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Statins Often Interact With Other Heart Drugs

Posted 17 Oct 2016 by Drugs.com

MONDAY, Oct. 17, 2016 – Cholesterol-lowering statins can interact with other drugs prescribed for heart disease. But there are ways to navigate the problem, according to new recommendations from the American Heart Association. Statins are among the mostly widely prescribed drugs in the United States. Roughly one-quarter of Americans age 40 and up are on a statin, according to a 2014 study by the U.S. Centers for Disease Control and Prevention. The drugs are prescribed to people who either have atherosclerosis (clogged arteries) or are at risk of it, which means many statin users also take other cardiovascular drugs, the heart association says. The benefits of those drug combinations will generally outweigh the risks, said Barbara Wiggins, a clinical pharmacy specialist in cardiology at the Medical University of South Carolina. But doctors and patients should be aware of how the drugs ... Read more

Related support groups: Warfarin, Coumadin, Amlodipine, Lipitor, Simvastatin, Crestor, Diltiazem, Atorvastatin, Norvasc, Pravastatin, Verapamil, Amiodarone, Digoxin, Nifedipine, Cardizem, Zocor, Azor, Lovastatin, Exforge, Rosuvastatin

FDA Warns of Cardiac Effect When Heart Drug Mixed With Hepatitis C Meds

Posted 25 Mar 2015 by Drugs.com

WEDNESDAY, March 25, 2015 – A potentially life-threatening slowing of the heart can occur when the common heart drug amiodarone is taken with new hepatitis C medications, the U.S. Food and Drug Administration warns. The dangerous slowing of the heart – called symptomatic bradycardia – can occur when amiodarone is taken with the hepatitis C drugs Harvoni (ledipasvir/sofosbuvir) or Sovaldi (sofosbuvir) and combined with another direct-acting antiviral for the treatment of hepatitis C. Harvoni and Sovaldi are two new medicines recently approved by the FDA to help rid the body of hepatitis C infection. If left untreated, hepatitis C infection can damage the liver and raise the odds of liver failure and liver cancer. Amiodarone is commonly used to treat heartbeat irregularities, the FDA noted in a news release. Information about the risk of the drugs used in combination is being added to ... Read more

Related support groups: Hepatitis C, Harvoni, Amiodarone, Sovaldi, Bradyarrhythmia, Sofosbuvir, Cordarone, Pacerone, Nexterone, Cordarone IV

FDA Medwatch Alert: Hepatitis C Treatments Containing Sofosbuvir in Combination With Another Direct Acting Antiviral Drug: Drug Safety Communication - Serious Slowing of Heart Rate When Used With Antiarrhythmic Drug Amiodarone

Posted 24 Mar 2015 by Drugs.com

[Posted 03/24/2015] ISSUE: FDA is warning that serious slowing of the heart rate can occur when the antiarrhythmic drug amiodarone is taken together with either the hepatitis C drug Harvoni (ledipasvir/sofosbuvir) or with Sovaldi (sofosbuvir) taken in combination with another direct acting antiviral for the treatment of hepatitis C infection. FDA is adding information about serious slowing of the heart rate, known as symptomatic bradycardia, to the Harvoni and Sovaldi labels. FDA is recommending that health care professionals should not prescribe either Harvoni or Sovaldi combined with another direct acting antiviral, such as the investigational drug daclatasvir or Olysio (simeprevir), with amiodarone. FDA review of submitted postmarketing adverse event reports found that patients can develop a serious and life-threatening symptomatic bradycardia when either Harvoni or Sovaldi ... Read more

Related support groups: Hepatitis C, Harvoni, Amiodarone, Sovaldi, Sofosbuvir, Cordarone, Pacerone, Ledipasvir/sofosbuvir, Olysio, Simeprevir, Cordarone IV, Nexterone

Health Tip: When Food and Drugs Interact

Posted 27 Feb 2014 by Drugs.com

-- When food and drinks interact with medication, the medication may not work sufficiently or the drug can become too powerful as the body has trouble handling it properly. The Academy of Nutrition and Dietetics mentions these common examples of food and drug interaction: Grapefruit juice interacts with several drugs and may affect the way the body metabolizes medication. Drugs that may interact with grapefruit juice include: some statins, antihistamines, thyroid medications, blood pressure medications, birth control pills, cough suppressants and medications that block stomach acids. Blood-thinning medications can interact with leafy green vegetables, affecting the blood's clotting ability. Natural black licorice may interact with certain blood pressure medications and blood-thinning medications. Salt substitutes can interact with ACE inhibitors and digoxin. Tyramine (found in foods ... Read more

