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Liver and Pancreatic Disease News

More Evidence Linking Obesity to Liver Cancer

Posted 14 Oct 2016 by Drugs.com

FRIDAY, Oct. 14, 2016 – Having a large waistline, a high body mass index (BMI) and type 2 diabetes, may raise your risk for liver cancer, a new study suggests. "We found that each of these three factors was associated, robustly, with liver cancer risk," said study co-author Peter Campbell. He's strategic director of digestive system cancer research at the American Cancer Society. Liver cancer rates have roughly tripled in the United States since the mid-1970s, "and the prognosis for patients diagnosed with this type of cancer is especially grim," Campbell said. He and his colleagues examined data on 1.57 million adults from 14 U.S. studies to look for an association between obesity and type 2 diabetes and liver cancer. None of the participants had cancer when the study began. Over time, 6.5 percent of the participants were diagnosed with type 2 diabetes, which is an obesity-related ... Read more

Related support groups: Obesity, Cancer, Liver and Pancreatic Disease, Hepatocellular Carcinoma, Hepatic Tumor

Teen Obesity May Mean Liver Disease Later

Posted 16 Jun 2016 by Drugs.com

THURSDAY, June 16, 2016 – Older teen boys who are overweight or obese could be at increased risk for severe liver disease later in life, a new study suggests. The research included nearly 45,000 Swedish males who entered military service in their late teens between 1969 and 1970. The investigators reviewed over 40 years of their health information. Nearly 400 of them were diagnosed with severe liver disease, the study authors said. Men who were overweight or obese in their late teens were 64 percent more likely to develop severe liver disease compared with men who had a low normal weight in their late teens. The researchers said that worked out to a 5 percent increased risk for every one point increase in body mass index (BMI). BMI is an estimate of body fat based on weight and height. Overweight is defined as a BMI above 25. Obesity is defined as a BMI above 30, according to the U.S. ... Read more

Related support groups: Obesity, Liver and Pancreatic Disease

Health Tip: Using Aspirin Therapy

Posted 27 May 2016 by Drugs.com

-- Aspirin therapy may help reduce the risk of heart attack by thinning the blood and preventing clots. But it's not safe for everyone. The University of California - Davis Health System says you should be wary of aspirin therapy if you: Have kidney or liver disease. Drink three or more alcoholic beverages daily. Have uncontrolled high blood pressure. Take a blood-thinning medication. Have any possible symptoms of stroke. Read more

Related support groups: High Blood Pressure, Aspirin, Hypertension, Ischemic Stroke, Excedrin, Alcoholism, Chronic Kidney Disease, Aggrenox, Alka-Seltzer, Fiorinal, Excedrin Migraine, Prevention of Cardiovascular Disease, Ecotrin, Fiorinal with Codeine, Arthritis Pain, Soma Compound, Arthritis Pain Formula, Cardiovascular Risk Reduction, Bayer Aspirin, Norgesic

Generic Hepatitis C Drugs as Effective as Pricey Brand Names: Study

Posted 18 Apr 2016 by Drugs.com

SATURDAY, April 16, 2016 – Low-cost generic antiviral drugs are as effective and safe as more expensive brand-name drugs in treating people with hepatitis C, researchers report. In many countries, people don't have access to a course of brand-name direct-acting antiviral drugs due to the high cost – as much as $94,000 a patient, the researchers explained. However, mass-produced generic versions are available for less than 1 percent of the retail price of the brand-name drugs, they added. "Our interim data suggests a potential solution for hepatitis C patients in areas where treatment access has been restricted as a result of the high prices demanded for branded treatment," said study author Dr. James Freeman, of GP2U Telehealth in Hobart, Australia. The study of patients in the United States, Canada, Africa, Australia, Europe and Southeast Asia found that generic direct-acting ... Read more

Related support groups: Hepatitis C, Harvoni, Sovaldi, Ribavirin, Sofosbuvir, Liver and Pancreatic Disease, Daklinza, Copegus, Ribasphere, Rebetol, Ledipasvir/sofosbuvir, Interferon Alfa-2B/Ribavirin, RibaPak, Rebetron, Virazole, Hepatic Tumor, Daclatasvir, Moderiba, RibaTab

