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Related terms: Familial Hypercholesterolemia, Heterozygous, Heterozygous Familial Hypercholesterolemia, Heterozygous FH, Hypercholesterolemia, Familial Heterozygous

Routine Checkup Should Assess Fitness, Too

Posted 17 days ago by Drugs.com

TUESDAY, Jan. 3, 2017 – Most people know they should have their height, weight, blood pressure and cholesterol checked regularly, but an exercise expert says cardiorespiratory fitness should also be part of a routine medical exam. Cardiorespiratory fitness is a measure of how much work your body can do during exercise. "This measurement is so important because it shows how the heart, lungs and muscles all work together, and it should be an element of assessment of heart disease risk along with factors like smoking history, diabetes, and [high blood pressure]," said Dr. Benjamin Levine. He is a professor of internal medicine at UT Southwestern Medical Center, and director of the Institute of Exercise and Environmental Medicine, which is run by UT Southwestern and Texas Health Resources. "Decades of tests have clearly demonstrated that the ability to do aerobic exercise is strongly ... Read more

Related support groups: High Blood Pressure, Obesity, Hypertension, High Cholesterol, Weight Loss, High Cholesterol - Familial Heterozygous, Prevention of Cardiovascular Disease, Cardiovascular Risk Reduction, Hypertensive Heart Disease

Migraine and Stroke Risk Linked Again

Posted 15 Nov 2016 by Drugs.com

TUESDAY, Nov. 15, 2016 – Women who experience migraines have more than double the risk of suffering a stroke, new research shows. The finding adds evidence to the suspected link between these two conditions. Although it's not yet clear why this connection may exist, study lead author Dr. Cecil Rambarat said it's important for health care providers to be aware of the link. "This is important since migraine is generally not considered a risk factor for cardiovascular disease," said Rambarat. He's a resident physician at the University of Florida Shands Hospital in Gainesville. "Maybe providers need to factor in migraine headaches as a potential risk factor for cardiovascular disease among women," he said. "This is not being done currently." Previous research has linked migraines – especially the form known as migraine with aura – to stroke. Migraine with aura is estimated to affect one ... Read more

Related support groups: Plan B, Migraine, Mirena, Sprintec, NuvaRing, Provera, Nexplanon, Implanon, Depo-Provera, Ortho Tri-Cyclen, Tri-Sprintec, Microgestin Fe 1/20, Yasmin, Loestrin 24 Fe, Plan B One-Step, Heart Disease, Smoking, Ortho Evra, TriNessa, High Cholesterol

Coming Soon: Lower Cholesterol From a Twice-a-Year Shot?

Posted 15 Nov 2016 by Drugs.com

TUESDAY, Nov. 15, 2016 – Instead of popping a pill every day, people might soon control "bad" LDL cholesterol by getting an injection at their doctor's office two or three times a year. Researchers testing a new injectable drug called Inclisiran found it cut LDL cholesterol by half or more. According to early clinical trial data, the effect could last for four to six months. Inclisiran produced "significant and durable reductions in LDL cholesterol, and thus could potentially impact cardiovascular events," said study presenter Dr. Kausik Ray, a professor of public health at Imperial College London in England. Such long-lasting effects could provide a major advance in preventing heart disease, heart attack and stroke, by helping reduce hardening of the arteries, the researchers said. The trial results were presented Tuesday at the American Heart Association annual meeting in New ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Rosuvastatin, Hypertriglyceridemia, High Cholesterol - Familial Heterozygous, Pravachol, Livalo, High Cholesterol - Familial Homozygous, Red Yeast Rice, Caduet, Repatha, Lescol, Hyperlipoproteinemia, Lescol XL

Parent-Child Screening Urged for Inherited Heart Condition

Posted 27 Oct 2016 by Drugs.com

WEDNESDAY, Oct. 26, 2016 – Young children should be screened for a type of genetic heart disease that significantly increases their risk of a heart attack at a young age, a new British study suggests. The screening could also identify parents with familial hypercholesterolemia. The condition, which causes high cholesterol levels, is the main inherited cause of early heart disease, the study authors said. Without preventive medication, people with familial hypercholesterolemia have a 10-fold increased risk of heart attack before age 40, the study noted. Researchers tested more than 10,000 children in England and found that one in 270 had familial hypercholesterolemia. That rate is nearly double the previously reported one in 500, the researchers said. After a child with familial hypercholesterolemia was identified, their parents underwent screening. Overall, one in every 125 persons ... Read more

Related support groups: High Cholesterol, High Cholesterol - Familial Heterozygous, High Cholesterol - Familial Homozygous, Prevention of Cardiovascular Disease, Cardiovascular Risk Reduction, Diagnosis and Investigation

Are There Alternatives to Statins?

