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Study Suggests Causes for Lupus' Impact on Immune System

Posted 8 Mar 2016 by Drugs.com

TUESDAY, March 8, 2016 – Scientists have found new clues that help explain what's going wrong in the immune systems of people with lupus – insight they hope will lead to new therapies, or help guide current treatment choices. Lupus has several forms, but the most common is systemic lupus erythematosus (SLE). In SLE, the immune system mistakenly produces antibodies against the body's own tissue. The onslaught can have widespread effects, damaging the skin, joints, heart, lungs, kidneys and brain, according to the Lupus Foundation of America. The disease mostly strikes women, usually starting in their 20s or 30s, the foundation says. In the new study, the researchers found evidence that in people with lupus, some of the immune system's "B cells" mature the wrong way – so that they promote inflammation instead of fighting it. The findings, published online March 8 in the journal ... Read more

Related support groups: Systemic Lupus Erythematosus, Plaquenil, Hydroxychloroquine, Rituxan, Prograf, Rituximab, Tacrolimus, Lupus Erythematosus, Cytoxan, Protopic, Cyclophosphamide, Envarsus XR, Quineprox, Astagraf XL, Neosar, Plaquenil Sulfate, Hecoria, Cytoxan Lyophilized

Ebola Linked to Rise in Malaria Deaths in Guinea

Posted 24 Jun 2015 by Drugs.com

WEDNESDAY, June 24, 2015 – The Ebola epidemic in West Africa appears to have led to an increase in malaria deaths last year, a new study finds. Research in Guinea, one of the countries hardest hit by the Ebola epidemic, indicates an extra 74,000 cases of malaria went untreated in 2014, compared to previous years. As a result, deaths associated with malaria (a mosquito-borne disease) also rose and will likely exceed Ebola deaths in Guinea, researchers reported June 23 in The Lancet Infectious Diseases. "One problem is that the early symptoms of malaria [fever, headache and body aches] mimic those of Ebola virus disease," said study author Dr. Mateusz Plucinski, from the U.S. Centers for Disease Control and Prevention. "Malaria is one of the main causes of fever and health facilities visits in Guinea, but our data suggest that since the start of the Ebola epidemic, people with fevers ... Read more

Related support groups: Doxycycline, Plaquenil, Hydroxychloroquine, Malaria, Quinine, Doryx, Malarone, Malaria Prevention, Oracea, Monodox, Chloroquine, Mefloquine, Doxy Lemmon, Lariam, Vibramycin, Adoxa, Malaria Prophylaxis, Doxy 100, Qualaquin, Artemether/Lumefantrine

Gene Discoveries Could Help Rheumatoid Arthritis Treatment

Posted 28 Apr 2015 by Drugs.com

TUESDAY, April 28, 2015 – Genetic variations may hold clues to rheumatoid arthritis – suggesting not only who will develop the painful condition, but also predicting its severity and even who might die from it, a new study says. "Genetic factors predisposing to disease, to disease severity, and response to treatment will allow tailoring treatment to individual patients' needs," said lead researcher Dr. Sebastien Viatte, a research fellow at the University of Manchester in England. Using data from several sources on thousands of patients in the United Kingdom, researchers found that gene mutations at a location on a chromosome called HLA-DRBl were associated with rheumatoid arthritis severity and the response to treatment with tumor necrosis factor (TNF) inhibitor drugs. This study, Viatte said, is a potentially important first step toward personalized medicine for patients with the ... Read more

Related support groups: Rheumatoid Arthritis, Methotrexate, Humira, Enbrel, Remicade, Plaquenil, Hydroxychloroquine, Rituxan, Otezla, Imuran, Orencia, Rituximab, Cimzia, Simponi, Leflunomide, Arava, Juvenile Rheumatoid Arthritis, Azathioprine, Xeljanz, Infliximab

