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Hyperlipoproteinemia News

New Drug, Canakinumab, May Fight Heart Disease in Whole New Way

Posted 28 Aug 2017 by Drugs.com

MONDAY, Aug. 28, 2017 – Move over, statins: New research finds that a medication aimed at dampening the body's inflammatory response may be a new tool to curb heart disease. The findings were presented Sunday at the European Society of Cardiology (ESC) Congress in Barcelona, Spain, and published in two major medical journals, The Lancet and the New England Journal of Medicine. The trial focused on a new drug called canakinumab, which lowered by 15 percent the overall rate of heart events such as heart attack, stroke and cardiovascular death in people who'd already had a heart attack. The people in the study also had high levels of a compound called C-reactive protein in their blood – a marker that is indicative of a heightened inflammatory response. For years, heart researchers have wondered if a drug that lowered inflammation might help curb heart disease. Cardiologists had mixed ... Read more

Related support groups: Heart Disease, High Cholesterol, Heart Attack, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Myocardial Infarction, Rosuvastatin, Hypertriglyceridemia, Pravachol, Livalo, Red Yeast Rice, Prevention of Cardiovascular Disease, Cardiovascular Risk Reduction, Thromboembolic Stroke Prophylaxis, Lescol

Powerful New Cholesterol Med Won't Harm Memory, Easing Concerns

Posted 17 Aug 2017 by Drugs.com

WEDNESDAY, Aug. 16, 2017 – Despite some early concerns, a new study suggests the powerful cholesterol drugs known as PCSK9 inhibitors may not cause memory problems or other mental symptoms. The drugs, which include evolocumab (Repatha) and alirocumab (Praluent), were approved in the United States in 2015. That came after trials showed they can dramatically slash LDL cholesterol (the "bad" kind), including in people with a genetic condition that often causes premature heart disease. But early findings also hinted at a potential side effect: cognitive problems such as memory lapses and confusion. The risk was small, though, and it was not clear whether the drugs were actually causing the problems. Enter the new study. It's the first to actually follow PCSK9 patients over time, looking for new memory problems or other cognitive issues, said lead researcher Dr. Robert Giugliano. The study ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Rosuvastatin, High Cholesterol - Familial Heterozygous, Pravachol, Mild Cognitive Impairment, Livalo, Red Yeast Rice, High Cholesterol - Familial Homozygous, Repatha, Praluent, Lescol, Hyperlipoproteinemia, Lescol XL

Less Than Half of U.S. Stroke Patients Get Rx for Statins

Posted 3 Aug 2017 by Drugs.com

WEDNESDAY, Aug. 2, 2017 – Fewer than half of U.S. stroke survivors are prescribed cholesterol-lowering statins, a new study finds. Statins are recommended for patients who have had an ischemic stroke or mini-stroke (transient ischemic attack) to reduce their risk for a repeat stroke or other cardiovascular events, according to the American Heart Association. Ischemic strokes, the most common kind, are caused by blocked blood flow to the brain. But a 10-year analysis of data from 323 ischemic stroke survivors found only 49 percent were prescribed statins when they were discharged from the hospital. The findings were published Aug. 2 in the Journal of the American Heart Association. The research also found that prescribing statins varied by patients' geographic location, gender, age and race. In particular, the researchers looked at the so-called Stroke Belt – the southeastern part of ... Read more

Related support groups: Ischemic Stroke, High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Transient Ischemic Attack, Zocor, Lovastatin, Rosuvastatin, Hypertriglyceridemia, Pravachol, Livalo, Red Yeast Rice, Ischemic Stroke - Prophylaxis, Lescol, Hyperlipoproteinemia, Lescol XL, Mevacor

Stopping Statins After Stroke May Raise Risk of Another

Posted 3 Aug 2017 by Drugs.com

WEDNESDAY, Aug. 2, 2017 – Stroke survivors who stop taking cholesterol-lowering statins are at increased risk for another stroke, a new study finds. Researchers studied more than 45,000 ischemic stroke survivors who were prescribed a statin within 90 days of leaving the hospital. Ischemic stroke is caused by blocked blood flow to the brain. It is the most common type of stroke. Compared to those who continued taking statins, patients who stopped three to six months after their stroke were 42 percent more likely to suffer another stroke within a year, and 37 percent more likely to die from any cause. There was no increased risk of another stroke or of death during the study period among patients who continued taking statins at a lower dose, the investigators found. Statins help prevent cholesterol from building up in the arteries. The study was published Aug. 2 in the Journal of the ... Read more

Related support groups: Ischemic Stroke, High Cholesterol, Transient Ischemic Attack, Ischemic Stroke - Prophylaxis, Hyperlipoproteinemia, Diagnosis and Investigation

Is the 'Anti-Statin' Trend Threatening Lives?

