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Immunodeficiency News

Nearly 3 Percent of U.S. Adults Have Weakened Immunity: Study

Posted 28 Oct 2016 by Drugs.com

FRIDAY, Oct. 28, 2016 – A new study reports that about 3 percent of people surveyed in the United States have a suppressed, or weakened, immune system. The statistics offer insight into the number of Americans who have immunity-suppressing conditions such as AIDS or take drugs that treat autoimmune disorders by weakening the immune system, the researchers said. The researchers believe these numbers are rising because of medical advances allowing immunosuppressed patients to live longer. Dr. Rafael Harpaz of the U.S. Centers for Disease Control and Prevention led the study. "Tracking immunosuppression over time is particularly important given the hundreds of clinical trials now under way to assess the use of immunosuppressive treatments for prevention or mitigation of common chronic diseases in highly prevalent risk groups," Harpaz and his colleagues wrote. The study authors explained ... Read more

Related support groups: HIV Infection, Autoimmune Disorders, Immunosuppression, Immunodeficiency

Shire Announces FDA Approval of Cuvitru [immune globulin subcutaneous (human)] for Primary Immunodeficiency

Posted 16 Sep 2016 by Drugs.com

Lexington, Mass. – September 14, 2016 – Shire plc (LSE: SHP, NASDAQ: SHPG) announced that the United States Food and Drug Administration (FDA) has granted approval for Cuvitru [Immune Globulin Subcutaneous (Human), 20% Solution] in adult and pediatric patients two years of age and older. Cuvitru is a treatment for patients with primary immunodeficiency (PI), a group of more than 300 genetic disorders in which part of the body’s immune system is missing or functions improperly; it affects up to six million people worldwide. With the approval of Cuvitru, Shire now has the broadest portfolio of intravenous and subcutaneous immunoglobulin (IG) products, including the only once-a-month subcutaneous treatment option. Cuvitru is the only 20% subcutaneous IG treatment option without proline and with the ability to infuse up to 60 mL (12 grams) per site and 60 mL per hour, per site as tolerat ... Read more

Related support groups: Primary Immunodeficiency Syndrome, Immunodeficiency, Immune Globulin Subcutaneous, Cuvitru

Baby's Immune System Might Hint at Autism Risk

Posted 11 May 2016 by Drugs.com

WEDNESDAY, May 11, 2016 – While the origins of autism remain mysterious, new research points to the infant immune system as a potential contributing factor. A team of Swedish and American researchers said levels of certain protein "markers" in newborns' blood seemed to predict which children would go on to develop an autism spectrum disorder. This is "important evidence that the immune system in early life may be a key determinant of later risk of autism spectrum disorders," wrote the team led by Dr. R. M. Gardner of the Karolinska Institute in Stockholm. The researchers examined blood from nearly 900 children who developed some form of autism. The children were born in Sweden between 1998 and 2000. The researchers compared those blood samples to blood from more than 1,100 kids who didn't develop the disorder. While the study can't prove cause-and-effect, babies who went on to develop ... Read more

Related support groups: Autism, Immunosuppression, Asperger Syndrome, Immunodeficiency, Diagnosis and Investigation

Mixing Lab Mice With Pet Store Peers Might Boost Research

Posted 20 Apr 2016 by Drugs.com

WEDNESDAY, April 20, 2016 – Placing pet store mice in the same cages as laboratory mice could help improve mouse-based research into human diseases, a new study suggests. Laboratory mice are used in many areas of medical research, but their immune systems are more similar to the immature immune systems of newborn humans than adult immune systems, according to researchers led by David Masopust at the University of Minnesota. That's because lab mice are kept in abnormally clean environments, the researchers said. When pet store mice were placed in the same cages as lab mice, the immune systems of the lab mice changed to more closely resemble adult human immune systems. Specifically, the lab mice housed with pet store mice had a more than 10,000 times improved immune response to a bacterial infection than typical lab mice, the study found. The findings suggest that exposing lab mice to ... Read more

Related support groups: Diagnosis and Investigation, Immunodeficiency

Gene Therapy May Offer Hope for 'Bubble Boy' Disease

Posted 20 Apr 2016 by Drugs.com

WEDNESDAY, April 20, 2016 – A new gene therapy shows preliminary promise against so-called "Bubble Boy" disease, researchers report. A small, early-stage trial assessed the safety and effectiveness of the gene therapy in five patients with Bubble Boy disease, formally known as severe combined immunodeficiency disease (SCID). Previous bone marrow transplants had failed to correct their immune function. SCID is a severe, inherited disorder that affects males and occurs in 1 in every 50,000 to 100,000 live births. It is caused by a mutation in the IL2RG gene that leaves boys with little or no immune system protection, the researchers said. According to the U.S. National Institute of Allergy and Infectious Diseases, SCID is fatal, often within the first year or two of life, unless infants receive immune-restoring treatments, such as transplants of blood-forming stem cells, gene therapy or ... Read more

