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FDA Approves Amgen's Parsabiv (etelcalcetide) for Secondary Hyperparathyroidism in Adult Patients on Hemodialysis

Posted 19 days ago by Drugs.com

THOUSAND OAKS, Calif., Feb. 7, 2017 /PRNewswire/ – Amgen (NASDAQ:AMGN) today announced that the U.S. Food and Drug Administration (FDA) has approved Parsabiv (etelcalcetide) for the treatment of secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis. Parsabiv is the first therapy approved for this condition in 12 years and the only calcimimetic that can be administered intravenously by the dialysis health care team three times a week at the end of the hemodialysis session. "We are excited about today's approval of Parsabiv in the U.S. and the opportunity to provide patients and health care providers with a novel option to help treat a complex disease that affects a significant number of patients on hemodialysis," said Sean E. Harper, M.D., executive vice president of Research and Development at Amgen. "Parsabiv not only has demonstrated ... Read more

Related support groups: Renal Failure, Dialysis, Chronic Kidney Disease, Hemodialysis, Hyperparathyroidism, Hyperparathyroidism Secondary to Renal Impairment, Parsabiv, Etelcalcetide

Depression Often Untreated in Dialysis Patients

Posted 27 Jan 2017 by Drugs.com

THURSDAY, Jan. 26, 2017 – Depression is common among kidney failure patients undergoing dialysis. But efforts to get them on antidepressants often fail, a new study finds. Many patients refuse to start or modify depression treatment. And in some cases kidney specialists don't want their patients taking antidepressant medication, researchers reported. "Our study demonstrated that many patients on chronic hemodialysis have depressive symptoms but do not wish to receive aggressive treatment to alleviate these symptoms," said study co-leader Dr. Steven Weisbord. "We also noted that when patients are willing to accept treatment, renal [kidney care] providers commonly do not prescribe treatment," said Weisbord, who's with the VA Pittsburgh Healthcare System. When kidneys fail, dialysis treatment is needed to remove wastes and salt from the blood. It's often done at a hospital, dialysis ... Read more

Related support groups: Depression, Lexapro, Zoloft, Cymbalta, Effexor, Prozac, Celexa, Major Depressive Disorder, Citalopram, Paxil, Sertraline, Pristiq, Amitriptyline, Venlafaxine, Fluoxetine, Effexor XR, Mirtazapine, Escitalopram, Savella, Remeron

Concern About Dialysis Safety Spurs CDC Action

Posted 29 Sep 2016 by Drugs.com

THURSDAY, Sept. 29, 2016 – Steps to reduce bloodstream infections in dialysis patients will be mapped out Thursday at a meeting of the U.S. Centers for Disease Control and Prevention and a coalition of kidney and dialysis groups. Dialysis treatment – either in a hospital, a dialysis unit or at home – is needed when the kidneys cannot filter wastes from the body sufficiently. Each year, about 37,000 dialysis patients in the United States develop potentially deadly bloodstream infections associated with their treatment, the CDC says. That number could be cut in half if dialysis facilities implemented CDC guidelines for dialysis safety, according to the agency. "Making evidence-based safety steps a routine part of patient care is a proven strategy to keep dialysis patients safe from bloodstream infections," CDC Director Dr. Tom Frieden said in an agency news release. "We appreciate the ... Read more

Related support groups: Infections, Renal Failure, Chronic Kidney Disease, Hemodialysis, Peritoneal dialysis

Coming Soon: A Wearable Artificial Kidney?

Posted 7 Jun 2016 by Drugs.com

TUESDAY, June 7, 2016 - Someday, dialysis patients might free themselves of clunky machines, moving about with a "wearable artificial kidney" instead. That's the promise of a new clinical trial that suggests this type of technology is finally within reach. "This would be a game changer," said one kidney specialist, Dr. Maria DeVita. "The fact that clinical trials are beginning gives us all hope that we will have a significant improvement in the care of those patients requiring ongoing hemodialysis." DeVita is associate director of nephrology at Lenox Hill Hospital in New York City. People with advanced kidney disease must often resort to spending hours a day at dialysis centers, with special machines cleansing their blood as their kidneys once did. The dream has long been a small portable device that could perform dialysis as patients went about their usual day. That dream may be ... Read more