Posted 25 Jul 2017 by Drugs.com

MONDAY, July 24, 2017 – A wave of anti-science skepticism may put people with high cholesterol at risk if they're convinced to quit life-saving statin medications, heart experts warn. An "internet-driven cult" is attacking the safety and effectiveness of cholesterol-lowering statins, despite mounds of clinical trial data showing the drugs work and produce minimal side effects, said Dr. Steven Nissen, chairman of cardiovascular medicine at the Cleveland Clinic. "Unfortunately, we're in an era now where, with the internet, people with fringe views like this can gain the upper hand," Nissen said. "They've been very aggressive promoting to the public the idea that these drugs that are responsible for saving millions of lives are somehow bad for you." Most side effects associated with statins are minor and can be addressed by adjusting the dose or switching to another type of statin, Nissen ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Rosuvastatin, High Cholesterol - Familial Heterozygous, Hypertriglyceridemia, Pravachol, Livalo, Red Yeast Rice, High Cholesterol - Familial Homozygous, Hyperlipoproteinemia Type IIa (Elevated LDL), Lescol, Hyperlipoproteinemia, Lescol XL, Mevacor

New Cholesterol Fighting Meds Target Key Gene

Posted 25 May 2017 by Drugs.com

THURSDAY, May 25, 2017 – New gene-based therapies appear to significantly decrease cholesterol levels in people, and could even cut down on arterial plaque, according to results from two early drug trials. Both treatments improve the body's ability to break down cholesterol by targeting a specific gene that inhibits that function, researchers reported. The angiopoietin-like 3 (ANGPTL3) gene normally restrains proteins involved in the breakdown of cholesterol, said Dr. Frederick Dewey, lead researcher of one of the trials. He is senior director and head of translational genetics at the Regeneron Genetics Center in Tarrytown, N.Y. Two separate research groups say they've successfully reduced cholesterol in humans by using different methods to block ANGPTL3: Evinacumab – an antibody-based therapy developed by Dewey and his team – reduced levels of triglycerides up to 76 percent and ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Rosuvastatin, Hypertriglyceridemia, Pravachol, Livalo, Red Yeast Rice, Lescol, Hyperlipoproteinemia, Lescol XL, Mevacor, Pitavastatin, Baycol, Fluvastatin

Conflicting Statin Guidelines Leave Millions in 'Gray Zone'

Posted 18 Apr 2017 by Drugs.com

TUESDAY, April 18, 2017 – Conflicting guidelines on statin use could leave about 9 million Americans unsure about treatment, a new study suggests. Researchers estimate that if all doctors followed the latest guidelines from the U.S. Preventive Services Task Force (USPSTF) for the cholesterol-lowering drugs, the number of Americans aged 40 to 75 on statin medications would rise by 16 percent. In absolute numbers, that would mean another 17 million statin users. If that sounds like a big jump, consider what would happen if all doctors followed the advice of the American College of Cardiology/American Heart Association: Statin use would climb by 24 percent – for an additional 26 million Americans on the drugs, the study authors estimated. The difference between the two sets of guidelines leaves 9 million Americans in a statin "gray zone." So, which guidelines are "right"? That's not ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Vytorin, Rosuvastatin, High Cholesterol - Familial Heterozygous, Hypertriglyceridemia, Pravachol, Livalo, Red Yeast Rice, High Cholesterol - Familial Homozygous, Caduet, Simcor, Lescol, Hyperlipoproteinemia

Who Really Needs Blood Pressure, Cholesterol Meds?

