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Gene Therapy May Fight Brain Cancer's Return

Posted 27 Oct 2017 by Drugs.com

FRIDAY, Oct. 27, 2017 – A new form of gene therapy shows promise in battling recurrent brain cancer. The phase 1 clinical trial included 56 patients with recurrent high-grade glioma brain cancer. Three years after the gene therapy treatment, more than a quarter of the patients were still alive. Median survival for patients was 14.4 months, compared with eight months typically seen in patients. "Given the deadly nature of this disease, three-year survival is rarely reported in the recurrent setting. It is notable that the survival benefit was seen across a range of patients, and not just limited to patients with specific genetic mutations," said study author Dr. Clark Chen. Chen is head of the department of neurosurgery at the University of Minnesota Medical School. He made his comments in news release from the American Association for Cancer Research. The study was sponsored by therapy ... Read more

Related support groups: Fluorouracil, Efudex, Brain Tumor, Carac, Glioblastoma Multiforme, Pituitary Tumor, Acromegaly, Fluoroplex, Pituitary Adenoma, Diagnosis and Investigation, Malignant Glioma, Tolak, Anaplastic Oligodendroglioma, Fluorac, Efudex Occlusion Pack, Angioblastoma, Adrucil, Diclofenac/fluorouracil, Anaplastic Astrocytoma

Common Painkillers Tied to Slight Rise in Heart Attack Risk

Posted 10 May 2017 by Drugs.com

TUESDAY, May 9, 2017 – Commonly used painkillers such as Motrin, Advil and Aleve might increase your risk for heart attack, even in the first week of use, a new study suggests. Overall, these drugs and others known as nonsteroidal anti-inflammatory drugs (NSAIDs) increase the risk of a heart attack by 20 to 50 percent, compared with not using them, researchers found. For most people, however, this represents only a small increased risk – about 1 percent a year, the researchers said. Still, "from the viewpoint of public health, even small increases in risk of heart attack are important because use of NSAIDs is so widespread," said lead researcher Michele Bally. She's an epidemiologist at the University of Montreal Hospital Research Center. The increased risk of heart attack associated with NSAIDs was seen at any dose taken for one week, one month or more than one month. And the risk ... Read more

Related support groups: Ibuprofen, Naproxen, Heart Disease, Ischemic Stroke, Heart Attack, Celebrex, Advil, Diclofenac, Aleve, Voltaren, Voltaren Gel, Motrin, Transient Ischemic Attack, Myocardial Infarction, Vicoprofen, Flector Patch, Flector, Advil PM, Arthrotec, Advil Cold and Sinus

Common Painkillers Don't Ease Back Pain, Study Finds

Posted 2 Feb 2017 by Drugs.com

THURSDAY, Feb. 2, 2017 – Painkillers like aspirin, Aleve and Advil don't help most people with back pain, a new review finds. The researchers estimated that only one in six people gained a benefit from taking these nonsteroidal anti-inflammatory drugs (NSAIDs). Meanwhile, previous research has suggested that another common painkiller, Tylenol (acetaminophen), isn't very useful either, the study authors added. The findings raise the prospect that no over-the-counter painkillers really ease back pain, at least in the short term, and some may raise the risk of gastrointestinal problems. "There are other effective and safer strategies to manage spinal pain," said review author Gustavo Machado. He is a research fellow with the George Institute for Global Health in Sydney, Australia. Back and neck pain are the leading cause of pain worldwide, the researchers said. For the review, the ... Read more

Related support groups: Pain, Back Pain, Percocet, Vicodin, Norco, Chronic Pain, Aspirin, Lortab, Tylenol, Ibuprofen, Celebrex, Acetaminophen, Advil, Diclofenac, Aleve, Voltaren, Voltaren Gel, Paracetamol, Motrin, Fioricet

Half Report Severe Side Effects From Breast Cancer Therapy

Posted 24 Jan 2017 by Drugs.com

TUESDAY, Jan. 24, 2017 – About half of early stage breast cancer patients experience severe side effects from their treatment, a new study finds. "It's in patients' best interest to receive their treatments on time and on schedule, whenever possible, to give them the best possible outcome," said study author Dr. Steven Katz. He's professor of health management and policy at the University of Michigan. "Unscheduled care for toxicities [side effects] – including clinic visits, emergency department visits and hospital stays – are expensive, inconvenient and disruptive to both doctors and patients. We need to avoid them whenever possible," Katz said in a university news release. For the study, researchers surveyed almost 2,000 early stage breast cancer patients an average of seven months after diagnosis. The women were asked to rate the severity of seven common treatment side effects: ... Read more

