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Morning Sickness Drug, Diclegis, May Not Work: Study

Posted 2 days 5 hours ago by Drugs.com

WEDNESDAY, Jan. 17, 2018 – The most commonly prescribed medicine for morning sickness may not work, a new report contends. The drug, Diclegis, failed to meet minimum effectiveness goals in the clinical trial relied upon by the U.S. Food and Drug Administration for its approval in 2013, Canadian researchers reported. "There was a very small difference between the women who got a placebo and the women who got this medicine," said Dr. Nav Persaud, a researcher and family physician at St. Michael's Hospital in Toronto. Given that, the FDA should reconsider its approval of Diclegis, Persaud said. "I think medications should only be approved and prescribed if they're proved to be effective," Persaud said. "The very basic question that needs to be answered is if it's effective. If the medication is not effective, it doesn't matter if it's safe or not." But one of the nation's leading medical ... Read more

Related support groups: Unisom, Alka-Seltzer, Doxylamine, Sleep Aid, Vitamin/Mineral Supplementation during Pregnancy/Lactation, Pyridoxine, Diclegis, Vitamin B6, All-Nite, Night Time, Nausea/Vomiting of Pregnancy, Dextromethorphan/Doxylamine, Nyquil Cold & Flu, Acetaminophen/Dextromethorphan/Doxylamine, Doxylamine/pyridoxine, Cyanocobalamin/Folic Acid/Pyridoxine/Strontium Gluconate, Calcium Carbonate/melatonin/pyridoxine, Acetaminophen/Doxylamine/Pseudoephedrine, Calcium/folic Acid/ginger/pyridoxine, Nighttime Sleepaid

FDA Warns Companies for Promoting Alternatives to Street Drugs

Posted 12 Dec 2017 by Drugs.com

December 12, 2017 – The U.S. Food and Drug Administration today posted a warning letter to the marketers and distributors of Legal Lean Syrup, a drink, and Coco Loko, a “snortable” chocolate powder, for selling unapproved new drugs and misbranded drugs. The warning letter explains how the claims made in the promotional materials for Legal Lean Syrup and Coco Loko demonstrate that the products are intended to be used as alternatives to illicit street drugs and that the products, as labeled and marketed, may pose safety concerns. Drug abuse is a serious public health issue, and the FDA is concerned that products like Legal Lean Syrup and Coco Loko encourage drug abuse in individuals, including minors. Street drug alternatives are products that claim to mimic the effects of recreational drugs and are intended to be used for recreational purposes to affect psychological states. “As a phys ... Read more

Related support groups: Unisom, Substance Abuse, Alka-Seltzer, Doxylamine, Sleep Aid, Guarana, Diclegis, All-Nite, Night Time, Toxic Reactions Incl Drug and Substance Abuse, Dextromethorphan/Doxylamine, Acetaminophen/Dextromethorphan/Doxylamine, Doxylamine/pyridoxine, Nyquil Cold & Flu, Nytol Maximum Strength, Dextromethorphan/doxylamine/pseudoephedrine, Nighttime Cough, Lortuss DM, Tylenol Sinus NightTime, NyCair

Study Casts Doubt on Long-Used Morning Sickness Drug

Posted 6 Jan 2017 by Drugs.com

THURSDAY, Jan. 5, 2017 – A drug commonly prescribed to ease the nausea of morning sickness may not be as effective as once believed, a new analysis suggests. Diclectin (pyridoxine-doxylamine) has been prescribed for millions of pregnant women for years. But an unpublished study from the 1970s used by the U.S. Food and Drug Administration and Health Canada to approve the drug may have overstated its benefits, the Canadian researchers behind the new research said. Study co-author Dr. Nav Persaud, a family physician at St. Michael's Hospital in Toronto, said the earlier study's data about the effectiveness of Diclectin is shaky at best. "We found two main problems with the [unpublished] study. Data was missing for 31 percent of participants. There are questions about the integrity of the data," Persaud said. "The approval and prescribing of this medication are based on this study. The ... Read more

Related support groups: Delivery, Unisom, Alka-Seltzer, Doxylamine, Sleep Aid, Vitamin/Mineral Supplementation during Pregnancy/Lactation, Vitamin B6, Diclegis, All-Nite, Night Time, Dextromethorphan/Doxylamine, Cesarean Section, Labor and Delivery including Augmentation, Acetaminophen/Dextromethorphan/Doxylamine, Prematurity/Underweight in Infancy, Nyquil Cold & Flu, Doxylamine/pyridoxine, Nytol Maximum Strength, Nighttime Sleepaid, Doxylamine/phenylephrine

