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Imbruvica Approval Expanded to Include Graft Versus Host Disease

Posted 3 Aug 2017 by Drugs.com

WEDNESDAY, Aug. 2, 2017 – The U.S. Food and Drug Administration on Wednesday expanded approval for the anti-cancer drug Imbruvica (ibrutinib) to include adults with chronic graft versus host disease (cGVHD). cGVHD is a deadly condition that affects up to 70 percent of people who receive a stem cell transplant to treat cancers of the blood or bone marrow, the FDA said in a news release. The condition occurs when the transplanted cells attack healthy cells in a patient's tissues. "This approval highlights how a known treatment for cancer is finding a new use in treating a serious and life-threatening condition that may occur in patients with blood cancer who receive a stem cell transplant," said Dr. Richard Pazdur, director of the FDA's Oncology Center of Excellence. Use of Imbruvica to treat cGVHD was studied in a clinical trial of 42 people whose symptoms lingered despite standard ... Read more

Related support groups: Prednisone, Bleeding Disorder, Methylprednisolone, Prednisolone, Hydrocortisone, Medrol, Cortisone, Dexamethasone, Triamcinolone, Betamethasone, Budesonide, Blood Transfusion, Entocort, Decadron, Solu-Medrol, Entocort EC, Florinef, Imbruvica, Fludrocortisone, Cortef

Scientists Spot Genes Behind Crohn's, Ulcerative Colitis

Posted 29 Jun 2017 by Drugs.com

THURSDAY, June 29, 2017 – Researchers say they've come closer to pinpointing genes linked with inflammatory bowel diseases such as Crohn's and ulcerative colitis. For the study, the investigators examined the genomes of nearly 68,000 people. Of the regions of the genome associated with inflammatory bowel disease (IBD), 18 could be traced to a single genetic variant with more than 95 percent certainty. "We have taken the biggest ever data set for IBD and applied careful statistics to narrow down to the individual genetic variants involved," said study co-author Dr. Jeffrey Barrett, from the Wellcome Trust Sanger Institute in the United Kingdom. "Now we have a clearer picture of which genes do and do not play a role in the disease. We are zooming in on the genetic culprits of IBD," he said in an institute news release. The findings could lead to improved effectiveness of current ... Read more

Related support groups: Prednisone, Methylprednisolone, Crohn's Disease, Ulcerative Colitis, Prednisolone, Hydrocortisone, Medrol, Cortisone, Dexamethasone, Triamcinolone, Crohn's Disease - Maintenance, Betamethasone, Ulcerative Colitis - Active, Inflammatory Bowel Disease, Budesonide, Crohn's Disease - Acute, Entocort, Decadron, Solu-Medrol, Ulcerative Colitis - Maintenance

Is It Wise to Take a Steroid for a Sore Throat?

Posted 18 Apr 2017 by Drugs.com

TUESDAY, April 18, 2017 – Researchers seeking new sore throat treatments report only modest success with a single dose of a steroid medication. Concerns about growing bacterial resistance to antibiotics have led scientists to look for alternative therapies for sore throat, a common reason for doctor visits. In this new British study, a steroid medication led to improvement in about one-third of patients with sore throat. But, two U.S. physicians said they aren't rushing to prescribe the drugs on the basis of these results. Steroid treatment "might mask a more serious problem. That's really pretty important," said Dr. Robert Centor, a professor of internal medicine at the University of Alabama at Birmingham. "Most sore throats are relatively simple, but some are relatively dangerous, and people can die or end up in the ICU," said Centor, who wasn't involved in the study. "Steroids could ... Read more

Related support groups: Prednisone, Methylprednisolone, Medrol, Dexamethasone, Sore Throat, Decadron, Solu-Medrol, TobraDex, MethylPREDNISolone Dose Pack, Ciprodex, Medrol Dosepak, Depo-Medrol, Maxitrol, Deltasone, Dexamethasone/Tobramycin, Maxidex, Tobradex ST, Decadron Tablets, Rayos, Dexamethasone/Neomycin/Polymyxin B

Drug Trio Shows Major Promise Against Myeloma

Posted 6 Oct 2016 by Drugs.com

THURSDAY, Oct. 6, 2016 – Adding a newer drug to a standard treatment for advanced cases of multiple myeloma may significantly boost patients' chances of a response and even recovery, a new clinical trial finds. Of patients given the drug, called daratumumab, 43 percent had a complete response – meaning there were no signs of the cancer left. That compared with 19 percent of patients who received a standard drug duo alone. And over 13.5 months, the daratumumab combination cut patients' risk of dying or seeing their cancer progress by 63 percent, the study found. Researchers called the results "unprecedented" for patients like these. All had relapsed or refractory myeloma – which means the cancer had either come back or failed to respond to the previous treatment. "It is very likely that (this regimen) will be rapidly adopted by practicing physicians," said lead researcher Dr. Meletios ... Read more