Posted 6 Apr 2017 by Drugs.com

THURSDAY, April 6, 2017 – High blood pressure and high cholesterol are known risk factors for heart attacks and strokes, but it's unclear who needs medication to help manage these conditions, a new report suggests. According to a new Consumer Reports review, patients should consider these factors when deciding whether to take medications: Weigh your risk. Everyone aged 40 and older should be aware of their 10-year risk for heart attack or stroke. Ideally, it should be less than 7.5 percent. Consumer Reports recommends using a calculator developed by the American College of Cardiology and the American Heart Association to determine your risk. Don't rush to medicate. Some lifestyle changes may be enough to manage slightly elevated blood pressure and cholesterol levels. Exercise alone can significantly improve blood pressure, the review noted. Get the right drug. If your doctor ... Read more

Related support groups: High Blood Pressure, Hypertension, Ischemic Stroke, Heart Attack, Transient Ischemic Attack, Myocardial Infarction, Ischemic Stroke - Prophylaxis, Hypertensive Emergency, Hyperlipoproteinemia, Myocardial Infarction - Prophylaxis, Hypertensive Heart Disease

Keys to Heart Disease Care: Communication and Trust

Posted 4 Apr 2017 by Drugs.com

MONDAY, April 3, 2017 – People with heart disease may fare better when they feel they can trust and talk to their doctor, two new studies suggest. In one study, researchers found that heart patients who thought their doctors were good communicators were more likely to take aspirin and cholesterol-lowering drugs. They were also less likely to land in the ER. In the other study, patients were more apt to take their blood pressure medication if they generally trusted the medical profession. It's no secret that communication and trust are important in any doctor-patient relationship, according to Dr. Victor Okunrintemi, the lead researcher on the communication study. What's not clear is how those things affect heart patients' health, said Okunrintemi, who is based at Baptist Health South Florida in Miami. The new findings, he said, don't prove that doctors can keep their patients out of ... Read more

Related support groups: Aspirin, High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Excedrin, Zocor, Lovastatin, Aggrenox, Rosuvastatin, Alka-Seltzer, Fiorinal, Excedrin Migraine, Arthritis Pain, Pravachol, Livalo, Red Yeast Rice, Prevention of Cardiovascular Disease

What You Need to Know About Cholesterol

Posted 28 Mar 2017 by Drugs.com

MONDAY, March 27, 2017 – Cholesterol plays a vital role in your health, so it's important to understand the different types of cholesterol and how to influence their levels, a heart specialist says. "Good cholesterol – high-density lipoprotein [HDL] – recycles cholesterol and fat in the body," said Dr. Alex Garton. He's a noninvasive cardiologist from PinnacleHealth CardioVascular Institute, based in central Pennsylvania. "What we call bad cholesterol, low-density lipoprotein [LDL], is 'bad' because any leftover LDL is deposited into the blood vessels, increasing the risk of vascular disease. HDL can help prevent this by 'recycling' excess amounts of bad cholesterol," Garton explained in an institute news release. Total cholesterol can be deceiving, so it's important to know the levels of both your bad cholesterol and good cholesterol. LDL levels should generally be kept below 130 ... Read more

Related support groups: High Blood Pressure, Hypertension, Smoking, High Cholesterol, Smoking Cessation, Prevention of Cardiovascular Disease, Cardiovascular Risk Reduction, Hyperlipoproteinemia

Guidelines May Miss Need for Statins in Many U.S. Blacks

Posted 19 Mar 2017 by Drugs.com

SATURDAY, March 18, 2017 – U.S. medical organizations have conflicting guidelines on the use of cholesterol-lowering statin drugs in blacks, a new study finds. Researchers say that about one in four black Americans who are recommended to take a statin under guidelines from the American College of Cardiology/American Heart Association would no longer qualify for such therapy under new guidelines from the U.S. Preventive Services Task Force (USPSTF). The USPSTF is an influential government-appointed group whose decisions often influence health care, including insurance coverage. The new study was led by Dr. Venkatesh Murthy of the University of Michigan, in Ann Arbor. His team noted that while many studies have used artery scans to assess the need for statins by white patients, no such studies have focused on black patients. However, compared with whites, black Americans are at higher ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Vytorin, Rosuvastatin, Hypertriglyceridemia, Pravachol, Livalo, Red Yeast Rice, Simcor, Lescol, Hyperlipoproteinemia, Lescol XL, Mevacor, Baycol

