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Related terms: Acquired Immune Deficiency Syndrome, Acquired Immunodeficiency Syndrome (AIDS), Acute HIV Infection, Acute Retroviral Syndrome, AIDS, AIDS-Related Complex, Chronic Symptomatic HIV Infection, HIV Infection, Acute, HIV Seroconversion Syndrome, Human Immunodeficiency Virus Infection, Primary HIV Infection, HIV, ARC, Acquired Immunodeficiency Syndrome, HIV/AIDS

Merck Receives FDA Approval for Isentress (raltegravir), in Combination with Other Antiretroviral Agents, for the Treatment of HIV-1 Infection in Newborns Weighing at Least 2 kg

Posted 4 days ago by Drugs.com

KENILWORTH, N.J. November 29, 2017 – Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration (FDA) has approved Isentress (raltegravir), the company’s integrase inhibitor, for use in combination with other antiretroviral agents, for the treatment of HIV-1 in neonates – newborn patients from birth to four weeks of age – weighing at least 2 kg. The FDA approval for the use of Isentress in the treatment of HIV-1 in neonates is supported by results from an open-label, multicenter clinical study, IMPAACT P1110, evaluating the safety and pharmacokinetics of Isentress for oral suspension in 42 full-term HIV-1 exposed newborns at high risk for acquiring HIV-1 infection from their mothers. “Because clinical research on the use of antiretroviral drugs to treat newborns with HIV-1 infection has been limited, few antiretro ... Read more

Related support groups: HIV Infection, Raltegravir, Isentress

Lung Cancer Drug Targets 'Hidden' HIV in French Patient

Posted 14 days ago by Drugs.com

FRIDAY, Dec. 1, 2017 – In a case that investigators say is a first, a lung cancer drug unmasked and then attacked the kind of HIV-infected cells that standard antiretroviral therapy has been unable to touch. The finding was reported on Dec. 1, which is also World AIDS Day, in the Annals of Oncology. While one AIDS expert said the findings were promising, she noted the drug did not "cure" the patient of HIV. The potential breakthrough centers on the experience of a single 51-year-old French man, who has been receiving treatment in Paris for advanced-stage non-small cell lung cancer for the past year. The patient – who is also HIV-positive – had undergone both surgery and chemotherapy for tumors that had initially been diagnosed in 2015, before he experienced a relapse in 2016. So, French clinicians gave him the cancer treatment nivolumab (Opdivo). The drug is commonly used for ... Read more

Related support groups: HIV Infection, Lung Cancer, Non-Small Cell Lung Cancer, Opdivo, Nivolumab

HIV Is Gaining Resistance to Lifesaving Drugs

Posted 14 days ago by Drugs.com

FRIDAY, Dec. 1, 2017 – A new study warns of a potential return to the "bad old days" when there were no effective drugs to fight HIV, the virus that causes AIDS. Timed for release on Dec. 1, World AIDS Day, the new study looked at data on more than 56,000 adults living with HIV in sub-Saharan Africa, Asia and Latin America. In total, patients in 63 low- and middle-income countries were screened, and all began or restarted treatment with antiretroviral drugs between 1996 and 2016. The study found that the virus is gaining resistance to the lifesaving medicines. Resistance to the drugs increased between 2001 and 2016 and is approaching and exceeding 10 percent of people tested. Drug resistance was increasing fastest in countries in Eastern and Southern Africa. If the trend continues, the researchers warned, even a resistance rate of 10 percent or more would mean 890,000 more deaths from ... Read more

Related support groups: HIV Infection, Pre-Exposure Prophylaxis, Truvada, Baraclude, Viread, Tenofovir, Hepsera, Abacavir, Entecavir, Lamivudine, Stavudine, Viramune, Sustiva, Zidovudine, Epivir, Ziagen, Edurant, Nevirapine, Viramune XR, Intelence

U.S.-Funded HIV Prevention Effort Reaps Rewards in Uganda

Posted 15 days ago by Drugs.com

THURSDAY, Nov. 30, 2017 – A program that includes male circumcision and antiviral drug treatment led to a sharp drop in HIV infection rates in a high-risk region of Uganda, researchers report. Their study of a U.S.-funded HIV prevention program in the rural Rakai District on the shore of Lake Victoria followed 34,000 people. The program provides a number of free services, including anti-HIV drugs for people who are infected, voluntary male circumcision, condoms and promotion of safe sex. While it's known that such measures reduce HIV risk at an individual level, their long-term population-wide impact has been less clear. The study, by Johns Hopkins researchers, found a 42 percent drop in new HIV infections in the Rakai District between the start of the program in the early 2000s and 2016. The decrease was greater among men (50 percent) than among women (30 percent). "This difference ... Read more