Related support groups: Dexamethasone, Multiple Myeloma, Revlimid, Decadron, TobraDex, Ciprodex, Maxitrol, Osteolytic Bone Lesions of Multiple Myeloma, Dexamethasone/Tobramycin, Tobradex ST, Dexamethasone/Neomycin/Polymyxin B, Maxidex, Lenalidomide, Decadron Tablets, Ozurdex, Adrenocot, Darzalex, Poly-Dex, Dexone, Neo-Poly-Dex

Immune-Based Drug May Ease Chronic Eye Condition

Posted 8 Sep 2016 by Drugs.com

WEDNESDAY, Sept. 7, 2016 – People with chronic eye inflammation known as uveitis may be able to keep the condition at bay with the immune-suppressing drug Humira (adalimumab), a new study finds. "Humira doesn't cure uveitis, but it does cause it to become quiet," said lead researcher Dr. Glenn Jaffe. He's a professor of ophthalmology at Duke University School of Medicine in Durham, N.C., and a consultant for Humira's maker, AbbVie. "The hope is while the disease is in a quiet state, the disease activity just burns itself out – but it can also come back," he said. The U.S. Food and Drug Administration approved Humira for the treatment of uveitis in June. The results of the study were published Sept. 8 in the New England Journal of Medicine. The study was funded by AbbVie. Uveitis – a term used to describe a group of inflammatory diseases inside the eye – can cause loss of vision and ... Read more

Related support groups: Prednisone, Eye Conditions, Humira, Methylprednisolone, Prednisolone, Hydrocortisone, Medrol, Cortisone, Triamcinolone, Dexamethasone, Betamethasone, Budesonide, Entocort, Decadron, Solu-Medrol, Uveitis, Entocort EC, Cortef, MethylPREDNISolone Dose Pack, Medrol Dosepak

Certain Steroids Raise Risk for Serious Staph Infections

Posted 9 Jun 2016 by Drugs.com

THURSDAY, June 9, 2016 – People who use powerful drugs called systemic glucocorticoids are at higher risk for life-threatening staph blood infections, a new study finds. The findings are "a reminder for clinicians to weigh carefully the elevated risk against the potential beneficial effect of glucocorticoid therapy," said study lead author Dr. Jesper Smit, of Aarhus University Hospital in Denmark. "This is especially pertinent in patients who are already vulnerable to infection," he added. Glucocorticoids – a form of steroids – are powerful immunosuppressive drugs used to treat a variety of medical conditions that involve inflammation. The drugs are "given by mouth or by injection, are anti-inflammatory, and can suppress the immune system," explained one U.S. expert, Dr. Gerald Bernstein. "Usually, short-term use in otherwise healthy people does not cause a problem, but long term ... Read more

Related support groups: Infections, Prednisone, Bacterial Infection, Methylprednisolone, Osteoporosis, Prednisolone, Hydrocortisone, Medrol, Cortisone, Methicillin-Resistant Staphylococcus Aureus Infection, Dexamethasone, Triamcinolone, Betamethasone, Fracture, bone, Budesonide, Prevention of Osteoporosis, Entocort, Decadron, Solu-Medrol, Entocort EC

Steroid Shot for Hip Pain May Carry Infection Risk If Too Close to Surgery

Posted 2 Mar 2016 by Drugs.com

WEDNESDAY, March 2, 2016 – Patients who've received a steroid injection for hip pain should wait at least three months before having hip replacement surgery, a new study suggests. "The risk of developing an infection after surgery increased significantly in patients who had a hip replacement within three months of receiving a steroid injection," study author Dr. William Schairer, from the Hospital for Special Surgery in New York City, said in a hospital news release. "However, in patients who had a steroid injection and then waited three months or longer to have the surgery, there was no increased risk at all." Steroid injections are widely used to ease pain and inflammation associated with arthritis. These injections can weaken the immune system, which could increase infection risk, the researchers explained. "Hip replacement is a common and safe procedure that relieves pain and ... Read more

Related support groups: Infections, Prednisone, Methylprednisolone, Prednisolone, Hydrocortisone, Medrol, Hip Replacement, Cortisone, Dexamethasone, Triamcinolone, Betamethasone, Budesonide, Orthopedic Surgery, Entocort, Decadron, Solu-Medrol, Florinef, Entocort EC, Fludrocortisone, Cortef

