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Liptruzet News

Drug Combo for Irregular Heartbeat Might Raise Bleeding Risk

Posted 14 days ago by Drugs.com

MONDAY, Nov. 21, 2016 – Because the irregular heartbeat known as atrial fibrillation can trigger stroke-inducing clots, many patients are prescribed a blood thinner. But a new Canadian study suggests that combining one blood thinner, Pradaxa, with certain statin medications could raise the odds for bleeding in these patients. "An increase in the risk of bleeding requiring hospital admission or emergency department visits was seen with lovastatin [Mevacor] and simvastatin [Zocor] compared with the other statins," said study author Tony Antoniou, a pharmacist at St. Michael's Hospital in Toronto. His team tracked outcomes for nearly 46,000 patients ages 65 and older. All had atrial fibrillation and took Pradaxa (dabigatran) to reduce their risk of stroke. Those who also took either lovastatin or simvastatin had a 40 percent higher risk of bleeding than those who took other statins, the ... Read more

Related support groups: Bleeding Disorder, Atrial Fibrillation, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Pradaxa, Zocor, Lovastatin, Prevention of Thromboembolism in Atrial Fibrillation, Vytorin, Rosuvastatin, Pravachol, Livalo, Red Yeast Rice, Caduet, Simcor, Lescol, Lescol XL

Coming Soon: Lower Cholesterol From a Twice-a-Year Shot?

Posted 20 days ago by Drugs.com

TUESDAY, Nov. 15, 2016 – Instead of popping a pill every day, people might soon control "bad" LDL cholesterol by getting an injection at their doctor's office two or three times a year. Researchers testing a new injectable drug called Inclisiran found it cut LDL cholesterol by half or more. According to early clinical trial data, the effect could last for four to six months. Inclisiran produced "significant and durable reductions in LDL cholesterol, and thus could potentially impact cardiovascular events," said study presenter Dr. Kausik Ray, a professor of public health at Imperial College London in England. Such long-lasting effects could provide a major advance in preventing heart disease, heart attack and stroke, by helping reduce hardening of the arteries, the researchers said. The trial results were presented Tuesday at the American Heart Association annual meeting in New ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Rosuvastatin, High Cholesterol - Familial Heterozygous, Hypertriglyceridemia, Pravachol, Livalo, High Cholesterol - Familial Homozygous, Red Yeast Rice, Caduet, Repatha, Lescol, Hyperlipoproteinemia, Lescol XL

High-Dose Statins Boost Survival: Study

Posted 9 Nov 2016 by Drugs.com

WEDNESDAY, Nov. 9, 2016 – Higher doses of the cholesterol-lowering drugs known as statins appear to boost survival slightly for certain people, a large new study reports. The study followed more than 509,000 patients with various forms of cardiovascular disease. The researchers found that survival increased by 9 percent when people took high versus moderate doses of statin for a little over a year. High doses – also called high-intensity statin therapy – included 40 to 80 milligrams (mg) of atorvastatin (Lipitor) or 20 to 40 mg of rosuvastatin (Crestor) daily. Examples of moderate doses include 10 to 20 mg of Lipitor and 5 to 10 mg of Crestor, the study reported. Unlike some previous studies, this study included adults over age 75. The study showed that people over 75 also have a survival benefit with high doses compared to moderate doses, said study author Dr. Fatima Rodriguez. ... Read more

Related support groups: Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Rosuvastatin, Pravachol, Livalo, Prevention of Cardiovascular Disease, Red Yeast Rice, Caduet, Cardiovascular Risk Reduction, Lescol, Lescol XL, Mevacor, Atorvastatin/Ezetimibe, Amlodipine/Atorvastatin, Fluvastatin

Are There Alternatives to Statins?

Posted 27 Sep 2016 by Drugs.com

TUESDAY, Sept. 27, 2016 – Statins are the go-to therapy for lowering "bad" LDL cholesterol, but other treatments also can effectively reduce risk of future heart problems, a new evidence review reports. These alternative therapies – including a heart-healthy diet, other cholesterol-lowering medications, and even intestinal bypass surgery – seem to confer the same level of heart health protection as statins when cholesterol levels decrease, according to the findings. Nonstatin therapies reduced the risk of heart problems by 25 percent for each 1 millimole per liter (mmol/L) decrease in LDL cholesterol levels. That's very similar to the 23 percent reduction per 1 mmol/L decrease seen with statins like atorvastatin (Lipitor) and simvastatin (Zocor), the researchers said. What's more, the benefits of these therapies stack up if more than one proves effective at lowering a person's ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Welchol, Zocor, Cholestyramine, Lovastatin, Zetia, Vytorin, Rosuvastatin, Gastric Bypass Surgery, High Cholesterol - Familial Heterozygous, Hypertriglyceridemia, Questran, Pravachol, Livalo, High Cholesterol - Familial Homozygous