Related support groups: Plan B, Hydrocodone, Mirena, NuvaRing, Sprintec, Provera, Nexplanon, Implanon, Depo-Provera, Codeine, Ortho Tri-Cyclen, Tri-Sprintec, Yasmin, Microgestin Fe 1/20, Amlodipine, Loestrin 24 Fe, Ortho Evra, Plan B One-Step, TriNessa, Lutera

Common Heart Drug Linked to Cancer Risk in Study

Posted 8 Apr 2013 by Drugs.com

MONDAY, April 8 – A drug called amiodarone that's widely used to treat heartbeat irregularities might raise a patient's risk of cancer, Taiwanese researchers report. The risk, which the researchers termed "borderline significantly increased," is more pronounced in men and patients who take high doses of the drug, according to the study, which was published online April 8 in the journal Cancer. "When prescribing amiodarone, doctors need to keep in mind that this medication may increase cancer risk," said lead author Dr. Vincent Yi-Fong Su, from the Taipei Veterans General Hospital. "We suggest that cancer events should be routinely reported in future amiodarone trials, and further observational research is necessary." Patients taking the drug, however, shouldn't fear they'll get cancer, one expert said. "Amiodarone is among the most effective antiarrhythmic medications available," said ... Read more

Related support groups: Amiodarone, Cordarone, Pacerone, Nexterone, Cordarone IV

More New Drugs a Bad Fit With Grapefruit, Study Finds

Posted 26 Nov 2012 by Drugs.com

MONDAY, Nov. 26 – Because of new chemical formulations, prescription drugs that interact badly with grapefruit have more than doubled in number since 2008, yet many doctors seem unaware of this, Canadian researchers report. "The number of drugs on the market with the potential to produce serious adverse and in many cases life-threatening effects when combined with grapefruit has markedly increased over the past few years from 17 to 43 in four years," said lead researcher David Bailey, from the Lawson Health Research Institute in London, Ontario. "There is much greater need for health care professionals to understand grapefruit/drug interactions and to apply this information to the safer use of these drugs in their clinical practice," Bailey said. Even small amounts of grapefruit or grapefruit juice have the potential to cause sudden death, acute kidney failure, respiratory failure, ... Read more

Related support groups: Plavix, Lipitor, Simvastatin, Atorvastatin, Pravastatin, Amiodarone, Clopidogrel, Nifedipine, Zocor, Cyclosporine, Adalat, Pravachol, Procardia, Procardia XL, Neoral, Cordarone, Nifedical XL, Nifediac CC, Adalat CC, Pacerone

Accidental Medication Poisonings in Kids on the Rise

Posted 16 Sep 2011 by Drugs.com

FRIDAY, Sept. 16 – Despite ongoing prevention efforts, a growing number of young children are being accidentally poisoned with medications, according to new research. The study, which was based on data reported to the American Association of Poison Control Centers between 2001 and 2008, found that medication poisoning among children aged 5 and under increased by 22 percent, although the number of children in the United States in this age group rose by only 8 percent during the study period. "The problem of pediatric poisoning in the U.S. is getting worse, not better," Dr. Randall Bond, of Cincinnati Children's Hospital Medical Center, said in a hospital news release. In conducting the study, which is scheduled for publication in the Journal of Pediatrics, the researchers reviewed information on over 544,000 children who landed in the emergency department due to medication poisoning ... Read more

Related support groups: Xanax, Suboxone, Oxycodone, Hydrocodone, Methadone, Percocet, OxyContin, Klonopin, Vicodin, Lisinopril, Norco, Fentanyl, Clonazepam, Morphine, Ativan, Ambien, Valium, Codeine, Metoprolol, Lortab

