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Intensive Type 2 Diabetes Treatment Can Extend Survival: Study

Posted 8 Sep 2016 by Drugs.com

WEDNESDAY, Sept. 7, 2016 – Intensive management of type 2 diabetes can make a difference in how long and how well you live, even if you don't start until middle age, researchers report. People who were already at risk of type 2 diabetes complications were randomly selected to continue with their normal treatment or to be placed in an aggressive and multipronged treatment group. Two decades after the study began, the researchers found that people in the aggressive treatment group lived almost eight years longer. Not only that, they lived better – their risk of heart disease, kidney disease and blindness all dropped. The only complication that didn't seem to improve was nerve damage caused by diabetes. "Early, intensified intervention in type 2 diabetes patients with microalbuminuria with both target-driven pharmacological (medication) and behavioral actions increased life span. And, ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Victoza, Lantus, Januvia, Glucophage, Novolog, Glipizide, Humalog, Bydureon, Janumet, Byetta, Saxenda, Glyburide, Lantus Solostar, Invokana, Levemir, Actos, Glimepiride

Intensive Blood Sugar Control May Be Too Much for Some With Type 2 Diabetes

Posted 6 Jun 2016 by Drugs.com

MONDAY, June 6, 2016 – Intensive treatment of blood sugar levels in some people with type 2 diabetes may cause serious complications, new research suggests. "In this study, we found that, particularly among older patients and patients with serious chronic conditions, intensive treatment nearly doubled the risk of severe hypoglycemia requiring medical attention, including hospitalization," said lead author Dr. Rozalina McCoy. She is an endocrinologist at the Mayo Clinic in Rochester, Minn. Hypoglycemia (low blood sugar) is a serious potential complication of diabetes treatment. The researchers said it can worsen quality of life and has been linked with cardiovascular events, dementia and death. The researchers reviewed information from more than 31,500 American adults. All had stable and controlled type 2 diabetes. None was taking insulin. None had a prior history of severe ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Lantus, Dementia, Glucophage, Novolog, Glipizide, Humalog, Hypoglycemia, Janumet, Glyburide, Lantus Solostar, Invokana, Levemir, Actos, Glimepiride, Novolin R, Amaryl, Mild Cognitive Impairment

Metformin Safer for Heart Than Other Common Type 2 Diabetes Drugs: Study

Posted 18 Apr 2016 by Drugs.com

MONDAY, April 18, 2016 – Metformin, the most frequently prescribed standalone drug for type 2 diabetes, is better for the heart than its closest competitors, a large analysis suggests. Metformin reduced the risk of dying from heart attack and stroke by about 30 percent to 40 percent compared with other commonly used drugs called sulfonylureas, such as glibenclamide, glimepiride, glipizide and tolbutamide, researchers report. "Pharmaceutical companies continue to make new drugs to reduce blood sugar and improve on safety concerns of the older drugs," said senior study author Dr. Shari Bolen. But, "while adults with diabetes often need more than one medication to control blood sugar, the newer medications do not appear to be safer than the older drugs," added Bolen. Metformin is still the safest and most effective type 2 diabetes medication, said Bolen. She is an assistant professor of ... Read more

Related support groups: Diabetes, Type 2, Metformin, Glucophage, Glipizide, Janumet, Glimepiride, Amaryl, Prevention of Cardiovascular Disease, Glucophage XR, GlipiZIDE XL, Glucotrol, Cardiovascular Risk Reduction, ActoPlus Met, Glucotrol XL, Glumetza, Glyburide/Metformin, Janumet XR, Avandamet, Jentadueto, Glucovance

Cost of Insulin Rises Threefold in Just a Decade: Study

Posted 5 Apr 2016 by Drugs.com

TUESDAY, April 5, 2016 – Americans with diabetes who rely on insulin to keep their blood sugar levels in check are facing sticker shock: A new study finds the price of insulin has tripled in only 10 years. Moreover, since 2010, per-person spending on insulin in the United States was more than spending on all other diabetes drugs, the study found. "The cost of insulin has risen rapidly over the last few years," said study senior author Philip Clarke, a professor of health economics at the University of Melbourne in Australia. Clarke added there should be an assessment to see whether this price hike is justifiable in terms of improved clinical outcomes. One reason for the price climb, he said, is a switch from human insulins to analog insulins, which cost more but may offer additional benefits. Also, doctors are more apt to prescribe insulin for people with type 2 diabetes now, Clarke ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Victoza, Lantus, Diabetes, Type 1, Januvia, Diabetic Neuropathy, Glucophage, Novolog, Glipizide, Humalog, Insulin Resistance, Bydureon, Byetta, Janumet, Saxenda, Diabetic Nerve Damage, Glyburide, Lantus Solostar