Knee Arthritis: Steroid Shots May Not Help Long-Term, Ozone Injections Promising

Posted 10 Nov 2015 by Drugs.com

TUESDAY, Nov. 10, 2015 – Millions of aging Americans are plagued by arthritic knees, and two new studies offer insight into what might – or might not – help curb the condition. Both studies were presented this week at the American College of Rheumatology's annual meeting in San Francisco. One study found that a popular therapy, steroid drug injections, do nothing to slow progression of osteoarthritis in the knee. This type of treatment is common, but has never been specifically tested, and there are concerns about its safety, according to a team led by Dr. Tim McAlindon, chief of rheumatology at Tufts Medical Center in Boston. His team tracked outcomes for 140 people – mainly overweight white women – with knee arthritis who averaged 58 years of age. The patients received either injections of the steroid triamcinolone hexacetonide, or placebo injections of saline, every three months ... Read more

Related support groups: Prednisone, Osteoarthritis, Testosterone, Methylprednisolone, Prednisolone, AndroGel, Hydrocortisone, Medrol, Cortisone, Dexamethasone, Triamcinolone, Testim, Betamethasone, Budesonide, Axiron, Entocort, Decadron, Kenalog, Androderm, Solu-Medrol

Crohn's Disease Treatments for Kids May Not Get Gut Back to Normal

Posted 14 Oct 2015 by Drugs.com

WEDNESDAY, Oct. 14, 2015 – Current therapies for children with Crohn's disease don't fully restore healthy bacteria and fungi populations in their digestive systems, a new study shows. These findings suggest that treatments don't have to bring bacteria and other microbe levels back to normal levels in the gut to be useful. This knowledge could lead to new approaches for diagnosing and treating inflammatory bowel disease, according to the Oct. 14 study in the journal Cell Host & Microbe. "We show that microbes in the gut respond to treatment of inflammatory bowel disease in a much more complex way than has been previously appreciated," co-principal investigator Gary Wu, from the University of Pennsylvania in Philadelphia, said in a journal news release. "The results of our study provide information that could be used to track or predict disease, as well as new diet-based therapeutic ... Read more

Related support groups: Prednisone, Methylprednisolone, Crohn's Disease, Prednisolone, Hydrocortisone, Medrol, Cortisone, Dexamethasone, Triamcinolone, Crohn's Disease - Maintenance, Betamethasone, Asacol, Sulfasalazine, Budesonide, Pentasa, Lialda, Entocort, Crohn's Disease - Acute, Decadron, Solu-Medrol

Steroid Injections Probably Won't Help Your Lower Back Pain

Posted 24 Aug 2015 by Drugs.com

MONDAY, Aug. 24, 2015 – Steroid injections for lower back pain may provide some relief for certain patients, but any benefits are temporary, a new study finds. Lower back pain related to herniated disk (when intervertebral disks become compressed and bulge) and, to a lesser degree, spinal stenosis (narrowing of the spinal canal), is often treated with epidural steroid injections, the researchers said. But after reviewing 38 previously published studies, the researchers found no strong evidence to support their use for these conditions. "These injections may not be as effective as perceived, and decisions should be based on an informed discussion of risks, benefits, and potential options, including surgery, medications and nonpharmacological options like exercise therapy," said lead researcher Dr. Roger Chou, a professor of medicine at the Oregon Health & Science University. Chou said ... Read more

Related support groups: Back Pain, Prednisone, Methylprednisolone, Sciatica, Prednisolone, Hydrocortisone, Herniated Disc, Medrol, Cortisone, Dexamethasone, Triamcinolone, Betamethasone, Scoliosis, Budesonide, Entocort, Decadron, Solu-Medrol, Entocort EC, Cortef, MethylPREDNISolone Dose Pack

Steroids May Help Speed Pneumonia Recovery, Study Finds

Posted 10 Aug 2015 by Drugs.com

MONDAY, Aug. 10, 2015 – Steroid treatment may hasten pneumonia patients' recovery and cut their risk of complications, a new review suggests. The findings "should lead to an important change in treatment for pneumonia," lead author Dr. Reed Siemieniuk, a physician and graduate student at McMaster University in Hamilton, Canada, said in a university news release. "Corticosteroids are inexpensive and readily available around the world. Millions of patients will benefit from this new evidence," he said. But one expert said a bit more research may be needed first. "With such modest – though measurable – effects of treatment, a large multi-center randomized clinical trial," would still be necessary to confirm the new findings and "perhaps justify a change in the standard of care," said Dr. Bruce Polsky. He is chair of the department of medicine at Winthrop-University Hospital in Mineola, ... Read more

Related support groups: Prednisone, Methylprednisolone, Pneumonia, Prednisolone, Hydrocortisone, Medrol, Cortisone, Triamcinolone, Dexamethasone, Betamethasone, Budesonide, Entocort, Decadron, Solu-Medrol, Entocort EC, Cortef, MethylPREDNISolone Dose Pack, Medrol Dosepak, Depo-Medrol, Orapred

