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New Drug Might Reduce Sickle Cell Pain Crises

Posted 2 hours 44 minutes ago by Drugs.com

SATURDAY, Dec. 3, 2016 – An experimental drug may help reduce episodes of pain associated with sickle cell disease, a new study finds. Results of an early trial showed the drug – called SelG1 for now – reduced episodes of sickle cell-related pain crises by 45 percent. In addition, the drug appeared safe and was well-tolerated, researchers say. "Patients with sickle cell disease have complications, the most common of which is pain crises that require medical care and sometimes hospitalization," said lead researcher Dr. Kenneth Ataga. He's director of the sickle cell program at the University of North Carolina at Chapel Hill. People with inherited sickle cell disease have abnormally shaped red blood cells. These sickle-shaped cells stick to the walls of blood vessels, slowing and blocking normal blood flow. Blockage results in less blood and oxygen reaching cells, which in turn causes ... Read more

Related support groups: Hydroxyurea, Anemia - Sickle Cell, Hydrea, Diagnosis and Investigation, Droxia, Mylocel

U.S. Pays Highest Prices for Cancer Meds: Study

Posted 6 Jun 2016 by Drugs.com

MONDAY, June 6, 2016 – The United States pays the highest prices in the world for generic and brand-name cancer drugs, a new study has found. However, as the world's wealthiest nation, the United States is better able to pay for those pricey drugs than poorer countries with somewhat lower medication prices, added study lead author Dr. Daniel Goldstein. People in China and India are much less able to afford cancer drugs than Americans, he said, even though U.S. monthly drug prices are about three to six times higher in the United States. That doesn't mean America came out on top in overall drug affordability, however. Developed nations such as Australia, England and Israel had the "best deal" in the world on cancer drugs, thanks to government programs that regulate drug pricing, the study found. "America is the wealthiest nation, but its drug prices are significantly higher – so much ... Read more

Related support groups: Cancer, Provera, Depo-Provera, Methotrexate, Breast Cancer, Accutane, Lupron, Tamoxifen, Medroxyprogesterone, Arimidex, Tretinoin, Fluorouracil, Lupron Depot, Femara, Gleevec, Colorectal Cancer, Lung Cancer, Rituxan, Isotretinoin, Claravis

'Precision' Cancer Treatment May Extend Lives

Posted 20 May 2016 by Drugs.com

THURSDAY, May 19, 2016 – "Precision" cancer treatment that's guided by genetic clues from the patient's own tumor appears to outperform traditional chemotherapy, a new research review finds. Patients given precision – or personalized – treatment experienced a tumor shrinkage rate six times that attained by regular chemotherapy. But, that only happened if doctors used genetic information to choose the appropriate targeted therapy, said lead researcher Maria Schwaederle. Those patients also experienced nearly double the length of time before their cancer resumed growing, according to the analysis of nearly 350 clinical trials. "It is not just that the therapies are better, but that targeted therapies must be given to the right patients," said Schwaederle, who's with the University of California, San Diego School of Medicine's Center for Personalized Cancer Therapy. She will present ... Read more

Related support groups: Cancer, Methotrexate, Breast Cancer, Accutane, Tretinoin, Fluorouracil, Gleevec, Colorectal Cancer, Lung Cancer, Isotretinoin, Claravis, Tarceva, Xeloda, Skin Cancer, BCG, Revlimid, Tasigna, Sprycel, Hydroxyurea, Zytiga

Drug Protects Lung Function in Kids With Sickle Cell: Study

Posted 18 May 2016 by Drugs.com

WEDNESDAY, May 18, 2016 – Children with sickle cell disease may breathe easier when they're given hydroxyurea – an effective, but underused, drug for the disease, new research suggests. In a study of 94 young people with sickle cell, researchers found that hydroxyurea helped slow the decline in lung function that is typical of the disease. The study appears to be the first to show that hydroxyurea can preserve kids' lung function, said lead researcher Dr. Anya McLaren, of the Hospital for Sick Children in Toronto. She said the findings should give doctors more reason to prescribe hydroxyurea. The drug, she noted, is already known to prevent severe bouts of pain and serious lung complications in people with sickle cell. An expert who was not involved with the study agreed. "This is further confirmation that this medication is beneficial," said Dr. George Buchanan. He is a pediatric ... Read more