Hepatitis C-Infected Liver Transplants May Work Well for Those With the Virus

Posted 15 Apr 2016 by Drugs.com

THURSDAY, April 14, 2016 – Here's some potentially good news for people with hepatitis C who are waiting for liver transplants: Hepatitis C-infected livers seem to do as well as healthy livers in these patients, a new study indicates. The findings suggest that using hepatitis C-infected (HCV-positive) livers could help reduce wait times for people with hepatitis C who need a transplant, the researchers said. Hepatitis C is a virus that can infect the liver, leading to inflammation, scarring and liver cancer. More than 15,000 people in the United States are on the liver transplant waiting list, and about 16 percent will die before they receive a new liver, according to background notes with the study. In the United States, use of HCV-positive livers for liver transplants in people with hepatitis C has tripled, from less than 3 percent in 1995 to more than 9 percent in 2013. Researchers ... Read more

Related support groups: Hepatitis C, Liver and Pancreatic Disease, Organ Transplant - Rejection Reversal, Rejection Reversal

More People Surviving Sudden Liver Failure

Posted 4 Apr 2016 by Drugs.com

MONDAY, April 4, 2016 – The chances of surviving acute liver failure have improved significantly over the past 16 years, a new study finds. In fact, 21-day patient survival increased from about 59 percent in 1998 to 75 percent in 2013, researchers found. Better diagnosis and treatment may account for this advance, they said. "Overall survival and transplant-free survival have improved, while the number of patients requiring transplantation has declined," said lead researcher Dr. William Lee, a liver specialist at the University of Texas Southwestern Medical Center at Dallas. Acute liver failure, though rare, affects young people and is often fatal, he said. "It involves the rapid destruction of liver cells by either drugs or viruses, such as hepatitis A or B, resulting in loss of consciousness and failure of multiple organ systems," Lee said. The main cause of acute liver failure in ... Read more

Related support groups: Cirrhosis, Liver Cirrhosis, Liver and Pancreatic Disease

Gene Variant May Explain Higher Rates of Some Cancers in Black People

Posted 31 Mar 2016 by Drugs.com

THURSDAY, March 31, 2016 – A single gene variant may explain why black Americans with common cancers have shorter survival times and higher death rates than other races, a new study suggests. While some researchers have examined possible socioeconomic factors to explain these differences, others have focused on genetics. "We may finally have a truly genetic explanation for why African-Americans are more prone to a variety of cancers," said study senior author Maureen Murphy. She is a professor and program leader in the Molecular and Cellular Oncogenesis program at the Wistar Institute in Philadelphia. "This is a variant that has never been observed in Caucasian populations, so identifying people who have this variant may be crucial for providing improved prognosis and personalized treatment that will lead to better outcomes," she said in an institute news release. In this study, ... Read more

Related support groups: Cancer, Hepatocellular Carcinoma, Liver and Pancreatic Disease, Hepatic Tumor

Many Donor Livers for Sickest Patients Rejected, Study Finds

Posted 5 Feb 2016 by Drugs.com

FRIDAY, Feb. 5, 2016 – It's common for transplant centers to reject donor livers for the sickest patients on the transplant waiting list, a new study suggests. That means those patients have a higher risk of death while they wait for a lifesaving transplant, the researchers found. The new study reviewed 23,000 donor liver offers to 13,255 U.S. patients on the liver transplant waiting list between May 2007 and June 2013. It found that only 37 percent of the organ offers were accepted for the sickest patients on the list. "We found that not only is there a wide variation in acceptance rates for donor organs among transplant centers, these variations directly correlated with whether the sickest patients would die waiting for a lifesaving transplant, with patients 27 percent more likely to die without a transplant for every 5 percent decrease in a center's adjusted organ offer acceptance ... Read more

Related support groups: Cirrhosis, Organ Transplant - Rejection Prophylaxis, Liver and Pancreatic Disease, Organ Transplant, Rejection Prophylaxis