Posted 27 Sep 2016 by Drugs.com

TUESDAY, Sept. 27, 2016 – Statins are the go-to therapy for lowering "bad" LDL cholesterol, but other treatments also can effectively reduce risk of future heart problems, a new evidence review reports. These alternative therapies – including a heart-healthy diet, other cholesterol-lowering medications, and even intestinal bypass surgery – seem to confer the same level of heart health protection as statins when cholesterol levels decrease, according to the findings. Nonstatin therapies reduced the risk of heart problems by 25 percent for each 1 millimole per liter (mmol/L) decrease in LDL cholesterol levels. That's very similar to the 23 percent reduction per 1 mmol/L decrease seen with statins like atorvastatin (Lipitor) and simvastatin (Zocor), the researchers said. What's more, the benefits of these therapies stack up if more than one proves effective at lowering a person's ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Welchol, Zocor, Cholestyramine, Lovastatin, Zetia, Vytorin, Rosuvastatin, Hypertriglyceridemia, High Cholesterol - Familial Heterozygous, Gastric Bypass Surgery, Questran, Pravachol, Livalo, High Cholesterol - Familial Homozygous

FDA Approves Repatha (evolocumab) Pushtronex - First And Only Single Monthly Injection for a PCSK9 Inhibitor

Posted 1 Aug 2016 by Drugs.com

THOUSAND OAKS, Calif., July 11, 2016 /PRNewswire/ – Amgen (NASDAQ:AMGN) today announced that the U.S. Food and Drug Administration (FDA) has approved the Repatha® (evolocumab) Pushtronex™ system (on-body infusor with prefilled cartridge), a new, monthly single-dose administration option.1 The Pushtronex system is a hands-free device designed to provide 420 mg of Repatha in a single dose. Repatha is a human monoclonal antibody that blocks a protein called proprotein convertase subtilisin/kexin type 9 (PCSK9), which inhibits the body's natural system for eliminating "bad" cholesterol (low-density lipoprotein cholesterol or LDL-C) from the blood.1 Repatha is the first and only PCSK9 inhibitor to offer a monthly single-dose delivery option. Repatha (evolocumab) Pushtronex system (on-body infusor with prefilled cartridge) "The Pushtronex system exemplifies Amgen's continued innovation and c ... Read more

Related support groups: High Cholesterol, High Cholesterol - Familial Heterozygous, Repatha, Evolocumab

Inherited Cholesterol Disorder Significantly Boosts Heart Risks

Posted 30 Jun 2016 by Drugs.com

THURSDAY, June 30, 2016 – People who inherit a genetic disorder that causes high levels of "bad" LDL cholesterol have an increased risk for heart disease and hardened arteries, a new study finds. The condition is called heterozygous familial hypercholesterolemia. It's believed to affect about 1.5 million people in the United States, the researchers said. The genes linked to this condition prevent the liver from removing LDL (low-density lipoprotein) cholesterol from the blood. This allows the bad cholesterol to build up. Doctors suspect this familial condition when LDL levels are above 190 milligrams per deciliter (mg/dL), the study authors explained. The researchers reviewed data from six groups of people involved in previous studies. Compared to people with average LDL cholesterol levels (less than 130 mg/dL), those with familial hypercholesterolemia had a five times higher risk for ... Read more

Related support groups: Heart Disease, High Cholesterol, High Cholesterol - Familial Heterozygous, Prevention of Cardiovascular Disease, Cardiovascular Risk Reduction

Genetic High-Cholesterol Condition More Common Than Thought

Posted 14 Mar 2016 by Drugs.com

MONDAY, March 14, 2016 – Twice as many people as previously thought are genetically predisposed to develop dangerously high cholesterol levels, new research suggests. Familial hypercholesterolemia, as this condition is called, significantly ups the risk for an early heart attack. The study found it affects about one in every 250 American men and women, rather than one in 500. The new numbers don't reflect a problem on the rise, however, said study author Dr. Sarah de Ferranti, an assistant professor of pediatrics at Harvard Medical School. Instead, the condition was previously "under-recognized," she explained. For those who have this potentially deadly condition, "it is extremely important to get early, consistent preventive care," de Ferranti said. "The key is for you and your clinician to understand and distinguish between mild to moderately high cholesterol that comes on in middle ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Zetia, Rosuvastatin, High Cholesterol - Familial Heterozygous, Hypertriglyceridemia, Pravachol, Livalo, High Cholesterol - Familial Homozygous, Red Yeast Rice, Ezetimibe, Hyperlipoproteinemia Type IIa (Elevated LDL), Lescol, Hyperlipoproteinemia