Related support groups: Renal Failure, Chronic Kidney Disease, Diabetic Kidney Disease, Nephrotic Syndrome, Peritoneal dialysis, Hemodialysis, Diabetic Nephropathy, Anemia Associated with Chronic Renal Failure, Diagnosis and Investigation, Polycystic Kidney Disease, Renal Osteodystrophy, Alport Syndrome, Hyperphosphatemia of Renal Failure, Anuria, Hypertensive Renal Disease, Hemodialysis Anticoagulation, Renal and Genitourinary Disorders

High-Salt Diets May Raise Heart Risks for Kidney Patients

Posted 24 May 2016 by Drugs.com

TUESDAY, May 24, 2016 – People with chronic kidney disease face higher odds of heart attack or stroke if they have high-salt diets, a new study suggests. "Moderate sodium reduction among patients with chronic kidney disease and high sodium intake may lower [heart] risk," concluded a team led by Dr. Jiang He, of Tulane University in New Orleans. About one in every 10 Americans is affected by chronic kidney disease, and more than one-third of U.S. adults have heart disease, the researchers noted. The role of daily salt intake in kidney patients – and its effect on heart risk – hasn't been clear, however. To learn more, the investigators looked at outcomes for almost 3,800 patients with chronic kidney disease at seven locations across the United States. The patients provided urine samples to researchers at the beginning of the study in 2003, and then once a year over the next two years. ... Read more

Related support groups: Ischemic Stroke, Heart Attack, Renal Failure, Transient Ischemic Attack, Chronic Kidney Disease, Myocardial Infarction, Sodium Chloride, Diabetic Kidney Disease, Ischemic Stroke - Prophylaxis, Peritoneal dialysis, Hemodialysis, Diabetic Nephropathy, Anemia Associated with Chronic Renal Failure, Hematuria, HalfLytely and Bisacodyl, Hyper-Sal, Myocardial Infarction - Prophylaxis, Rhinaris, Dextrose/Sodium Chloride, Thermotabs

Kidney Dialysis Might Not Extend Survival of Elderly

Posted 18 Mar 2016 by Drugs.com

THURSDAY, March 17, 2016 – Dialysis does not significantly improve survival for elderly kidney failure patients, a new study indicates. The findings suggest that conservative care may be a reasonable option for some kidney failure patients over 80. The researchers don't say that dialysis treatment should not be given to anybody older than 80 or with severe co-occurring conditions. "But we show that the treatment is on average of little advantage regarding survival," said study co-leader Dr. Wouter Verberne of St. Antonius Hospital in Nieuwegein, the Netherlands. The findings were published online March 17 in the Clinical Journal of the American Society of Nephrology. "Our next task is to predict who benefits and who does not," Verberne said in a journal news release. "Until we are able to give a better prediction of the results of dialysis treatment at high age, we can merely suggest ... Read more

Related support groups: Renal Failure, Chronic Kidney Disease, Diabetic Kidney Disease, Hemodialysis, Peritoneal dialysis, Diabetic Nephropathy, Hyperphosphatemia of Renal Failure, Renal and Genitourinary Disorders

Hepatitis C Reported at 19 Dialysis Clinics: CDC

Posted 28 Jan 2016 by Drugs.com

THURSDAY, Jan. 28, 2016 – Reports of hepatitis C infections among dialysis patients in the United States are rising, largely because of poor infection control practices, health officials say. Between 2014 and 2015, the U.S. Centers for Disease Control and Prevention received reports of about 36 cases of hepatitis C infection at 19 kidney dialysis clinics in eight states. So far, investigators have determined that patient-to-patient transmission of hepatitis C occurred at nine of those clinics. Lapses in infection control procedures – such as injection safety, cleaning and disinfection, and hand hygiene – were common at these clinics, the CDC reported Wednesday. The exact means of hepatitis C transmission could not be pinpointed, but all of these deficiencies could contribute to transmission of the virus. Hepatitis C, which can cause lifelong liver disease, is spread primarily through ... Read more

Related support groups: Hepatitis C, Renal Failure, Chronic Kidney Disease, Hemodialysis, Peritoneal dialysis

Do Taller Patients Fare Worse on Dialysis?

