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Pradaxa Blood Thinner May Beat Warfarin After Bleeding Episode: Study

Posted 8 days ago by Drugs.com

THURSDAY, Dec. 1, 2016 – Use of a blood thinner is routine for many heart patients, but these drugs come with a risk of episodes of excess bleeding. What, if any, anticoagulant (blood thinner) should these patients take after such episodes arise? A new study suggests that the blood thinner Pradaxa (dabigatran) may be a better choice than the standby drug warfarin in these cases. The reason: Pradaxa is less likely than warfarin to cause recurrent bleeding in patients who recently suffered a bleeding stroke or other major bleeding event, the researchers found. "Our results should encourage clinicians to seriously consider resuming anticoagulation among patients who survived a major bleeding event, particularly if the source of bleeding was identified and addressed," said study senior author Dr. Samir Saba. He's associate chief of cardiology at the University of Pittsburgh Heart and ... Read more

Related support groups: Bleeding Disorder, Warfarin, Coumadin, Ischemic Stroke, Xarelto, Pradaxa, Lovenox, Eliquis, Transient Ischemic Attack, Heparin, Rivaroxaban, Ischemic Stroke - Prophylaxis, Enoxaparin, Apixaban, Fragmin, Clexane, Arixtra, Hep-Pak, Intracranial Hemorrhage, Jantoven

Gene Test May ID Chemo Patients at Risk of Clots: Study

Posted 1 Nov 2016 by Drugs.com

TUESDAY, Nov. 1, 2016 – Genetic testing could help identify breast cancer patients at high risk for the formation of blood clots in their veins, new research suggests. This problem, called venous thromboembolism (VTE), is a serious and potentially fatal complication that can occur during cancer treatment, particularly chemotherapy. Because breast cancer is one of the most common cancers, breast cancer patients account for a large number of cancer-related VTE cases, said study author Judith Brand. She's a postdoctoral researcher in the department of medical epidemiology and biostatistics at Karolinska Institute in Stockholm, Sweden. Venous thromboembolism is preventable through treatment with an anti-clotting drug. But side effects, such as bleeding, mean this therapy is not routinely used in patients undergoing chemotherapy, the researchers explained. The new study included more than ... Read more

Related support groups: Blood Disorders, Cancer, Warfarin, Coumadin, Breast Cancer, Xarelto, Prostate Cancer, Pradaxa, Lovenox, Eliquis, Lung Cancer, Colorectal Cancer, Heparin, Melanoma, Rivaroxaban, Enoxaparin, Fragmin, Apixaban, Clexane, Arixtra

The Pill, Hormone Therapy Safe for Women Taking Blood Thinners: Study

Posted 22 Dec 2015 by Drugs.com

TUESDAY, Dec. 22, 2015 – Women on blood thinners can also take contraceptives that contain estrogen, or hormone replacement therapy, without raising their risk for blood clots or uterine bleeding, a new Italian study finds. Currently, women diagnosed with blood clots may be advised to stop hormone therapy or use of the contraceptive pill – even if they are already on a blood thinner. The reason: Doctors are often concerned that these drug combinations might raise the patient's risk for more clots. However, "there has been no evidence to support this decision," said the study's senior author, Dr. Ida Martinelli, of the A. Bianchi Bonomi Hemophilia and Thrombosis Center in Milan. "We conducted this study to address the fear felt by both the physician and patient when making the decision to stop or continue hormone therapy in this setting," she explained in a news release from the ... Read more

Related support groups: Birth Control, Contraception, Blood Disorders, Emergency Contraception, Bleeding Disorder, Warfarin, Coumadin, Hot Flashes, Estradiol, Menopausal Disorders, Xarelto, Premarin, Pradaxa, Ethinyl Estradiol, Postcoital Contraception, Estrace, Postmenopausal Symptoms, Lovenox, Eliquis, Vagifem

Most Don't Need 'Bridging' When They Stop Warfarin Temporarily

Posted 26 Aug 2015 by Drugs.com

WEDNESDAY, Aug. 26, 2015 – Heart patients on the clot-preventing drug warfarin usually have to stop the medication before having surgery. Now, a new study shows they can safely do that without taking another anti-clotting drug – and they may even be better off. The study, reported in the Aug. 27 New England Journal of Medicine, helps answer long-standing questions about how to manage patients taking warfarin (Coumadin) for an irregular heart rhythm known as atrial fibrillation. Because warfarin is a powerful anticoagulant – which means it prevents blood clots – it can also raise the risk of internal bleeding. That's why people typically have to stop using warfarin in the days before and after an elective surgery. But it hadn't been clear whether those patients need what doctors call "bridging anticoagulation." That means taking another type of anti-clotting medication that is ... Read more

