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Imbruvica Approval Expanded to Include Graft Versus Host Disease

Posted 3 Aug 2017 by Drugs.com

WEDNESDAY, Aug. 2, 2017 – The U.S. Food and Drug Administration on Wednesday expanded approval for the anti-cancer drug Imbruvica (ibrutinib) to include adults with chronic graft versus host disease (cGVHD). cGVHD is a deadly condition that affects up to 70 percent of people who receive a stem cell transplant to treat cancers of the blood or bone marrow, the FDA said in a news release. The condition occurs when the transplanted cells attack healthy cells in a patient's tissues. "This approval highlights how a known treatment for cancer is finding a new use in treating a serious and life-threatening condition that may occur in patients with blood cancer who receive a stem cell transplant," said Dr. Richard Pazdur, director of the FDA's Oncology Center of Excellence. Use of Imbruvica to treat cGVHD was studied in a clinical trial of 42 people whose symptoms lingered despite standard ... Read more

Related support groups: Prednisone, Bleeding Disorder, Methylprednisolone, Prednisolone, Medrol, Hydrocortisone, Cortisone, Triamcinolone, Dexamethasone, Betamethasone, Budesonide, Blood Transfusion, Entocort, Decadron, Solu-Medrol, Entocort EC, Florinef, Fludrocortisone, Imbruvica, Cortef

Scientists Spot Genes Behind Crohn's, Ulcerative Colitis

Posted 29 Jun 2017 by Drugs.com

THURSDAY, June 29, 2017 – Researchers say they've come closer to pinpointing genes linked with inflammatory bowel diseases such as Crohn's and ulcerative colitis. For the study, the investigators examined the genomes of nearly 68,000 people. Of the regions of the genome associated with inflammatory bowel disease (IBD), 18 could be traced to a single genetic variant with more than 95 percent certainty. "We have taken the biggest ever data set for IBD and applied careful statistics to narrow down to the individual genetic variants involved," said study co-author Dr. Jeffrey Barrett, from the Wellcome Trust Sanger Institute in the United Kingdom. "Now we have a clearer picture of which genes do and do not play a role in the disease. We are zooming in on the genetic culprits of IBD," he said in an institute news release. The findings could lead to improved effectiveness of current ... Read more

Related support groups: Prednisone, Methylprednisolone, Crohn's Disease, Ulcerative Colitis, Prednisolone, Medrol, Hydrocortisone, Cortisone, Dexamethasone, Triamcinolone, Crohn's Disease - Maintenance, Betamethasone, Inflammatory Bowel Disease, Budesonide, Ulcerative Colitis - Active, Crohn's Disease - Acute, Entocort, Decadron, Ulcerative Colitis - Maintenance, Solu-Medrol

Immune-Based Drug May Ease Chronic Eye Condition

Posted 8 Sep 2016 by Drugs.com

WEDNESDAY, Sept. 7, 2016 – People with chronic eye inflammation known as uveitis may be able to keep the condition at bay with the immune-suppressing drug Humira (adalimumab), a new study finds. "Humira doesn't cure uveitis, but it does cause it to become quiet," said lead researcher Dr. Glenn Jaffe. He's a professor of ophthalmology at Duke University School of Medicine in Durham, N.C., and a consultant for Humira's maker, AbbVie. "The hope is while the disease is in a quiet state, the disease activity just burns itself out – but it can also come back," he said. The U.S. Food and Drug Administration approved Humira for the treatment of uveitis in June. The results of the study were published Sept. 8 in the New England Journal of Medicine. The study was funded by AbbVie. Uveitis – a term used to describe a group of inflammatory diseases inside the eye – can cause loss of vision and ... Read more

Related support groups: Prednisone, Eye Conditions, Humira, Methylprednisolone, Prednisolone, Medrol, Hydrocortisone, Cortisone, Triamcinolone, Dexamethasone, Betamethasone, Budesonide, Entocort, Decadron, Solu-Medrol, Entocort EC, Uveitis, Cortef, MethylPREDNISolone Dose Pack, Medrol Dosepak