More Evidence Diabetes Drug Actos Raises Bladder Cancer Risk a Bit

Posted 31 Mar 2016 by Drugs.com

WEDNESDAY, March 30, 2016 – More evidence linking the diabetes drug Actos to an increased risk of bladder cancer has surfaced in a new study that also finds the risk rises with increased use. Actos (pioglitazone) appears to increase risk of bladder cancer by 63 percent, Canadian researchers say. The findings, published March 30 in The BMJ, stem from an analysis of nearly 146,000 patients treated between 2000 and 2013. The data also showed that bladder cancer risk increases if Actos is used for more than two years, or if someone takes more than 28,000 milligrams over the course of their lives. The overall risk is small, however. Still, "the more you accumulate the drug into your system, the higher the risk," said senior researcher Laurent Azoulay, an associate professor of oncology at McGill University in Montreal. Azoulay and his colleagues did not find a similar link between bladder ... Read more

Related support groups: Diabetes, Type 2, Insulin Resistance, Actos, Pre-Diabetes, Pioglitazone, Diabetes Mellitus, Avandia, Bladder Cancer, ActoPlus Met, Avandamet, Abnormal Glucose Tolerance, Rosiglitazone, Metformin/Pioglitazone, Oseni, ActosPlus Met, Alogliptin/pioglitazone, Glimepiride/Pioglitazone, Avandaryl, Glimepiride/Rosiglitazone, Duetact

FDA Medwatch Alert: Rosiglitazone-containing Diabetes Medicines: Drug Safety Communication - FDA Eliminates the Risk Evaluation and Mitigation Strategy (REMS)

Posted 16 Dec 2015 by Drugs.com

ISSUE: FDA is eliminating the Risk Evaluation and Mitigation Strategy (REMS) for rosiglitazone-containing type 2 diabetes medicines, which are approved as Avandia, Avandamet, Avandaryl, and generics. The REMS is no longer necessary to ensure that the benefits of rosiglitazone medicines outweigh their risks. In 2013, FDA required removal of the prescribing and dispensing restrictions for rosiglitazone medicines after determining that data did not demonstrate an increased risk of heart attack with rosiglitazone medicines compared to the standard type 2 diabetes medicines metformin and sulfonylurea. FDA also required the drug manufacturers to provide educational training to health care professionals about the current state of knowledge regarding the heart risks of rosiglitazone medicines. Manufacturers have since fulfilled these requirements. FDA has continued monitoring these medicines ... Read more

Related support groups: Diabetes, Type 2, Avandia, Avandamet, Rosiglitazone, Glimepiride/Rosiglitazone, Avandaryl, Metformin/Rosiglitazone

Blood Thinner, Certain Diabetes Drugs Are a Bad Combo

Posted 8 Dec 2015 by Drugs.com

TUESDAY, Dec. 8, 2015 – Taking the blood thinner warfarin at the same time as certain diabetes drugs increases the risk of hospitalization, a new study warns. Researchers analyzed data from nearly 466,000 Medicare patients. They found that those who took warfarin along with the diabetes drugs glipizide or glimepiride – also known as sulfonylureas – had a 22 percent increased risk of making an emergency room visit or being hospitalized for low blood sugar (hypoglycemia). While doctors are warned about potential interaction between the drugs, there has been little actual data, said study author John Romely, an associate professor at the University of Southern California Center for Health Policy and Economics and School of Public Policy. "Until now, no one had really studied the interactions between them," he said in a university news release. The risk was especially high for men aged ... Read more

Related support groups: Diabetes, Type 2, Warfarin, Coumadin, Glipizide, Glyburide, Glimepiride, Amaryl, GlipiZIDE XL, Glucotrol, Glucotrol XL, Jantoven, Glipizide/Metformin, DiaBeta, Glimepiride/Pioglitazone, Glynase, Micronase, Glycron, Tolazamide, Chlorpropamide, Orinase