Posted 1 Oct 2015 by Drugs.com

THURSDAY, Oct. 1, 2015 – Tallness may be linked with an increased risk for premature death in kidney failure patients on dialysis, a new study suggests. While the researchers only found an association and not a cause-and-effect link, tall people on dialysis appeared to have higher rates of premature death than people in the general population. The risk was higher in men than in women, and among patients with shorter dialysis treatment times, the researchers said. The researchers analyzed data from just over 1 million Americans who began dialysis between 1995 and 2008 and were followed for up to five years. Being tall was associated with increased risk of premature death among dialysis patients who were American Indian/Alaska natives, Asians and whites, but this was not the case among black patients in the study. Tall black dialysis patients' risk of premature death was the same as in ... Read more

Related support groups: Renal Failure, Chronic Kidney Disease, Diabetic Kidney Disease, Hemodialysis, Diabetic Nephropathy, Anemia Associated with Chronic Renal Failure, Hemodialysis Anticoagulation, Renal and Genitourinary Disorders, Anuria

Dialysis Patients May Be Unprepared for Natural Disasters

Posted 28 Jul 2015 by Drugs.com

TUESDAY, July 28, 2015 – Many kidney dialysis patients may be unprepared for natural disasters, a new study finds. These patients with kidney disease depend on machines at treatment centers for dialysis, which filters wastes from their blood. Dialysis patients are especially vulnerable during emergencies or disasters because they rely on technology and infrastructure such as electricity, water and transportation to stay alive, the researchers noted. The study authors assessed the preparedness of more than 350 adult patients receiving outpatient dialysis at five facilities in New York City that lost power for several days when Hurricane Sandy struck in October 2012. About 26 percent of the patients missed dialysis sessions and about 66 percent received dialysis at non-regular dialysis units. Slightly more than three-quarters of them carried insurance information with them. But only 44 ... Read more

Related support groups: Hemodialysis, Peritoneal dialysis

Genes May Be Tied to Cardiac Arrest Risk in Dialysis Patients

Posted 16 Apr 2015 by Drugs.com

THURSDAY, April 16, 2015 – Genes may play a role in cardiac arrest risk among kidney patients who are on dialysis, new research suggests. In a study of pairs of kidney patients who were on dialysis, the risk of cardiac arrest was 70 percent higher in the pairs where the two patients were blood relatives. In general, patients on dialysis are 20 times more likely to suffer cardiac arrest than people in the general population, and cardiac arrest is the leading cause of death among patients on dialysis, the researchers noted. The finding suggests that genes may play a role in cardiac arrest risk among these patients, and that pinpointing these genes may lead to new treatments to lower the risk, the researchers added. The study was published online April 16 in the Journal of the American Society of Nephrology. "These findings advance the science because they suggest that genetic factors – ... Read more

Related support groups: Heart Attack, Renal Failure, Chronic Kidney Disease, Myocardial Infarction, Hemodialysis, Peritoneal dialysis

Millions of Kidney Failure Patients Die for Lack of Treatment: Study

Posted 13 Mar 2015 by Drugs.com

FRIDAY, March 13, 2015 – More than 2 million kidney failure patients worldwide die prematurely every year because they can't get treatment, a new study finds. Researchers analyzed data from 123 countries with 93 percent of the world's population, and found there were between 5 million to almost 10 million kidney failure patients who required either dialysis or a kidney transplant in 2010. Of the 2.6 million patients who were treated, 78 percent received dialysis. Of those who received treatment, nearly 93 percent lived in high- to high-middle-income nations, the findings showed. The investigators also calculated that between 2 million and 7 million kidney failure patients who could have been kept alive if they received either dialysis or a kidney transplant died prematurely because they could not get treatment. Most of the premature deaths occurred in China, India, Indonesia, Pakistan ... Read more

Related support groups: Renal Failure, Chronic Kidney Disease, Hemodialysis, Peritoneal dialysis