Related support groups: Anemia, Hydroxyurea, Anemia - Sickle Cell, Hydrea, Respiratory Distress Syndrome, Droxia, Mylocel

HIV Patients Less Likely to Get Treatment for Cancer: Study

Posted 17 May 2016 by Drugs.com

TUESDAY, May 17, 2016 – While powerful HIV medications are granting longer lives to many people infected with the virus, a new U.S. study shows these same patients are less likely to get treatment for cancer if it develops. It's not clear why the difference exists. It could reflect the decisions of physicians, patients or both. Whatever the case, the finding confirms that the gap persists even when patients have private insurance or are otherwise healthy, the study authors said. Previous research has suggested that "people with well-controlled HIV infection should be treated similarly to patients without HIV," said study author Dr. Gita Suneja. However, "even looking at cancer patients with private health insurance only, we saw that those with HIV infection were less likely to receive cancer treatment for many common cancer types," said Suneja. She is an assistant professor of ... Read more

Related support groups: Cancer, Methotrexate, HIV Infection, Fluorouracil, Lung Cancer, Xeloda, Hydroxyurea, Mercaptopurine, Hydrea, Carboplatin, Cisplatin, Cytoxan, Temodar, Cyclophosphamide, Dacogen, Bendamustine, Treanda, Oxaliplatin, Gemzar, Capecitabine

Could Talk Therapy Ease Chemo-Related Memory Issues?

Posted 2 May 2016 by Drugs.com

MONDAY, May 2, 2016 – A type of psychotherapy might help cancer survivors deal with the long-term thinking problems some experience after chemotherapy, researchers say. It's estimated that about half of those who undergo chemotherapy for cancer develop what's often called "chemo brain." For instance, they may have trouble following conversations or remembering the steps in a project, according to background notes with the new study. Although usually mild, these changes can affect quality of life, job performance and relationships, said the researchers from the Eastern Maine Medical Center and Lafayette Family Cancer Center in Bangor, Maine. The researchers developed a cognitive-behavioral therapy (CBT) program called Memory and Attention Adaptation Training to help cancer survivors prevent or manage these memory problems. Their study involved 47 breast cancer survivors who underwent ... Read more

Related support groups: Cancer, Methotrexate, Breast Cancer, Prostate Cancer, Fluorouracil, Gleevec, Colorectal Cancer, Lung Cancer, Renal Cell Carcinoma, Brain Tumor, Non-Small Cell Lung Cancer, Breast Cancer, Metastatic, Melanoma, Xeloda, Skin Cancer, Tasigna, Pancreatic Cancer, Ovarian Cancer, Endometrial Cancer, Sprycel

Fewer Childhood Cancer Survivors Dying From 'Late' Effects

Posted 13 Jan 2016 by Drugs.com

WEDNESDAY, Jan. 13, 2016 – Fewer childhood cancer survivors are dying years later from lingering effects of the treatment that conquered their cancer, a new study finds. Experts called the report, published in the Jan. 14 issue of the New England Journal of Medicine, "very good news." "The findings substantiate what experts in the field have hoped would be true," said lead researcher Dr. Gregory Armstrong, of St. Jude Children's Research Hospital, in Memphis, Tenn. Survival rates from many childhood cancers are high, but survivors still face what doctors call "late effects" – health problems that develop months to years after the cancer treatment has ended. Among U.S. children who survived cancer back in the 1970s and '80s, 18 percent died within the next 25 years, Armstrong said. Sometimes, the initial cancer comes back. Often though, the health issues are related to the very ... Read more

Related support groups: Cancer, Methotrexate, Fluorouracil, Xeloda, Hydroxyurea, Mercaptopurine, Hydrea, Carboplatin, Cisplatin, Cytoxan, Cyclophosphamide, Temodar, Dacogen, Bendamustine, Treanda, Oxaliplatin, Gemcitabine, Capecitabine, Hodgkin's Lymphoma, Acute Lymphoblastic Leukemia