New Diabetes Cases Among Americans Drop for First Time in Decades: CDC

Posted 1 Dec 2015 by Drugs.com

TUESDAY, Dec. 1, 2015 – In a sign that Americans may finally be turning the corner in the fight against diabetes – and possibly obesity – federal health statistics released Tuesday show that the number of new cases of diabetes has dropped for the first time in decades. The decline wasn't sudden or dramatic. But, the number of new diabetes cases went from 1.7 million in 2009 to 1.4 million in 2014, according to the U.S. Centers for Disease Control and Prevention. "It seems pretty clear that incidence rates have now actually started to drop. Initially it was a little surprising because I had become so used to seeing increases everywhere we looked," CDC researcher Edward Gregg told The New York Times. The proportion of Americans with diabetes is still twice what it was in the early 1990s. And not every racial group has made strides against the blood sugar disease, which is often ... Read more

Related support groups: Obesity, Diabetes, Type 2, Metformin, Weight Loss, Insulin, Victoza, Lantus, Januvia, Glucophage, Novolog, Glipizide, Humalog, Bydureon, Byetta, Janumet, Saxenda, Glyburide, Lantus Solostar, Invokana, Levemir

Too Many Seniors With Diabetes Are Overtreated, Study Suggests

Posted 29 Oct 2015 by Drugs.com

THURSDAY, Oct. 29, 2015 – When it comes to treating seniors with diabetes, new research suggests that doctors often don't cut back on medications, even when treatment goals are surpassed. The study found that when people had potentially dangerous low blood sugar levels, just 27 percent had their medicines decreased. And when blood pressure treatments lowered blood pressure levels too much, just 19 percent saw a reduction in their medications. "As people get older, the risks of overtreating become greater, and the benefits become shorter. We have to start emphasizing that more isn't always better," said study author Dr. Jeremy Sussman, an assistant professor of internal medicine at the University of Michigan in Ann Arbor and a primary care doctor at the Ann Arbor VA System. The findings were published online Oct. 26 in the journal JAMA Internal Medicine. Practice guidelines generally ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Victoza, Lantus, Januvia, Glucophage, Novolog, Glipizide, Humalog, Bydureon, Byetta, Janumet, Saxenda, Glyburide, Lantus Solostar, Invokana, Levemir, Actos, Glimepiride

How to Dispose of Unused or Expired Prescription Drugs

Posted 25 Sep 2015 by Drugs.com

FRIDAY, Sept. 25, 2015 – Many people hold on to extra prescription drugs, but saving old medications is unwise, a pharmacist warns. "Medications that are expired have passed their half-life, which leads to them being ineffective," said Kimberly Cimarelli, pharmacy manager at Penn State Milton S. Hershey Medical Center, in Hershey, Pa. Expired medications can even be dangerous, the U.S. Food and Drug Administration says. Their chemical composition can change and, over time, expired drugs may become less effective or potentially harmful. Getting rid of old, unused medications can also help ensure children don't accidentally get their hands on them. Having fewer medications at home can also help prevent mix-ups, the experts pointed out. "Older people who may be easily confused could take the wrong medication because the unwanted or expired medication wasn't disposed of," Officer Rebecca ... Read more

Related support groups: Oxycodone, Hydrocodone, Methadone, Tramadol, OxyContin, Fentanyl, Morphine, Codeine, Acetaminophen, Metoprolol, Ibuprofen, Tylenol, Opana, Subutex, Naproxen, Atenolol, Dilaudid, Meloxicam, Advil, Ultram

Tight Control of Type 2 Diabetes May Help Prevent Dementia

Posted 15 Sep 2015 by Drugs.com

TUESDAY, Sept. 15, 2015 – Keeping blood sugar levels in check may have a protective effect against dementia in people who have type 2 diabetes, new Swedish research suggests. "The positive association between [average blood sugar levels] and risk of dementia in fairly young patients with type 2 diabetes indicates a potential for prevention of dementia with improved blood sugar control," study author Dr. Aidin Rawshani, from the National Diabetes Register and Institute of Medicine in Gothenburg, Sweden, and colleagues wrote. However, the study wasn't able to definitively prove a cause-and-effect relationship between blood sugar levels and dementia; it was only able to show an association between these factors. The study included almost 350,000 people with type 2 diabetes. They were all registered in the Swedish National Diabetes Registry between January 2004 and December 2012. They had ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Lantus, Dementia, Alzheimer's Disease, Glucophage, Novolog, Glipizide, Humalog, Janumet, Glyburide, Lantus Solostar, Invokana, Levemir, Actos, Glimepiride, Novolin R, Amaryl, Mild Cognitive Impairment

Could Common Diabetes Drugs Help Fight Leukemia?