Related support groups: Autoimmune Disorders, Immunosuppression, Diagnosis and Investigation, Immunodeficiency

Smog Linked to Organ Rejection, Deaths in Lung Transplant Patients

Posted 29 Sep 2015 by Drugs.com

TUESDAY, Sept. 29, 2015 – Living near busy roads with high levels of air pollution raises lung transplant patients' risk of organ rejection and death, but some antibiotics lower that risk, a new study shows. Researchers examined data gathered from more than 5,700 lung transplant patients in 10 European countries between 1987 and 2013. The analysis revealed that patients who lived in areas where air pollution was above maximum levels recommended by the World Health Organization (WHO) were 10 percent more likely to die than those in areas with lower levels of pollution. But this increased risk of death was not seen among patients who took a class of antibiotics called macrolides, which include azithromycin (Zithromax) and clarithromycin (Biaxin), according to the study presented Tuesday at a meeting of the European Respiratory Society in Amsterdam. "Short and long-term exposure to air ... Read more

Related support groups: Azithromycin, Zithromax, Erythromycin, Clarithromycin, Upper Respiratory Tract Infection, Biaxin, Immunosuppression, Zithromax Z-Pak, MY-E, Organ Transplant - Rejection Prophylaxis, Z-Pak, Erythrocin, Organ Transplant, Respiratory Tract Disease, Ery-Tab, Azithromycin Dose Pack, Immunodeficiency, Respiratory Distress Syndrome, Biaxin XL, Organ Transplant - Rejection Reversal

Deadly Skin Cancer More Common in Organ Transplant Recipients: Study

Posted 17 Aug 2015 by Drugs.com

MONDAY, Aug. 17, 2015 – People who've received organ transplants may face an increased risk for the deadly skin cancer melanoma, a new study suggests. The researchers said the increased risk may stem from the immune system-suppressing drugs that must be taken to prevent rejection of the new organs. The analysis of data from hundreds of thousands of transplant recipients and melanoma patients in the United States showed that transplant recipients were twice as likely to develop melanoma and three times more likely to die of the disease than people who had not undergone a transplant. The researchers also found that transplant recipients were four times more likely to be diagnosed with melanomas that had already spread to other parts of the body. "We knew that melanoma was more likely in transplant recipients, but we thought it might be a function of intensive screening since they are ... Read more

Related support groups: Melanoma, Skin Cancer, Melanoma - Metastatic, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Immunodeficiency, Rejection Prophylaxis

Gene Therapy Shows Potential for 'Bubble Boy' Disease

Posted 9 Oct 2014 by Drugs.com

WEDNESDAY, Oct. 8, 2014 – A new form of gene therapy may offer a safe and effective way to treat "bubble boy" disease – a severe immune deficiency that is fatal unless treated in infancy. Researchers have long known that gene therapy can cure the disease, known medically as severe combined immunodeficiency, or SCID. Over a decade ago, trials in Europe showed that gene therapy worked – but five of the 20 children treated developed leukemia (a type of cancer) within two to five years, according to background information in the study. In the new trial, reported in the Oct. 9 New England Journal of Medicine, researchers refined the gene therapy approach to hopefully negate the leukemia risk. Eight of nine children who received the therapy are still alive one to three years later, the investigators report. And so far, none has developed leukemia. It's too early to say the therapy carries ... Read more

Related support groups: Immunodeficiency

Early Stem Cell Transplant Vital in 'Bubble Boy' Disease

Posted 30 Jul 2014 by Drugs.com

WEDNESDAY, July 30, 2014 – Babies born with so-called "bubble boy" disease can often be cured with a stem cell transplant, regardless of the donor – but early treatment is critical, a new study finds. Severe combined immunodeficiency (SCID), as the condition is medically known, actually refers to a group of rare genetic disorders that all but eliminate the immune system. That leaves children at high risk of severe infections. The term "bubble boy" became popular after a Texas boy with SCID lived in a plastic bubble to ward off infections. The boy, David Vetter, died in 1984 at the age of 12, after an unsuccessful bone marrow transplant – an attempt to give him a functioning immune system. Today, children with SCID have a high chance of survival if they receive an early stem cell transplant, researchers report in the July 31 issue of the New England Journal of Medicine. In the ... Read more

Related support groups: Immunodeficiency

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Immunosuppression, Primary Immunodeficiency Syndrome, Immunoglobulin Deficiency, Chronic Granulomatous Disease, Adenosine Deaminase Deficiency

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