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Elderly With Advanced Colon Cancer Often Get Costly, Dubious Treatments: Study

Posted 10 Mar 2016 by Drugs.com

THURSDAY, March 10, 2016 – Expensive drugs are being given far more often to elderly patients with advanced colon cancer, but they offer almost no benefit, a new study suggests. "This research found that there is a trend for elderly late-stage colorectal cancer patients to receive newer, more expensive drugs," said lead author Cathy Bradley, associate director for population science research at the University of Colorado Cancer Center. "However, in spite of their receiving more drugs, no [significant] survival benefit was observed." In the study, published recently in the journal Medical Care, Bradley and her colleagues analyzed data on more than 16,000 Medicare patients with advanced, or metastatic, colon cancer and 4,000 patients with advanced rectal cancer. (Metastatic means the cancer has spread from the original tumor to other parts of the body.) They discovered that among ... Read more

Related support groups: Cancer, Colorectal Cancer, Avastin, Erbitux, Oxaliplatin, Leucovorin, Vectibix, Eloxatin, Wellcovorin

Cheaper Alternative to Turing's Pricey Daraprim Soon Available

Posted 1 Dec 2015 by Drugs.com

A low-cost alternative to the infection-fighting drug Daraprim will be available to patients as soon as next week. The price of Daraprim rose 5,000 percent after it was acquired by Turing Pharmaceuticals earlier this year. The drug is used to treat a parasitic infection called toxoplasmosis. On Tuesday, Imprimis Pharmaceuticals announced it found a backer to distribute a $1-per-pill alternative to the $750-a-pill Daraprim. The backer is Express Scripts, the largest pharmacy benefits management company in the United States, CNN reported. The active ingredient in Daraprim is pyrimethamine. The new drug is a compound of pyrimethamine and leucovorin. Express Scripts said it will collaborate with medical groups to educate doctors about the new drug, CNN reported. Read more

Related support groups: Toxoplasmosis, Leucovorin, Daraprim, Fansidar, Pyrimethamine/Sulfadoxine, Wellcovorin, Toxoplasmosis - Prophylaxis, Pyrimethamine

FDA Medwatch Alert: Leucovorin Calcium Injection (Bedford Laboratories): Recall - Visible Particulate Matter

Posted 10 Jul 2012 by Drugs.com

  [Posted 07/06/2012] ISSUE: Bedford Laboratories issued a nationwide recall of three lots of Leucovorin Calcium Injection, due to the discovery of visible crystalline particulate matter in a small number of vials. To date, there have been no reports of any adverse events for the lots being recalled. The particulate matter has been identified as active drug substance and not foreign material or contamination. Particulate matter has been recognized as a potential health hazard. Adverse reactions may include vein irritation and phlebitis, clinically occult pulmonary granulomas detected at routine autopsy examination, local tissue infarction, severe pulmonary dysfunction, occlusion of capillaries and arteries, anaphylactic shock and death. See the Press Release for a listing of lot numbers affected. The shipping dates for these recalled lots were between January 2011 and June 2011. ... Read more

Related support groups: Leucovorin, Wellcovorin

Chemo Combo May Help Stave Off Pancreatic Cancer Death

Posted 11 May 2011 by Drugs.com

WEDNESDAY, May 11 – A four-drug chemotherapy regimen for deadly pancreatic cancer nearly doubled patients' survival time compared to standard chemotherapy, a new study suggests. In late-stage trials, French researchers split a group of 342 patients with advanced pancreatic adenocarcinoma, the most common form of the disease, into two groups. Half received gemcitabine, the standard treatment, while the rest received FOLFIRINOX, a four-drug combination of oxaliplatin, irinotecan, leucovorin and fluorouracil. The median survival time improved from 6.8 months for those in the gemcitabine group to 11.1 months in the FOLFIRINOX group, according to the study, which is published in the May 12 issue of the New England Journal of Medicine. Those in the combination group did suffer greater side effects from treatment, however. "We explain to the patients the advantages and toxicities of both ... Read more

Related support groups: Fluorouracil, Pancreatic Cancer, Oxaliplatin, Leucovorin, Irinotecan, Eloxatin, Adrucil, Camptosar, Wellcovorin

FDA Approves Fusilev for Use in Patients with Colorectal Cancer

Posted 2 May 2011 by Drugs.com

IRVINE, Calif.--(BUSINESS WIRE)--Apr 30, 2011 - Spectrum Pharmaceuticals a biotechnology company with fully integrated commercial and drug development operations with a primary focus in oncology, received approval from the U.S. Food and Drug Administration (FDA) on April 29, 2011, for the use of Fusilev (levoleucovorin) in combination with 5-fluorouracil in the palliative treatment of patients with advanced metastatic colorectal cancer. This new, expanded indication supplements the original 2008 FDA approval of Fusilev. "We are pleased that the FDA has approved Fusilev for use in colorectal cancer," said Rajesh C. Shrotriya, MD, Chairman, Chief Executive Officer, and President of Spectrum Pharmaceuticals. "Although the NCCN Guidelines in the United States already recommend levoleucovorin in the treatment of colorectal cancer patients, we could not promote Fusilev for this indication ... Read more

Related support groups: Leucovorin, Fusilev

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Methotrexate Rescue, Folic Acid Antagonist Overdose, Colorectal Cancer, Anemia, Megaloblastic, Methotrexate Overdosage, Toxoplasmosis - Prophylaxis, Toxoplasmosis, Pneumocystis Pneumonia Prophylaxis, Pneumocystis Pneumonia

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