Some Arthritis Meds Cost Seniors Thousands Annually

Posted 21 Apr 2015 by Drugs.com

TUESDAY, April 21, 2015 – Arthritis medications known as biologic disease-modifying drugs can cost Medicare patients more than $2,700 in co-payments a year, a new report finds. Researchers say the tab is an immense burden on patients with disabling conditions such as rheumatoid arthritis, a chronic disorder that affects an estimated 1.3 million Americans. Biologic anti-rheumatic medications – which include drugs such as adalimumab (Humira), anakinra (Kineret) and etanercept (Enbrel) – have allowed patients to gain better control of rheumatoid arthritis when taken early in the course of disease, the researchers explained. But some of the new drugs top $20,000 annually, according to the April 21 online report in the journal Arthritis & Rheumatology. "Many patients face a growing and unacceptable financial burden for access to treatment," said study lead author Dr. Jinoos Yazdany of the ... Read more

Related support groups: Rheumatoid Arthritis, Methotrexate, Humira, Enbrel, Remicade, Plaquenil, Hydroxychloroquine, Rituxan, Otezla, Imuran, Rituximab, Orencia, Leflunomide, Arava, Azathioprine, Xeljanz, Infliximab, Adalimumab, Etanercept, Apremilast

Expensive or Not, Rheumatoid Arthritis Drugs Have Similar Effect: Study

Posted 1 Jul 2013 by Drugs.com

MONDAY, July 1 – Treatment with a pricey biological drug was no better than cheaper, conventional therapy in terms of reducing time off from work for people with rheumatoid arthritis, a new study finds. Swedish researchers assessed lost work days among rheumatoid arthritis patients who had not responded to initial treatment with a standard medication, methotrexate. The group of 204 patients were randomly given either the biological drug infliximab (Remicade) or conventional combination therapy with the non-biologics sulfasalazine plus hydroxychloroquine. At the start of the study, the average amount of lost work time was 17 days per month for all patients. During the 21-month study, the patients receiving conventional therapy lost about six fewer days of work per month, compared with about five fewer days for those taking Remicade – not a significant difference. Regardless of the ... Read more

Related support groups: Rheumatoid Arthritis, Methotrexate, Remicade, Plaquenil, Hydroxychloroquine, Sulfasalazine, Infliximab, Azulfidine, Sulfazine, Trexall, Methotrexate LPF Sodium, Plaquenil Sulfate, Folex PFS, Quineprox, Rheumatrex Dose Pack, Azulfidine EN-tabs

Standard Rheumatoid Arthritis Therapy as Good as Costlier Newcomer: Study

Posted 12 Jun 2013 by Drugs.com

TUESDAY, June 11 – Newer, costlier treatment for rheumatoid arthritis appears no better than an older, less-expensive regimen for people who don't respond to the first-line drug methotrexate, a new study suggests. "Newer isn't always better," said researcher Dr. Ted Mikuls, an associate professor in the rheumatology division at the University of Nebraska Medical Center, in Omaha. "Some of the older medications can be effective." Rheumatoid arthritis causes inflammation in the joints, resulting in swelling, stiffness, pain and reduced joint function. It can also affect other parts of the body. "We compared two different ways of treating rheumatoid arthritis – one that included a new biologic [medication] with an older, more conventional oral medication," Mikuls explained. "We basically showed that at the end of the day patients, regardless of what they got, looked very similar in terms ... Read more

Related support groups: Rheumatoid Arthritis, Methotrexate, Enbrel, Plaquenil, Hydroxychloroquine, Sulfasalazine, Azulfidine, Etanercept, Sulfazine, Trexall, Methotrexate LPF Sodium, Folex PFS, Quineprox, Plaquenil Sulfate, Rheumatrex Dose Pack, Azulfidine EN-tabs

Strides Made in Diagnosing, Treating Lupus

Posted 10 May 2012 by Drugs.com

THURSDAY, May 10 – Sometimes it takes years for people to get diagnosed with lupus. That wasn't the case for Marisa Zeppieri-Caruana, who had so many of the classic systemic lupus erythematosus symptoms – such as a butterfly-shaped rash on her face, a daily fever and achy joints – that her doctor knew right away that the 23-year-old had the illness. Since then, Zeppieri-Caruana, now 34, has been hospitalized 30 times and has had four mini-strokes along with numerous other problems related to her lupus. Most people who have lupus go through periods where they have active disease (flares) and periods where they don't have any symptoms (remission). Unfortunately, Zeppieri-Caruana said she's never had a time where she's been totally in remission. "An average day for me includes fatigue and fever. It's really hard to try to put weight on, and I usually don't feel like doing anything. I ... Read more