Statins May Reduce Heart Risks Linked to Sleep Apnea: Study

Posted 6 Jan 2016 by Drugs.com

WEDNESDAY, Jan. 6, 2016 – A new discovery about the way sleep apnea may raise the risk of heart disease also suggests that taking cholesterol-lowering statin drugs might reduce that risk, according to a new study. Sleep apnea is a common disorder that involves irregular breathing while asleep, with oxygen intake dropping frequently for brief periods. The condition can triple a person's risk of stroke, high blood pressure and other heart problems, said study author Dr. Sanja Jelic, an associate professor of medicine at Columbia University Medical Center in New York City. Statins such as Crestor (rosuvastatin) and Lipitor (atorvastatin) are already taken by millions of Americans to reduce their risk of heart disease. "If the beneficial effects of statins on blood vessel health in patients with obstructive sleep apnea is confirmed in larger clinical trials, obstructive sleep apnea may ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Sleep Apnea, Zocor, Lovastatin, Rosuvastatin, Hypertriglyceridemia, High Cholesterol - Familial Heterozygous, Pravachol, Livalo, High Cholesterol - Familial Homozygous, Red Yeast Rice, Cardiovascular Risk Reduction, Hyperlipoproteinemia Type IIa (Elevated LDL), Lescol, Obstructive Sleep Apnea/Hypopnea Syndrome

U.S. Task Force Backs Statins for Those 40 to 75 at Heightened Heart Risk

Posted 22 Dec 2015 by Drugs.com

MONDAY, Dec. 21, 2015 – Cholesterol-lowering statin drugs should be used to prevent a first heart attack or stroke in certain at-risk patients, according to a draft recommendation released Monday by the nation's leading experts in preventive medicine. The U.S. Preventive Services Task Force said statins can provide maximum preventive benefits for adults 40 to 75 years old who have an existing risk factor for heart disease and at least a 10 percent or greater risk of a heart attack or stroke sometime within the next 10 years. The independent panel added that people with a 10-year risk of heart attack and stroke between 7.5 percent and 10 percent might also benefit from statins, and should discuss the matter with their doctor. "Cardiovascular disease is a leading cause of death, and people with no signs or symptoms or past history of cardiovascular disease can still be at risk," said ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Rosuvastatin, Hypertriglyceridemia, High Cholesterol - Familial Heterozygous, Pravachol, Livalo, High Cholesterol - Familial Homozygous, Red Yeast Rice, Hyperlipoproteinemia Type IIa (Elevated LDL), Lescol, Hyperlipoproteinemia, Mevacor, Hyperlipoproteinemia Type IIb (Elevated LDL + VLDL)

U.S. Task Force Stays Neutral on Cholesterol Screening for Kids

Posted 22 Dec 2015 by Drugs.com

MONDAY, Dec. 21, 2015 – There's not enough evidence to recommend screening all children and teens for high cholesterol, experts say. It's not clear if such screening up to age 20 reduces the risk of cardiovascular disease in adulthood, the U.S. Preventive Services Task Force said in a draft recommendation released Monday. This is unchanged from a 2007 recommendation. "There is currently not enough research to determine whether screening all average-risk children and adolescents without symptoms leads to better cardiovascular health in adulthood," task force vice chair Dr. David Grossman said in a news release from the task force. "In addition, the potential harms of long-term use of cholesterol-lowering medication by children and adolescents are not yet understood," Grossman added. The task force is an independent, volunteer panel of national experts in prevention and evidence-based ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Rosuvastatin, High Cholesterol - Familial Heterozygous, Hypertriglyceridemia, Pravachol, Livalo, High Cholesterol - Familial Homozygous, Red Yeast Rice, Hyperlipoproteinemia Type IIa (Elevated LDL), Lescol, Hyperlipoproteinemia, Mevacor, Lescol XL

