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Drug Combo for Irregular Heartbeat Might Raise Bleeding Risk

Posted 18 days ago by Drugs.com

MONDAY, Nov. 21, 2016 – Because the irregular heartbeat known as atrial fibrillation can trigger stroke-inducing clots, many patients are prescribed a blood thinner. But a new Canadian study suggests that combining one blood thinner, Pradaxa, with certain statin medications could raise the odds for bleeding in these patients. "An increase in the risk of bleeding requiring hospital admission or emergency department visits was seen with lovastatin [Mevacor] and simvastatin [Zocor] compared with the other statins," said study author Tony Antoniou, a pharmacist at St. Michael's Hospital in Toronto. His team tracked outcomes for nearly 46,000 patients ages 65 and older. All had atrial fibrillation and took Pradaxa (dabigatran) to reduce their risk of stroke. Those who also took either lovastatin or simvastatin had a 40 percent higher risk of bleeding than those who took other statins, the ... Read more

Related support groups: Bleeding Disorder, Atrial Fibrillation, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Pradaxa, Zocor, Lovastatin, Prevention of Thromboembolism in Atrial Fibrillation, Rosuvastatin, Vytorin, Pravachol, Livalo, Red Yeast Rice, Caduet, Simcor, Lescol, Lescol XL

Are There Alternatives to Statins?

Posted 27 Sep 2016 by Drugs.com

TUESDAY, Sept. 27, 2016 – Statins are the go-to therapy for lowering "bad" LDL cholesterol, but other treatments also can effectively reduce risk of future heart problems, a new evidence review reports. These alternative therapies – including a heart-healthy diet, other cholesterol-lowering medications, and even intestinal bypass surgery – seem to confer the same level of heart health protection as statins when cholesterol levels decrease, according to the findings. Nonstatin therapies reduced the risk of heart problems by 25 percent for each 1 millimole per liter (mmol/L) decrease in LDL cholesterol levels. That's very similar to the 23 percent reduction per 1 mmol/L decrease seen with statins like atorvastatin (Lipitor) and simvastatin (Zocor), the researchers said. What's more, the benefits of these therapies stack up if more than one proves effective at lowering a person's ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Welchol, Zocor, Cholestyramine, Lovastatin, Zetia, Rosuvastatin, Vytorin, Hypertriglyceridemia, High Cholesterol - Familial Heterozygous, Gastric Bypass Surgery, Questran, Pravachol, Livalo, High Cholesterol - Familial Homozygous

Intensive Type 2 Diabetes Treatment Can Extend Survival: Study

Posted 8 Sep 2016 by Drugs.com

WEDNESDAY, Sept. 7, 2016 – Intensive management of type 2 diabetes can make a difference in how long and how well you live, even if you don't start until middle age, researchers report. People who were already at risk of type 2 diabetes complications were randomly selected to continue with their normal treatment or to be placed in an aggressive and multipronged treatment group. Two decades after the study began, the researchers found that people in the aggressive treatment group lived almost eight years longer. Not only that, they lived better – their risk of heart disease, kidney disease and blindness all dropped. The only complication that didn't seem to improve was nerve damage caused by diabetes. "Early, intensified intervention in type 2 diabetes patients with microalbuminuria with both target-driven pharmacological (medication) and behavioral actions increased life span. And, ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Victoza, Lantus, Januvia, Glucophage, Novolog, Glipizide, Humalog, Janumet, Byetta, Glyburide, Saxenda, Bydureon, Lantus Solostar, Invokana, Levemir, Actos, Glimepiride

Just a Little of Statins' Effect Enough to Help Heart: Study

Posted 20 Jun 2016 by Drugs.com

MONDAY, June 20, 2016 – Giving high doses of statins to patients with heart disease doesn't lower the risk of future heart trouble any more than moderate doses of the cholesterol-lowering drugs do, a new study finds. Having heart disease raises the risk of heart attack and stroke, as blood vessels become clogged and cut the normal flow of blood and oxygen to the heart. These patients are typically prescribed statins on a long-term basis, to lower levels of vessel-clogging LDL ("bad") cholesterol. But experts remain conflicted about exactly how low LDL cholesterol levels should go. "Our study demonstrates that physicians treating patients with heart disease and elevated levels of cholesterol with statins have to ensure that patients meet a target of less than 100 mg/dL to prevent future [heart] events," said study author Dr. Morton Leibowitz. He is a senior physician with the Clalit ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Rosuvastatin, Vytorin, Pravachol, Livalo, Prevention of Cardiovascular Disease, Red Yeast Rice, Caduet, Cardiovascular Risk Reduction, Simcor, Lescol, Mevacor, Lescol XL