Related support groups: Prednisone, Aspirin, Systemic Lupus Erythematosus, Methylprednisolone, Prednisolone, Plaquenil, Hydrocortisone, Medrol, Cortisone, Dexamethasone, Triamcinolone, Hydroxychloroquine, Betamethasone, Budesonide, Decadron, Lupus Erythematosus, Entocort, Solu-Medrol, Ecotrin, Entocort EC

New Guidelines Issued for Severe Lupus

Posted 3 May 2012 by Drugs.com

THURSDAY, May 3 – When diagnosed with lupus, one in three people already has kidney inflammation, and during the first 10 years with the disease as many as 60 percent of patients will have some kidney problems. Because kidney inflammation (also called lupus nephritis) is so common in people with lupus, the American College of Rheumatology has issued new guidelines for the screening and management of this potentially devastating complication of lupus. "Without treatment, lupus nephritis can lead to end-stage-renal disease, which requires dialysis or a kidney transplant. But, not all types are this serious. It depends on the pattern of damage to the kidneys," said the lead author of the new guidelines, Dr. Bevra Hahn, a professor of medicine and chief of rheumatology at the David Geffen School of Medicine at the University of California, Los Angeles. Hahn said the course of lupus ... Read more

Related support groups: Prednisone, Lisinopril, Losartan, Systemic Lupus Erythematosus, Benicar, Methylprednisolone, Diovan, Prednisolone, Plaquenil, Hydrocortisone, Medrol, Ramipril, Cortisone, Dexamethasone, Triamcinolone, Cozaar, Micardis, Hydroxychloroquine, Enalapril, Valsartan

As Venus Williams Bows Out of U.S. Open, Little-Known Disease Takes Center Court

Posted 1 Sep 2011 by Drugs.com

THURSDAY, Sept. 1 – Venus Williams' surprising withdrawal from the U.S. Open on Wednesday has shifted the spotlight from the tennis star's daunting serve to her diagnosis with a little-known disease known as Sjogren's syndrome. Williams, 31, said the disease has diminished her energy level and caused joint pain, curtailing her ability to continue in the tournament. More than 4 million Americans have the chronic autoimmune disease, which also causes dry mouth and dry eyes. Ninety percent of those with the disease are women. Sjogren's syndrome "targets and destroys over time the exocrine glands responsible for tear production and saliva – and is characterized by dryness of the mouth and eyes," said Dr. Michael Belmont, an associate professor of medicine in the division of rheumatology at NYU Langone Medical Center and medical director for Hospital for Joint Diseases. Less commonly, it ... Read more

Related support groups: Methotrexate, Plaquenil, Hydroxychloroquine, Sjogren's Syndrome, Trexall, Methotrexate LPF Sodium, Plaquenil Sulfate, Rheumatrex Dose Pack, Folex PFS, Quineprox

Some Drugs for Rheumatoid Arthritis, Psoriasis May Cut Diabetes Risk

Posted 22 Jun 2011 by Drugs.com

TUESDAY, June 21 – Some medications commonly used to treat rheumatoid arthritis and psoriasis may help patients with these autoimmune disorders lower their risk of developing diabetes, researchers say. New research found that a particular class of disease-modifying antirheumatic drugs (DMARDs) known as tumor necrosis factor (TNF) inhibitors and the antimalarial drug hydroxychloroquine can reduce diabetes risk by 38 percent and 46 percent, respectively, in people with rheumatoid arthritis or psoriasis. "If you have rheumatoid arthritis or psoriasis, you may be at an increased risk of diabetes, and a number of different antirheumatic drugs may reduce your future risk of diabetes," said study author Dr. Daniel Solomon, chief of clinical science in rheumatology at Brigham and Women's Hospital in Boston. However, Solomon was quick to point out that this was an observational study, and does ... Read more

Related support groups: Humira, Enbrel, Remicade, Plaquenil, Hydroxychloroquine, Infliximab, Adalimumab, Etanercept, Plaquenil Sulfate, Quineprox

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Rheumatoid Arthritis, Systemic Lupus Erythematosus, Sjogren's Syndrome, Undifferentiated Connective Tissue Disease, Lyme Disease - Arthritis, Dermatomyositis, Malaria, Malaria Prevention, Malaria Prophylaxis

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