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Intensive Treatment Shows Potential Against Type 2 Diabetes

Posted 15 Mar 2017 by Drugs.com

WEDNESDAY, March 15, 2017 – Instead of managing type 2 diabetes as a chronic condition, what if people could beat the disease? That was the thinking behind a small pilot study, which suggested that intensive treatment with oral medicine, insulin, diet and exercise might knock out the disease, at least for several months, in certain patients. Up to 40 percent of patients who were treated experienced complete or partial remission for three months, the study found. "We are now able to possibly reverse diabetes, and that really motivates patients to do their best in terms of losing weight and making sure their sugars are normalized," said lead author Dr. Natalia McInnes. She's an assistant professor of endocrinology and metabolism at McMaster University in Ontario, Canada. However, relatively few participants remained in remission a year later, diabetes experts noted. "Rates of diabetes ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Glucophage, Insulin Resistance, Janumet, Diabetes Mellitus, Glucophage XR, ActoPlus Met, Acarbose, Glumetza, Glyburide/Metformin, Janumet XR, Avandamet, Jentadueto, Glucovance, Abnormal Glucose Tolerance, Metformin/Pioglitazone, Precose, Kombiglyze XR

Dealing With Diabetes Distress

Posted 16 Feb 2017 by Drugs.com

THURSDAY, Feb. 16, 2017 – People with diabetes have to think about their condition and make treatment decisions constantly – and all that extra work and worry can lead to psychological distress at times. "Diabetes distress" isn't the same as depression, however, diabetes experts note. It's a condition unique to the 24/7 demands that come with diabetes, particularly for people dependent on insulin. "The day you develop diabetes, it's like the universe just handed you a new full-time job that you have to do in addition to whatever else you're doing. It's a special job that has a big impact on the rest of your life. There's no pay and no vacation," said William Polonsky, president of the Behavioral Diabetes Institute in San Diego. Alicia McAuliffe-Fogarty, vice president of lifestyle management at the American Diabetes Association, put it this way: "Diabetes distress is the extra burden ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Lantus, Diabetes, Type 1, Glucophage, Novolog, Glipizide, Humalog, Insulin Resistance, Janumet, Glyburide, Lantus Solostar, Invokana, Levemir, Actos, Pre-Diabetes, Glimepiride, Novolin R, Amaryl

Is There a Link Between Diabetes and Pancreatic Cancer?

Posted 31 Jan 2017 by Drugs.com

TUESDAY, Jan. 31, 2017 – Developing or worsening type 2 diabetes could be an early sign of pancreatic cancer, new research suggests. Researchers analyzed data from nearly a million patients with type 2 diabetes or pancreatic cancer in Italy and Belgium. Half of all pancreatic cancer cases were diagnosed within a year of patients being diagnosed with diabetes, the findings showed. The investigators also found that type 2 diabetes patients whose condition deteriorated rapidly requiring more aggressive treatment were also at increased risk for pancreatic cancer. The study findings, which don't prove an association between type 2 diabetes and pancreatic cancer, were presented Monday at the European Cancer Congress (ECC) in Amsterdam. Research presented at medical meetings is typically considered preliminary until published in a peer-reviewed journal. "Doctors and their diabetic patients ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Lantus, Glucophage, Glipizide, Novolog, Humalog, Janumet, Glyburide, Lantus Solostar, Levemir, Glimepiride, Pancreatic Cancer, Novolin R, Amaryl, Novolin N, Humulin N, Lantus Solostar Pen, Glucophage XR

Insulin Makers Conspired to Raise Prices: Lawsuit

Posted 31 Jan 2017 by Drugs.com

Three makers of insulin conspired to boost the prices of the lifesaving diabetes drug, according to a lawsuit filed Monday in federal court in Massachusetts. A recent study in the Journal of the American Medical Association said the price of insulin nearly tripled between 2002 and 2013, and three manufacturers – Sanofi, Novo Nordisk and Eil Lilly – have raised the list prices of their insulin in near unison, The New York Times reported. The price increases have triggered anger among patient groups and doctors, who say the rising cost of insulin appears to have little to do with higher production costs. "People who have to pay out of pocket for insulin are paying enormous prices, when they shouldn't be," Steve Berman, a lawyer for the patients, told The Times. The lawsuits alleges that the three companies increased the list prices on their insulin in order to win favor with pharmacy ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Lantus, Diabetes, Type 1, Glucophage, Glipizide, Novolog, Humalog, Insulin Resistance, Janumet, Glyburide, Lantus Solostar, Levemir, Pre-Diabetes, Actos, Glimepiride, Novolin R, Amaryl, Novolin N