Related support groups: Surgery, Breast Cancer, Fluorouracil, Efudex, Breast Cancer, Metastatic, Carac, Herceptin, Taxol, Breast Cancer - Adjuvant, Taxotere, Breast Cancer, Prevention, Carboplatin, Cytoxan, Cyclophosphamide, Paclitaxel, Breast Cancer - Palliative, Fluoroplex, Doxorubicin, Adriamycin, Kadcyla

Skin Cancer Cream Linked to 5 Dog Deaths: FDA

Posted 20 Jan 2017 by Drugs.com

THURSDAY, Jan. 19, 2017 – Five dogs have died from exposure to a skin cancer cream prescribed for people, according to the U.S. Food and Drug Administration. Ingesting very small amounts of the drug – fluorouracil topical cream USP 5% (5-FU) – can sicken or kill family pets, said the FDA. "Although the FDA has not to date received any reports involving cats, they are also expected to be extremely sensitive to fluorouracil cream," the agency said in a news release. The drug is also marketed under the brand names Carac, Efudex and Fluoroplex, the FDA said. It's used to treat precancerous sun-damaged skin as well as some basal cell skin cancers, according to the American Cancer Society. In one case, a dog merely punctured the tube of fluorouracil in its mouth before its owner could grab it. The pooch died 12 hours later, after vomiting and suffering seizures. In another instance, a dog ... Read more

Related support groups: Fluorouracil, Efudex, Basal Cell Carcinoma, Carac, Skin Cancer, Melanoma, Melanoma - Metastatic, Fluoroplex, Tolak, History - Skin Cancer, Efudex Occlusion Pack, Fluorac, Adrucil, Diclofenac/fluorouracil

Acetaminophen Won't Help Arthritis Pain, Study Finds

Posted 18 Mar 2016 by Drugs.com

THURSDAY, March 17, 2016 – Acetaminophen – commonly known as Tylenol in the United States – isn't an effective choice for relieving osteoarthritis pain in the hip or knee, or for improving joint function, a new study finds. Although the drug rated slightly better than placebo in studies, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) or diclofenac are better choices for short-term pain relief, the researchers said. "Regardless of dose, the prescription drug diclofenac is the most effective drug among painkillers in terms of improving pain and function in osteoarthritis," said lead researcher Dr. Sven Trelle. He's co-director of clinical trials at the University of Bern in Switzerland. However, even diclofenac comes with side effects. "If you are thinking of using a painkiller for osteoarthritis, you should consider diclofenac," Trelle said, but also ... Read more

Related support groups: Pain, Percocet, Vicodin, Norco, Osteoarthritis, Lortab, Tylenol, Ibuprofen, Naproxen, Meloxicam, Acetaminophen, Advil, Diclofenac, Aleve, Voltaren, Mobic, Voltaren Gel, Knee Joint Replacement, Hip Replacement, Paracetamol

Retail Prices of Dermatology Drugs Skyrocket

Posted 25 Nov 2015 by Drugs.com

WEDNESDAY, Nov. 25, 2015 – Patients using prescription creams, gels, sprays and pills for skin conditions may shell out substantially more at the pharmacy than they did just six years ago, a new study suggests. Between 2009 and 2015, retail prices of brand-name dermatologic drugs rose 401 percent, on average, study authors reported Nov. 25 in JAMA Dermatology. Even generics have succumbed to price inflation, up 279 percent between 2011 and 2014, based on the drugs surveyed. Price increases for skin treatments far outpaced the general inflation rate of 11 percent during the six-year study period, the researchers said. "Cancer drugs were the worst in terms of the numbers" – up 1,240 percent or nearly $11,000 over the six-year study period – primarily because of two medicines, said Dr. Steven Rosenberg, voluntary professor of dermatology at the University of Miami Miller School of ... Read more