First Device Approved for Dialysis-Related Amyloidosis

Posted 6 Mar 2015 by Drugs.com

FRIDAY, March 6, 2015 – The U.S. Food and Drug Administration has approved the first device to treat dialysis-related amyloidosis (DRA), a complication of dialysis used to treat kidney failure. DRA is a rare, yet chronic, condition caused by blood buildup of a protein called beta 2-microglobulin. It occurs most often among people aged 60 or older who have been on dialysis for more than five years, the FDA said in a news release. Symptoms if the protein spreads to the bones may include painful and stiff joints, bone cysts and torn tendons and ligaments. The newly approved device, the Lixelle Beta 2-microglobulin Apheresis Column, removes the protein from the blood using porous cellulose beads. It was evaluated among 100 clinical trial patients in Japan. The most common side effects noted were temporary low blood pressure and a drop in red blood cell count. The FDA ordered Japanese ... Read more

Related support groups: Hemodialysis, Peritoneal dialysis, Amyloidosis

Aerobic Exercise May Boost Quality of Life for Dialysis Patients

Posted 3 Oct 2014 by Drugs.com

THURSDAY, Oct. 2, 2014 – Aerobic exercise may improve the physical and mental health of kidney dialysis patients and may also extend their lives, new research suggests. The study included more than 5,700 kidney failure patients on dialysis who were followed for a median of 1.6 years. Those who did aerobic workouts had fewer symptoms of depression, better health-related quality of life and were 40 percent less likely to die during the study than those who were did little or no exercise. These benefits were similar regardless of patients' age, sex, length of time they'd been on dialysis, and diabetes status. While this study found an association between aerobic exercise and mood, quality of life and risk of an earlier death, it wasn't designed to prove that exercise was the direct cause of these improvements. Aerobic activity wasn't linked to an earlier risk of death for those on ... Read more

Related support groups: Renal Failure, Hemodialysis, Peritoneal dialysis

Iron Dosing Tricky for Dialysis Patients: Study

Posted 20 Jun 2013 by Drugs.com

THURSDAY, June 20 – Large doses of intravenous iron increase kidney dialysis patients' chances of developing a serious infection, but smaller doses given less frequently do not raise the risk, a new study shows. Dialysis patients often develop anemia and must be given intravenous treatments of iron to correct the condition. Intravenous iron, however, can promote bacterial growth and weaken the immune system, putting patients at increased risk for infections. This is the first large study to examine how different intravenous iron dosing regimens might affect this risk. Researchers analyzed data from more than 117,000 dialysis patients who were followed for three months. Of these patients, 12 percent received a large amount of iron over a short period of time (bolus dosing); 49 percent received smaller, less frequent amounts of iron (maintenance dosing); and 38 percent received no iron. ... Read more

Related support groups: Ferrous Sulfate, Iron Deficiency Anemia, Ferrous Fumarate, Ferrous Gluconate, Peritoneal dialysis, Hemodialysis, Ferralet, Ferrocite, Hemocyte, Fergon, Ferrets, Ircon, Iron Gluconate, Simron, Ferretts, FE-40, Feostat, Nephro-Fer, Iron Fumarate, Ferrimin 150

CDC Guidelines Could Cut Bloodstream Infections From Dialysis

Posted 15 May 2013 by Drugs.com

TUESDAY, May 14 – Dialysis facilities could cut bloodstream infection rates among their patients by up to half by following a set of recommendations from the U.S. Centers for Disease Control and Prevention, according to new research. The CDC suggested that adopting their protocols could save lives and reduce health care costs. "Dialysis patients often have multiple health concerns, and the last thing they need is a bloodstream infection from dialysis," CDC director Dr. Tom Frieden said in an agency news release. "These infections are preventable. CDC has simple tools that dialysis facilities can use to help ensure patients have access to the safe health care they deserve." In 2010 alone, more than 380,000 people in the United States required hemodialysis for end-stage kidney disease. In the majority of patients, this treatment is started with a central line, which is a tube that a ... Read more

Related support groups: Bacterial Infection, Hemodialysis, Peritoneal dialysis

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Hemodialysis Anticoagulation, Renal and Genitourinary Disorders