Childhood Cancer Treatment May Raise Adult Heart Disease Risk

Posted 5 Jan 2016 by Drugs.com

MONDAY, Jan. 4, 2016 – Children who survive cancer may face a higher risk of heart disease as adults, new research suggests. The lingering effects of the treatments that saved their lives as children may trigger the development of heart abnormalities that might not cause apparent symptoms, the researchers explained. The investigators found that heart disease appears to affect between 3 percent and 24 percent of pediatric cancer survivors by the time they reach their 30s. Those figures rose to between 10 and 37 percent among patients 40 and older, the study found. However, while the study revealed a link between childhood cancer treatment and later heart disease, it didn't prove cause-and-effect. "The prevalence of these cardiac findings might be expected in an older adult population, but not necessarily in this young a population," said study lead author Dr. Daniel Mulrooney. ... Read more

Related support groups: Cancer, Heart Disease, Methotrexate, Fluorouracil, Xeloda, Cardiac Arrhythmia, Cardiomyopathy, Hydroxyurea, Left Ventricular Dysfunction, Mercaptopurine, Hydrea, Carboplatin, Cisplatin, Cytoxan, Temodar, Dacogen, Cyclophosphamide, Bendamustine, Treanda, Oxaliplatin

Sickle Cell Drug Doesn't Relieve Pain Crises: Study

Posted 8 Dec 2015 by Drugs.com

TUESDAY, Dec. 8, 2015 – The anti-clotting drug prasugrel does little to reduce the risk of pain crises in children with sickle cell disease, a new study shows. The research included 341 patients in 13 countries in Africa, the Americas, Asia, Europe and the Middle East. About half took prasugrel (Effient) for between nine and 24 months. The other half took a placebo. There was little difference between the two groups in rates of pain crises caused by interrupted blood flow in small blood vessels, the scientists found. Over time, repeated pain crises lead to tissue damage and chronic inflammation. The study was led by researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and University of California, San Francisco's Benioff Children's Hospital Oakland. "Although we were disappointed that prasugrel does not appear to ease the suffering of children with sickle cell ... Read more

Related support groups: Pain, Effient, Hydroxyurea, Anemia - Sickle Cell, Hydrea, Prasugrel, Droxia, Mylocel

U.S. Oncologists Decry High Cost of Cancer Drugs

Posted 23 Jul 2015 by Drugs.com

THURSDAY, July 23, 2015 – Soaring costs for cancer drugs are hurting patient care in the United States, a group of top oncologists claim. "High cancer-drug prices are affecting the care of patients with cancer and our health care system," Dr. Ayalew Tefferi, a hematologist at Mayo Clinic in Rochester, Minn., said in a Mayo news release. Tefferi and his colleagues made a number of recommendations on how to address the problem in a commentary published July 23 in the Mayo Clinic Proceedings. Allowing Medicare to negotiate drug prices is one of the suggestions the team of 118 leading cancer experts offered as a possible solution. Along with their recommendations, the group also expressed support for a patient-based grassroots movement on change.org that is demanding action on the issue. "The average gross household income in the U.S. is about $52,000 per year. For an insured patient with ... Read more

Related support groups: Cancer, Provera, Depo-Provera, Methotrexate, Breast Cancer, Accutane, Lupron, Prostate Cancer, Tamoxifen, Medroxyprogesterone, Arimidex, Tretinoin, Fluorouracil, Femara, Lupron Depot, Gleevec, Colorectal Cancer, Lung Cancer, Renal Cell Carcinoma, Isotretinoin

Few Sickle Cell Patients Receiving Beneficial Drug, Study Finds

Posted 28 Apr 2015 by Drugs.com

TUESDAY, April 28, 2015 – Few U.S. adults with sickle cell anemia are getting a recommended medication that can help them manage pain, breathing problems and other debilitating symptoms, according to a new study. Using a national database, researchers found that less than one-quarter of sickle cell patients who should have been taking a drug called hydroxyurea actually were. "This is a medication that's highly beneficial and yet most people aren't getting it," said Dr. George Buchanan, a sickle cell expert, and a professor at the University of Texas Southwestern Medical Center at Dallas, who was not involved in the new study. Findings from the study were reported in the April 28 issue of the Journal of the American Medical Association. Sickle cell anemia is an inherited disease that mainly affects people of African, South American or Mediterranean descent. In the United States, about ... Read more

Related support groups: Hydroxyurea, Anemia - Sickle Cell, Hydrea, Droxia, Mylocel