Screening Inmates for Hepatitis C Benefits General Community: Study

Posted 23 Nov 2015 by Drugs.com

MONDAY, Nov. 23, 2015 – A prison-based hepatitis C screening and treatment program could benefit the broader community, researchers suggest. Besides reducing the spread of hepatitis C after prisoners are released, "universal [hepatitis C] testing and treatment in prisons would reduce outcomes of advanced [hepatitis C] such as liver cancer, end-stage liver disease and death among prisoners," said study senior author Jagpreet Chhatwal, of Massachusetts General Hospital's Institute for Technology Assessment in Boston. "We now have highly effective treatments for [hepatitis C], so we wanted to know the impact of providing routine testing and treatment to inmates, a group in which the infection is highly prevalent," Chhatwal said in a hospital news release. More than 1 percent of the U.S. population has hepatitis C, but the virus affects more than 17 percent of prisoners, the researchers ... Read more

Related support groups: Cancer, Hepatitis C, Liver Cirrhosis, Liver and Pancreatic Disease, Hepatocellular Carcinoma, Benign Liver Tumor, Hepatic Coma, Liver Metastasis in Adenocarcinoma, Hepatic Tumor

Charges Filed Against Makers of Nutritional Supplements

Posted 18 Nov 2015 by Drugs.com

WEDNESDAY, Nov. 18, 2015 – Criminal charges and civil injunctions have been filed against 117 makers and/or distributors of potentially dangerous dietary supplements, U.S. government agencies announced Tuesday. One of the targets of the investigation – conducted by the U.S. Food and Drug Administration, the Department of Justice and other federal agencies – was USPlabs LLC of Dallas, which sold popular workout and weight loss supplements. The government says USPlabs and its executives claimed to use natural plant extracts in products called Jack3d and OxyElite Pro. However, they actually used a synthetic stimulant made in a Chinese chemical factory and knew of studies that linked these products to liver toxicity, the government said. In October 2013, USPlabs said it would stop distribution of OxyElite Pro because it had been linked to an outbreak of liver damage. However, the company ... Read more

Related support groups: Belviq, Dietary Supplementation, Vitamin/Mineral Supplementation and Deficiency, Liver Cirrhosis, Poisoning, Meridia, Sibutramine, Organ Transplant, Liver and Pancreatic Disease, Lorcaserin, Toxic Reactions Incl Drug and Substance Abuse, Dietary Fiber Supplementation

Substance Abuse, Suicide Killing More White, Middle-Aged Americans: Report

Posted 2 Nov 2015 by Drugs.com

MONDAY, Nov. 2, 2015 – A largely unnoticed "epidemic" is killing white, middle-aged Americans in growing numbers, a new analysis reveals. Princeton University researchers report that the overall death rate of white adults in midlife has risen sharply over the past 15 years, largely because of drug and alcohol overdoses, suicide, chronic liver disease and cirrhosis of the liver. The tally is on par with the nation's AIDS deaths, they added. "We sort of fell off our chairs when we saw that in the data, because that's just not what's happening elsewhere," said study author Anne Case, a professor of economics and public affairs. No other industrialized nation has experienced a similar deterioration in health during the timeframe studied – 1999 to 2013, the researchers said in background notes. Meanwhile, death rates of U.S. Hispanics and blacks continue to plummet. Results of the ... Read more

Related support groups: Oxycodone, Hydrocodone, OxyContin, Vicodin, Roxicodone, Cirrhosis, Liver Cirrhosis, Biliary Cirrhosis, Vicodin ES, Vicodin HP, Liver and Pancreatic Disease, Hysingla ER, OxyIR, Zohydro ER, Ethanol, Oxyfast, Portal Hypertension, Hepatic Coma, Ethyl Alcohol, Dazidox