Language Barrier May Keep Some Hispanics From Good Diabetes Care

Posted 23 Jan 2017 by Drugs.com

MONDAY, Jan. 23, 2017 – Hispanic-American type 2 diabetes patients who lack proficiency in English may end up with poorer care, a new study finds. Specifically, these patients were found to be much less likely than non-Hispanic patients to take newly prescribed diabetes medications as directed, the researchers said. The study "suggests that more needs to be done to improve adherence to newly prescribed medications among Latino patients at all levels of English proficiency," wrote a team led by Dr. Alicia Fernandez, of the University of California, San Francisco. A diabetes specialist who reviewed the study wasn't surprised by the results. The research "further validates what many clinicians already know: Patients who do not understand English tend to do worse with management of chronic disease," said Dr. Maria Pena. She is an endocrinologist who directs the Center for Weight Management ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Lantus, Diabetes, Type 1, Glucophage, Novolog, Glipizide, Humalog, Insulin Resistance, Janumet, Glyburide, Lantus Solostar, Invokana, Levemir, Pre-Diabetes, Actos, Glimepiride, Novolin R, Amaryl

Native Americans Make Progress Against Diabetes Complication

Posted 10 Jan 2017 by Drugs.com

TUESDAY, Jan. 10, 2017 – Diabetes-related kidney failure among Native American adults fell by more than half over almost 20 years, a U.S. Centers for Disease Control and Prevention report shows. The change is due to improvements in diabetes and kidney care, according to the report. The new research also found that among these patients, blood sugar control improved 10 percent between 1996 and 2014, and the use of medicine to protect kidneys rose from 42 percent to 74 percent over 5 years. Average blood pressure in Native Americans with diabetes and high blood pressure was well controlled (133/76 in 2015), the findings showed. In addition, more than 60 percent of Native Americans aged 65 and older with diabetes had a urine test for kidney damage in 2015, compared with 40 percent of Medicare patients with diabetes in 2013, the researchers said. "The Indian Health Service (IHS) has made ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Lantus, Renal Failure, Glucophage, Glipizide, Novolog, Humalog, Insulin Resistance, Janumet, Glyburide, Lantus Solostar, Levemir, Pre-Diabetes, Glimepiride, Chronic Kidney Disease, Novolin R, Amaryl, Novolin N

Metformin Still Best Choice for First Type 2 Diabetes Treatment

Posted 3 Jan 2017 by Drugs.com

MONDAY, Jan. 2, 2017 – Newly updated guidelines reaffirm that metformin is the first-line drug for people with type 2 diabetes, and that several other medications – including newer ones – can be added if needed. The recommendations come from the American College of Physicians (ACP). The American Academy of Family Physicians endorsed the new guidelines. The ACP updated the guidelines because of new research into diabetes drugs, and the U.S. Food and Drug Administration approval of new diabetes drugs. "Metformin, unless contraindicated, is an effective treatment strategy because it has better effectiveness, is associated with fewer adverse effects, and is cheaper than most other oral medications," ACP president Dr. Nitin Damle said in a college news release. "The escalating rates of obesity in the U.S. are increasing the incidence and prevalence of diabetes substantially. Metformin has ... Read more

Related support groups: Diabetes, Type 2, Metformin, Januvia, Glucophage, Glipizide, Janumet, Glyburide, Invokana, Pre-Diabetes, Actos, Glimepiride, Amaryl, Pioglitazone, Tradjenta, Avandia, Glucophage XR, GlipiZIDE XL, Farxiga, Glucotrol, Jardiance

Intensive Type 2 Diabetes Treatment Can Extend Survival: Study

Posted 8 Sep 2016 by Drugs.com

WEDNESDAY, Sept. 7, 2016 – Intensive management of type 2 diabetes can make a difference in how long and how well you live, even if you don't start until middle age, researchers report. People who were already at risk of type 2 diabetes complications were randomly selected to continue with their normal treatment or to be placed in an aggressive and multipronged treatment group. Two decades after the study began, the researchers found that people in the aggressive treatment group lived almost eight years longer. Not only that, they lived better – their risk of heart disease, kidney disease and blindness all dropped. The only complication that didn't seem to improve was nerve damage caused by diabetes. "Early, intensified intervention in type 2 diabetes patients with microalbuminuria with both target-driven pharmacological (medication) and behavioral actions increased life span. And, ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Victoza, Lantus, Januvia, Glucophage, Novolog, Glipizide, Humalog, Saxenda, Janumet, Glyburide, Byetta, Lantus Solostar, Bydureon, Invokana, Levemir, Actos, Trulicity