Certain Steroids Raise Risk for Serious Staph Infections

Posted 9 Jun 2016 by Drugs.com

THURSDAY, June 9, 2016 – People who use powerful drugs called systemic glucocorticoids are at higher risk for life-threatening staph blood infections, a new study finds. The findings are "a reminder for clinicians to weigh carefully the elevated risk against the potential beneficial effect of glucocorticoid therapy," said study lead author Dr. Jesper Smit, of Aarhus University Hospital in Denmark. "This is especially pertinent in patients who are already vulnerable to infection," he added. Glucocorticoids – a form of steroids – are powerful immunosuppressive drugs used to treat a variety of medical conditions that involve inflammation. The drugs are "given by mouth or by injection, are anti-inflammatory, and can suppress the immune system," explained one U.S. expert, Dr. Gerald Bernstein. "Usually, short-term use in otherwise healthy people does not cause a problem, but long term ... Read more

Related support groups: Infections, Prednisone, Bacterial Infection, Methylprednisolone, Osteoporosis, Prednisolone, Medrol, Hydrocortisone, Cortisone, Methicillin-Resistant Staphylococcus Aureus Infection, Triamcinolone, Dexamethasone, Betamethasone, Fracture, bone, Budesonide, Prevention of Osteoporosis, Entocort, Decadron, Solu-Medrol, Entocort EC

Steroid Shot for Hip Pain May Carry Infection Risk If Too Close to Surgery

Posted 2 Mar 2016 by Drugs.com

WEDNESDAY, March 2, 2016 – Patients who've received a steroid injection for hip pain should wait at least three months before having hip replacement surgery, a new study suggests. "The risk of developing an infection after surgery increased significantly in patients who had a hip replacement within three months of receiving a steroid injection," study author Dr. William Schairer, from the Hospital for Special Surgery in New York City, said in a hospital news release. "However, in patients who had a steroid injection and then waited three months or longer to have the surgery, there was no increased risk at all." Steroid injections are widely used to ease pain and inflammation associated with arthritis. These injections can weaken the immune system, which could increase infection risk, the researchers explained. "Hip replacement is a common and safe procedure that relieves pain and ... Read more

Related support groups: Infections, Prednisone, Methylprednisolone, Prednisolone, Medrol, Hydrocortisone, Hip Replacement, Cortisone, Dexamethasone, Triamcinolone, Betamethasone, Budesonide, Orthopedic Surgery, Entocort, Decadron, Solu-Medrol, Entocort EC, Florinef, Fludrocortisone, Cortef

Steroid May Be Safe, Effective Gout Treatment, Study Finds

Posted 23 Feb 2016 by Drugs.com

MONDAY, Feb. 22, 2016 – A steroid pill may be as good as a nonsteroidal anti-inflammatory drug (NSAID) for treating painful gout, new research suggests. Researchers who compared the steroid prednisolone with the arthritis medication indomethacin found both drugs offered a similar degree of pain reduction. And while indomethacin (Indocin) appeared to cause more minor side effects, neither treatment prompted serious complications, the researchers said. Smaller investigations have pointed in the same direction, said study lead author Dr. Timothy Rainer, a professor of emergency medicine at Cardiff University in Wales. But because the new findings are the product of a "larger and better-designed" effort, Rainer said steroid pills may gain standing among gout experts who usually stick with NSAIDs as their first-line treatment. The bottom line is that there are choices, said Dr. Philip ... Read more

Related support groups: Gout, Prednisolone, Indomethacin, Gout - Acute, Pred Forte, Indocin, Gouty Arthritis, Orapred, Omnipred, Prelone, Econopred, Prednisol, Econopred Plus, Pred Mild, Uric Acid Nephrolithiasis, AK-Cide, Gout - Prophylaxis, Veripred 20, Blephamide, Indocin SR

Knee Arthritis: Steroid Shots May Not Help Long-Term, Ozone Injections Promising

Posted 10 Nov 2015 by Drugs.com

TUESDAY, Nov. 10, 2015 – Millions of aging Americans are plagued by arthritic knees, and two new studies offer insight into what might – or might not – help curb the condition. Both studies were presented this week at the American College of Rheumatology's annual meeting in San Francisco. One study found that a popular therapy, steroid drug injections, do nothing to slow progression of osteoarthritis in the knee. This type of treatment is common, but has never been specifically tested, and there are concerns about its safety, according to a team led by Dr. Tim McAlindon, chief of rheumatology at Tufts Medical Center in Boston. His team tracked outcomes for 140 people – mainly overweight white women – with knee arthritis who averaged 58 years of age. The patients received either injections of the steroid triamcinolone hexacetonide, or placebo injections of saline, every three months ... Read more