Related support groups: Monistat, RID, Monistat 3, Eczema, Monistat 7, Voltaren Gel, Dermatitis, Clobetasol, Contact Dermatitis, Mupirocin, Sulfur, Epiduo, Drysol, Therapeutic, Efudex, Basal Cell Carcinoma, Maintain, Bactroban, Retin-A, Silver

Experts Urge Caution With Popular Painkillers After FDA Warning

Posted 10 Jul 2015 by Drugs.com

FRIDAY, July 10, 2015 – People who regularly reach for widely used painkillers like ibuprofen and naproxen may need to think carefully before they pop those pills, heart experts say. Mounting evidence has shown that chronic use of non-steroidal anti-inflammatory drugs (NSAIDs) can raise a person's risk of heart attack and stroke. The evidence is strong enough that the U.S. Food and Drug Administration on Thursday ordered drug makers to toughen warning labels on both prescription and over-the-counter NSAIDs. The tougher warning does not include aspirin, an NSAID that has been shown to lower heart risks in some patients. Most people who occasionally take ibuprofen (Advil, Motrin) or naproxen (Aleve) for infrequent headaches or pain don't have to worry, as long as they follow the dosage directions on the bottle, said Dr. Richard Chazal, president-elect of the American College of ... Read more

Related support groups: Pain, Ibuprofen, Naproxen, Meloxicam, Celebrex, Advil, Diclofenac, Aleve, Voltaren, Mobic, Voltaren Gel, Motrin, Indomethacin, Toradol, Etodolac, Vicoprofen, Nabumetone, Ketorolac, Flector Patch, Flector

FDA Strengthens Heart Attack, Stroke Warning for Popular Painkillers

Posted 10 Jul 2015 by Drugs.com

THURSDAY, July 9, 2015 – The U.S Food and Drug Administration on Thursday strengthened the warning labels for widely used painkillers like ibuprofen and naproxen, saying they can increase the risk of heart attack or stroke. The FDA is asking people to think carefully about their use of nonsteroidal anti-inflammatory drugs (NSAIDs), particularly if they've already had a heart attack, according to a consumer update on the agency's website. The agency said it is taking this action based on recent data that shows the risk of heart attack or stroke can increase even after using NSAIDs for a short time. "They used to say they might cause risk of heart attack or stroke. Now we are saying they do cause increased risk of heart attack and stroke," FDA spokesman Eric Pahon told NBC News. In particular, people should avoid taking multiple products that contain NSAIDs, according to the revised FDA ... Read more

Related support groups: Ibuprofen, Naproxen, Meloxicam, Celebrex, Advil, Diclofenac, Aleve, Voltaren, Mobic, Voltaren Gel, Motrin, Indomethacin, Toradol, Etodolac, Vicoprofen, Nabumetone, Ketorolac, Flector, Flector Patch, Advil PM

FDA Medwatch Alert: Non-aspirin Nonsteroidal Anti-inflammatory Drugs (NSAIDs): Drug Safety Communication - FDA Strengthens Warning of Increased Chance of Heart Attack or Stroke

Posted 10 Jul 2015 by Drugs.com

[Posted 07/09/2015] ISSUE:  FDA is strengthening an existing label warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) increase the chance of a heart attack or stroke. Based on FDAs comprehensive review of new safety information, FDA is requiring updates to the drug labels of all prescription NSAIDs. As is the case with current prescription NSAID labels, the Drug Facts labels of over-the-counter (OTC) non-aspirin NSAIDs already contain information on heart attack and stroke risk. FDA will also request updates to the OTC non-aspirin NSAID Drug Facts labels. See the FDA Drug Safety Communication (Table 1) for a list of non-aspirin nonsteroidal anti-inflammatory drug products. Prescription NSAID labels will be revised to reflect the following information: The risk of heart attack or stroke can occur as early as the first weeks of using an NSAID. The risk may increase ... Read more

Related support groups: Ibuprofen, Naproxen, Meloxicam, Celebrex, Advil, Diclofenac, Aleve, Voltaren, Mobic, Voltaren Gel, Motrin, Indomethacin, Toradol, Etodolac, Vicoprofen, Nabumetone, Ketorolac, Flector Patch, Flector, Advil PM

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