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FDA Medwatch Alert: Methylprednisolone Sodium Succinate for Injection 40mg, 125mg, and 1g by Sagent Pharmaceuticals: Recall - High Out of Specification Impurity Results

Posted 8 Mar 2018 by Drugs.com

ISSUE: Sagent Pharmaceuticals, Inc. announced the voluntary nationwide recall of ten lots of Methylprednisolone Sodium Succinate for Injection, USP, 40mg, 125mg, and 1g. A detailed listing of products and lots is listed in the recall notice. These products were manufactured by Gland Pharma Ltd. and distributed by Sagent Pharmaceuticals. Sagent has initiated this voluntary recall of ...

Boosting Steroid Dose May Not Reduce Kids' Asthma Flare-Ups

Posted 5 Mar 2018 by Drugs.com

SATURDAY, March 3, 2018 – Temporarily boosting the dose of inhaled steroids may not do much to reduce the frequency of severe asthma flare-ups in children, according to two new studies. Short-term increases in inhaled steroids might even be tied to slightly slowed growth in kids, one of the studies suggested. Asthma flare-ups in children are common and many doctors increase doses of inhaled ...

Imbruvica Approval Expanded to Include Graft Versus Host Disease

Posted 3 Aug 2017 by Drugs.com

WEDNESDAY, Aug. 2, 2017 – The U.S. Food and Drug Administration on Wednesday expanded approval for the anti-cancer drug Imbruvica (ibrutinib) to include adults with chronic graft versus host disease (cGVHD). cGVHD is a deadly condition that affects up to 70 percent of people who receive a stem cell transplant to treat cancers of the blood or bone marrow, the FDA said in a news release. The ...

Methylprednisolone for Kidney Disease Tied to Infection Risk

Posted 1 Aug 2017 by Drugs.com

TUESDAY, Aug. 1, 2017 – A drug used for some cases of kidney disease can raise the risk of serious infections, researchers say. A clinical trial was stopped early when researchers discovered that patients on the drug – a corticosteroid called methylprednisolone – suffered a concerning number of serious side effects. Most often, that meant severe infections, including pneumonia and meningitis. ...

Scientists Spot Genes Behind Crohn's, Ulcerative Colitis

Posted 29 Jun 2017 by Drugs.com

THURSDAY, June 29, 2017 – Researchers say they've come closer to pinpointing genes linked with inflammatory bowel diseases such as Crohn's and ulcerative colitis. For the study, the investigators examined the genomes of nearly 68,000 people. Of the regions of the genome associated with inflammatory bowel disease (IBD), 18 could be traced to a single genetic variant with more than 95 percent ...

Forget Steroid Shots for Long-Term Relief of Arthritic Knees

Posted 16 May 2017 by Drugs.com

TUESDAY, May 16, 2017 – Steroid shots are a common treatment for arthritic knees. But, a new study says their long-term use is ineffective and may even reduce cartilage. Knee osteoarthritis patients who got steroid injections every three months for two years had no less pain than those taking a placebo treatment. And they had greater loss of cartilage, the rubbery tissue that acts as a cushion ...

Is It Wise to Take a Steroid for a Sore Throat?

Posted 18 Apr 2017 by Drugs.com

TUESDAY, April 18, 2017 – Researchers seeking new sore throat treatments report only modest success with a single dose of a steroid medication. Concerns about growing bacterial resistance to antibiotics have led scientists to look for alternative therapies for sore throat, a common reason for doctor visits. In this new British study, a steroid medication led to improvement in about one-third of ...

Steroid Shots Offer No Long-Term Relief for Low-Back Pain

Posted 20 Mar 2017 by Drugs.com

MONDAY, March 20, 2017 – Chronic lower back pain affects millions of Americans. Many try steroid injections to ease their discomfort, but researchers now say this remedy provides only short-term relief. In their study, investigators from France focused on 135 patients with back pain seemingly caused by inflammation between the discs and bones (vertebrae) in the lower spine. The researchers found ...

Immune-Based Drug May Ease Chronic Eye Condition

Posted 8 Sep 2016 by Drugs.com

WEDNESDAY, Sept. 7, 2016 – People with chronic eye inflammation known as uveitis may be able to keep the condition at bay with the immune-suppressing drug Humira (adalimumab), a new study finds. "Humira doesn't cure uveitis, but it does cause it to become quiet," said lead researcher Dr. Glenn Jaffe. He's a professor of ophthalmology at Duke University School of Medicine in Durham, N.C., and a ...

Certain Steroids Raise Risk for Serious Staph Infections

Posted 9 Jun 2016 by Drugs.com

THURSDAY, June 9, 2016 – People who use powerful drugs called systemic glucocorticoids are at higher risk for life-threatening staph blood infections, a new study finds. The findings are "a reminder for clinicians to weigh carefully the elevated risk against the potential beneficial effect of glucocorticoid therapy," said study lead author Dr. Jesper Smit, of Aarhus University Hospital in ...

Steroid Shot for Hip Pain May Carry Infection Risk If Too Close to Surgery

Posted 2 Mar 2016 by Drugs.com

WEDNESDAY, March 2, 2016 – Patients who've received a steroid injection for hip pain should wait at least three months before having hip replacement surgery, a new study suggests. "The risk of developing an infection after surgery increased significantly in patients who had a hip replacement within three months of receiving a steroid injection," study author Dr. William Schairer, from the ...

Knee Arthritis: Steroid Shots May Not Help Long-Term, Ozone Injections Promising

Posted 10 Nov 2015 by Drugs.com

TUESDAY, Nov. 10, 2015 – Millions of aging Americans are plagued by arthritic knees, and two new studies offer insight into what might – or might not – help curb the condition. Both studies were presented this week at the American College of Rheumatology's annual meeting in San Francisco. One study found that a popular therapy, steroid drug injections, do nothing to slow progression of ...

Crohn's Disease Treatments for Kids May Not Get Gut Back to Normal

Posted 14 Oct 2015 by Drugs.com

WEDNESDAY, Oct. 14, 2015 – Current therapies for children with Crohn's disease don't fully restore healthy bacteria and fungi populations in their digestive systems, a new study shows. These findings suggest that treatments don't have to bring bacteria and other microbe levels back to normal levels in the gut to be useful. This knowledge could lead to new approaches for diagnosing and treating ...

'Tennis Elbow' Usually Heals Without Therapy, Study Finds

Posted 1 Oct 2015 by Drugs.com

THURSDAY, Oct. 1, 2015 – Most people with tennis elbow recover without physical therapy and steroid injections, according to a study by researchers in Norway. "I'm not surprised because that's really been the classic teaching," said Dr. Joshua Dines, an orthopedic surgeon at the Hospital for Special Surgery in New York City. "The number that's often cited is that 90 percent of tennis elbow, ...

Steroid Injections Probably Won't Help Your Lower Back Pain

Posted 24 Aug 2015 by Drugs.com

MONDAY, Aug. 24, 2015 – Steroid injections for lower back pain may provide some relief for certain patients, but any benefits are temporary, a new study finds. Lower back pain related to herniated disk (when intervertebral disks become compressed and bulge) and, to a lesser degree, spinal stenosis (narrowing of the spinal canal), is often treated with epidural steroid injections, the researchers ...

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