Related support groups: HIV Infection, Sexually Transmitted Diseases, Pre-Exposure Prophylaxis, Incivek, Truvada, Victrelis, Baraclude, Viread, Norvir, Prezista, Kaletra, Telaprevir, Tenofovir, Ritonavir, Boceprevir, Hepsera, Abacavir, Entecavir, Lamivudine, Atazanavir

HIV Diagnoses Occurring More Quickly, CDC Says

Posted 17 days ago by Drugs.com

TUESDAY, Nov. 28, 2017 – U.S. health care providers are getting better at detecting new cases of HIV infection, although it still can take years for people to know they've acquired the dreaded virus, federal officials reported Tuesday. The average time between HIV infection and diagnosis was three years in 2015, seven months earlier than it had been in 2011, according to researchers from the U.S. Centers for Disease Control and Prevention. A seven-month improvement in four years is a considerable decrease and shows that the United States is on the right track, the CDC said. "Overall, it reveals that we as a nation are making great progress in HIV prevention," Dr. Brenda Fitzgerald, the CDC director, said during a news briefing on the newly released data. "These findings are more encouraging signs that the tide continues to turn on our nation's HIV epidemic," she said earlier in a ... Read more

Related support groups: HIV Infection, Pre-Exposure Prophylaxis, Truvada

Pot May Alter Brain Function of Some With HIV

Posted 18 days ago by Drugs.com

MONDAY, Nov. 27, 2017 – Using marijuana when you have HIV could lead to problems with brain function if you also abuse alcohol or drugs, a new study finds. "People with HIV infection have many reasons to have cognitive dysfunction, from the virus itself to medications for HIV infection and related conditions, particularly as they age," said lead researcher Richard Saitz. He's a professor and chair of community health sciences at Boston University School of Public Health. "They also have symptoms like chronic pain and mental health symptoms, and use of marijuana, medically or recreationally, may seem like an option to consider," Saitz said in a university news release. "But at least among people with substance use disorders, it appears to have detrimental effects on cognitive function." Little research has been done on the combined effects that alcohol and marijuana have on the brain ... Read more

Related support groups: Smoking, Smoking Cessation, HIV Infection, Pre-Exposure Prophylaxis, Substance Abuse, Cannabis, Toxic Reactions Incl Drug and Substance Abuse

FDA Approves Juluca (dolutegravir and rilpivirine) for the Maintenance Treatment of Virologically Suppressed HIV-1 Infection

Posted 22 Nov 2017 by Drugs.com

November 21, 2017 – The U.S. Food and Drug Administration today approved Juluca, the first complete treatment regimen containing only two drugs to treat certain adults with human immunodeficiency virus type 1 (HIV-1) instead of three or more drugs included in standard HIV treatment. Juluca is a fixed-dose tablet containing two previously approved drugs (dolutegravir and rilpivirine) to treat adults with HIV-1 infections whose virus is currently suppressed on a stable regimen for at least six months, with no history of treatment failure and no known substitutions associated with resistance to the individual components of Juluca. “Limiting the number of drugs in any HIV treatment regimen can help reduce toxicity for patients,” said Debra Birnkrant, M.D., director of the Division of Antiviral Products in the FDA’s Center for Drug Evaluation and Research. HIV weakens a person’s immune sys ... Read more

Related support groups: HIV Infection, Tivicay, Dolutegravir, Edurant, Dolutegravir/rilpivirine, Juluca, Rilpivirine

Almost 21 Million Worldwide Now Have Access to HIV Meds

Posted 21 Nov 2017 by Drugs.com

TUESDAY, Nov. 21, 2017 – The number of people with HIV who take life-saving antiretroviral medications has increased by tens of millions worldwide in recent decades, a United Nations report says. The number rose from 685,000 in 2000 to 20.9 million as of June 2017, according to UNAIDS, the Joint United Nations Program on HIV and AIDS. "Many people do not remember that in 2000 there were only 90 people in South Africa on treatment," Michel Sidibe, executive director of UNAIDS, said in an agency news release. "Today, South Africa has the biggest life-saving treatment program in the world, with more than 4 million people on treatment," Sidibe said. "This is the kind of acceleration we need to encourage, sustain and replicate." The new report also said that because more people with HIV are receiving treatment, more of them are alive and well. Research also shows that people with HIV who ... Read more

