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Posted 8 Mar 2012 by Drugs.com
WEDNESDAY, March 7 – The drug misoprostol reduced major complications from early surgical abortion by nearly one-third, according to a new study. Doctors often use misoprostol for cervical preparation prior to surgical abortion (vacuum aspiration). Until now, however, there were no studies large enough to determine whether the drug reduces the risk of serious complications, either immediate or delayed, according to background information in the study published in the March 8 online edition of The Lancet. For the study, researchers from the World Health Organization (WHO) in Geneva compared rates of complications among nearly 5,000 women in nine countries who underwent surgical abortion before 12 weeks of gestation. Complications included cervical tear, uterine perforation, incomplete abortion and pelvic inflammatory disease. Women were randomly assigned to receive either vaginal ... Read more
Posted 8 Jul 2009 by Drugs.com
WEDNESDAY, July 8 – Two changes to the way Planned Parenthood clinics perform medical abortion resulted in a 93 percent drop in the rate of serious infections, a new report says. The changes involved administering the drug misoprostol to the area between the gum and the cheek (buccal administration), not the vagina, and introducing routine treatment with antibiotics. "Planned Parenthood is very happy with the regimen," said Mary Fjerstad, lead author of a paper appearing in the July 9 issue of the New England Journal of Medicine. "We've got the same head-to-head efficacy as with vaginal delivery and a significant reduction in infections. And, since we added antibiotics, we have a further drop in serious infections," added Fjerstad, a nurse practitioner who was director of clinical quality improvement at the Planned Parenthood Federation of America when the study was conducted. She is ... Read more