Just a Little of Statins' Effect Enough to Help Heart: Study

Posted 20 Jun 2016 by Drugs.com

MONDAY, June 20, 2016 – Giving high doses of statins to patients with heart disease doesn't lower the risk of future heart trouble any more than moderate doses of the cholesterol-lowering drugs do, a new study finds. Having heart disease raises the risk of heart attack and stroke, as blood vessels become clogged and cut the normal flow of blood and oxygen to the heart. These patients are typically prescribed statins on a long-term basis, to lower levels of vessel-clogging LDL ("bad") cholesterol. But experts remain conflicted about exactly how low LDL cholesterol levels should go. "Our study demonstrates that physicians treating patients with heart disease and elevated levels of cholesterol with statins have to ensure that patients meet a target of less than 100 mg/dL to prevent future [heart] events," said study author Dr. Morton Leibowitz. He is a senior physician with the Clalit ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Vytorin, Rosuvastatin, Pravachol, Livalo, Prevention of Cardiovascular Disease, Red Yeast Rice, Caduet, Cardiovascular Risk Reduction, Simcor, Lescol, Lescol XL, Mevacor

Statins Might Not Lower Colon Cancer Risk: Study

Posted 26 Apr 2016 by Drugs.com

TUESDAY, April 26, 2016 – Long-term use of cholesterol-lowering statins does not appear to reduce the risk of colon cancer, but a person's cholesterol levels might affect risk, a new study suggests. Both statins and cholesterol levels have been linked with lower colon cancer risk, but pinpointing which one is actually responsible has been difficult, the University of Pennsylvania researchers explained. So, they compared statin use and cholesterol levels in more than 22,000 British patients with colon cancer and more than 86,500 without the disease. The results confirmed findings from previous studies that showed a lower risk of colon cancer in people who take statins. But the risk was not significantly different between people who kept taking statins and those who stopped taking the drugs. Instead, the higher the cholesterol level, the lower the colon cancer risk for patients, ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Colonoscopy, Atorvastatin, Pravastatin, Colorectal Cancer, Zocor, Lovastatin, Vytorin, Rosuvastatin, Pravachol, Livalo, Red Yeast Rice, Caduet, Simcor, Lescol, Lescol XL, Mevacor

Negative News on Statins Tied to Dropped Prescriptions

Posted 2 Dec 2015 by Drugs.com

WEDNESDAY, Dec. 2, 2015 – News reports on the downsides of statins may push some people to stop taking the cholesterol-lowering drugs, a new study hints. The findings, published Dec. 2 in the European Heart Journal, cannot prove that media stories drive statin users to give up their prescriptions. Instead, Danish researchers found a broad correlation between "negative" media coverage and people's odds of quitting a statin within six months of their first prescription. But even without a clear cause-and-effect connection, experts said it's reasonable to assume that media stories had an influence over some statin users in the study. It rings true to Dr. Thomas Whayne Jr., of the Gill Heart Institute at the University of Kentucky. "I've seen this happen a lot," said Whayne, who was not involved in the study. "News stories come out, and you have patients saying, 'I'm not going to take ... Read more

Related support groups: Diabetes, Type 2, Muscle Pain, Heart Disease, High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Zetia, Pre-Diabetes, Vytorin, Rosuvastatin, Hypertriglyceridemia, Pravachol, Livalo, Red Yeast Rice, Cardiovascular Risk Reduction

Statins Might Reduce Complications After Major Lung Surgery

Posted 26 Jun 2015 by Drugs.com

FRIDAY, June 26, 2015 – Widely used cholesterol-lowering drugs known as statins might help reduce major complications after lung surgery, new research suggests. Statins have been linked to fewer complications after heart surgery, and researchers at Memorial Sloan Kettering Cancer Center in New York City theorized they might also benefit patients undergoing major lung surgery. The researchers randomly assigned more than 160 study participants to receive the statin Lipitor (atorvastatin) or an inactive placebo before and after lung resection – removal of part of the lung. Complications – such as pneumonia, heart attack and acute respiratory failure – were reported in 22 percent of patients receiving placebo, compared with 12 percent taking statins. Statins were also linked to a nearly 50 percent reduction in post-surgery rates of atrial fibrillation (abnormal heart rhythm), the ... Read more

