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Lennox-Gastaut Syndrome News

Seizure Control Key to Avoiding Sudden Death With Epilepsy

Posted 25 Apr 2017 by Drugs.com

TUESDAY, April 25, 2017 – In rare cases, seizures that cause convulsions and a loss of consciousness can raise the odds of sudden death in people with epilepsy, neurologists warn. These attacks are known as generalized tonic-clonic seizures, according to a new guideline from the American Academy of Neurology (AAN) and the American Epilepsy Society. Just how rare is sudden death linked to these seizures? According to guideline researchers, these tragedies occur in 1 in 1,000 men and women each year and only 1 in 4,500 children annually. Still, although rare, it's crucial that the possibility of sudden death linked to seizures and risk factors for these events "are communicated to persons and families affected by epilepsy," said guideline author Dr. Cynthia Harden. She's with Mount Sinai Health System in New York City. "Our guideline brings clarity to the discussion, giving health care ... Read more

Related support groups: Klonopin, Seizures, Clonazepam, Ativan, Valium, Topamax, Lorazepam, Epilepsy, Diazepam, Topiramate, Dilantin, Seizure Prevention, Phenobarbital, Diamox, Phenytoin, Zonisamide, Primidone, Zonegran, Acetazolamide, Seizure Prophylaxis

Pot Ingredient Might Ease Severe Epilepsy

Posted 19 Apr 2017 by Drugs.com

TUESDAY, April 18, 2017 – An ingredient in marijuana may reduce seizures in people with a severe form of epilepsy, a new study suggests. The ingredient in question is cannabidiol – a molecule from the marijuana plant that does not create a "high." The drug is being developed by GW Pharmaceuticals, which funded the new study. Researchers used cannabidiol to treat a type of epilepsy known as Lennox-Gastaut syndrome. "The seizures in Lennox-Gastaut syndrome can be very difficult to treat, and the ones that cause falling can be dangerous and occur multiple times in a day," explained an expert in epilepsy treatment, Dr. Derek Chong. He directs the division of epilepsy at Lenox Hill Hospital in New York City. The new study was led by Dr. Anup Patel, of Nationwide Children's Hospital and The Ohio State University College of Medicine in Columbus. His team tested cannabidiol in 225 young ... Read more

Related support groups: Seizures, Smoking, Epilepsy, Smoking Cessation, Seizure Prevention, Cannabis, Seizure Prophylaxis, Lennox-Gastaut Syndrome

'Epilepsy Gene Network' Identified in Brain

Posted 14 Dec 2016 by Drugs.com

WEDNESDAY, Dec. 14, 2016 – Scientists say they have identified a gene network in the brain that's associated with epilepsy. Although the research is in the early stages, the investigators hope their discovery can revive interest in finding new epilepsy treatments. "Identifying groups of genes that work together, and then targeting these networks of genes, may lead to more effective treatments," said study senior author Michael Johnson. He's a professor of medicine at Imperial College London in England. "Our proof-of-concept study suggests this network biology approach could help us identify new medications for epilepsy, and the methods can also be applied to other diseases," Johnson said in a college news release. The newly discovered "epilepsy network" includes 320 genes believed to be involved in how brain cells communicate with one another. When the network malfunctions, it triggers ... Read more

Related support groups: Seizures, Epilepsy, Seizure Prevention, Seizure Prophylaxis, West Syndrome, Diagnosis and Investigation, Status Epilepticus, Lennox-Gastaut Syndrome, Head Imaging

Marijuana Derivative May Curb Tough-to-Treat Epilepsy

Posted 6 Dec 2016 by Drugs.com

TUESDAY, Dec. 6, 2016 – A purified oral version of a marijuana compound may help with treatment-resistant forms of epilepsy, two new clinical trials show. The researchers found that the compound, cannabidiol (CBD), helped reduce seizure frequency in children and adults with two hard-to-treat forms of epilepsy: Dravet syndrome and Lennox-Gastaut syndrome. The drug is still experimental, and doctors stressed that it did not help everyone and is not a "cure." On the other hand, they called the results "very encouraging," given how difficult it is to manage the seizure disorders. "It's always a good day when we have a potential new option to offer these patients," said Dr. Amy Brooks-Kayal, a pediatric neurologist at Children's Hospital Colorado who was not involved in the research. She had another caveat, however: The CBD used in the trials is a "purified, pharmaceutical-grade" pill. ... Read more