Posted 2 Sep 2015 by Drugs.com

WEDNESDAY, Sept. 2, 2015 – Common diabetes drugs might help eradicate drug-resistant cancer cells in a certain form of leukemia when added to standard treatment, a small new study suggests. Researchers found that patients with chronic myeloid leukemia (CML) who received a glitazone – a class of drug for type 2 diabetes – along with the standard CML drug imatinib remained disease-free for up to nearly five years. Imatinib, known commercially as Gleevec, boasts an impressive track record in controlling chronic myeloid leukemia and allowing patients to lead virtually normal lives. But despite its effectiveness, dormant, drug-resistant leukemic cells typically lay in wait in bone marrow. They can later transform into highly aggressive cells. "Gleevec can control the disease but never get rid of the source of the disease," said Lee Greenberger, chief scientific officer for the Leukemia & ... Read more

Related support groups: Chronic Myelogenous Leukemia (CML), Gleevec, Actos, Pioglitazone, Avandia, ActoPlus Met, Imatinib, Avandamet, Rosiglitazone, Metformin/Pioglitazone, Oseni, Alogliptin/pioglitazone, Glimepiride/Pioglitazone, ActosPlus Met, Avandaryl, Metformin/Rosiglitazone, Duetact, Glimepiride/Rosiglitazone

Health Tip: Diabetes Can Take a Toll on Teeth and Mouth

Posted 10 Aug 2015 by Drugs.com

-- Diabetes, especially when uncontrolled, can cause damage to your mouth and teeth. The Mouthhealthy.org website says possible effects of diabetes on the teeth and mouth include: Dry mouth, due to decreased saliva production. Increased risk of cavities due to less saliva. Gingivitis, characterized by bleeding, inflamed gums. Difficulty tasting food. Slower healing of mouth wounds. Increased risk of infection. Among diabetic children. teeth emerging earlier than expected. Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Xerostomia, Victoza, Oral and Dental Conditions, Lantus, Toothache, Diabetes, Type 1, Burning Mouth Syndrome, Januvia, Diabetic Neuropathy, Glucophage, Novolog, Glipizide, Humalog, Insulin Resistance, Bydureon, Byetta, Aphthous Ulcer

People With Type 2 Diabetes Do Benefit From Blood Sugar Checks

Posted 5 Aug 2015 by Drugs.com

WEDNESDAY, Aug. 5, 2015 – Personalized blood sugar self-monitoring benefits people with type 2 diabetes even if they're not taking insulin, a new small study shows. Some experts have questioned the value of self-monitoring in this group, and many insurers – including Medicare – limit the reimbursement of blood sugar (glucose) testing strips to one a day for people with type 2 diabetes. This study included 11 people with type 2 diabetes who worked with the researchers to create personalized, structured self-monitoring blood glucose schedules. In most cases, self-monitoring twice a day was the most helpful in providing meaningful information about blood sugar levels. However, there was room for individualization based on a patient's type of lifestyle and needs. For example, a patient might check their blood sugar twice a day three days a week instead of once a day seven days a week, ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Victoza, Lantus, Januvia, Glucophage, Novolog, Glipizide, Humalog, Bydureon, Byetta, Janumet, Saxenda, Glyburide, Lantus Solostar, Invokana, Levemir, Actos, Glimepiride

High Blood Sugar May Boost Alzheimer's Risk

Posted 27 Jul 2015 by Drugs.com

MONDAY, July 27, 2015 – High blood sugar associated with prediabetes may increase the risk for Alzheimer's disease, a new study suggests. Researchers found that insulin resistance – higher-than-normal levels of blood sugar that often precede type 2 diabetes – was related to poorer performance on memory tests taken by late-middle-age adults. "The findings are interesting because people with diabetes are at increased risk for developing Alzheimer's disease, but we are only now learning why they may be at increased risk," said lead researcher Barbara Bendlin, an assistant professor of medicine at the University of Wisconsin-Madison. The study results suggest that insulin resistance could increase the risk for Alzheimer's disease by altering the way the brain uses sugar (glucose), which is its primary fuel, she said. However, "by altering insulin resistance in midlife, it may be possible ... Read more

Related support groups: Diabetes, Type 2, Insulin, Lantus, Alzheimer's Disease, Novolog, Humalog, Janumet, Lantus Solostar, Levemir, Pre-Diabetes, Novolin R, Novolin N, Lantus Solostar Pen, Humulin N, Humulin R, NovoLog FlexPen, Humalog KwikPen, ActoPlus Met, Apidra, Toujeo

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