Older Drug May Help Type 1 Diabetics' Heart Health

Posted 6 Sep 2016 by Drugs.com

TUESDAY, Sept. 6, 2016 – An inexpensive medication normally given to people with type 2 diabetes may help preserve heart health in people with the less common form of diabetes – type 1, a small new study finds. Metformin is the standard first-line treatment for type 2 diabetes to help bring blood sugar levels down. It also appears to help repair damaged blood cells by increasing the number of blood vessel (vascular) stem cells, researchers said. "We have shown – both in test tube and in patients – the mechanism behind the cardioprotective effects of metformin," said the study's senior author, Dr. Jolanta Weaver. She's a senior lecturer in diabetes medicine at Newcastle University in England. "This is likely to lead to the development of new drugs for heart disease in diabetes," she added. Sanjoy Duttais is assistant vice president of translational development at JDRF, a nonprofit ... Read more

Related support groups: Metformin, Diabetes, Type 1, Glucophage, Janumet, Prevention of Cardiovascular Disease, Glucophage XR, Cardiovascular Risk Reduction, ActoPlus Met, Glumetza, Janumet XR, Glyburide/Metformin, Avandamet, Glucovance, Jentadueto, Metformin/Pioglitazone, Riomet, Fortamet, Kombiglyze XR, Xigduo XR, Synjardy

Diabetes Drug May Help Kids With Autism Fight Unwanted Pounds

Posted 24 Aug 2016 by Drugs.com

WEDNESDAY, Aug. 24, 2016 – The diabetes drug metformin may help overweight children and teens with autism slim down, a new study suggests. The study included 60 people with autism, aged 6 to 17. The patients were overweight due to the side effects of taking antipsychotic medications for irritability and agitation. For the study, participants were given either metformin or an inactive placebo for 16 weeks. Those given metformin had much greater reductions in body mass index (BMI) than those who took the placebo, the findings showed. BMI is an estimate of body fat based on weight and height. "Our results showed that [gastrointestinal] side effects occurred for more days in the metformin group compared to placebo group, but the large majority of children taking metformin were able to maintain their treatment. Importantly, the metformin didn't cause behavioral changes, such as increased ... Read more

Related support groups: Obesity, Metformin, Weight Loss, Glucophage, Autism, Janumet, Asperger Syndrome, Glucophage XR, ActoPlus Met, Glumetza, Janumet XR, Glyburide/Metformin, Jentadueto, Avandamet, Glucovance, Metformin/Pioglitazone, Riomet, Kombiglyze XR, Xigduo XR, Fortamet

Which Diabetes Drug Is Best?

Posted 19 Jul 2016 by Drugs.com

TUESDAY, July 19, 2016 – No single drug to treat type 2 diabetes stands out from the pack when it comes to reducing the risks of heart disease, stroke or premature death, a new research review finds. The analysis of hundreds of clinical trials found no evidence that any one diabetes drug, or drug combination, beats out the others. Researchers said the results bolster current recommendations to first try an older, cheaper drug – metformin (Glumetza, Glucophage) – for most patients with type 2 diabetes. "There are very few things experts agree on, but this is one of them," said Dr. Kevin Pantalone, a diabetes specialist at the Cleveland Clinic and a member of the Endocrine Society. "Metformin, in the absence of contraindications or intolerability, should be the first-line agent to treat patients with type 2 diabetes," he said. Metformin can cause upset stomach and diarrhea, so some ... Read more

Related support groups: Diabetes, Type 2, Metformin, Glucophage, Janumet, Prevention of Cardiovascular Disease, Glucophage XR, Cardiovascular Risk Reduction, ActoPlus Met, Glumetza, Janumet XR, Glyburide/Metformin, Avandamet, Glucovance, Jentadueto, Metformin/Pioglitazone, Riomet, Fortamet, Kombiglyze XR, Xigduo XR, Synjardy

FDA Approves Once-Daily Jentadueto XR (linagliptin and metformin hydrochloride extended-release) for Type 2 Diabetes

