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Constipation - Drug Induced News

Trouble With Number Twos? One Simple Step May Help

Posted 16 Oct 2017 by Drugs.com

MONDAY, Oct. 16, 2017 – If you're constipated, try grabbing a small footstool before you plunk yourself down on the potty, a new study suggests. Most Westerners sit down on the proverbial throne the way they would sit on a chair, but a novel leg-lifting device offers an option that seems to encourage good bowel movements, researchers report. The footstool helps sitters assume a squat-like position while conducting their business. And that position appears to alter an individual's anatomical angle in a positive way. "A large portion of the world – including Asia, Africa, and [the] Middle East – utilize some form of squatting while having a bowel movement," explained study author Dr. Rohan Modi. In contrast, most people living in the developed countries "have largely transitioned to toilets," he noted. But for those struggling with chronic constipation, the footstool "had a positive ... Read more

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Big Rise in Hospitalized Kids With Opioid Side Effects

Posted 18 Sep 2017 by Drugs.com

MONDAY, Sept. 18, 2017 – There has been a large increase in the number of young hospital patients in the United States who suffer harmful side effects from opioid painkillers, a new study says. The findings show an urgent need for safer pain medications for young patients, the researchers said. The researchers reviewed federal government data on hospital stays by children from 1 month to 17 years old. The data revealed the rate of opioid-related problems among these young hospital patients rose by more than 50 percent over nine years. The overall rate of opioid-related side effects during the study period was almost 17 per 10,000 discharges, the study found. Rates were highest among white children. That finding suggests that race may be a factor in which children are prescribed opioids to treat pain, the researchers said. Opioid-related problems included: opioid withdrawal (3 percent), ... Read more

Related support groups: Oxycodone, Hydrocodone, Percocet, OxyContin, Vicodin, Norco, Constipation, Lortab, Roxicodone, Endocet, Acetaminophen/Hydrocodone, Percocet 10/325, Vicoprofen, Acetaminophen/Oxycodone, Constipation - Drug Induced, Hydromet, Roxicet, Tussionex Pennkinetic, Vicodin ES, Lorcet 10/650

Health Tip: Help Manage Constipation

Posted 20 Apr 2017 by Drugs.com

-- Many lifestyle factors – such as diet, exercise and fluid intake – are associated with constipation. To help tame the problem, the Cleveland Clinic recommends: Drink two-to-four cups of water daily. Also drink warm liquids, particularly in the morning. Eat plenty of fruit (such as prunes) and vegetables. Eat bran cereals. Take a fiber supplement. Get regular exercise. Use a mild stool softener or laxative, but don't take it for longer than necessary (two weeks maximum). See your doctor if symptoms don't improve within three weeks. Read more

Related support groups: Peri-DS, Constipation, MiraLax, Magnesium Citrate, Constipation - Chronic, Dulcolax, Suprep, Lactulose, Milk of Magnesia, Metamucil, Fleet Enema, Polyethylene Glycol 3350, Bisacodyl, Epsom Salt, MoviPrep, Senokot, Constipation - Acute, Senna, Constipation - Drug Induced, Suprep Bowel Prep Kit

FDA Approves Symproic (naldemedine) for the Treatment of Opioid-Induced Constipation

Posted 24 Mar 2017 by Drugs.com

OSAKA, Japan and FLORHAM PARK, N.J. and STAMFORD, Conn., March 23, 2017 /PRNewswire/ – Shionogi Inc. and Purdue Pharma L.P. announced today that the U.S. Food and Drug Administration (FDA) approved Symproic® (naldemedine) 0.2 mg tablets C-II as a once-daily oral peripherally-acting mu-opioid receptor antagonist (PAMORA) medication for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain. Symproic is currently a Schedule II controlled substance because it is structurally related to naltrexone. Shionogi Inc. submitted a petition for the descheduling of Symproic, or removal of the controlled substance classification, to the U.S. Drug Enforcement Administration (DEA), which is currently under evaluation. Symproic will be jointly launched and commercialized in the U.S. with Purdue Pharma and is expected to be commercially available mid-summer. ... Read more

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Trulance Approved for Chronic Constipation