Related support groups: Surgery, Warfarin, Coumadin, Atrial Fibrillation, Heparin, Prevention of Thromboembolism in Atrial Fibrillation, Surgical Prophylaxis, Hep-Pak, Jantoven, Heparin Sodium, Hep-Pak CVC

Health Tip: Know Your Risk for Deep Vein Thrombosis

Posted 4 Aug 2015 by Drugs.com

-- A dangerous condition called deep vein thrombosis (DVT) occurs when a blood clot develops in a vein deep inside the body. The U.S. National Heart Lung and Blood Institute mentions these potential risk factors: Having had a previous DVT, or taking medication that thickens the blood or promotes clotting. Having had surgery, a broken bone or other injury that affects a deep vein. Having reduced blood flow to a deep vein as a result of inactivity. Typical causes are post-surgical recovery, or taking a long trip that limits your ability to move around. Being pregnant. Being treated for cancer. Having a central venous catheter. Being over the age of 60, being a smoker or being obese. Read more

Related support groups: Blood Disorders, Warfarin, Coumadin, Xarelto, Deep Vein Thrombosis (DVT), Pradaxa, Lovenox, Eliquis, Deep Vein Thrombosis, Heparin, Deep Vein Thrombosis - First Event, Deep Vein Thrombosis - Recurrent Event, Rivaroxaban, Enoxaparin, Deep Vein Thrombosis Prophylaxis after Knee Replacement Surgery, Fragmin, Apixaban, Clexane, Arixtra, Hep-Pak

How Long Do Patients With Clots in the Lung Need Blood Thinners?

Posted 7 Jul 2015 by Drugs.com

TUESDAY, July 7, 2015 – People who suffer a blood clot in the lungs with no obvious cause can ward off a new clot with extended use of blood-thinning medications, a new study shows. However, the length of time those blood thinners should be given is unclear, since their benefits wear off soon after use is discontinued, the French researchers found. The clots are called pulmonary emboli, explained one U.S. expert, Dr. Richard Hayes. "Pulmonary emboli are clots in the blood vessels to the lungs that arise from the veins of the leg or thigh," said Hayes, a cardiologist at Lenox Health in New York City. One type of clot is deep vein thrombosis (DVT), often nicknamed "economy-class syndrome" because of cases occurring after long-haul flights. In many cases, Hayes said, there's a trigger – extended bedrest, obesity, recent surgery – for the clot, but in other cases the clots seem to arise ... Read more

Related support groups: Warfarin, Coumadin, Xarelto, Pradaxa, Pulmonary Embolism, Lovenox, Eliquis, Heparin, Rivaroxaban, Pulmonary Embolism - Recurrent Event, Enoxaparin, Apixaban, Fragmin, Clexane, Arixtra, Hep-Pak, Jantoven, Dabigatran, Fondaparinux, Dalteparin

White Men May Get Better Treatment for Abnormal Heartbeat

Posted 30 Jun 2015 by Drugs.com

TUESDAY, June 30, 2015 – Women, Hispanics and blacks are less likely than white men to receive optimal treatment for atrial fibrillation in the United States, researchers say. The study of more than a half-million Medicare patients found that women with this abnormal heart rhythm are less likely than men to get blood thinners to prevent stroke, which is a serious risk with atrial fibrillation. Women, blacks and Hispanics are also less likely to get catheter ablation, a surgical procedure that can restore the heart's normal rhythm. "Across the board, women are offered less aggressive care, particularly in cardiology," said lead researcher Dr. Prashant Bhave, a clinical assistant professor of internal medicine at University of Iowa Health Care. "There are still gaps in how patients are treated," he said. "The most important one is the difference in prescribing blood thinners. Ablation ... Read more

Related support groups: Warfarin, Coumadin, Atrial Fibrillation, Xarelto, Pradaxa, Lovenox, Eliquis, Heparin, Prevention of Thromboembolism in Atrial Fibrillation, Rivaroxaban, Enoxaparin, Fragmin, Apixaban, Clexane, Thromboembolic Stroke Prophylaxis, Arixtra, Hep-Pak, Jantoven, Fondaparinux, Dalteparin