One in Five U.S. Kids Over Age 5 Has Unhealthy Cholesterol: CDC

Posted 10 Dec 2015 by Drugs.com

THURSDAY, Dec. 10, 2015 – Twenty-one percent of American children and teens have some form of "abnormal" blood cholesterol reading that leaves them at heightened risk for heart disease and stroke as they reach adulthood. That's the conclusion of a review of 2011-2014 federal health data compiled by researchers at the U.S. Centers for Disease Control and Prevention. Overall, slightly more than 13 percent of kids had unhealthily low levels of HDL ("good") cholesterol – the kind that actually might help clear out arteries. The CDC says just over 8 percent had too-high levels of other forms of cholesterol that are bad for arteries, and more than 7 percent had unhealthily high levels of "total" cholesterol. Obesity helped drive these trends, the CDC said. For example, more than 43 percent of children who were obese had some form of abnormal cholesterol reading, compared to less than 14 ... Read more

Related support groups: Obesity, High Cholesterol, Weight Loss, Lipitor, Simvastatin, Crestor, Atorvastatin, Pravastatin, Zocor, Lovastatin, Rosuvastatin, Hypertriglyceridemia, High Cholesterol - Familial Heterozygous, Pravachol, Livalo, High Cholesterol - Familial Homozygous, Ischemic Stroke - Prophylaxis, Red Yeast Rice, Cardiovascular Risk Reduction, Thromboembolic Stroke Prophylaxis

Study Sees Link Between High Cholesterol and Tendon Trouble

Posted 16 Oct 2015 by Drugs.com

FRIDAY, Oct. 16, 2015 – High cholesterol levels may increase your risk of tendon problems and pain, a new study suggests. Tendons are the tough fibers connecting the body's muscles and bones. The researchers suspect cholesterol buildup in immune cells can lead to chronic low-level inflammation, prompting tendon abnormalities and pain. They analyzed 17 studies published between 1973 and 2014 that included more than 2,600 people. Compared to those with normal tendon structure, people with abnormal tendon structure had higher total cholesterol. They also had higher levels of "bad" low-density cholesterol, lower levels of "good" high-density cholesterol, and higher levels of blood fats called triglycerides, the researchers found. People with high cholesterol levels were also much more likely to have tendon injuries, higher levels of musculoskeletal-related pain in their arms, and thicker ... Read more

Related support groups: High Cholesterol, Tendonitis, Hypertriglyceridemia, High Cholesterol - Familial Heterozygous, High Cholesterol - Familial Homozygous, Hyperlipoproteinemia

FDA Approves Repatha for High Cholesterol

Posted 31 Aug 2015 by Drugs.com

FRIDAY, Aug. 28, 2015 – Repatha (evolocumab) has been approved by the U.S. Food and Drug Administration, the second non-statin drug in its class approved to treat high cholesterol. The injected drug, among a new class called PCSK9 inhibitors, is sanctioned for people who are unable to reduce levels of the so-called LDL "bad" cholesterol with statin therapy and exercise, the agency said in a news release. Low-density lipoprotein, commonly known as LDL, builds up in the blood from natural and food sources, and is a leading cause of heart disease. About one in four deaths in the United States is linked to heart disease, making it the top cause of death among men and women. The condition kills about 610,000 people in the United States annually, the FDA said. Repatha is an antibody that targets the PCSK9 protein, which inhibits the liver's ability to remove LDL from the blood. Its most ... Read more

Related support groups: High Cholesterol, High Cholesterol - Familial Heterozygous, High Cholesterol - Familial Homozygous, Repatha, Evolocumab

FDA Approves Repatha - Second Drug in New Class of Cholesterol-Lowering Medications

Posted 31 Aug 2015 by Drugs.com

THURSDAY, Aug. 27, 2015 – The U.S. Food and Drug Administration on Thursday approved a second drug that's part of a potent new class of medications that sharply cut levels of "bad" LDL cholesterol. Repatha (evolocumab), an injectable drug, works by blocking a protein that interferes with the liver's ability to remove LDL cholesterol from the blood. In July, the FDA approved Praluent (alirocumab), another injectable drug in the same class of medications as Repatha. Both drugs are called PCSK9 inhibitors, which don't seem to cause the muscle problems that cholesterol-lowering statin drugs sometimes can. "Repatha provides another treatment option in this new class of drugs for patients with familial hypercholesterolemia or with known cardiovascular disease who have not been able to lower their LDL cholesterol enough with statins," said Dr. John Jenkins, director of the FDA's Office of New ... Read more

Related support groups: High Cholesterol, High Cholesterol - Familial Heterozygous, High Cholesterol - Familial Homozygous, Repatha, Evolocumab

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