Intensive Blood Sugar Control May Be Too Much for Some With Type 2 Diabetes

Posted 6 Jun 2016 by Drugs.com

MONDAY, June 6, 2016 – Intensive treatment of blood sugar levels in some people with type 2 diabetes may cause serious complications, new research suggests. "In this study, we found that, particularly among older patients and patients with serious chronic conditions, intensive treatment nearly doubled the risk of severe hypoglycemia requiring medical attention, including hospitalization," said lead author Dr. Rozalina McCoy. She is an endocrinologist at the Mayo Clinic in Rochester, Minn. Hypoglycemia (low blood sugar) is a serious potential complication of diabetes treatment. The researchers said it can worsen quality of life and has been linked with cardiovascular events, dementia and death. The researchers reviewed information from more than 31,500 American adults. All had stable and controlled type 2 diabetes. None was taking insulin. None had a prior history of severe ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Lantus, Dementia, Glucophage, Novolog, Glipizide, Humalog, Hypoglycemia, Janumet, Glyburide, Lantus Solostar, Invokana, Levemir, Actos, Glimepiride, Amaryl, Novolin R, Novolin N

Statins Might Not Lower Colon Cancer Risk: Study

Posted 26 Apr 2016 by Drugs.com

TUESDAY, April 26, 2016 – Long-term use of cholesterol-lowering statins does not appear to reduce the risk of colon cancer, but a person's cholesterol levels might affect risk, a new study suggests. Both statins and cholesterol levels have been linked with lower colon cancer risk, but pinpointing which one is actually responsible has been difficult, the University of Pennsylvania researchers explained. So, they compared statin use and cholesterol levels in more than 22,000 British patients with colon cancer and more than 86,500 without the disease. The results confirmed findings from previous studies that showed a lower risk of colon cancer in people who take statins. But the risk was not significantly different between people who kept taking statins and those who stopped taking the drugs. Instead, the higher the cholesterol level, the lower the colon cancer risk for patients, ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Colonoscopy, Atorvastatin, Pravastatin, Zocor, Colorectal Cancer, Lovastatin, Rosuvastatin, Vytorin, Pravachol, Livalo, Red Yeast Rice, Caduet, Simcor, Lescol, Mevacor, Lescol XL

Cost of Insulin Rises Threefold in Just a Decade: Study

Posted 5 Apr 2016 by Drugs.com

TUESDAY, April 5, 2016 – Americans with diabetes who rely on insulin to keep their blood sugar levels in check are facing sticker shock: A new study finds the price of insulin has tripled in only 10 years. Moreover, since 2010, per-person spending on insulin in the United States was more than spending on all other diabetes drugs, the study found. "The cost of insulin has risen rapidly over the last few years," said study senior author Philip Clarke, a professor of health economics at the University of Melbourne in Australia. Clarke added there should be an assessment to see whether this price hike is justifiable in terms of improved clinical outcomes. One reason for the price climb, he said, is a switch from human insulins to analog insulins, which cost more but may offer additional benefits. Also, doctors are more apt to prescribe insulin for people with type 2 diabetes now, Clarke ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Victoza, Lantus, Diabetes, Type 1, Januvia, Glucophage, Novolog, Diabetic Neuropathy, Glipizide, Humalog, Insulin Resistance, Janumet, Diabetic Nerve Damage, Byetta, Glyburide, Saxenda, Bydureon, Lantus Solostar

Negative News on Statins Tied to Dropped Prescriptions

Posted 2 Dec 2015 by Drugs.com

WEDNESDAY, Dec. 2, 2015 – News reports on the downsides of statins may push some people to stop taking the cholesterol-lowering drugs, a new study hints. The findings, published Dec. 2 in the European Heart Journal, cannot prove that media stories drive statin users to give up their prescriptions. Instead, Danish researchers found a broad correlation between "negative" media coverage and people's odds of quitting a statin within six months of their first prescription. But even without a clear cause-and-effect connection, experts said it's reasonable to assume that media stories had an influence over some statin users in the study. It rings true to Dr. Thomas Whayne Jr., of the Gill Heart Institute at the University of Kentucky. "I've seen this happen a lot," said Whayne, who was not involved in the study. "News stories come out, and you have patients saying, 'I'm not going to take ... Read more