Illnesses, Deaths Spur FDA Warning on Hepatitis C Drugs

Posted 23 Oct 2015 by Drugs.com

FRIDAY, Oct. 23, 2015 – Reports of deaths and illnesses occurring soon after use are prompting the U.S. Food and Drug Administration to issue warnings on two drugs used to fight the hepatitis C virus. The drugs, called Viekira Pak and Technivie, appeared linked to serious liver damage in patients with advanced liver disease, the agency warned in a statement issued Thursday. Of 26 cases reported worldwide where use of the medications has been the possible or probable cause of illness, 10 patients either died or required organ transplant after liver failure, and 16 patients had some form of liver dysfunction. In most cases, liver damage occurred within one to four weeks of patients starting treatment, the FDA said. The cases occurred after the two drugs were approved by the FDA – Viekira Pak in December of 2014 and Technivie in July of 2015, the statement said. The agency believes that ... Read more

Related support groups: Hepatitis C, Liver and Pancreatic Disease, Viekira Pak, Technivie

Live Liver Transplants Seem Safe, Effective for Sudden Liver Failure

Posted 19 Mar 2015 by Drugs.com

THURSDAY, March 19, 2015 – Liver transplants from live donors appear to work just as well as traditional transplants for patients with sudden (acute) liver failure, new research suggests. What's more, people who donate a portion of their liver (live donors) don't seem to have any serious complications as a result of the donation procedure. "Since acute liver failure can deteriorate within hours or days to coma or death, waiting time is critical for this patient group," wrote Dr. Markus Selzner, of the Multi-Organ Transplant Program at Toronto General Hospital in Canada. "If a living donor is available, liver transplantation can be performed without delay, reducing the risk of death or permanent disability of the recipient," he said. The study authors explained that without a liver transplant, more than 80 percent of people with acute liver failure ultimately fall into a coma and die. ... Read more

Related support groups: Liver and Pancreatic Disease, Organ Transplant

Alcohol Fuels Liver Disease in Those With HIV and Hepatitis C

Posted 7 May 2014 by Drugs.com

WEDNESDAY, May 7, 2014 – People infected with both HIV and hepatitis C are much more likely to develop advanced liver disease if they drink any alcohol at all, according to a new study. Researchers analyzed data from thousands of participants in a Veterans Affairs study on aging and found the risk of advanced liver fibrosis increased overall with alcohol use but was especially striking in patients with both HIV and hepatitis C (co-infected patients). The data included more than 700 people who were infected with both HIV and hepatitis C, more than 1,400 infected with HIV only, nearly 300 infected with hepatitis C only, and nearly 1,160 uninfected people. Among the study participants who were light drinkers, co-infected patients were 13 times more likely than non-infected people to have advanced liver fibrosis. Among participants who were heavy drinkers, co-infected patients were 21 ... Read more

Related support groups: Hepatitis C, HIV Infection, Liver and Pancreatic Disease, Alcoholic Liver Damage, Acute Alcohol Intoxication

Study Finds Steroids May Not Be Helpful After Infant Liver Surgery

Posted 6 May 2014 by Drugs.com

SATURDAY, May 3, 2014 – High doses of steroids may not benefit infants who've had surgery for a serious liver disease, and the drugs may even cause harm, according to a new study. The findings offer new evidence in a controversy over whether steroid treatment in addition to surgery helps infants with a liver disease called biliary atresia. This condition is the leading reason for liver transplants in children, according to the study authors. "The results from this clinical trial differ from previous reports of a benefit from steroid therapy on bile drainage or survival in biliary atresia," co-lead investigator Dr. Jorge Bezerra, from Cincinnati Children's Hospital Medical Center, said in a news release from the hospital. "Although we cannot exclude some small potential benefit from steroid treatment, we observed no statistical differences in two-year survival between patients receiving ... Read more

Related support groups: Prednisone, Methylprednisolone, Prednisolone, Hydrocortisone, Medrol, Dexamethasone, Cortisone, Triamcinolone, Betamethasone, Budesonide, Decadron, Entocort, Solu-Medrol, Entocort EC, Celestone, Cortef, Medrol Dosepak, Orapred, Kenalog-10, Pulmicort Flexhaler

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Nonalcoholic Fatty Liver Disease, Pancreatic Exocrine Dysfunction, Liver Cirrhosis, Hyperbilirubinemia, Portal Hypertension, Hepatic Tumor, Benign Liver Tumor, Liver Metastasis in Adenocarcinoma, Hepatic Coma, Bile Acid Synthesis Disorders, Liver Abscess