Related support groups: Seizures, Epilepsy, Seizure Prevention, Cannabis, Seizure Prophylaxis, Status Epilepticus, Lennox-Gastaut Syndrome

Study Sheds Light on Safety of Driving With Epilepsy

Posted 5 Dec 2016 by Drugs.com

SUNDAY, Dec. 4, 2016 – People with epilepsy who experienced longer seizures during a simulated driving test may face an increased risk for crashes while on the road, a new study suggests. About 75 percent of people with epilepsy use medication to control their seizures and are able to drive. The remainder of patients typically keep a journal of seizures, noting how long they last, and doctors use that information to determine whether patients can drive safely, the study authors explained. The new study included 16 people with epilepsy who used a driving simulator for between one to 10 hours, most for an average of three to four hours. In total, the patients had 20 seizures, seven of which resulted in "crashes." The longer the seizure, the greater the chance of a "crash." Seizures lasted an average of 75 seconds among patients who crashed and 30 seconds among those who didn't crash. The ... Read more

Related support groups: Seizures, Topamax, Epilepsy, Keppra, Tegretol, Topiramate, Dilantin, Qsymia, Seizure Prevention, Carbamazepine, Levetiracetam, Phenytoin, Tegretol XR, Valproic Acid, Epitol, Carbatrol, Seizure Prophylaxis, Keppra XR, Depakene, West Syndrome

Newer Epilepsy Drugs May Be Safer During Pregnancy

Posted 1 Sep 2016 by Drugs.com

THURSDAY, Sept. 1, 2016 – Women who take the new epilepsy drugs levetiracetam and topiramate during pregnancy don't run the risk of harming their infant's mental development, British researchers report. But the commonly prescribed anti-seizure drug valproate was linked with lower IQs in children, especially when taken at higher doses, researchers say. "The treatment of epilepsy in women who are considering a pregnancy or are pregnant involves optimizing the health of the mother as well as keeping the risk to the fetus as low as possible," said lead researcher Rebecca Bromley, a research fellow at the Institute for Human Development at the University of Manchester. In the study, children exposed to levetiracetam (Keppra) or topiramate (Topamax) in the womb did not differ from children not exposed to these drugs. And they had better outcomes than the children exposed to valproate ... Read more

Related support groups: Birth Control, Contraception, Emergency Contraception, Seizures, Topamax, Epilepsy, Keppra, Topiramate, Qsymia, Seizure Prevention, Postcoital Contraception, Levetiracetam, Vitamin/Mineral Supplementation during Pregnancy/Lactation, Keppra XR, Seizure Prophylaxis, West Syndrome, Status Epilepticus, Lennox-Gastaut Syndrome, Trokendi XR, Topamax Sprinkle

Young People With Epilepsy Struggle on Many Fronts

Posted 10 Aug 2016 by Drugs.com

WEDNESDAY, Aug. 10, 2016 – Children and young adults with epilepsy face an array of psychological, physical and social challenges, a new analysis reveals. Australian researchers reviewed 43 studies that included a total of more than 950 children, teens and young adults, and delved into their experiences with the seizure disorder. "Children with epilepsy feel vulnerable from a physical and a social perspective," said study author Deepak Gill. He is a pediatric neurologist who heads the Children's Comprehensive Epilepsy Service at the Children's Hospital of Westmead, in New South Wales. "One theme that came out was the loss of bodily control, and that the person during a seizure can feel physically overpowered, with worry that the seizures would lead to serious injury," Gill added. Those with epilepsy also reported feeling inferior and discriminated against. Some of the comments from the ... Read more