Related support groups: Diabetes, Type 2, Muscle Pain, Heart Disease, High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Zetia, Pre-Diabetes, Rosuvastatin, Vytorin, Hypertriglyceridemia, Pravachol, Livalo, Red Yeast Rice, Cardiovascular Risk Reduction

New Diabetes Cases Among Americans Drop for First Time in Decades: CDC

Posted 1 Dec 2015 by Drugs.com

TUESDAY, Dec. 1, 2015 – In a sign that Americans may finally be turning the corner in the fight against diabetes – and possibly obesity – federal health statistics released Tuesday show that the number of new cases of diabetes has dropped for the first time in decades. The decline wasn't sudden or dramatic. But, the number of new diabetes cases went from 1.7 million in 2009 to 1.4 million in 2014, according to the U.S. Centers for Disease Control and Prevention. "It seems pretty clear that incidence rates have now actually started to drop. Initially it was a little surprising because I had become so used to seeing increases everywhere we looked," CDC researcher Edward Gregg told The New York Times. The proportion of Americans with diabetes is still twice what it was in the early 1990s. And not every racial group has made strides against the blood sugar disease, which is often ... Read more

Related support groups: Diabetes, Type 2, Obesity, Metformin, Insulin, Weight Loss, Victoza, Lantus, Januvia, Glucophage, Novolog, Glipizide, Humalog, Janumet, Byetta, Saxenda, Glyburide, Bydureon, Lantus Solostar, Invokana, Levemir

Too Many Seniors With Diabetes Are Overtreated, Study Suggests

Posted 29 Oct 2015 by Drugs.com

THURSDAY, Oct. 29, 2015 – When it comes to treating seniors with diabetes, new research suggests that doctors often don't cut back on medications, even when treatment goals are surpassed. The study found that when people had potentially dangerous low blood sugar levels, just 27 percent had their medicines decreased. And when blood pressure treatments lowered blood pressure levels too much, just 19 percent saw a reduction in their medications. "As people get older, the risks of overtreating become greater, and the benefits become shorter. We have to start emphasizing that more isn't always better," said study author Dr. Jeremy Sussman, an assistant professor of internal medicine at the University of Michigan in Ann Arbor and a primary care doctor at the Ann Arbor VA System. The findings were published online Oct. 26 in the journal JAMA Internal Medicine. Practice guidelines generally ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Victoza, Lantus, Januvia, Glucophage, Novolog, Glipizide, Humalog, Janumet, Byetta, Glyburide, Saxenda, Bydureon, Lantus Solostar, Invokana, Levemir, Actos, Glimepiride

How to Dispose of Unused or Expired Prescription Drugs

Posted 25 Sep 2015 by Drugs.com

FRIDAY, Sept. 25, 2015 – Many people hold on to extra prescription drugs, but saving old medications is unwise, a pharmacist warns. "Medications that are expired have passed their half-life, which leads to them being ineffective," said Kimberly Cimarelli, pharmacy manager at Penn State Milton S. Hershey Medical Center, in Hershey, Pa. Expired medications can even be dangerous, the U.S. Food and Drug Administration says. Their chemical composition can change and, over time, expired drugs may become less effective or potentially harmful. Getting rid of old, unused medications can also help ensure children don't accidentally get their hands on them. Having fewer medications at home can also help prevent mix-ups, the experts pointed out. "Older people who may be easily confused could take the wrong medication because the unwanted or expired medication wasn't disposed of," Officer Rebecca ... Read more

Related support groups: Oxycodone, Hydrocodone, Methadone, Tramadol, OxyContin, Fentanyl, Morphine, Codeine, Metoprolol, Tylenol, Opana, Ibuprofen, Subutex, Naproxen, Atenolol, Dilaudid, Meloxicam, Acetaminophen, Opana ER, Advil