Health Tip: Avoid These 5 Pre-Bedtime Don'ts

Posted 2 Oct 2016 by Drugs.com

-- Your habits just before you slip into bed could be sabotaging your night of sleep. The National Sleep Foundation says do NOT: Take any over-the-counter medications that contain pseudoephedrine, found in common cold medicines, which can keep you awake. Opt for a nighttime formula that may help you feel drowsy. Text, watch TV or spend time on the computer shortly before bed. Take a hot shower or bath just before bed. It's best to do so about an hour before you plan to sleep, as that gives your body temperature time to drop again. Indulge in a greasy, fattening, salty bedtime snack, which can be stimulating and trigger nightmares. Drink caffeine beyond the morning, as it can stay in your system for as long as 12 hours. Read more

Related support groups: Sleep Disorders, Insomnia, Fatigue, Sta-D, Caffeine, Fioricet, Excedrin, Pseudoephedrine, Claritin-D, Alert, Mucinex D, DayQuil, Fiorinal, Allegra-D, Excedrin Migraine, Bromfed DM, Tylenol Cold, Advil Cold and Sinus, Cafergot, Keep Going

Health Tip: Enjoy a Healthier Plane Ride

Posted 28 Apr 2016 by Drugs.com

-- Planning a plane trip? There are steps you can take for a better, healthier excursion. Here are suggestions from the American Academy of Family Physicians: Store medication to be taken during the trip in a carry-on bag. Pack extra meds in case of unexpected delays. Talk to your doctor about whether you'll need to adjust your meds during your trip. Keep an identification card with you at all times if you have epilepsy or diabetes. Also, bring a list of all medications and doses, and your doctor's contact information. Drink plenty of water before and during your flight to prevent dehydration. Read more

Related support groups: Benadryl, Promethazine, Diphenhydramine, Phenergan, NyQuil, Tylenol PM, Unisom, Alka-Seltzer, Motion Sickness, Doxylamine, Advil PM, Benadryl Allergy, Promethazine DM, Aleve PM, ZzzQuil, Itch Relief, Cyclizine, Sominex, Diclegis, Simply Sleep

Women Don't Have to Suffer Through Severe Morning Sickness, Experts Say

Posted 19 Aug 2015 by Drugs.com

WEDNESDAY, Aug. 19, 2015 – Expectant mothers hit hard with nausea and vomiting in early pregnancy don't need to muddle through debilitating symptoms, new recommendations say. In updating 11-year-old guidelines on treating morning sickness, the American College of Obstetricians and Gynecologists (ACOG) now suggests women pair vitamin B6 and the antihistamine doxylamine to treat persistent, disruptive nausea and vomiting. The medications are sold separately over-the-counter or combined in prescription form. Meanwhile, further review of a commonly used morning sickness drug, ondansetron (Zofran), has prompted ACOG to pull back on supporting its use since more recent data suggest the drug may be linked to birth defects. "I think it's up to each individual patient, in talking with her clinician, to decide what steps they want to take to treat nausea and vomiting," said Dr. Aaron Caughey, a ... Read more

Related support groups: Zofran, NyQuil, Ondansetron, Unisom, Alka-Seltzer, Doxylamine, Diclegis, Nyquil Cold Medicine, All-Nite, Night Time, Zofran ODT, Nausea/Vomiting of Pregnancy, Dextromethorphan/Doxylamine, NyQuil Multi-Symptom, Doxylamine/pyridoxine, Nyquil Cold & Flu, Acetaminophen/Dextromethorphan/Doxylamine, Nighttime Cough, Lortuss DM, NyQuil D

Health Tip: Avoid These Things Before Bedtime

Posted 20 Jul 2015 by Drugs.com

-- If you're not getting enough sleep, it could be due to your activities before you hit the hay. The National Sleep Foundation warns against: Taking medications that contain pseudoephedrine, a stimulant. If you need relief from cold or allergy symptoms, opt for an antihistamine designed for night-time use. Don't watch TV, work at a computer or use a tablet or smartphone. Light from these screens can over-stimulate your brain. Opt for a book or music instead. Don't take a hot bath just before bed. Bathe at least an hour before so your body has time to cool off before sleep. Don't go to sleep with a full belly, especially if it's loaded with foods high in fat and salt. Don't drink beverages that contain caffeine after the morning. Caffeine can stay in your system for up to 12 hours. Read more

Related support groups: Sleep Disorders, Insomnia, Benadryl, Hydroxyzine, Sta-D, Zyrtec, Promethazine, Claritin, Loratadine, Diphenhydramine, Allegra, Phenergan, Sudafed, Vistaril, Cetirizine, NyQuil, Cyproheptadine, Pseudoephedrine, Atarax, Claritin-D

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