Related support groups: HIV Infection, Pre-Exposure Prophylaxis, Incivek, Truvada, Victrelis, Baraclude, Viread, Norvir, Prezista, Telaprevir, Kaletra, Tenofovir, Ritonavir, Hepsera, Abacavir, Entecavir, Boceprevir, Lamivudine, Atazanavir, Reyataz

Lack of Awareness May Spur Spread of Hep C

Posted 1 Nov 2017 by Drugs.com

WEDNESDAY, Nov. 1, 2017 – Only about half of people in the United States with hepatitis C know they have the curable disease, new data shows. That lack of awareness contributes to increasing rates of hepatitis C infection and means the country is unlikely to meet its own or World Health Organization target dates for eliminating the disease, researchers said. Hepatitis C can cause liver disease, cirrhosis and liver cancer and led to about 23,000 deaths in the United States in 2016 – a toll that's rising every year, according to the data gathered by researchers with the Polaris Observatory and the Center for Disease Analysis Foundation in Colorado. Currently, the number of hepatitis C deaths in the United States each year is greater than the number of HIV-related deaths. Since 2012, hepatitis C deaths have outnumbered deaths from all other reportable infectious diseases combined, the ... Read more

Related support groups: Hepatitis C, HIV Infection, Cirrhosis, Liver Cirrhosis, Hepatocellular Carcinoma, Liver and Pancreatic Disease, Hepatic Tumor

Are HIV and AIDS Poised for a Comeback?

Posted 25 Oct 2017 by Drugs.com

WEDNESDAY, Oct. 25, 2017 – The advent of powerful drugs in the mid-1990s brought remarkable gains in survival for HIV patients who had access to the medications. But a team of experts now warns that the global HIV pandemic continues and is at risk of expanding, given the worrisome global rise of HIV resistance to antiretroviral (ART) medications. "Current trends in HIV drug resistance are very concerning," said Dr. Chris Beyrer, lead author of an overview on the state of global HIV drug resistance. "Resistance levels have been found to be highest in ART-exposed infants and children," he added. "Which is a real concern, since children are already among the least-treated age group in many developing countries." Beyrer is professor of epidemiology with the Johns Hopkins Bloomberg School of Public Health in Baltimore. He and his colleagues noted that roughly 19.5 million HIV patients – or ... Read more

Related support groups: HIV Infection, Pre-Exposure Prophylaxis, Incivek, Truvada, AIDS Related Wasting, Victrelis, Baraclude, Viread, Norvir, Prezista, Kaletra, Telaprevir, Tenofovir, Ritonavir, Boceprevir, Hepsera, Abacavir, Entecavir, Lamivudine, Atazanavir

Antibody Injections in Pregnancy Might Shield Fetus From Zika

Posted 4 Oct 2017 by Drugs.com

WEDNESDAY, Oct. 4, 2017 – A new antibody "cocktail" promises to provide effective, if temporary, protection against the Zika virus, a new study reports. A blend of three potent antibodies completely prevented Zika infection in a group of four lab monkeys, said senior researcher David Watkins, a professor of pathology with the University of Miami Miller School of Medicine. Regular injections of these antibodies potentially could provide vital protection to pregnant women either living in or traveling to areas where Zika is widespread, Watkins said. Zika can cause devastating neurological birth defects, including microcephaly, a condition in which the brain and skull are underdeveloped. "I would say if you were to give a woman in the first trimester an injection and then another injection at the middle of the second trimester, that would suffice" to protect her unborn child from Zika ... Read more

Related support groups: HIV Infection, Pre-Exposure Prophylaxis, Diagnosis and Investigation, Zika Virus Infection