Steroids No Better for Sciatica Pain Than Placebo, Study Finds

Posted 19 May 2015 by Drugs.com

TUESDAY, May 19, 2015 – Doctors often prescribe steroid pills to ease the discomfort of sciatica – back and leg pain usually caused by a herniated disk in the lower back. But a new study finds steroids are no more effective than a placebo pill for the pain and provide only modest improvement in function. Sciatica affects about one in 10 people in their lifetime, the researchers said. For this study, 269 people with sciatica were randomly assigned to take an oral steroid (prednisone) or a placebo (a dummy medication) for 15 days. The participants were followed for up to a year. "When we compared the prednisone to placebo, there was a modest improvement in function," said study researcher Dr. Harley Goldberg, director of spine care services at Kaiser Permanente San Jose Medical Center in California. People reported they could go about their daily activities somewhat better than before. ... Read more

Related support groups: Pain, Back Pain, Prednisone, Chronic Pain, Neuralgia, Methylprednisolone, Sciatica, Prednisolone, Neuropathic Pain, Hydrocortisone, Medrol, Cortisone, Dexamethasone, Triamcinolone, Betamethasone, Budesonide, Entocort, Decadron, Breakthrough Pain, Solu-Medrol

They Overcame Childhood Cancer, But Now Obesity?

Posted 11 May 2015 by Drugs.com

MONDAY, May 11, 2015 – Certain treatments may increase a childhood cancer survivor's risk of obesity later in life, a new study says. "The ability to identify patients at increased risk may guide selection of therapeutic protocols that will maximize treatment outcomes while simultaneously minimizing the risk of long-term complications among children diagnosed with cancer," said study co-leader Kirsten Ness, of St. Jude Children's Research Hospital in Memphis. The researchers looked at nearly 2,000 people who'd been diagnosed with childhood cancer at least 10 years earlier. They found that almost half who underwent cranial radiation were obese. This compared with just over 29 percent of those who did not receive that type of treatment. Cranial radiation is used to prevent or delay the spread of cancer to the brain. The risk of obesity among survivors treated with cranial radiation was ... Read more

Related support groups: Obesity, Cancer, Prednisone, Methylprednisolone, Prednisolone, Hydrocortisone, Medrol, Cortisone, Dexamethasone, Triamcinolone, Betamethasone, Budesonide, Entocort, Decadron, Solu-Medrol, Entocort EC, Cortef, MethylPREDNISolone Dose Pack, Medrol Dosepak, Depo-Medrol

FDA Panel Mulls Worth of Steroid Shots For Back Pain

Posted 25 Nov 2014 by Drugs.com

TUESDAY, Nov. 25, 2014 – An expert advisory panel of the U.S. Food and Drug Administration will decide Tuesday whether to recommend that doctors stop giving steroid injections for back pain. These shots are commonly used to treat back pain, but they are not approved for this use and whether the risks outweigh the benefits is a matter of debate. According to the FDA, serious but rare side effects with these shots can include death, spinal cord blockage, paralysis, blindness, stroke, seizures, nerve injury and brain swelling. And experts are divided on whether steroid shots actually ease back pain. A study published earlier this year in the New England Journal of Medicine found that people who have lower back pain caused by spinal stenosis – a common condition among those over the age of 60 in which the open space in the spinal canal narrows from inflammation – are unlikely to get ... Read more

Related support groups: Back Pain, Prednisone, Methylprednisolone, Prednisolone, Hydrocortisone, Medrol, Cortisone, Triamcinolone, Dexamethasone, Betamethasone, Budesonide, Entocort, Decadron, Solu-Medrol, Entocort EC, Cortef, MethylPREDNISolone Dose Pack, Medrol Dosepak, Depo-Medrol, Orapred

Newer Drug Helps Myeloma Patients Who Can't Have Transplant

Posted 3 Sep 2014 by Drugs.com

WEDNESDAY, Sept. 3, 2014 – A cancer drug that targets the immune system may help improve the outlook for older adults with multiple myeloma, though a stem cell transplant remains the standard of care for relatively younger patients. Those are some of the findings from two studies in the Sept. 4 issue of the New England Journal of Medicine. Multiple myeloma is a cancer that begins in certain white blood cells. In the United States, it accounts for about 1 percent of cancers, and for those who develop it, it's often deadly. About 45 percent of Americans with the disease are still alive five years after diagnosis, according to the U.S. National Cancer Institute. For years, the standard treatment – at least for patients younger than 65 – has involved removing blood-forming stem cells from the patient's bone marrow or bloodstream, then using high-dose chemo to kill off the myeloma cells. ... Read more

Related support groups: Prednisone, Dexamethasone, Multiple Myeloma, Revlimid, Decadron, Thalidomide, Deltasone, Alkeran, Decadron Tablets, Rayos, Lenalidomide, Sterapred, Dexone, Adrenocot, Thalomid, Melphalan, Sterapred DS, Adrenocot LA, Liquid Pred, Dalalone DP

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