Related support groups: Prednisone, Osteoarthritis, Testosterone, Methylprednisolone, Prednisolone, AndroGel, Medrol, Hydrocortisone, Cortisone, Dexamethasone, Triamcinolone, Testim, Betamethasone, Budesonide, Axiron, Entocort, Kenalog, Decadron, Androderm, Solu-Medrol

Crohn's Disease Treatments for Kids May Not Get Gut Back to Normal

Posted 14 Oct 2015 by Drugs.com

WEDNESDAY, Oct. 14, 2015 – Current therapies for children with Crohn's disease don't fully restore healthy bacteria and fungi populations in their digestive systems, a new study shows. These findings suggest that treatments don't have to bring bacteria and other microbe levels back to normal levels in the gut to be useful. This knowledge could lead to new approaches for diagnosing and treating inflammatory bowel disease, according to the Oct. 14 study in the journal Cell Host & Microbe. "We show that microbes in the gut respond to treatment of inflammatory bowel disease in a much more complex way than has been previously appreciated," co-principal investigator Gary Wu, from the University of Pennsylvania in Philadelphia, said in a journal news release. "The results of our study provide information that could be used to track or predict disease, as well as new diet-based therapeutic ... Read more

Related support groups: Prednisone, Methylprednisolone, Crohn's Disease, Prednisolone, Medrol, Hydrocortisone, Cortisone, Dexamethasone, Triamcinolone, Crohn's Disease - Maintenance, Betamethasone, Asacol, Sulfasalazine, Pentasa, Budesonide, Lialda, Crohn's Disease - Acute, Entocort, Decadron, Solu-Medrol

Steroid Injections Probably Won't Help Your Lower Back Pain

Posted 24 Aug 2015 by Drugs.com

MONDAY, Aug. 24, 2015 – Steroid injections for lower back pain may provide some relief for certain patients, but any benefits are temporary, a new study finds. Lower back pain related to herniated disk (when intervertebral disks become compressed and bulge) and, to a lesser degree, spinal stenosis (narrowing of the spinal canal), is often treated with epidural steroid injections, the researchers said. But after reviewing 38 previously published studies, the researchers found no strong evidence to support their use for these conditions. "These injections may not be as effective as perceived, and decisions should be based on an informed discussion of risks, benefits, and potential options, including surgery, medications and nonpharmacological options like exercise therapy," said lead researcher Dr. Roger Chou, a professor of medicine at the Oregon Health & Science University. Chou said ... Read more

Related support groups: Back Pain, Prednisone, Methylprednisolone, Sciatica, Prednisolone, Medrol, Hydrocortisone, Herniated Disc, Cortisone, Triamcinolone, Dexamethasone, Betamethasone, Scoliosis, Budesonide, Entocort, Decadron, Solu-Medrol, Entocort EC, Cortef, MethylPREDNISolone Dose Pack

Steroids May Help Speed Pneumonia Recovery, Study Finds

Posted 10 Aug 2015 by Drugs.com

MONDAY, Aug. 10, 2015 – Steroid treatment may hasten pneumonia patients' recovery and cut their risk of complications, a new review suggests. The findings "should lead to an important change in treatment for pneumonia," lead author Dr. Reed Siemieniuk, a physician and graduate student at McMaster University in Hamilton, Canada, said in a university news release. "Corticosteroids are inexpensive and readily available around the world. Millions of patients will benefit from this new evidence," he said. But one expert said a bit more research may be needed first. "With such modest – though measurable – effects of treatment, a large multi-center randomized clinical trial," would still be necessary to confirm the new findings and "perhaps justify a change in the standard of care," said Dr. Bruce Polsky. He is chair of the department of medicine at Winthrop-University Hospital in Mineola, ... Read more

Related support groups: Prednisone, Methylprednisolone, Pneumonia, Prednisolone, Medrol, Hydrocortisone, Cortisone, Dexamethasone, Triamcinolone, Betamethasone, Budesonide, Entocort, Decadron, Solu-Medrol, Entocort EC, Cortef, MethylPREDNISolone Dose Pack, Depo-Medrol, Medrol Dosepak, Kenalog-40

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