Blood Thinners OK for Cancers That Spread to Brain, Study Finds

Posted 2 Jun 2015 by Drugs.com

TUESDAY, June 2, 2015 – Blood-thinning drugs are safe for treating blood clots in patients with cancer that has spread to the brain from other areas of the body, according to new research. Cancer normally increases a person's risk of blood clots, the study authors explained in a news release from the American Society of Hematology. When a cancer patient develops a clot, a blood thinner – also called an anticoagulant – is often added to the cancer treatment regimen to prevent the risk of blood clots traveling to the lungs. Such a clot can be fatal. However, if cancer spreads from other parts of the body to the brain (called brain metastases), doctors are hesitant to prescribe blood thinners because of concern they might cause bleeding in the head, which is already a risk for these patients, the study authors added. The new findings show that the use of blood thinners in these patients ... Read more

Related support groups: Cancer, Warfarin, Coumadin, Xarelto, Pradaxa, Lovenox, Eliquis, Heparin, Brain Tumor, Rivaroxaban, Enoxaparin, Fragmin, Apixaban, Clexane, Arixtra, Hep-Pak, Jantoven, Dabigatran, Fondaparinux, Innohep

Most Treatments for Blood Clots Appear Safe, Effective

Posted 16 Sep 2014 by Drugs.com

TUESDAY, Sept. 16, 2014 – Almost all the various treatment options for blood clots that form in veins are equally safe and effective, new research shows. In exploring the safety and effectiveness of treatments for such blood clots as deep vein thrombosis or pulmonary embolism (blood clot in a lung), Canadian researchers analyzed outcomes associated with eight blood-thinning options, including unfractionated heparin, low-molecular-weight heparin (LMWH) and fondaparinux in combination with vitamin K antagonists. The investigators also examined LMWH with dabigatran (Pradaxa), edoxaban, rivaroxaban (Xarelto), apixaban (Eliquis), as well as LMWH alone. After examining nearly 50 randomized studies, the researchers found that unfractionated heparin combined with vitamin K antagonist was associated with a higher percentage of recurrent blood clots over the course of three months than the ... Read more

Related support groups: Xarelto, Deep Vein Thrombosis (DVT), Pradaxa, Pulmonary Embolism, Eliquis, Deep Vein Thrombosis, Heparin, Rivaroxaban, Apixaban, Thrombotic/Thromboembolic Disorder, Arixtra, Hep-Pak, Fondaparinux, Dabigatran, Venous Thromboembolism, Pulmonary Thromboembolism, Heparin Sodium, Arixtra 7.5 mg/dose, Hep-Pak CVC, Arixtra 5 mg/dose

FDA Medwatch Alert: Heparin Sodium, 1,000 USP Heparin Units/500 mL (2 USP Heparin Units/mL), In 0.9 percent Sodium Chloride Injection, 500 mL by Hospira: Recall - Particulate Matter

Posted 15 Sep 2014 by Drugs.com

ISSUE: Hospira, Inc. announced a voluntary nationwide user-level recall of one lot of Heparin Sodium, 1,000 USP Heparin Units/500 mL (2 USP Heparin Units/mL), in 0.9% Sodium Chloride Injection, 500 mL, NDC 0409-7620-03 Lot 41-046-JT with expiration date of 01NOV 2015. This action is due to one confirmed customer report of particulate in a single unit. The foreign particle was confirmed by Hospira as human hair, sealed between the tube and the film at the round seal of the unused Administrative Port on the non-print side of the container. Injected particulate material may result in local inflammation, phlebitis, and/or low-level allergic response. Capillaries which may be as small as the size of a red blood cell, approximately seven microns in diameter, may become occluded. Patients with preexisting condition of trauma or other medical condition that adversely affects the microvascular ... Read more

Related support groups: Heparin, Thrombotic/Thromboembolic Disorder, Hep-Pak, Heparin Sodium, Hep-Pak CVC

Pros, Cons to Dissolving Lung Clots: Study

Posted 17 Jun 2014 by Drugs.com

TUESDAY, June 17, 2014 – Drugs used to break up blood clots in the lungs may lower the risk of death, but they also increase the risk of bleeding, a new study finds. Researchers analyzed data from 16 trials involving use of clot-busting drugs called thrombolytics to treat life-threatening clots in the lungs (pulmonary embolism). Despite the drugs' apparent life-saving benefits, the risk of major bleeding, particularly in the brain, remains a concern, experts say. "The study advances our understanding, but is not enough to provide a definitive recommendation for use in all patients," said Dr. Joshua Beckman, director of the cardiovascular fellowship program at Brigham and Women's Hospital in Boston, who was not involved in the study. The evidence suggests that clot-busting therapy has merit but needs more study to refine the method by which it is given and to whom, added Beckman. What's ... Read more