Posted 22 Jan 2017 by Drugs.com

FRIDAY, Jan. 20, 2017 – Trulance (plecanatide) has been approved by the U.S. Food and Drug Administration to treat persistent constipation of unknown (idiopathic) cause in adults. Some 42 million people in the United States are affected by constipation, according to the National Institutes of Health. Once-daily Trulance is designed to stimulate the upper gastrointestinal tract to secrete fluid and "support regular bowel function," the FDA said in a news release. The oral drug was evaluated in two 12-week clinical studies involving a total of 1,775 adults with chronic constipation. Diarrhea was the most common side effect. If diarrhea becomes severe, users should stop taking Trulance and contact a doctor, the FDA advised. Trulance is produced by New York City-based Synergy Pharmaceuticals. More information Visit the FDA to learn more about this approval. Read more

Related support groups: Diarrhea, Constipation, Constipation - Chronic, Constipation - Drug Induced, Trulance, Diarrhea, Acute, Fecal Impaction, Plecanatide

Constipation, Kidney Disease May Be Linked, New Research Shows

Posted 11 Nov 2016 by Drugs.com

THURSDAY, Nov. 10, 2016 – People with constipation are more likely to develop kidney disease, a new study finds. The discovery suggests kidney problems might be prevented or treated by managing constipation, according to researchers at the University of Tennessee Health Science Center and Memphis VA Medical Center. They studied the medical records of 3.5 million U.S. veterans with normal kidney function. They were tracked from 2004 to 2006, and followed through 2013. Those with constipation were 13 percent more likely than patients without constipation to develop chronic kidney disease and 9 percent more likely to experience kidney failure. The risk was even higher for those whose constipation was more severe. The study did not prove that constipation causes kidney disease or failure, however. Instead, "Our findings highlight the plausible link between the gut and the kidneys and ... Read more

Related support groups: Constipation, Renal Failure, Constipation - Chronic, Chronic Kidney Disease, Constipation - Acute, Constipation - Drug Induced, Fecal Impaction, Renal and Genitourinary Disorders

Can Acupuncture Ease Severe Constipation?

Posted 12 Sep 2016 by Drugs.com

MONDAY, Sept. 12, 2016 – People with severe chronic constipation may get relief from a more modern type of acupuncture, new research suggests. After eight weeks of treatment with electroacupuncture – acupuncture involving electrical stimulation – study participants experienced significant symptom and quality-of-life improvements, the study found. Electroacupuncture uses thin needles inserted beneath the skin that are attached to a device that sends electric pulses into the body. The study findings suggest a safe and effective option for difficult-to-treat patients, several gastroenterologists said. "It is heartening to see such rigorously tested alternative therapies, since so many of them are administered without any evidence to support them," said Dr. Christopher Andrews. He's a clinical associate professor in the gastroenterology division at University of Calgary Cumming School of ... Read more

Related support groups: Constipation, Constipation - Chronic, Constipation - Acute, Constipation - Drug Induced

Valeant and Progenics Announce FDA Approves Relistor Tablets for the Treatment of Opioid-Induced Constipation in Adults with Chronic Non-Cancer Pain

Posted 28 Jul 2016 by Drugs.com

LAVAL, Quebec and TARRYTOWN, N.Y., July 19, 2016 /PRNewswire/ – Valeant Pharmaceuticals International, Inc. (NYSE & TSX: VRX) and Progenics Pharmaceuticals, Inc. (Nasdaq: PGNX) today announced that the U.S. Food and Drug Administration has approved Relistor (methylnaltrexone bromide) Tablets for the treatment of opioid-induced constipation (OIC) in adults with chronic non-cancer pain. Valeant expects to commence sales of Relistor Tablets in the U.S. in the third quarter of 2016. "Opioid-induced constipation represents a long-lasting and potentially debilitating side effect of opioid therapy for millions of patients suffering from chronic pain," commented Joseph C. Papa, Chief Executive Officer of Valeant. "We believe Oral Relistor represents a new alternative treatment for OIC, and we look forward to introducing the more convenient oral formulation as soon as practicable." "We are ... Read more

Related support groups: Constipation, Constipation - Drug Induced, Relistor, Methylnaltrexone

Health Tip: Laxatives Have Side Effects

Posted 8 Jun 2016 by Drugs.com

-- Laxatives can have unpleasant side effects, especially when overused. The American Academy of Family Physicians says possible problems associated with laxative use include: Abdominal cramps or nausea. Gas, diarrhea or bloating. Electrolyte imbalance, which can affect the muscles, nerves and organs. Those most at risk include children and people with kidney disease or diabetes. Muscle weakness or muscle spasms. Fatigue, confusion, headache or vomiting. Read more