Related support groups: Surgery, Atrial Fibrillation, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Rosuvastatin, Pravachol, Livalo, Red Yeast Rice, Caduet, Cardiovascular Risk Reduction, Lescol, Lescol XL, Mevacor, Atorvastatin/Ezetimibe, Amlodipine/Atorvastatin

One-Third of Americans Have Dangerous Mix of Heart Risk Factors

Posted 19 May 2015 by Drugs.com

TUESDAY, May 19, 2015 – More than one-third of U.S. adults have a combination of health problems collectively known as metabolic syndrome that increase the risk of heart disease and diabetes, according to new research. What's worse, the researchers found the rate of metabolic syndrome increases dramatically with age. Almost half of people 60 or older in the United States have metabolic syndrome, the study found. "That's concerning, because we know the population of the U.S. is aging," said senior author Dr. Robert Wong, an assistant clinical professor at University of California, San Francisco. "I think it will potentially place a huge burden on our health care system." Metabolic syndrome is a "perfect storm" of conditions that include high blood pressure, abnormal cholesterol levels, increased levels of blood sugar, and a wider waist circumference, Wong said. Medical experts are ... Read more

Related support groups: High Blood Pressure, Diabetes, Type 2, Hypertension, Heart Disease, High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Niacin, Angina, Insulin Resistance, Zocor, Niaspan, Lovastatin, Pre-Diabetes, Vytorin, Rosuvastatin, Hypertriglyceridemia

Can Statins Help Lower Lung Cancer Death Risk?

Posted 1 May 2015 by Drugs.com

FRIDAY, May 1, 2015 – Taking the cholesterol-lowering medications known as statins for a year before getting a diagnosis of lung cancer was associated with a 12 percent lower risk of dying from that cancer, new research suggests. The researchers from Northern Ireland also found indications that those who had a minimum of 12 statin prescriptions filled after being diagnosed with lung cancer saw their lung cancer death risk drop by as much as 19 percent. But, study lead author Chris Cardwell stressed that the degree of the association seen between statin use and a lower risk for lung cancer death was "relatively small." And while the study found an association between statin use and a lower risk of lung cancer death, it wasn't designed to prove a cause-and-effect relationship. Cardwell said there are any number of other differences between patients who take statins and patients who don't ... Read more

Related support groups: Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Lung Cancer, Zocor, Lovastatin, Non-Small Cell Lung Cancer, Vytorin, Rosuvastatin, Pravachol, Livalo, Red Yeast Rice, Caduet, Simcor, Lescol, Lescol XL, Mevacor, Amlodipine/Atorvastatin

Merck Recalls Cholesterol Drug Liptruzet

Posted 14 Jan 2014 by Drugs.com

TUESDAY, Jan. 14, 2014 – Packaging defects have prompted a recall of a combination cholesterol drug called Liptruzet, produced by Merck & Co., temporarily affecting the entire U.S. stock. Merck said the foil pouches holding Liptruzet pills could allow air and moisture inside, potentially decreasing the drug's effectiveness. The recall covers all four dose strengths and every batch that's gone out since Liptruzet hit the market in May. Liptruzet combines two medications that work together to reduce "bad" cholesterol levels: Atorvastatin, the generic version of the widely used cholesterol medication Lipitor, which reduces the body's natural cholesterol production, and Zetia (ezetimibe), a Merck-produced drug that decreases the amount of cholesterol absorbed from food. Cardiologists expect no health problems to result from the recall, in part because both atorvastatin and Zetia will ... Read more

Related support groups: Atorvastatin/Ezetimibe, Liptruzet

Merck Voluntarily Recalls All Lots of Liptruzet in the United States From Wholesalers Due to Packaging Defects

Posted 14 Jan 2014 by Drugs.com

WHITEHOUSE STATION, N.J., – January 14, 2014 - Merck (NYSE: MRK), known as MSD outside the United States and Canada, is voluntarily recalling all lots of Liptruzet (ezetimibe and atorvastatin) 10/10 mg, 10/20 mg, 10/40 mg and 10/80 mg tablets in the United States, including Puerto Rico, due to packaging defects. Merck is recalling from wholesalers all lots of Liptruzet that have been distributed since the product was introduced in May 2013. Some of the outer laminate foil pouches may allow in air and moisture, which could potentially decrease the effectiveness or change the characteristics of the product. The likelihood of the packaging defects decreasing the effectiveness of Liptruzet on a patient’s lipid profile or negatively impacting the safety of the product is remote. The decision to recall Liptruzet was not based on any reported adverse experiences or product quality c ... Read more

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