Related support groups: Xarelto, Pradaxa, Pulmonary Embolism, Heparin, Rivaroxaban, Arixtra, Hep-Pak, Fondaparinux, Activase, Dabigatran, Streptokinase, Heparin Sodium, Urokinase, Cathflo Activase, Alteplase, Kinlytic, Arixtra 5 mg/dose, Abbokinase, Hep-Pak CVC, Kabikinase

FDA Medwatch Alert: Heparin: Drug Safety Communication - Important change to heparin container labels to clearly state the total drug strength

Posted 7 Dec 2012 by Drugs.com

ISSUE: FDA is notifying health care professionals, caregivers, and patients about a change to the container and carton labels for heparin products. This label change will require manufacturers of Heparin Lock Flush Solution, USP and Heparin Sodium Injection, USP to clearly state the strength of the entire container of the medication followed by how much of the medication is in 1 milliliter (mL). These modifications will eliminate the need for health care professionals to calculate the total amount of heparin medication in a product containing more than 1 mL, thereby reducing the risk of miscalculations that may result in medication errors. BACKGROUND: Heparin is used to prevent blood clots from forming in people who have certain medical conditions or who are undergoing certain medical procedures that may increase the chance that clots will form, or to stop the growth of clots that have ... Read more

Related support groups: Deep Vein Thrombosis (DVT), Deep Vein Thrombosis, Heparin, Hep-Pak, Heparin Lock Flush, Heparin Sodium, Heparin Flush, Hep-Lock, PosiFlush, Hep-Pak CVC

Irregular Heartbeat May Pose Higher Stroke Risk for Women Than Men

Posted 31 Aug 2012 by Drugs.com

FRIDAY, Aug. 31 – Women older than 75 who have a heart rhythm disorder called atrial fibrillation are 20 percent more likely to have a stroke than men in the same age group with atrial fibrillation, according to a large new study. However, researchers said the findings suggest that being a woman should not be included as an independent risk factor for stroke or blood clots, either in guidelines for treatment or risk assessment of patients with atrial fibrillation, because the difference doesn't hold for women younger than 75. The study included more than 87,000 atrial fibrillation patients in Denmark. Of those patients, more than 51 percent were female. After one year of follow-up, female patients younger than 75 did not have an increased risk of stroke, but those over age 75 had a 20 percent increased risk, the investigators found. The study was presented Sunday at the European ... Read more

Related support groups: Warfarin, Coumadin, Atrial Fibrillation, Xarelto, Pradaxa, Lovenox, Heparin, Prevention of Thromboembolism in Atrial Fibrillation, Rivaroxaban, Enoxaparin, Fragmin, Clexane, Arixtra, Hep-Pak, Jantoven, Dabigatran, Fondaparinux, Dalteparin, Innohep, Tinzaparin

Blood Thinner May Cause Skin Lesions

Posted 16 Jul 2010 by Drugs.com

MONDAY, Sept. 28 – Heparin, a common blood thinner, can cause skin lesions that are harmless in most cases but could indicate a life-threatening condition induced by the drug, a new study suggests. Researchers examined 320 people who were given heparin injections at a German hospital. Of those, 7.5 percent developed skin lesions as a result of the treatment. That's higher than the 2 percent rate the researchers had anticipated. "During the study, we were surprised by the high number of patients with heparin-induced skin lesions," the study authors wrote. "For most patients, the diagnosis was made because of our study." The researchers found that in most cases, the lesions resulted from an allergic reaction. Women were more likely to have the reaction, and three factors – pregnancy, obesity and long-term heparin use – resulted in a higher likelihood of the condition, the study found. ... Read more

Related support groups: Heparin, Hep-Pak, Heparin Lock Flush, Heparin Sodium, Hep-Lock, Hep-Pak CVC

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Deep Vein Thrombosis (DVT), Deep Vein Thrombosis, Anticoagulation During Pregnancy, Deep Vein Thrombosis - Prophylaxis, Antiphospholipid Syndrome, Angina, Thrombotic / Thromboembolic Disorder, Myocardial Infarction, Heart Attack, Pulmonary Embolism

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