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Movantik Approved for Constipation From Opioids

Posted 16 Sep 2014 by Drugs.com

TUESDAY, Sept. 16, 2014 – Movantik (naloxegol) has been approved by the U.S. Food and Drug Administration to treat opioid-induced constipation, the agency said Tuesday. Opioids are powerful painkillers that commonly cause constipation. Movantik's safety and effectiveness to treat the problem were evaluated in two clinical studies involving 1,352 people who had taken opioids for at least four weeks for non-cancer related pain. The most common side effects of Movantik were abdominal pain, diarrhea, headache and excessive gas, the FDA said in a news release. Manufacturer AstraZeneca will be required to do an additional study to further evaluate the drug's cardiovascular safety, the agency added. AstraZeneca is based in Wilmington, Del. More information Visit the FDA to learn more. Read more

Related support groups: Suboxone, Oxycodone, Tramadol, Hydrocodone, Methadone, Percocet, OxyContin, Vicodin, Norco, Fentanyl, Morphine, Codeine, Lortab, Opana, Subutex, Dilaudid, Opana ER, MS Contin, Roxicodone, Butrans

New Drug May Treat Constipation Caused by Strong Painkillers

Posted 9 Jun 2014 by Drugs.com

MONDAY, June 9, 2014 – A new drug holds promise as a safe and effective treatment for constipation caused by prescription narcotic painkillers, new research states. Constipation is a common side effect experienced by patients taking these powerful medications for chronic pain. When laxatives failed to provide relief, two phase 3 trials found the once-daily drug naloxegol could help. "The studies showed rapid and sustained improvement for these patients, without compromising their pain management," study author Dr. William Chey, a gastroenterologist and professor of internal medicine at the University of Michigan Health System, said in a university news release. The U.S. Food and Drug Administration, as well as health agencies in Canada and Europe, are reviewing the drug for possible approval. Naloxegol was specifically designed to treat constipation caused by the narcotic painkillers ... Read more

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FDA Approves Amitiza for Opioid-Induced Constipation

Posted 23 Apr 2013 by Drugs.com

BETHESDA, Md. & DEERFIELD, Ill.--(BUSINESS WIRE)--Apr. 23, 2013-- Sucampo Pharmaceuticals, Inc. and Takeda Pharmaceuticals U.S.A., Inc. announced today that the United States (U.S.) Food and Drug Administration (FDA) has approved Sucampo’s supplemental new drug application (sNDA) for Amitiza (lubiprostone) (24 mcg twice daily) as the first and only oral medication for the treatment of opioid-induced constipation (OIC) in adult patients with chronic, non-cancer pain. The effectiveness of Amitiza in the treatment of opioid-induced constipation in patients taking diphenylheptane opioids (e.g., methadone) has not been established. This is the third indication for Amitiza, which is also approved in the U.S. for the treatment of chronic idiopathic constipation (CIC) in adults (24 mcg twice daily) and irritable bowel syndrome with constipation (IBS-C) in adult women (8 mcg twice daily). There ... Read more

Related support groups: Constipation, Amitiza, Constipation - Drug Induced, Lubiprostone

Constipation Treatments Not Equally Effective: Review

Posted 28 Jan 2013 by Drugs.com

MONDAY, Jan. 28 – Some treatments are more effective than others for relieving constipation in seniors, according to a new review. And laxatives aren't always enough, researchers say. Constipation is common in seniors and can have serious health consequences and affect quality of life. Excessive straining in frail elderly people can cause them to faint and put them at risk of injury or falling, or restrict blood flow to the heart and brain. Chronic constipation can lead to fecal impaction, a large lump of hard stool that remains stuck in the rectum. Fecal impaction can cause nausea, pain and loss of appetite. "Given the growing proportion of older adults in North America, effective management of constipation by health care professionals will be increasingly necessary," Dr. Dov Gandell, of Sunnybrook Health Sciences Centre in Toronto, and colleagues wrote in an article appearing Jan. 28 ... Read more

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Amitiza, Movantik, Relistor, lubiprostone, methylnaltrexone, naloxegol