Fighting HIV on Multiple Fronts Might Lead to Vaccine

Posted 20 Sep 2017 by Drugs.com

WEDNESDAY, Sept. 20, 2017 – A combination antibody strategy could be the key to halting the spread of HIV, according to results from two promising animal studies. Two separate research groups completely protected their own sets of lab monkeys from HIV infection using this combination vaccination strategy, albeit in two very different ways. One group inoculated their monkeys with a "cocktail" of two HIV antibodies, while the other group genetically engineered a single antibody capable of attacking HIV in three different ways. There's just one downside: Because these antibodies are injected into the body rather than naturally created by the immune system, people will have to receive shots on a regular basis to retain their protection against the AIDS-causing virus. The strategy focuses on broadly neutralizing HIV antibodies, a type of antibody that attaches to the virus and prevents it ... Read more

Related support groups: HIV Infection, Pre-Exposure Prophylaxis, Atripla, Incivek, Truvada, Stribild, Genvoya, Complera, Victrelis, Baraclude, Viread, Norvir, Prezista, Telaprevir, Kaletra, Tenofovir, Ritonavir, Entecavir, Boceprevir, Hepsera

HIV and Smoking a Lethal Combo for the Lungs

Posted 18 Sep 2017 by Drugs.com

MONDAY, Sept. 18, 2017 – HIV patients who take their medication but also smoke are about 10 times more likely to die from lung cancer than from AIDS-related causes, a new study estimates. Lifesaving antiretroviral drugs have improved life expectancy to the point that patients now have more to fear from tobacco than HIV, said lead researcher Dr. Krishna Reddy. "Thanks to antiretroviral medicines, people with HIV are living longer," said Reddy, a pulmonologist and critical care doctor with Massachusetts General Hospital in Boston. "The bad news is that they're living long enough to get cancer." Based on the new findings, smoking cessation should be a focus of treatment, he and his colleagues said. More than 40 percent of people with HIV are smokers, a rate more than double that of the general population, Reddy said. Fatalism and depression among HIV patients often lead them to take up ... Read more

Related support groups: Smoking, Smoking Cessation, HIV Infection, Nicotine, Lung Cancer, Pre-Exposure Prophylaxis, Non-Small Cell Lung Cancer, Nicorette, Small Cell Lung Cancer, Nicoderm CQ, Nicotrol Inhaler, Commit, Habitrol, Nicorette DS, Nicotrol NS, ProStep, Nicotrol TD, Bronchogenic Carcinoma, Nicorelief

Semen Harbors Wide Range of Viruses

Posted 13 Sep 2017 by Drugs.com

WEDNESDAY, Sept. 13, 2017 – Human semen provides a potential hiding place and breeding ground for a host of dangerous viruses, a new evidence review reports. The analysis of current medical literature revealed genetic evidence of 27 infectious viruses found in semen, including dread-inducing agents like Zika, Ebola, Marburg, Lassa fever and chikungunya, along with mumps, Epstein-Barr and chicken pox. "Clinicians and researchers need to consider the possibility that traditionally non-sexually transmitted viruses can persist in semen, and this therefore raises the possibility of sexual transmission," said lead researcher Alex Salam. He is a clinical researcher with the University of Oxford's epidemic diseases research group in the United Kingdom. However, the presence of viruses in semen does not mean that every virus can be sexually transmitted, the researchers noted. "Detection means ... Read more

Related support groups: Hepatitis C, HIV Infection, Herpes Simplex, Hepatitis B, Viral Infection, Exposure to Hepatitis B Virus, Mumps Polyneuropathy

Truvada Helped Protect Gay Teen Males From HIV

Posted 5 Sep 2017 by Drugs.com

TUESDAY, Sept. 5, 2017 – A group of gay and bisexual teenage males safely used a medication that prevents HIV infection, though some failed to follow the drug regimen fully and became infected, researchers report. People at risk for becoming infected with the virus that causes AIDS can dramatically lower their risk of infection by taking the drug Truvada in what is known as the PrEP regimen, but its use is only approved for adults. "Several studies have shown that daily oral PrEP is effective in preventing HIV among people at high risk of becoming infected, but none of them included adolescents under age 18," explained study author Dr. Bill Kapogiannis, of the U.S. National Institute of Child Health and Human Development. "Our study suggests that this therapy can safely reduce HIV risk for those under 18." For the study, researchers led by Sybil Hosek, of the Cook County Health & ... Read more

Related support groups: HIV Infection, Sexually Transmitted Diseases, Pre-Exposure Prophylaxis, Truvada

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