Tight Control of Type 2 Diabetes May Help Prevent Dementia

Posted 15 Sep 2015 by Drugs.com

TUESDAY, Sept. 15, 2015 – Keeping blood sugar levels in check may have a protective effect against dementia in people who have type 2 diabetes, new Swedish research suggests. "The positive association between [average blood sugar levels] and risk of dementia in fairly young patients with type 2 diabetes indicates a potential for prevention of dementia with improved blood sugar control," study author Dr. Aidin Rawshani, from the National Diabetes Register and Institute of Medicine in Gothenburg, Sweden, and colleagues wrote. However, the study wasn't able to definitively prove a cause-and-effect relationship between blood sugar levels and dementia; it was only able to show an association between these factors. The study included almost 350,000 people with type 2 diabetes. They were all registered in the Swedish National Diabetes Registry between January 2004 and December 2012. They had ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Lantus, Dementia, Glucophage, Alzheimer's Disease, Novolog, Glipizide, Humalog, Janumet, Glyburide, Lantus Solostar, Invokana, Levemir, Actos, Glimepiride, Amaryl, Novolin R, Novolin N

FDA Warns of Joint Pain Tied to Common Type 2 Diabetes Drugs

Posted 31 Aug 2015 by Drugs.com

FRIDAY, Aug. 28, 2015 – Use of a class of widely prescribed medications for type 2 diabetes is tied to severe joint pain in some patients, the U.S. Food and Drug Administration warned on Friday. The drugs – sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta) and alogliptin (Nesina) – come from a newer class of medications called DPP-4 inhibitors. The drugs can be taken alone or used in conjunction with other diabetes drugs, such as metformin. DPP-4 inhibitors help fight type 2 diabetes by boosting the amount of insulin the body produces after each meal, when blood sugar levels are typically high. However, in a statement, the FDA said the medications "may cause joint pain that can be severe and disabling," and the agency "has added a new Warning and Precaution about this risk to the labels of all medicines in this drug class." The FDA stressed that patients who take ... Read more

Related support groups: Diabetes, Type 2, Metformin, Januvia, Glucophage, Janumet, Pre-Diabetes, Onglyza, Tradjenta, Diabetes Mellitus, Glucophage XR, ActoPlus Met, Sitagliptin, Glumetza, Janumet XR, Glyburide/Metformin, Jentadueto, Avandamet, Glyxambi, Glucovance, Metformin/Pioglitazone

FDA Medwatch Alert: DPP-4 Inhibitors for Type 2 Diabetes: Drug Safety Communication - May Cause Severe Joint Pain

Posted 28 Aug 2015 by Drugs.com

ISSUE: The U.S. Food and Drug Administration (FDA) is warning that the type 2 diabetes medicines sitagliptin, saxagliptin, linagliptin, and alogliptin may cause joint pain that can be severe and disabling. FDA has added a new Warning and Precaution about this risk to the labels of all medicines in this drug class, called dipeptidyl peptidase-4 (DPP-4) inhibitors. See the Drug Safety Communication for a complete list of all FDA-approved DPP-4 inhibitors. BACKGROUND: DPP-4 inhibitors are used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. When untreated, type 2 diabetes can lead to serious problems, including blindness, nerve and kidney damage, and heart disease. These medicines are available as single-ingredient products and in combination with other diabetes medicines such as metformin. RECOMMENDATION: Patients should not stop taking their DPP-4 ... Read more

Related support groups: Diabetes, Type 2, Januvia, Janumet, Onglyza, Tradjenta, Sitagliptin, Janumet XR, Jentadueto, Glyxambi, Linagliptin, Oseni, Saxagliptin, Kombiglyze XR, Alogliptin, Nesina, Kazano, Metformin/Sitagliptin, Alogliptin/pioglitazone, Simvastatin/sitagliptin, Linagliptin/metformin

Health Tip: Diabetes Can Take a Toll on Teeth and Mouth

Posted 10 Aug 2015 by Drugs.com

-- Diabetes, especially when uncontrolled, can cause damage to your mouth and teeth. The Mouthhealthy.org website says possible effects of diabetes on the teeth and mouth include: Dry mouth, due to decreased saliva production. Increased risk of cavities due to less saliva. Gingivitis, characterized by bleeding, inflamed gums. Difficulty tasting food. Slower healing of mouth wounds. Increased risk of infection. Among diabetic children. teeth emerging earlier than expected. Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Victoza, Oral and Dental Conditions, Xerostomia, Lantus, Toothache, Diabetes, Type 1, Januvia, Glucophage, Novolog, Burning Mouth Syndrome, Diabetic Neuropathy, Glipizide, Humalog, Insulin Resistance, Janumet, Diabetic Nerve Damage, Aphthous Ulcer

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