Related support groups: Seizures, Epilepsy, Seizure Prevention, Seizure Prophylaxis, West Syndrome, Status Epilepticus, Lennox-Gastaut Syndrome

Genetic Insights May Help Kids Battling Developmental Delays

Posted 26 May 2016 by Drugs.com

WEDNESDAY, May 25, 2016 – There's new hope for children stricken by mysterious developmental delays, with a new study showing that extensive genetic analysis may help determine the cause of their disability. Canadian researchers found a precise genetic cause for seven out of every 10 children suffering from a previously undiagnosed condition that caused developmental delays. In many cases, the genetic analysis led to groundbreaking discoveries. Researchers discovered 11 new disease genes linked to developmental delays, and described new physical traits and symptoms for a number of known diseases. And based on the new genetic diagnosis, doctors were able to offer targeted treatments in four of 10 cases, said senior researcher Dr. Clara van Karnebeek. She is a pediatrician and biochemical geneticist at BC Children's Hospital and principal investigator with the Center for Molecular ... Read more

Related support groups: Epilepsy, Autism, Vitamin/Mineral Supplementation and Deficiency, Diagnosis and Investigation, Lennox-Gastaut Syndrome

Even Controlled, Epilepsy May Still Cause Problems for Kids

Posted 31 Mar 2016 by Drugs.com

THURSDAY, March 31, 2016 – Even when their seizures are well-controlled, children with epilepsy can still have learning and behavioral disorders that lead to social and educational problems when they're young adults, a new study finds. "Frequency and intensity of seizures remain important predictors of how well a child does into adulthood. But, somewhat to our surprise we also found seizures are by no means the sole influencers of social and educational outcomes among adults with childhood epilepsy," said study lead author Anne Berg. Berg is a scientist with the Ann and Robert H. Lurie Children's Hospital of Chicago, and professor of pediatrics and neurology at Northwestern University Feinberg School of Medicine. The research included 241 children and teens in Connecticut who were diagnosed with uncomplicated epilepsy from 1993 to 1997. They were followed for an average of 12 years. ... Read more

Related support groups: Seizures, Epilepsy, Seizure Prevention, Seizure Prophylaxis, West Syndrome, Status Epilepticus, Lennox-Gastaut Syndrome

MS Patients May Be Prone to Other Chronic Illnesses, Study Finds

Posted 9 Mar 2016 by Drugs.com

WEDNESDAY, March 9, 2016 – People with multiple sclerosis (MS) are more likely to have other chronic health problems than those without the nervous system disorder, a new study indicates. Researchers looked at how common several chronic conditions – high blood pressure, diabetes, high cholesterol, heart disease, chronic lung disease, epilepsy, fibromyalgia, inflammatory bowel disease, depression, anxiety, bipolar disorder and schizophrenia – were in nearly 23,400 people newly diagnosed with MS and more than 116,600 people without MS. The MS patients had higher rates of all the conditions, with high cholesterol being the exception. Their rates of mental illness, particularly depression, were also high. Nineteen percent of MS patients and 9 percent of those without MS had depression, the study found. For many of the chronic conditions, there were significant gender differences. High ... Read more

Related support groups: High Blood Pressure, Diabetes, Type 2, Seizures, Hypertension, Asthma, Chronic Obstructive Pulmonary Disease, Multiple Sclerosis, Heart Disease, Epilepsy, High Cholesterol, Heart Attack, Schizophrenia, Mania, Schizoaffective Disorder, Seizure Prevention, Angina, Diabetic Neuropathy, Upper Respiratory Tract Infection, Insulin Resistance, Diabetic Nerve Damage

