transplants: Hepatitis C-infected livers seem to do as well as healthy livers in these patients, a new study indicates. The findings suggest that using hepatitis C-infected (HCV-positive) livers could help reduce wait times for people with hepatitis C who need a transplant, the researchers said. Hepatitis C is a virus that can infect the liver, leading to inflammation, scarring and liver cancer. More than 15,000 people in the United States are on the liver transplant waiting list, and about 16 percent will die before they receive a new liver, according to background notes with the study. In the United States, use of HCV-positive livers for liver transplants in people with hepatitis C has tripled, from less than 3 percent in 1995 to more than 9 percent in 2013. Researchers ... Read more

Related support groups: Hepatitis C, Liver and Pancreatic Disease, Organ Transplant - Rejection Reversal, Rejection Reversal

Transplant From Incompatible Living Donor Boosts Kidney Patients' Survival

Posted 10 Mar 2016 by Drugs.com

WEDNESDAY, March 9, 2016 – In what experts call a possible "paradigm shift," a new study shows kidney disease patients may live far longer if they receive a transplant from an incompatible living donor rather than wait for a good match. The findings could offer another choice for kidney patients who might otherwise die waiting for a compatible deceased donor. Specifically, experts said the results offer hope to "highly sensitized" transplant candidates. That refers to patients who have a large number of immune system antibodies ready to attack a donor organ. It's common among people who've had a prior kidney transplant, according to the United Network for Organ Sharing. Patients who have had multiple blood transfusions while on dialysis, or who have been pregnant several times, can also become sensitized. Finding a compatible donor for sensitized patients is "nearly impossible," said ... Read more

Related support groups: Infections, Bacterial Infection, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Organ Transplant - Rejection Reversal, Rejection Prophylaxis, Rejection Reversal

Woman Who Had 1st U.S. Uterus Transplant Loses the Organ Due to Complication

Posted 9 Mar 2016 by Drugs.com

WEDNESDAY, March 9, 2016 – The first U.S. woman to receive a transplanted uterus has had the implanted organ removed due to an unnamed "sudden complication," her doctors at the Cleveland Clinic announced Wednesday. "At this time, the circumstance of the complication is under review and more information will be shared as it becomes available," the hospital said in a statement. "There is a known risk in solid organ transplantation that the transplanted organ may have to be removed should a complication arise," the clinic added. "The medical team took all necessary precautions and measures to ensure the safety of our patient." The patient is a 26-year-old woman, identified only as Lindsey. Along with her husband Blake, she has adopted three children, but always longed to give birth to her own child. "At 16, I was told I would never have children. From that moment on," she said in a news ... Read more

Related support groups: Female Infertility, Ovulation Induction, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Organ Transplant - Rejection Reversal, Primary Ovarian Failure, Rejection Prophylaxis

New Kidney Transplant Drug Cuts Risk of Earlier Death: Study

Posted 28 Jan 2016 by Drugs.com

WEDNESDAY, Jan. 27, 2016 – A newer drug used for preventing organ rejection might improve the long-term outlook for kidney transplant recipients, a new study finds. Over seven years, patients given the drug belatacept (brand name: Nulojix) were 43 percent less likely to die or see their donor kidney fail compared to patients given an older drug called cyclosporine. Experts said the findings should encourage more doctors and patients to choose belatacept over standard anti-rejection medications. "This is a potentially transformational drug," said study lead researcher Dr. Flavio Vincenti, a transplant specialist at the University of California, San Francisco. The study – funded by the drug's maker, Bristol-Myers Squibb – was published in the Jan. 28 issue of the New England Journal of Medicine. Belatacept was first approved by the U.S. Food and Drug Administration in 2011 for ... Read more

Related support groups: Renal Failure, Kidney Infections, Restasis, Cyclosporine, Chronic Kidney Disease, Organ Transplant - Rejection Prophylaxis, Peritoneal dialysis, Organ Transplant, Neoral, Organ Transplant - Rejection Reversal, Pyelonephritis, Renal Osteodystrophy, Gengraf, Graft-versus-host disease, Rejection Prophylaxis, Sandimmune, Hyperphosphatemia of Renal Failure, Belatacept, Nulojix