Posted 11 Jun 2016 by Drugs.com

Ridgefield, Conn., and Indianapolis, May 31, 2016 – The U.S. Food and Drug Administration (FDA) has approved Jentadueto XR (linagliptin and metformin hydrochloride extended-release) tablets for the treatment of type 2 diabetes (T2D) in adults. Jentadueto XR, which is marketed by Boehringer Ingelheim and Eli Lilly and Company (NYSE: LLY), is the seventh new treatment from the Boehringer Ingelheim-Lilly Diabetes alliance to be approved by the FDA in the last five years. Jentadueto XR combines 2.5 mg or 5 mg of linagliptin with 1000 mg of metformin. Linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, works by increasing hormones that stimulate the pancreas to produce more insulin and the liver to produce less glucose. Metformin, a commonly prescribed initial treatment for T2D, lowers glucose production by the liver and its absorption in the intestine. “Adults with type 2 diabetes are ... Read more

Related support groups: Diabetes, Type 2, Metformin, Diabetes Mellitus, Jentadueto, Linagliptin, Linagliptin/metformin

Intensive Blood Sugar Control May Be Too Much for Some With Type 2 Diabetes

Posted 6 Jun 2016 by Drugs.com

MONDAY, June 6, 2016 – Intensive treatment of blood sugar levels in some people with type 2 diabetes may cause serious complications, new research suggests. "In this study, we found that, particularly among older patients and patients with serious chronic conditions, intensive treatment nearly doubled the risk of severe hypoglycemia requiring medical attention, including hospitalization," said lead author Dr. Rozalina McCoy. She is an endocrinologist at the Mayo Clinic in Rochester, Minn. Hypoglycemia (low blood sugar) is a serious potential complication of diabetes treatment. The researchers said it can worsen quality of life and has been linked with cardiovascular events, dementia and death. The researchers reviewed information from more than 31,500 American adults. All had stable and controlled type 2 diabetes. None was taking insulin. None had a prior history of severe ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Lantus, Dementia, Glucophage, Glipizide, Novolog, Humalog, Hypoglycemia, Janumet, Glyburide, Lantus Solostar, Invokana, Levemir, Actos, Glimepiride, Novolin R, Amaryl, Novolin N

Coffee, Wine Good for Healthy Gut, Sodas May Be Bad

Posted 28 Apr 2016 by Drugs.com

THURSDAY, April 28, 2016 – The food you eat and the medicines you take can alter your gut bacteria in ways that either help or harm your health, two new studies suggest. Foods like fruits, vegetables, coffee, tea, wine, yogurt and buttermilk can increase the diversity of bacteria in a person's intestines. And that diversity can help ward off illness, said Dr. Jingyuan Fu, senior author of one of the studies. "It is believed that higher diversity and richness [in gut bacteria] is beneficial," explained Fu. She is an associate professor of genetics at the University of Groningen in the Netherlands. On the other hand, foods containing loads of simple carbohydrates appear to reduce bacterial diversity in the gut, Fu and colleagues found. These include high-fat whole milk and sugar-sweetened soda. In addition, medications can also play a part in the makeup of your gut bacteria. Antibiotics, ... Read more

Related support groups: Metformin, Smoking, Heart Attack, Smoking Cessation, Caffeine, Glucophage, Fioricet, Excedrin, Janumet, Alert, Myocardial Infarction, Gastroenteritis, Fiorinal, Excedrin Migraine, Cafergot, Glucophage XR, Fiorinal with Codeine, Keep Going, Esgic, Norgesic

Metformin Safer for Heart Than Other Common Type 2 Diabetes Drugs: Study

Posted 18 Apr 2016 by Drugs.com

MONDAY, April 18, 2016 – Metformin, the most frequently prescribed standalone drug for type 2 diabetes, is better for the heart than its closest competitors, a large analysis suggests. Metformin reduced the risk of dying from heart attack and stroke by about 30 percent to 40 percent compared with other commonly used drugs called sulfonylureas, such as glibenclamide, glimepiride, glipizide and tolbutamide, researchers report. "Pharmaceutical companies continue to make new drugs to reduce blood sugar and improve on safety concerns of the older drugs," said senior study author Dr. Shari Bolen. But, "while adults with diabetes often need more than one medication to control blood sugar, the newer medications do not appear to be safer than the older drugs," added Bolen. Metformin is still the safest and most effective type 2 diabetes medication, said Bolen. She is an assistant professor of ... Read more

Related support groups: Diabetes, Type 2, Metformin, Glucophage, Glipizide, Janumet, Glimepiride, Amaryl, Prevention of Cardiovascular Disease, Glucophage XR, Cardiovascular Risk Reduction, GlipiZIDE XL, Glucotrol, ActoPlus Met, Glucotrol XL, Glumetza, Glyburide/Metformin, Janumet XR, Avandamet, Glucovance, Jentadueto

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Linagliptin / metformin Patient Information at Drugs.com