Sickle Cell Anemia Treatment So Successful in Kids That Trial Is Halted

Posted 21 Nov 2014 by Drugs.com

FRIDAY, Nov. 21, 2014 – A clinical trial of hydroxyurea therapy for children with sickle cell anemia has been halted a year early because the results show it is a safe and effective way to manage the disease and reduce the risk of stroke. The announcement about the research, which was conducted at 25 medical centers in the United States and Canada, was made this week by the U.S. National Heart, Lung, and Blood Institute (NHLBI). Researchers compared monthly blood transfusions with daily hydroxyurea pills among children with sickle cell anemia who were at high risk of stroke. To determine this, they measured the velocity of blood flow to the brain in these young patients. With sickle cell anemia, red blood cells become stiff and sickle-shaped, blocking blood flow throughout the body. Hydroxyurea was first developed as a cancer drug, but with sickle cell anemia it reduces the number of ... Read more

Related support groups: Hydroxyurea, Anemia - Sickle Cell, Hydrea, Droxia, Mylocel

Medicines Are Biggest Culprit in Fatal Allergic Reactions: Study

Posted 10 Oct 2014 by Drugs.com

THURSDAY, Oct. 9, 2014 – Although food allergies have garnered a lot of attention lately, a new study reports that medications are actually the biggest cause of sudden deaths related to allergy. Over a little more than a decade, nearly 60 percent of the allergy-related deaths were caused by medications, while less than 7 percent were caused by food allergies, the study found. "Medications can be dangerous," said study researcher Dr. Elina Jerschow, director of the Drug Allergy Center at Montefiore Medical Center and assistant professor of medicine at Albert Einstein College of Medicine, in New York City. While research from other countries has reported medications as a major culprit in anaphylaxis-related deaths, Jerschow said, the problem has been less defined in the United States. One reason is that there is no national registry for anaphylaxis deaths, she said. The study was ... Read more

Related support groups: Provera, Depo-Provera, Amoxicillin, Metronidazole, Doxycycline, Cephalexin, Clindamycin, Penicillin, Methotrexate, Azithromycin, Bactrim, Cipro, Ciprofloxacin, Accutane, Augmentin, Levaquin, Lupron, Flagyl, Keflex, Zithromax

New Guidelines for Sickle Cell Disease

Posted 10 Sep 2014 by Drugs.com

WEDNESDAY, Sept. 10, 2014 – An expert panel has issued new guidelines for managing sickle cell disease, stressing the use of the drug hydroxyurea and transfusions for many with the genetic disorder. "This is a major step forward to try to put together all of the evidence and try to highlight what is most important," said Dr. Barbara Yawn, professor of family and community health at Olmsted Medical Center in Rochester, Minn. Yawn was also co-chair of the panel convened by the U.S. National Heart, Lung, and Blood Institute to develop the new guidelines. As many as 100,000 Americans have sickle cell disease, according to background information with the guidelines. In sickle cell disease, the body makes sickle-shaped or crescent-shaped red blood cells. Normal red blood cells are disc-shaped, like a doughnut without holes, allowing the cells to move easily through blood vessels. Sickle ... Read more

Related support groups: Hydroxyurea, Anemia - Sickle Cell, Hydrea, Droxia, Mylocel

Sickle Cell Drug Reduces Symptoms, Health Costs Alike, Study Finds

Posted 17 Sep 2013 by Drugs.com

MONDAY, Sept. 16 – A drug used to treat sickle cell disease can not only reduce complications, but also cut health-care costs associated with treating children affected by this painful condition, according to a new study. Sickle cell disease is a genetic disorder affecting people of African, Middle Eastern, Mediterranean and Hispanic descent. The new cost-benefit analysis found that young children whose treatment included a daily dose of hydroxyurea had fewer hospitalizations, blood transfusions and less pain. They also had medical costs that were on average $3,000 less than children who received standard therapy. "In addition to alleviating the human suffering in sickle cell disease, we found that hydroxyurea had the pleasant 'side effect' of substantially lowering the cost of care among children treated with it," study investigator Dr. James Casella, director of pediatric hematology ... Read more

Related support groups: Hydroxyurea, Anemia - Sickle Cell, Hydrea, Droxia, Mylocel

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