Kidney Transplant Prospects Worse for Native Americans: Study

Posted 5 Dec 2015 by Drugs.com

FRIDAY, Dec. 4, 2015 – Native Americans are less likely than whites to get kidney transplants and more likely to die while waiting for a new organ, researchers say. The investigators also found that Native Americans who do receive kidney transplants have slightly lower three-year survival rates compared to whites in the United States. The results from an analysis of 16 years of national data were presented recently at a meeting of the American Society of Nephrology, in San Diego. The lower three-year survival rate "is driven primarily by the prevalence of lower-quality donors among Native Americans and a greater negative impact from such donor characteristics on survival among Native Americans," lead researcher Sarah Stith, from the University of New Mexico, and colleagues said in a society news release. "Native Americans also tend to receive transplants at centers associated with ... Read more

Related support groups: Renal Failure, Chronic Kidney Disease, Organ Transplant - Rejection Prophylaxis, Peritoneal dialysis, Organ Transplant, Organ Transplant - Rejection Reversal, Graft-versus-host disease, Rejection Prophylaxis, Rejection Reversal

Rule Changes Might Lead to More Lung Transplants for Kids

Posted 5 Nov 2015 by Drugs.com

THURSDAY, Nov. 5, 2015 – Twice as many young people in the United States could get lung transplants if donor lungs were available from a wider geographic area, a new study contends. "Children are dying while waiting for an organ. Geography should be one less barrier to pediatric patients receiving a potentially lifesaving transplant," said senior study author Dr. Maryam Valapour. She is a senior lung investigator at the Cleveland Clinic's Scientific Registry of Transplant Recipients and director of Lung Transplant Outcomes. Currently, donor lungs are first offered to transplant candidates near the donor hospital. If there are no local candidates, the lungs are offered beyond the local area in 500-mile radius increments. Child candidates are given priority for child donor lungs within a 1,000-mile radius of the donor hospital, followed by teens and then adults. Teen candidates get ... Read more

Related support groups: Organ Transplant - Rejection Prophylaxis, Organ Transplant, Organ Transplant - Rejection Reversal, Respiratory Distress Syndrome, Graft-versus-host disease, Respiratory Failure, Rejection Prophylaxis

Smog Linked to Organ Rejection, Deaths in Lung Transplant Patients

Posted 29 Sep 2015 by Drugs.com

TUESDAY, Sept. 29, 2015 – Living near busy roads with high levels of air pollution raises lung transplant patients' risk of organ rejection and death, but some antibiotics lower that risk, a new study shows. Researchers examined data gathered from more than 5,700 lung transplant patients in 10 European countries between 1987 and 2013. The analysis revealed that patients who lived in areas where air pollution was above maximum levels recommended by the World Health Organization (WHO) were 10 percent more likely to die than those in areas with lower levels of pollution. But this increased risk of death was not seen among patients who took a class of antibiotics called macrolides, which include azithromycin (Zithromax) and clarithromycin (Biaxin), according to the study presented Tuesday at a meeting of the European Respiratory Society in Amsterdam. "Short and long-term exposure to air ... Read more

Related support groups: Azithromycin, Zithromax, Erythromycin, Clarithromycin, Upper Respiratory Tract Infection, Biaxin, Immunosuppression, Zithromax Z-Pak, Z-Pak, MY-E, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Erythrocin, Respiratory Tract Disease, Ery-Tab, Azithromycin Dose Pack, Immunodeficiency, Respiratory Distress Syndrome, Organ Transplant - Rejection Reversal, Biaxin XL

Finding May Help Doctors Pinpoint Likelihood of Kidney Transplant Failure

Posted 25 Sep 2013 by Drugs.com

WEDNESDAY, Sept. 25 – Kidney transplant patients who develop a specific type of antibody response may be at particular risk of having the organ fail within a few years, a new study suggests. Experts said the results could help pinpoint those who are at the highest risk of a transplant failure – and possibly aid in finding a good donor organ for some patients. "This is a very exciting paper," Dr. Jacqueline Lappin, a transplant surgeon at Scott & White Healthcare in Temple, Texas, said of the study, which appears in the Sept. 26 issue of the New England Journal of Medicine. Lappin, who was not involved in the research, said the findings give insight into the specific type of immune response that is dangerous to a donor organ. And that could have implications for patients both before and after a kidney transplant, she added. For the study, French researchers followed 1,016 patients who ... Read more

Related support groups: Organ Transplant, Organ Transplant - Rejection Reversal

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Prograf, cyclosporine, tacrolimus, Neoral, Gengraf, Sandimmune, Hecoria