Generic, Brand-Name Heart Drugs Seem to Have Same Effect on Thyroid

Posted 13 Jul 2011 by Drugs.com

WEDNESDAY, July 13 – For patients taking the heart rhythm drug amiodarone (Cordarone), generic versions of the drug do not cause more incidents of thyroid dysfunction than the brand-name medication, researchers report. When it comes to thyroid disease, there is no difference between the two drugs, according to the report released online July 11 in CMAJ (Canadian Medical Association Journal). Amiodarone, a drug used to control arrhythmia – a type of irregular heartbeat – is known to cause hypothroidism and hyperthyroidism. These conditions affect the body's metabolism by altering the amount of hormone produced by the thyroid gland. Not enough thyroid hormone causes the body to slow down, resulting in weight gain, thinning hair and muscle pain. On the flip side, too much thyroid hormone results in nervousness, weight loss, rapid heart rate and diarrhea. In conducting the study, ... Read more

Related support groups: Amiodarone, Cordarone, Pacerone, Nexterone, Cordarone IV

FDA Medwatch Alert: Needleless Pre-filled Glass Syringes: Stakeholder Advisory - Compatibility Problems with Needleless Intravenous Access Systems

Posted 7 May 2011 by Drugs.com

Reports Received on Adenosine and Amiodarone Products   [UPDATED 05/06/2011] FDA recommends that, to reduce the potential risks to patients, healthcare professionals and risk managers stock crash carts, ambulances, and emergency rooms with adenosine and amiodarone supplied in vials or pre-filled plastic syringes, if possible. The use of needleless pre-filled glass syringes in emergency situations should be avoided. Refer to the May 2011 FDA Drug Safety Communication, featuring photos, a list of affected adenosine and amiodarone products, and IV access systems known to be incompatible with adenosine and amiodarone pre-filled glass syringes.   [Posted 11/17/2010]   ISSUE: FDA is notifying healthcare professionals, especially those working in emergency and critical care settings, of reports of compatibility problems when certain needleless pre-filled glass syringes are used with some ne ... Read more

Related support groups: Amiodarone, Adenosine, Cordarone, Pacerone, Adeno-jec, Nexterone, Adenoscan, Cordarone IV, Adenocard, My-O-Den

FDA Medwatch Alert: Cordarone (amiodarone HCl)

Posted 10 Jan 2005 by Drugs.com

FDA and Wyeth notified pharmacists and physicians of a new Medication Guide for Cordarone (amiodarone hydrochloride tablets). The FDA regulation 21CFR 208 requires a Medication Guide to be provided with each prescription that is dispensed for products that FDA determines pose a serious and significant public health concern. A list of currently approved Medication Guides are available at http://www.fda.gov/cder/Offices/ODS/labeling.htm. The Medication Guide and current Prescribing Information for Cordarone and its generic equivalents are also provided below.[December 30, 2004 - Dear Healthcare Professional Letter - Wyeth] PDF Format[December 30, 2004 - Dear Pharmacist Letter - Wyeth] PDF Format[December, 2004 - Label - Wyeth][December, 2004 - Medication Guide - Wyeth] Read more

Related support groups: Cordarone

FDA Medwatch Alert: Simvastatin Used With Amiodarone

Posted 8 Aug 2008 by Drugs.com

[Posted 08/08/2008] FDA notified healthcare professionals of the risk of muscle injury, rhabdomyolysis, which can lead to kidney failure or death, when simvastatin is used with amiodarone. This risk is dose-related and increases when a dose of simvastatin greater than 20 mg per day is given with amiodarone. Although a revision of the simvastatin labeling in 2002 described an increased risk of rhabdomyolysis when amiodarone is taken with simvastatin doses greater than 20 mg daily, FDA continues to receive reports of rhabdomyolysis in patients treated concurrently with amiodarone and simvastatin. Prescribers should be aware of the increased risk of rhabdomyolysis when simvastatin is prescribed with amiodarone, and they should avoid doses of simvastatin greater than 20 mg per day in patients taking amiodarone.[August 08, 2008 - Drug Information Page - FDA][August 08, 2008 - Information for ... Read more

Related support groups: Zocor, Vytorin, Simcor, Cordarone

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Arrhythmia, Ventricular Tachycardia, Ventricular Fibrillation, Supraventricular Tachycardia

Cordarone Patient Information at Drugs.com