Wearable Devices Aim to Monitor Epileptic Seizures

Posted 8 Dec 2015 by Drugs.com

TUESDAY, Dec. 8, 2015 – Wearable devices aimed at tracking seizures in epilepsy patients are being developed, researchers report. Three such devices – a patch, an arm band system and wrist-worn monitors – were reviewed in three separate studies and presented this week at an American Epilepsy Society meeting in Philadelphia. They do not yet have U.S. Food and Drug Administration approval as medical devices for recording seizures. However, their success could be very helpful to neurologists treating patients with epilepsy, said Dr. Clifford Segil, a neurologist at Providence Saint John's Health Center in Santa Monica, Calif. Segil was not involved in the research. "Wearable technology being used by neurologists is not as up-to-date as technology being used by cardiologists in 2015," Segil said. "Seizures are a very diverse group of disorders, which are not easily managed, and work ... Read more

Related support groups: Seizures, Epilepsy, Seizure Prevention, Seizure Prophylaxis, West Syndrome, Diagnosis and Investigation, Status Epilepticus, Lennox-Gastaut Syndrome, Seizure Prophylaxis During or Following Neurosurgery

Marijuana Chemical Shows Promise for Hard-to-Treat Epilepsy in Kids

Posted 7 Dec 2015 by Drugs.com

MONDAY, Dec. 7, 2015 – Evidence is mounting that a marijuana-derived oil might benefit some children with epilepsy whose seizures aren't controlled by approved medications, two new studies show. Cannabidiol (CBD) significantly reduced seizures in as many as half of children with epilepsy, researchers planned to report Monday at the American Epilepsy Society's annual meeting, in Philadelphia. But experts say these positive findings may have been influenced by a "placebo effect." All participants in these studies knew they were taking the oil, which could have affected reports of its effectiveness. "We know that our placebo rates can be as high as 30 percent, and sometimes higher," said Dr. Amy Brooks-Kayal, American Epilepsy Society president, who wasn't involved in the studies. "We don't know the real effect of the cannabidiol, and we won't until we complete the studies that are ... Read more

Related support groups: Seizures, Epilepsy, Seizure Prevention, Cannabis, Seizure Prophylaxis, West Syndrome, Status Epilepticus, Lennox-Gastaut Syndrome

Eisai Receives Approval for Antiepileptic Drug Banzel (rufinamide) As Adjunctive Treatment For Pediatric Patients

Posted 15 Feb 2015 by Drugs.com

Tokyo, Japan – February 16, 2015 – Eisai Co., Ltd. announced today that its U.S. subsidiary Eisai Inc. has received approval of an additional pediatric indication for Eisai’s antiepileptic drug (AED) Banzel (rufinamide) from the U.S. Food and Drug Administration (FDA). Through this approval, Banzel, which had been approved for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in children four years older and adults, is now additionally approved for the same indication in pediatric patients from one to less than four years of age in the United States. The additional indication approval is based on an interim analysis of a Phase III clinical trial (Study 303) in pediatric patients from one to less than four years of age comparing Banzel with other existing AEDs as add-on treatments. The study showed that the pharmacokinetic and safety profiles are c ... Read more

Related support groups: Seizures, Banzel, Lennox-Gastaut Syndrome, Rufinamide

FDA Medwatch Alert: Onfi (clobazam): Drug Safety Communication - Risk of Serious Skin Reactions

Posted 3 Dec 2013 by Drugs.com

ISSUE: FDA is warning the public that the anti-seizure drug Onfi (clobazam) can cause rare but serious skin reactions that can result in permanent harm and death. FDA approved changes to the Onfi drug label and the patient Medication Guide to describe the risk of these serious skin reactions.    These skin reactions, called Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), can occur at any time during Onfi treatment. However, the likelihood of skin reactions is greater during the first 8 weeks of treatment or when Onfi is stopped and then re-started. All cases of SJS and TEN in the FDA case series have resulted in hospitalization, one case resulted in blindness, and one case resulted in death. See the FDA Drug Safety Communication for a Data Summary and additional information. The Onfi drug label has been revised to add information about the risk for serious skin re ... Read more

Related support groups: Onfi, Clobazam, Lennox-Gastaut Syndrome

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Topamax, topiramate, Onfi, Banzel, clobazam, Trokendi XR, Felbatol, Topamax Sprinkle, Qudexy XR, rufinamide, felbamate, Topiragen