New Cholesterol Drugs May Beat Statins, But Price Tag Is High

Posted 17 Mar 2017 by Drugs.com

FRIDAY, March 17, 2017 – Two different injectable drugs can lower cholesterol levels even further than statins do, potentially warding off future heart attacks or strokes, new research suggests. However, some heart experts question whether the pricey medications, one of which costs roughly $14,000 a year to take, perform well enough to make them worth the extra money. In fact, some cardiologists said the drugs should be reserved only for patients with the highest heart risks. The drugs, evolocumab (Repatha) and inclisiran, both work by targeting PCSK9, an enzyme that regulates the liver's ability to remove "bad" LDL cholesterol from the bloodstream. By blocking the enzyme, the medications spur the body to screen out more cholesterol. Clinical trial results showed that evolocumab was linked to a 15 percent reduction in the risk of major heart events in patients who are already taking ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Rosuvastatin, Hypertriglyceridemia, Pravachol, Livalo, Red Yeast Rice, Repatha, Praluent, Lescol, Hyperlipoproteinemia, Lescol XL, Mevacor, Alirocumab

Too Much Screen Time May Raise Kids' Diabetes Risk

Posted 14 Mar 2017 by Drugs.com

TUESDAY, March 14, 2017 – Kids who get too much screen time may be more likely to have risk factors that increase their chances of type 2 diabetes, new research says. Watching television, playing video games or sitting in front of a computer or other device for more than three hours each day was linked to more body fat and insulin resistance. Those factors mean the body is less able to keep blood sugar levels under control, the British researchers said. They said limiting children's screen time could be necessary to prevent health issues later on. "Our findings suggest that reducing screen time may be beneficial in reducing type 2 diabetes risk factors, in both boys and girls and in different ethnic groups from an early age," wrote the study authors, led by Claire Nightingale, from St. George's University of London. "This is particularly relevant, given rising levels of type 2 ... Read more

Related support groups: Diabetes, Type 2, High Cholesterol, Insulin Resistance, Pre-Diabetes, Hypertriglyceridemia, Diabetes Mellitus, Hyperlipoproteinemia, Abnormal Glucose Tolerance, Intravenous Insulin Drip

1 in 7 Obese People Has Normal Blood Pressure, Cholesterol

Posted 9 Mar 2017 by Drugs.com

THURSDAY, March 9, 2017 – Can people really be healthy and obese? In one of the largest studies to date, researchers quantified the number of U.S. adults who are overweight or obese but don't have typical risk factors for heart disease and diabetes. Of 1.3 million overweight and obese people studied, 14 percent had normal blood sugar, cholesterol and blood pressure readings, the study found. Doctors use these "cardiometabolic" measures to help identify people at greater risk of having a heart attack or stroke or developing type 2 diabetes. But calling these people "healthy obese" is a misnomer, said lead author Gregory Nichols. "Just because they don't currently have risk factors doesn't mean they're not going to," said Nichols, a senior investigator at the Kaiser Permanente Center for Health Research in Portland, Ore. The study suggests that might be true: Less than 2.8 percent of ... Read more

Related support groups: High Blood Pressure, Obesity, Hypertension, High Cholesterol, Insulin Resistance, Pre-Diabetes, Hypertriglyceridemia, Diabetes Mellitus, Hyperlipoproteinemia, Abnormal Glucose Tolerance, Hypertensive Heart Disease

Cholesterol's Impact on Heart Attack Risk May Change With Age

Posted 8 Mar 2017 by Drugs.com

WEDNESDAY, March 8, 2017 – Cholesterol's impact on heart attack may differ by age, new research suggests. The study found that younger heart attack patients are much more likely to have significantly low levels of HDL ("good") cholesterol, rather than high levels of LDL ("bad") cholesterol. The findings might help doctors pinpoint which of their younger patients are in need of cholesterol-lowering therapies, the researchers said. "We . . . want to look at prescribing patterns for statins in younger patients who are at increased risk for heart disease," said study lead author Bradley Collins, a fourth-year student at Harvard Medical School. "Ultimately, we would like to develop new tools for calculating heart attack risk that are more applicable to younger people," Collins said in a news release from the American College of Cardiology (ACC). Most people who get their cholesterol checked ... Read more

Related support groups: Obesity, Weight Loss, High Cholesterol, Heart Attack, Myocardial Infarction, Hypertriglyceridemia, Hyperlipoproteinemia, Myocardial Infarction - Prophylaxis

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Hyperlipoproteinemia Type IIa (Elevated LDL), Hyperlipoproteinemia Type IIb (Elevated LDL + VLDL), Hyperlipoproteinemia Type IV (Elevated VLDL), Hyperlipoproteinemia Type V (Elevated Chylomicrons + VLDL), Hyperlipoproteinemia Type III (Elevated beta-VLDL + IDL), High Cholesterol

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